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  1. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

    Citation: Journal of Intensive Care 2021 9:22

    Content type: Correction

    Published on:

    The original article was published in Journal of Intensive Care 2021 9:14

  2. Cellular patterns in bronchoalveolar lavage fluid (BALF) are used to distinguish or rule out particular diseases in patients with acute respiratory failure (ARF). However, whether BALF cellular patterns can pr...

    Authors: Yasutaka Hirasawa, Taka-aki Nakada, Takashi Shimazui, Mitsuhiro Abe, Yuri Isaka, Masashi Sakayori, Kenichi Suzuki, Keiichiro Yoshioka, Takeshi Kawasaki, Jiro Terada, Kenji Tsushima and Koichiro Tatsumi

    Citation: Journal of Intensive Care 2021 9:21

    Content type: Research

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  3. Coronavirus disease 2019 (COVID-19) infection is associated with a prothrombotic state. We performed a meta-analysis of proportions to estimate the weighted average incidence of pulmonary thromboembolism (PTE)...

    Authors: Jun Jie Ng, Zhen Chang Liang and Andrew M. T. L. Choong

    Citation: Journal of Intensive Care 2021 9:20

    Content type: Research

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  4. Immune and inflammatory dysfunction was reported to underpin critical COVID-19(coronavirus disease 2019). We aim to develop a machine learning model that enables accurate prediction of critical COVID-19 using ...

    Authors: Yue Gao, Lingxi Chen, Jianhua Chi, Shaoqing Zeng, Xikang Feng, Huayi Li, Dan Liu, Xinxia Feng, Siyuan Wang, Ya Wang, Ruidi Yu, Yuan Yuan, Sen Xu, Chunrui Li, Wei Zhang, Shuaicheng Li…

    Citation: Journal of Intensive Care 2021 9:19

    Content type: Research

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  5. The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model is widely used to predict mortality in Japanese intensive care units (ICUs). Although the model’s discrimination is excellent, its calibr...

    Authors: Hideki Endo, Shigehiko Uchino, Satoru Hashimoto, Yoshitaka Aoki, Eiji Hashiba, Junji Hatakeyama, Katsura Hayakawa, Nao Ichihara, Hiromasa Irie, Tatsuya Kawasaki, Junji Kumasawa, Hiroshi Kurosawa, Tomoyuki Nakamura, Hiroyuki Ohbe, Hiroshi Okamoto, Hidenobu Shigemitsu…

    Citation: Journal of Intensive Care 2021 9:18

    Content type: Research

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  6. Acute respiratory distress syndrome (ARDS) is a fatal condition with insufficiently clarified etiology. Supportive care for severe hypoxemia remains the mainstay of essential interventions for ARDS. In recent ...

    Authors: Shinichiro Ohshimo

    Citation: Journal of Intensive Care 2021 9:17

    Content type: Review

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  7. Unavailability or saturation of the intensive care unit may be associated with the fatality of COVID-19. Prioritizing the patients for hospitalization and intensive care may be critical for reducing the fatali...

    Authors: JoonNyung Heo, Deokjae Han, Hyung-Jun Kim, Daehyun Kim, Yeon-Kyeng Lee, Dosang Lim, Sung Ok Hong, Mi-Jin Park, Beomman Ha and Woong Seog

    Citation: Journal of Intensive Care 2021 9:16

    Content type: Research

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  8. Inappropriate authors’ self-citation (A-SC) is a growing mal-practice possibly boosted by the raising importance given to author’s metrics. Similarly, also excessive journals’ self-citation (J-SC) practice may...

    Authors: Filippo Sanfilippo, Stefano Tigano, Alberto Morgana, Paolo Murabito and Marinella Astuto

    Citation: Journal of Intensive Care 2021 9:15

    Content type: Commentary

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  9. The acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing p...

    Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

    Citation: Journal of Intensive Care 2021 9:14

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2021 9:22

  10. Persistent apnea despite an adequate rise in arterial pressure of CO2 is an essential component of the criteria for brain death (BD) determination. Current guidelines vary regarding the utility of arterial pH cha...

    Authors: Ibrahim Migdady, Moein Amin, Aaron Shoskes, Catherine Hassett, Sung-Min Cho, Pravin George and Alexander Rae-Grant

    Citation: Journal of Intensive Care 2021 9:13

    Content type: Research

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  11. Sepsis is characterized by various hemodynamic alterations which could happen concomitantly in the heart, pulmonary and systemic circulations. A comprehensive demonstration of their interactions in the clinica...

    Authors: François Bagate, Paul Masi, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux, Genevieve Derumeaux and Armand Mekontso Dessap

    Citation: Journal of Intensive Care 2021 9:12

    Content type: Research

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  12. SARS-CoV-2 may cause acute lung injury, and secondary infections are thus relevant complications in patients with COVID-19 pneumonia. However, detailed information on community- and hospital-acquired infection...

    Authors: Kirstine K. Søgaard, Veronika Baettig, Michael Osthoff, Stephan Marsch, Karoline Leuzinger, Michael Schweitzer, Julian Meier, Stefano Bassetti, Roland Bingisser, Christian H. Nickel, Nina Khanna, Sarah Tschudin-Sutter, Maja Weisser, Manuel Battegay, Hans H. Hirsch, Hans Pargger…

    Citation: Journal of Intensive Care 2021 9:10

    Content type: Research

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  13. This systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19).

    Authors: Arief Wibowo, Raymond Pranata, Astri Astuti, Badai Bhatara Tiksnadi, Erwan Martanto, Januar Wibawa Martha, Augustine Purnomowati and Mohammad Rizki Akbar

    Citation: Journal of Intensive Care 2021 9:9

    Content type: Research

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  14. The use of indirect calorimetry is strongly recommended to guide nutrition therapy in critically ill patients, preventing the detrimental effects of under- and overfeeding. However, the course of energy expend...

    Authors: Hanneke Pierre Franciscus Xaverius Moonen, Karin Josephina Hubertina Beckers and Arthur Raymond Hubert van Zanten

    Citation: Journal of Intensive Care 2021 9:8

    Content type: Review

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  15. To demonstrate feasibility of a music medicine intervention trial in pediatric intensive care and to obtain information on sedation and analgesia dose variation to plan a larger trial.

    Authors: Gonzalo Garcia Guerra, Ari R. Joffe, Cathy Sheppard, Krista Hewson, Irina A. Dinu, Morteza Hajihosseini, Allan deCaen, Hsing Jou, Lisa Hartling and Sunita Vohra

    Citation: Journal of Intensive Care 2021 9:7

    Content type: Research

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  16. Accidental hypothermia is a critical condition with high risks of fatal arrhythmia, multiple organ failure, and mortality; however, there is no established model to predict the mortality. The present study aim...

    Authors: Yohei Okada, Tasuku Matsuyama, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Ryoji Iiduka and Shigeru Ohtsuru

    Citation: Journal of Intensive Care 2021 9:6

    Content type: Research

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  17. During COVID-19 pandemic, visits have been prohibited in most French ICUs. Psychological effects, for reference persons (RPs), of remote-only communication have been assessed.

    Authors: Jessy Cattelan, Sara Castellano, Hamid Merdji, Jean Audusseau, Baptiste Claude, Léa Feuillassier, Sibylle Cunat, Marc Astrié, Camille Aquin, Guillaume Buis, Edgar Gehant, Amandine Granier, Hassiba Kercha, Camille Le Guillou, Guillaume Martin, Kevin Roulot…

    Citation: Journal of Intensive Care 2021 9:5

    Content type: Research

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  18. Improving neurological outcomes after cardiac arrest (CA) is the most important patient-oriented outcome for CA research. Near-infrared spectroscopy (NIRS) enables a non-invasive, real-time measurement of regi...

    Authors: Ryosuke Takegawa, Kei Hayashida, Rishabh Choudhary, Daniel M. Rolston and Lance B. Becker

    Citation: Journal of Intensive Care 2021 9:4

    Content type: Letter to the Editor

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  19. The lack of precise information on the epidemiology of peripheral intravascular catheter (PIVC)-related phlebitis and complications in critically ill patients results in the absence of appropriate preventive m...

    Authors: Hideto Yasuda, Ryohei Yamamoto, Yoshiro Hayashi, Yuki Kotani, Yuki Kishihara, Natsuki Kondo, Kosuke Sekine, Nobuaki Shime, Keita Morikane, Takayuki Abe, Toru Takebayashi, Mikihiro Maeda, Takuya Shiga, Taku Furukawa, Mototaka Inaba, Sachito Fukuda…

    Citation: Journal of Intensive Care 2021 9:3

    Content type: Research

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  20. Globally, mortality rates of patients admitted to the intensive care unit (ICU) have decreased over the last two decades. However, evaluations of the temporal trends in the characteristics and outcomes of ICU ...

    Authors: Lowell Ling, Chun Ming Ho, Pauline Yeung Ng, King Chung Kenny Chan, Hoi Ping Shum, Cheuk Yan Chan, Alwin Wai Tak Yeung, Wai Tat Wong, Shek Yin Au, Kit Hung Anne Leung, Jacky Ka Hing Chan, Chi Keung Ching, Oi Yan Tam, Hin Hung Tsang, Ting Liong, Kin Ip Law…

    Citation: Journal of Intensive Care 2021 9:2

    Content type: Research

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  21. Aggressive fluid administration is recommended in the resuscitation of septic patients. However, the delivery of a rapid fluid bolus might cause harm by inducing degradation of the endothelial glycocalyx. This...

    Authors: Jutamas Saoraya, Lipda Wongsamita, Nattachai Srisawat and Khrongwong Musikatavorn

    Citation: Journal of Intensive Care 2021 9:1

    Content type: Research

    Published on:

  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lorenzo Gamberini, Tommaso Tonetti, Savino Spadaro, Gianluca Zani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Alberto Fogagnolo, Maurizio Fusari…

    Citation: Journal of Intensive Care 2020 8:96

    Content type: Correction

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:80

  23. Clinical evidence showing the effectiveness of recombinant human soluble thrombomodulin (rhTM) for treating sepsis-induced disseminated intravascular coagulation (DIC) and organ dysfunction (particularly renal...

    Authors: Masayuki Akatsuka, Yoshiki Masuda, Hiroomi Tatsumi and Tomoko Sonoda

    Citation: Journal of Intensive Care 2020 8:94

    Content type: Research

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  24. Focused cardiac ultrasound (FoCUS) is a valuable skill for rapid assessment of cardiac function and volume status. Despite recent widespread adoption among physicians, there is limited data on the optimal trai...

    Authors: Lauren E. Gibson, Gabrielle A. White-Dzuro, Patrick J. Lindsay, Sheri M. Berg, Edward A. Bittner and Marvin G. Chang

    Citation: Journal of Intensive Care 2020 8:93

    Content type: Review

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  25. Current evidence supporting the utility of electromagnetic (EM)-guided method as the preferred technique for post-pyloric feeding tube placement is limited. We conducted a meta-analysis to compare the performa...

    Authors: Yaping Wei, Zheng Jin, Ying Zhu and Wei Hu

    Citation: Journal of Intensive Care 2020 8:92

    Content type: Research

    Published on:

  26. The effect of corticosteroid treatment on survival outcome in early acute respiratory distress syndrome (ARDS) is still debated. We conducted a systematic review and meta-analysis of randomized controlled tria...

    Authors: Yohei Hirano, Shunsuke Madokoro, Yutaka Kondo, Ken Okamoto and Hiroshi Tanaka

    Citation: Journal of Intensive Care 2020 8:91

    Content type: Research

    Published on:

  27. This study aimed to identify the association between total visitation restriction because of the coronavirus 2019 (COVID-19) pandemic and the incidence of delirium for emergency inpatients.

    Authors: Kenji Kandori, Yohei Okada, Wataru Ishii, Hiromichi Narumiya, Yoshiro Maebayashi and Ryoji Iizuka

    Citation: Journal of Intensive Care 2020 8:90

    Content type: Research

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  28. Ginsenosides have antioxidant and anti-inflammatory features. This study aimed to evaluate the biologic effects of ginsenoside Rb2 pretreatment on ventilator-induced lung injury (VILI) in rats.

    Authors: Woo Hyun Cho, Yun Hak Kim, Hye Jin Heo, Dohyung Kim, Tae Won Kwak, Kwang Ho Kim and Hye Ju Yeo

    Citation: Journal of Intensive Care 2020 8:89

    Content type: Research

    Published on:

  29. The clinical significance of cardiac troponin measurement in patients hospitalised for coronavirus disease 2019 (covid-19) is uncertain. We investigated the prevalence of elevated troponins in these patients a...

    Authors: Bing-Cheng Zhao, Wei-Feng Liu, Shao-Hui Lei, Bo-Wei Zhou, Xiao Yang, Tong-Yi Huang, Qi-Wen Deng, Miao Xu, Cai Li and Ke-Xuan Liu

    Citation: Journal of Intensive Care 2020 8:88

    Content type: Research

    Published on:

  30. Lower limb muscle atrophy is often observed in critically ill patients. Although upper limb muscles can undergo atrophy, it remains unclear how this atrophy is associated with clinical outcomes. We hypothesize...

    Authors: Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Yusuke Akimoto, Yuki Nakano and Masaji Nishimura

    Citation: Journal of Intensive Care 2020 8:87

    Content type: Research

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  31. Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but breakpoints of target attainment are mostly based on expert opinions. Studies that show a correlation between target attainment and...

    Authors: Christina Scharf, Uwe Liebchen, Michael Paal, Max Taubert, Michael Vogeser, Michael Irlbeck, Michael Zoller and Ines Schroeder

    Citation: Journal of Intensive Care 2020 8:86

    Content type: Research

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  32. Cardiogenic shock complicates 5–10% of myocardial infarction (MI) cases. Data about the benefit of glycoprotein IIb/IIIa inhibitors (GPI) in these patients is sparse and conflicting.

    Authors: Carolina Saleiro, Rogério Teixeira, Diana De Campos, João Lopes, Bárbara Oliveiros, Marco Costa and Lino Gonçalves

    Citation: Journal of Intensive Care 2020 8:85

    Content type: Review

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  33. Norepinephrine (NE) has currently been the first-choice vasopressor in treating septic shock despite generally insufficient for patients with refractory septic shock. The aim of this update meta-analysis was t...

    Authors: Lei Zhong, Xiao-Wei Ji, Hai-Li Wang, Guang-Ming Zhao, Qing Zhou and Bo Xie

    Citation: Journal of Intensive Care 2020 8:83

    Content type: Research

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  34. Patients in the intensive care unit (ICU) are increasingly being transferred between ICUs due to a shortage of ICU beds, although this practice is potentially harmful. However, in tertiary units, the transfer ...

    Authors: Jonatan Oras, Marko Strube and Christian Rylander

    Citation: Journal of Intensive Care 2020 8:82

    Content type: Research

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  35. Ventilator-associated pneumonia (VAP) is reported as the second most common nosocomial infection among critically ill patients with the incidence ranging from 2 to 16 episodes per 1000 ventilator days. The use...

    Authors: Priyam Batra, Kapil Dev Soni and Purva Mathur

    Citation: Journal of Intensive Care 2020 8:81

    Content type: Review

    Published on:

  36. A large proportion of patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure requiring admission to the intensive care unit (ICU) and about 80% of them need mechanical ventilation...

    Authors: Lorenzo Gamberini, Tommaso Tonetti, Savino Spadaro, Gianluca Zani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Alberto Fogagnolo, Maurizio Fusari…

    Citation: Journal of Intensive Care 2020 8:80

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2020 8:96

  37. Acute respiratory distress syndrome (ARDS) and volume overload are associated with increased hospital mortality. Evidence supports conservative fluid management in ARDS, but whether current practice reflects t...

    Authors: Kevin P. Seitz, Ellen S. Caldwell and Catherine L. Hough

    Citation: Journal of Intensive Care 2020 8:78

    Content type: Research

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  38. The prolonged β-lactam infusion strategy has emerged as the standard treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess the efficacy of prolonged versus intermittent ...

    Authors: Yutaka Kondo, Kohei Ota, Haruki Imura, Naoki Hara and Nobuaki Shime

    Citation: Journal of Intensive Care 2020 8:77

    Content type: Research

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  39. Sepsis, a dysregulated host response following infection, is associated with massive immune activation and high mortality rates. There is still a need to define further risk factors and laboratory parameters p...

    Authors: Anna Brandtner, Piotr Tymoszuk, Manfred Nairz, Georg F. Lehner, Gernot Fritsche, Anja Vales, Andreas Falkner, Harald Schennach, Igor Theurl, Michael Joannidis, Günter Weiss and Christa Pfeifhofer-Obermair

    Citation: Journal of Intensive Care 2020 8:76

    Content type: Research

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  40. The prevalence of frailty, an important risk factor for short- and long-term outcomes in hospitalized adults, differs by sex. Studies in critically ill adults have also found differences in mortality and organ...

    Authors: Erin Hessey, Carmel Montgomery, Danny J. Zuege, Darryl Rolfson, Henry T. Stelfox, Kirsten M. Fiest and Sean M. Bagshaw

    Citation: Journal of Intensive Care 2020 8:75

    Content type: Research

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  41. In response to comments raised, we acknowledge the shortcomings of our study. It is a small study. However, it is a pilot study, which is not meant to create generalizable data, rather to explore new potential...

    Authors: Ofer Sadan and Owen Samuels

    Citation: Journal of Intensive Care 2020 8:74

    Content type: Commentary

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:73

  42. Sadan et al. find an association between acute kidney injury and high chloride containing a hypertonic solution. Recent large prospective non-randomized studies bring conflicting results on the relationship be...

    Authors: Gildas Gueret, Pierre Lefebvre, Pascale Le Maguet and Renaud Fabre

    Citation: Journal of Intensive Care 2020 8:73

    Content type: Commentary

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:32

    The Commentary to this article has been published in Journal of Intensive Care 2020 8:74

  43. Scientific evidence indicates that endothelial glycocalyx (EG) shedding contributes to the pathophysiological installation of acute respiratory distress syndrome (ARDS) after bacterial sepsis. The aim was to e...

    Authors: Maira Nilson Benatti, Alexandre Todorovic Fabro and Carlos Henrique Miranda

    Citation: Journal of Intensive Care 2020 8:72

    Content type: Research

    Published on:

  44. A high rate of thrombotic complications, such as pulmonary embolism, has been linked to mortality in COVID-19, and appropriate treatment of thrombosis is important for lifesaving. Although heparin is frequentl...

    Authors: Hidesaku Asakura and Haruhiko Ogawa

    Citation: Journal of Intensive Care 2020 8:71

    Content type: Letter to the Editor

    Published on:

  45. Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and...

    Authors: Samhati Mondal, Ashley L. Quintili, Kunal Karamchandani and Somnath Bose

    Citation: Journal of Intensive Care 2020 8:70

    Content type: Review

    Published on:

  46. The choice of intravenous infusion products for critically ill patients has been studied extensively because it can affect prognosis. However, there has been little research on drug diluents in this context. T...

    Authors: Yukari Aoyagi, Takuo Yoshida, Shigehiko Uchino, Masanori Takinami and Shoichi Uezono

    Citation: Journal of Intensive Care 2020 8:69

    Content type: Research

    Published on: