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  1. Ginsenosides have antioxidant and anti-inflammatory features. This study aimed to evaluate the biologic effects of ginsenoside Rb2 pretreatment on ventilator-induced lung injury (VILI) in rats.

    Authors: Woo Hyun Cho, Yun Hak Kim, Hye Jin Heo, Dohyung Kim, Tae Won Kwak, Kwang Ho Kim and Hye Ju Yeo

    Citation: Journal of Intensive Care 2020 8:89

    Content type: Research

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  2. The clinical significance of cardiac troponin measurement in patients hospitalised for coronavirus disease 2019 (covid-19) is uncertain. We investigated the prevalence of elevated troponins in these patients a...

    Authors: Bing-Cheng Zhao, Wei-Feng Liu, Shao-Hui Lei, Bo-Wei Zhou, Xiao Yang, Tong-Yi Huang, Qi-Wen Deng, Miao Xu, Cai Li and Ke-Xuan Liu

    Citation: Journal of Intensive Care 2020 8:88

    Content type: Research

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  3. Lower limb muscle atrophy is often observed in critically ill patients. Although upper limb muscles can undergo atrophy, it remains unclear how this atrophy is associated with clinical outcomes. We hypothesize...

    Authors: Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Yusuke Akimoto, Yuki Nakano and Masaji Nishimura

    Citation: Journal of Intensive Care 2020 8:87

    Content type: Research

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  4. Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but breakpoints of target attainment are mostly based on expert opinions. Studies that show a correlation between target attainment and...

    Authors: Christina Scharf, Uwe Liebchen, Michael Paal, Max Taubert, Michael Vogeser, Michael Irlbeck, Michael Zoller and Ines Schroeder

    Citation: Journal of Intensive Care 2020 8:86

    Content type: Research

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  5. Cardiogenic shock complicates 5–10% of myocardial infarction (MI) cases. Data about the benefit of glycoprotein IIb/IIIa inhibitors (GPI) in these patients is sparse and conflicting.

    Authors: Carolina Saleiro, Rogério Teixeira, Diana De Campos, João Lopes, Bárbara Oliveiros, Marco Costa and Lino Gonçalves

    Citation: Journal of Intensive Care 2020 8:85

    Content type: Review

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  6. Norepinephrine (NE) has currently been the first-choice vasopressor in treating septic shock despite generally insufficient for patients with refractory septic shock. The aim of this update meta-analysis was t...

    Authors: Lei Zhong, Xiao-Wei Ji, Hai-Li Wang, Guang-Ming Zhao, Qing Zhou and Bo Xie

    Citation: Journal of Intensive Care 2020 8:83

    Content type: Research

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  7. Patients in the intensive care unit (ICU) are increasingly being transferred between ICUs due to a shortage of ICU beds, although this practice is potentially harmful. However, in tertiary units, the transfer ...

    Authors: Jonatan Oras, Marko Strube and Christian Rylander

    Citation: Journal of Intensive Care 2020 8:82

    Content type: Research

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  8. Ventilator-associated pneumonia (VAP) is reported as the second most common nosocomial infection among critically ill patients with the incidence ranging from 2 to 16 episodes per 1000 ventilator days. The use...

    Authors: Priyam Batra, Kapil Dev Soni and Purva Mathur

    Citation: Journal of Intensive Care 2020 8:81

    Content type: Review

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  9. A large proportion of patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure requiring admission to the intensive care unit (ICU) and about 80% of them need mechanical ventilation...

    Authors: Lorenzo Gamberini, Tommaso Tonetti, Savino Spadaro, Gianluca Zani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Alberto Fogagnolo, Maurizio Fusari…

    Citation: Journal of Intensive Care 2020 8:80

    Content type: Research

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  10. Acute respiratory distress syndrome (ARDS) and volume overload are associated with increased hospital mortality. Evidence supports conservative fluid management in ARDS, but whether current practice reflects t...

    Authors: Kevin P. Seitz, Ellen S. Caldwell and Catherine L. Hough

    Citation: Journal of Intensive Care 2020 8:78

    Content type: Research

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  11. The prolonged β-lactam infusion strategy has emerged as the standard treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess the efficacy of prolonged versus intermittent ...

    Authors: Yutaka Kondo, Kohei Ota, Haruki Imura, Naoki Hara and Nobuaki Shime

    Citation: Journal of Intensive Care 2020 8:77

    Content type: Research

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  12. Sepsis, a dysregulated host response following infection, is associated with massive immune activation and high mortality rates. There is still a need to define further risk factors and laboratory parameters p...

    Authors: Anna Brandtner, Piotr Tymoszuk, Manfred Nairz, Georg F. Lehner, Gernot Fritsche, Anja Vales, Andreas Falkner, Harald Schennach, Igor Theurl, Michael Joannidis, Günter Weiss and Christa Pfeifhofer-Obermair

    Citation: Journal of Intensive Care 2020 8:76

    Content type: Research

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  13. The prevalence of frailty, an important risk factor for short- and long-term outcomes in hospitalized adults, differs by sex. Studies in critically ill adults have also found differences in mortality and organ...

    Authors: Erin Hessey, Carmel Montgomery, Danny J. Zuege, Darryl Rolfson, Henry T. Stelfox, Kirsten M. Fiest and Sean M. Bagshaw

    Citation: Journal of Intensive Care 2020 8:75

    Content type: Research

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  14. In response to comments raised, we acknowledge the shortcomings of our study. It is a small study. However, it is a pilot study, which is not meant to create generalizable data, rather to explore new potential...

    Authors: Ofer Sadan and Owen Samuels

    Citation: Journal of Intensive Care 2020 8:74

    Content type: Commentary

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    The original article was published in Journal of Intensive Care 2020 8:73

  15. Sadan et al. find an association between acute kidney injury and high chloride containing a hypertonic solution. Recent large prospective non-randomized studies bring conflicting results on the relationship be...

    Authors: Gildas Gueret, Pierre Lefebvre, Pascale Le Maguet and Renaud Fabre

    Citation: Journal of Intensive Care 2020 8:73

    Content type: Commentary

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    The original article was published in Journal of Intensive Care 2020 8:32

    The Commentary to this article has been published in Journal of Intensive Care 2020 8:74

  16. Scientific evidence indicates that endothelial glycocalyx (EG) shedding contributes to the pathophysiological installation of acute respiratory distress syndrome (ARDS) after bacterial sepsis. The aim was to e...

    Authors: Maira Nilson Benatti, Alexandre Todorovic Fabro and Carlos Henrique Miranda

    Citation: Journal of Intensive Care 2020 8:72

    Content type: Research

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  17. A high rate of thrombotic complications, such as pulmonary embolism, has been linked to mortality in COVID-19, and appropriate treatment of thrombosis is important for lifesaving. Although heparin is frequentl...

    Authors: Hidesaku Asakura and Haruhiko Ogawa

    Citation: Journal of Intensive Care 2020 8:71

    Content type: Letter to the Editor

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  18. Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and...

    Authors: Samhati Mondal, Ashley L. Quintili, Kunal Karamchandani and Somnath Bose

    Citation: Journal of Intensive Care 2020 8:70

    Content type: Review

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  19. The choice of intravenous infusion products for critically ill patients has been studied extensively because it can affect prognosis. However, there has been little research on drug diluents in this context. T...

    Authors: Yukari Aoyagi, Takuo Yoshida, Shigehiko Uchino, Masanori Takinami and Shoichi Uezono

    Citation: Journal of Intensive Care 2020 8:69

    Content type: Research

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  20. The usefulness of non-invasive mechanical ventilation (NIMV) in oncohematological patients is still a matter of debate.

    Authors: Lídia Miranda Barreto, Cecilia Gómez Ravetti, Thiago Bragança Athaíde, Renan Detoffol Bragança, Nathália Costa Pinho, Lucas Vieira Chagas, Fabrício de Lima Bastos and Vandack Nobre

    Citation: Journal of Intensive Care 2020 8:68

    Content type: Research

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  21. Despite improvements in antimicrobial therapy and supportive care, sepsis is still a major public health issue. Recently, CD100 and its receptor in the immune system CD72 were shown to play a major role in imm...

    Authors: Yang Yang, Jiajun Chen, Manli Tang, Chengla Yi, Wei Gao, Xiangjun Bai, Zhanfei Li and Fan Yang

    Citation: Journal of Intensive Care 2020 8:67

    Content type: Research

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  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ofer Sadan, Kai Singbartl, Jacqueline Kraft, Joao McONeil Plancher, Alexander C. M. Greven, Prem Kandiah, Cederic Pimentel, C. L. Hall, Alexander Papangelou, William H. Asbury, John J. Hanfelt and Owen Samuels

    Citation: Journal of Intensive Care 2020 8:66

    Content type: Correction

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    The original article was published in Journal of Intensive Care 2020 8:32

  23. Many patients with emergent heart failure (HF) readmission have a delay between symptom onset and hospitalization. The present study aimed to characterize the interval between symptom onset and hospitalization...

    Authors: Makoto Takei, Kazumasa Harada, Yasuyuki Shiraishi, Junya Matsuda, Yoichi Iwasaki, Yoshiya Yamamoto, Kenichi Matsushita, Tetsuro Miyazaki, Takamichi Miyamoto, Kiyosi Iida, Shuzo Tanimoto, Yuji Nagatomo, Toru Hosoda, Shun Kohsaka, Takeshi Yamamoto, Ken Nagao…

    Citation: Journal of Intensive Care 2020 8:65

    Content type: Research

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  24. As extracorporeal membrane oxygenation (ECMO) has been widely used, the patient quality of life following ECMO termination has become an important issue as same as the patient’s survival. To date, the factors ...

    Authors: Hye Ju Yeo, Yun Seong Kim, Dohyung Kim and Woo Hyun Cho

    Citation: Journal of Intensive Care 2020 8:64

    Content type: Research

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  25. Influenza virus-associated encephalopathy (IAE) can lead to neurological sequela and mortality among children. Therefore, instant recognition and therapeutic intervention for IAE are crucial. In some clinical ...

    Authors: Takeshi Hatachi, Nobuaki Michihata, Muneyuki Takeuchi, Hiroki Matsui, Kiyohide Fushimi and Hideo Yasunaga

    Citation: Journal of Intensive Care 2020 8:62

    Content type: Research

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  26. Intracranial pressure control has long been recognized as an important requirement for patients with severe traumatic brain injury. Hypertonic saline has drawn attention as an alternative to mannitol in this s...

    Authors: Yukari Miyoshi, Yutaka Kondo, Hidetaka Suzuki, Tatsuma Fukuda, Hideto Yasuda and Shoji Yokobori

    Citation: Journal of Intensive Care 2020 8:61

    Content type: Research

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  27. Triage becomes necessary when demand for intensive care unit (ICU) resources exceeds supply. Without triage, there is a risk that patients will be admitted to the ICU in the sequence that they present, disadva...

    Authors: Devanand Anantham, Crystal Chai-Lim, Jamie Xuelian Zhou and Ghee Chee Phua

    Citation: Journal of Intensive Care 2020 8:59

    Content type: Review

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  28. Extracorporeal cardiopulmonary resuscitation (ECPR) with extracorporeal membrane oxygenation (ECMO) is a promising therapy for out-of-hospital cardiac arrest (OHCA) compared with conventional cardiopulmonary r...

    Authors: Maki Kitada, Tadashi Kaneko, Shu Yamada, Masahiro Harada and Takeshi Takahashi

    Citation: Journal of Intensive Care 2020 8:58

    Content type: Research

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  29. Critically ill patients are at high risk of developing neurological complications. Among all the potential aetiologies, brain hypoperfusion has been advocated as one of the potential mechanisms. Impairment of ...

    Authors: Armin Quispe Cornejo, Carla Sofía Fernandes Vilarinho, Ilaria Alice Crippa, Lorenzo Peluso, Lorenzo Calabrò, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

    Citation: Journal of Intensive Care 2020 8:57

    Content type: Research

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  30. Studies have shown the potential benefit of stress ulcer prophylaxis including histamine-2 receptor antagonists (H2RA) and proton pump inhibitors (PPI) in critically ill patients. However, the adverse effects ...

    Authors: Jun Suzuki, Yusuke Sasabuchi, Shuji Hatakeyama, Hiroki Matsui, Teppei Sasahara, Yuji Morisawa, Toshiyuki Yamada and Hideo Yasunaga

    Citation: Journal of Intensive Care 2020 8:56

    Content type: Research

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  31. We are appreciative to Dr. Jouffroy and Pr. Vivien for their responses and insights, and we agree with their words about the controversial aspect timing to antibiotic administration. Nevertheless, we stand fir...

    Authors: Johana Ascuntar, Deibie Mendoza and Fabián Jaimes

    Citation: Journal of Intensive Care 2020 8:55

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:52

  32. To treat patients with acute respiratory distress syndrome (ARDS), it is important to diagnose specific lung diseases and identify common risk factors. Our facility focuses on using bronchoalveolar lavage (BAL...

    Authors: Michihito Kyo, Koji Hosokawa, Shinichiro Ohshimo, Yoshiko Kida, Yuko Tanabe and Nobuaki Shime

    Citation: Journal of Intensive Care 2020 8:54

    Content type: Research

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  33. This is the response to the comment from Dr. Romain Jouffroy and his colleague, on the manuscript “Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients ...

    Authors: Yohei Okada, Takeyuki Kiguchi, Tetsuhisa Kitamura and Taku Iwami

    Citation: Journal of Intensive Care 2020 8:53

    Content type: Letter to the Editor

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    The original article was published in Journal of Intensive Care 2020 8:42

  34. In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we belie...

    Authors: Romain Jouffroy and Benoît Vivien

    Citation: Journal of Intensive Care 2020 8:52

    Content type: Letter to the Editor

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    The original article was published in Journal of Intensive Care 2020 8:28

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:55

  35. Postoperative respiratory failure is associated with increased perioperative complications. Our aim is to compare outcomes between non-invasive ventilation (NIV), high-flow nasal cannula (HFNC), and standard o...

    Authors: Yazan Zayed, Babikir Kheiri, Mahmoud Barbarawi, Laith Rashdan, Inderdeep Gakhal, Esra’a Ismail, Josiane Kerbage, Fatima Rizk, Saadia Shafi, Areeg Bala, Shima Sidahmed, Ghassan Bachuwa and Elfateh Seedahmed

    Citation: Journal of Intensive Care 2020 8:51

    Content type: Research

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  36. Over 5,488,000 cases of coronavirus disease-19 (COVID-19) have been reported since December 2019. We aim to explore risk factors associated with mortality in COVID-19 patients and assess the use of D-dimer as ...

    Authors: Yumeng Yao, Jiatian Cao, Qingqing Wang, Qingfeng Shi, Kai Liu, Zhe Luo, Xiang Chen, Sisi Chen, Kaihuan Yu, Zheyong Huang and Bijie Hu

    Citation: Journal of Intensive Care 2020 8:49

    Content type: Research

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  37. Patient transfer between hospitals can be one of the biases when evaluating the hospital performance in severe burn care. Optimal handling of such a population is challenging in the analysis of an inpatient da...

    Authors: Akira Endo, Atsushi Shiraishi, Kiyohide Fushimi and Yasuhiro Otomo

    Citation: Journal of Intensive Care 2020 8:48

    Content type: Letter to the Editor

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    The original article was published in Journal of Intensive Care 2020 8:47

  38. This is a critical comment on the paper by Endo et al. on the volume-outcome relationship on survival and cost benefits in severe burn injury which addresses biases related to patient transfer and burn severit...

    Authors: Akinori Osuka, Daiki Miyao and Yuichi Kuroki

    Citation: Journal of Intensive Care 2020 8:47

    Content type: Letter to the Editor

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    The original article was published in Journal of Intensive Care 2019 7:7

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:48

  39. The exacerbation of intracranial bleeding is critical in traumatic brain injury (TBI) patients. Tranexamic acid (TXA) has been used to improve outcomes in TBI patient. However, the effectiveness of TXA treatme...

    Authors: Shoji Yokobori, Tomoaki Yatabe, Yutaka Kondo and Kosaku Kinoshita

    Citation: Journal of Intensive Care 2020 8:46

    Content type: Review

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  40. Sepsis-associated encephalopathy (SAE) is related to increased short-term mortality in patients with sepsis. We aim to establish a user-friendly nomogram for individual prediction of 30-day risk of mortality i...

    Authors: Yang Yang, Shengru Liang, Jie Geng, Qiuhe Wang, Pan Wang, Yuan Cao, Rong Li, Guodong Gao and Lihong Li

    Citation: Journal of Intensive Care 2020 8:45

    Content type: Research

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  41. Diagnosing sepsis remains difficult because it is not a single disease but a syndrome with various pathogen- and host factor-associated symptoms. Sepsis-3 was established to improve risk stratification among p...

    Authors: Toshikazu Abe, Kazuma Yamakawa, Hiroshi Ogura, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Yasuhiro Otomo, Joji Kotani, Yutaka Umemura, Yuichiro Sakamoto, Junichi Sasaki, Yasukazu Shiino, Naoshi Takeyama, Takehiko Tarui, Shin-ichiro Shiraishi, Ryosuke Tsuruta…

    Citation: Journal of Intensive Care 2020 8:44

    Content type: Research

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  42. Acute respiratory distress syndrome (ARDS) is a common and disabling disease with high rates of mortality and morbidity. The role of steroids in treating ARDS remains controversial. We aim to examine the evide...

    Authors: Yazan Zayed, Mahmoud Barbarawi, Esraa Ismail, Varun Samji, Josiane Kerbage, Fatima Rizk, Mohammad Salih, Areeg Bala, Michele Obeid, Smit Deliwala, Sherry Demian, Ibrahim Al-Sanouri and Raju Reddy

    Citation: Journal of Intensive Care 2020 8:43

    Content type: Research

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  43. Recently, Okada et al. reported an association between low pH value before the implementation of extracorporeal cardiopulmonary resuscitation (ECPR) and 1-month unfavorable neurological outcome among out-of-ho...

    Authors: Romain Jouffroy and Benoît Vivien

    Citation: Journal of Intensive Care 2020 8:42

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:34

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:53

  44. The ROX index (ratio of pulse oximetry/FIO2 to respiratory rate) has been validated to predict high flow nasal cannula therapy (HFNC) outcomes in patients with pneumonia. We evaluated a modified ROX index incorpo...

    Authors: Ken Junyang Goh, Hui Zhong Chai, Thun How Ong, Duu Wen Sewa, Ghee Chee Phua and Qiao Li Tan

    Citation: Journal of Intensive Care 2020 8:41

    Content type: Research

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  45. Appropriate critical care delivery for Coronavirus disease 2019 (COVID-19) is a cornerstone in saving lives. Earlier publications worldwide demonstrate higher mortality among patients receiving mechanical vent...

    Authors: Nobuaki Shime

    Citation: Journal of Intensive Care 2020 8:40

    Content type: Letter to the Editor

    Published on: