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  1. Target temperature management (TTM) is suggested to reduce brain damage in the presence of global or local ischemia. Prompt TTM application may help to improve outcomes, but it is often hindered by technical p...

    Authors: Michela Masè, Alessandro Micarelli, Marika Falla, Ivo B. Regli and Giacomo Strapazzon

    Citation: Journal of Intensive Care 2021 9:43

    Content type: Review

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  2. Since the start of the coronavirus disease 2019 (COVID-19) pandemic, it has remained unknown whether conventional risk prediction tools used in intensive care units are applicable to patients with COVID-19. Th...

    Authors: Hideki Endo, Hiroyuki Ohbe, Junji Kumasawa, Shigehiko Uchino, Satoru Hashimoto, Yoshitaka Aoki, Takehiko Asaga, Eiji Hashiba, Junji Hatakeyama, Katsura Hayakawa, Nao Ichihara, Hiromasa Irie, Tatsuya Kawasaki, Hiroshi Kurosawa, Tomoyuki Nakamura, Hiroshi Okamoto…

    Citation: Journal of Intensive Care 2021 9:42

    Content type: Letter to the Editor

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  3. Airway management, including noninvasive endotracheal intubation or invasive tracheostomy, is an essential treatment strategy for patients with deep neck space abscess (DNSA) to reverse acute hypoxia, which ai...

    Authors: Yu Lin, Wenxiang Gao, Huijun Yue, Weixiong Chen, Tianrun Liu, Jin Ye, Qian Cai, Fei Ye, Long He, Xingqiang Xie, Guoping Xiong, Bin Wang, Feng Pang, Pei Li, Jianhui Wu, Bin Wang…

    Citation: Journal of Intensive Care 2021 9:41

    Content type: Research

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  4. β-blockers may protect against catecholaminergic myocardial injury in critically ill patients. Long-term β-blocker users are known to have lower lactate concentrations and favorable sepsis outcomes. However, the ...

    Authors: Ming-Jen Kuo, Ruey-Hsing Chou, Ya-Wen Lu, Jiun-Yu Guo, Yi-Lin Tsai, Cheng-Hsueh Wu, Po-Hsun Huang and Shing-Jong Lin

    Citation: Journal of Intensive Care 2021 9:40

    Content type: Research

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  5. The use of ultrashort-acting β1-blockers recently has attracted attention in septic patients with non-compensatory tachycardia. We summarized the metabolic and hemodynamic effects and the clinical evidence of ...

    Authors: Daisuke Hasegawa, Ryota Sato and Osamu Nishida

    Citation: Journal of Intensive Care 2021 9:39

    Content type: Commentary

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  6. Tracheal intubation is the gold standard for securing the airway, and it is not uncommon to encounter intubation difficulties in intensive care units and emergency rooms. Currently, there is a need for an obje...

    Authors: Tatsuya Hayasaka, Kazuharu Kawano, Kazuki Kurihara, Hiroto Suzuki, Masaki Nakane and Kaneyuki Kawamae

    Citation: Journal of Intensive Care 2021 9:38

    Content type: Research

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  7. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Intestinal mucosal barrier injury is one of the important manifestations of sepsis. Interleukin-9 (IL-9) and ...

    Authors: Jia-Kui Sun, Jing Zhou, Xin-Pei Sun, Xiao Shen, Dong-Mei Zhu, Xiang Wang, Su-Ming Zhou and Xin-Wei Mu

    Citation: Journal of Intensive Care 2021 9:37

    Content type: Research

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  8. Acute respiratory distress syndrome (ARDS) is a leading cause of morbidity and mortality in the intensive care unit. Biochemical markers of cardiac dysfunction are associated with high mortality in many respir...

    Authors: Dilip Jayasimhan, Simon Foster, Catherina L. Chang and Robert J. Hancox

    Citation: Journal of Intensive Care 2021 9:36

    Content type: Research

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  9. Heatstroke is associated with exposure to high ambient temperature (AT) and relative humidity (RH), and an increased risk of organ damage or death. Previously proposed animal models of heatstroke disregard the...

    Authors: Kazuyuki Miyamoto, Keisuke Suzuki, Hirokazu Ohtaki, Motoyasu Nakamura, Hiroki Yamaga, Masaharu Yagi, Kazuho Honda, Munetaka Hayashi and Kenji Dohi

    Citation: Journal of Intensive Care 2021 9:35

    Content type: Research

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  10. REMAP-CAP, a randomized, embedded, multifactorial adaptive platform trial for community-acquired pneumonia, is an international clinical trial that is rapidly expanding its scope and scale in response to the C...

    Authors: Kazuhiro Kamata, Kazuaki Jindai, Nao Ichihara, Hiroki Saito, Hideaki Kato, Hiroyuki Kunishima, Ayumi Shintani, Osamu Nishida and Shigeki Fujitani

    Citation: Journal of Intensive Care 2021 9:34

    Content type: Letter to the Editor

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  11. Septic patients with cardiac impairment are with high mortality. Afterload-related cardiac performance (ACP), as a new tool for diagnosing septic cardiomyopathy (SCM), still needs to be evaluated for its impac...

    Authors: Wei-yan Chen, Zhen-hui Zhang, Li-li Tao, Qi Xu, Xing Wei and Min-sheng Chen

    Citation: Journal of Intensive Care 2021 9:33

    Content type: Research

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  12. Noninvasive respiratory support devices may reduce the tracheal intubation rate compared with conventional oxygen therapy (COT). To date, few studies have compared high-flow nasal cannula (HFNC) use with nonin...

    Authors: Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Masaki Nakane and Nobuaki Shime

    Citation: Journal of Intensive Care 2021 9:32

    Content type: Research

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  13. A significant number of COVID-19 patients have been treated using invasive mechanical ventilation (IMV). The ability to evaluate functional status of COVID-19 survivors early on at ICU and hospital discharge m...

    Authors: Benjamin Musheyev, Lara Borg, Rebeca Janowicz, Michael Matarlo, Hayle Boyle, Gurinder Singh, Victoria Ende, Ioannis Babatsikos, Wei Hou and Tim Q. Duong

    Citation: Journal of Intensive Care 2021 9:31

    Content type: Research

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  14. The COVID-19 global pandemic has placed unprecedented strain on healthcare and critical care services around the world. Whilst most resources have focused on the acute phase of the disease, there is likely to ...

    Authors: Matthew Cadd and Maya Nunn

    Citation: Journal of Intensive Care 2021 9:29

    Content type: Commentary

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  15. Dynamic change of heart rate in the acute phase and clinical outcomes after intracerebral hemorrhage (ICH) remains unknown. We aimed to investigate the associations of heart rate trajectories and variability w...

    Authors: Shoujiang You, Yupin Wang, Zian Lu, Dandan Chu, Qiao Han, Jiaping Xu, Chun-Feng Liu, Yongjun Cao and Chongke Zhong

    Citation: Journal of Intensive Care 2021 9:28

    Content type: Research

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  16. The purpose of this study is to investigate the time course of syndecan-1 (Syn-1) plasma levels, the correlation between Syn-1 and organ damage development, and the associations of Syn-1 level with cumulative ...

    Authors: Yuka Kajita, Tsuguaki Terashima, Hisatake Mori, Md. Monirul Islam, Takayuki Irahara, Masanobu Tsuda, Hideki Kano and Naoshi Takeyama

    Citation: Journal of Intensive Care 2021 9:27

    Content type: Research

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  17. We comment on the study by Hirano et al. about the effect of steroids in patients with acute respiratory distress syndrome. It might be necessary to include only the existing randomized control trials and to r...

    Authors: Shodai Yoshihiro and Shunsuke Taito

    Citation: Journal of Intensive Care 2021 9:25

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:91

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2021 9:26

  18. Physical restraint has been commonly indicated to patients with brain dysfunction in neurocritical care. The effect of physical restraints on outcomes of critically ill adults remains controversial as no rando...

    Authors: Kyoko Akiyama, Akihiko Inoue, Toru Hifumi, Kentaro Nakamura, Takuya Taira, Shun Nakagawa, Keisuke Jinno, Arisa Manabe, Sayaka Kinugasa, Hikaru Matsumura, Hajime Shishido, Shota Yokoyama, Tomoya Okazaki, Hideyuki Hamaya, Koshiro Takano, Kazutaka Kiridume…

    Citation: Journal of Intensive Care 2021 9:24

    Content type: Research

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  19. We aimed to describe the use of high-flow nasal oxygen (HFNO) in patients with COVID-19 acute respiratory failure and factors associated with a shift to invasive mechanical ventilation.

    Authors: Ricard Mellado-Artigas, Luis Eduardo Mujica, Magda Liliana Ruiz, Bruno Leonel Ferreyro, Federico Angriman, Egoitz Arruti, Antoni Torres, Enric Barbeta, Jesús Villar and Carlos Ferrando

    Citation: Journal of Intensive Care 2021 9:23

    Content type: Research

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  20. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

    Citation: Journal of Intensive Care 2021 9:22

    Content type: Correction

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    The original article was published in Journal of Intensive Care 2021 9:14

  21. Cellular patterns in bronchoalveolar lavage fluid (BALF) are used to distinguish or rule out particular diseases in patients with acute respiratory failure (ARF). However, whether BALF cellular patterns can pr...

    Authors: Yasutaka Hirasawa, Taka-aki Nakada, Takashi Shimazui, Mitsuhiro Abe, Yuri Isaka, Masashi Sakayori, Kenichi Suzuki, Keiichiro Yoshioka, Takeshi Kawasaki, Jiro Terada, Kenji Tsushima and Koichiro Tatsumi

    Citation: Journal of Intensive Care 2021 9:21

    Content type: Research

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  22. Coronavirus disease 2019 (COVID-19) infection is associated with a prothrombotic state. We performed a meta-analysis of proportions to estimate the weighted average incidence of pulmonary thromboembolism (PTE)...

    Authors: Jun Jie Ng, Zhen Chang Liang and Andrew M. T. L. Choong

    Citation: Journal of Intensive Care 2021 9:20

    Content type: Research

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  23. Immune and inflammatory dysfunction was reported to underpin critical COVID-19(coronavirus disease 2019). We aim to develop a machine learning model that enables accurate prediction of critical COVID-19 using ...

    Authors: Yue Gao, Lingxi Chen, Jianhua Chi, Shaoqing Zeng, Xikang Feng, Huayi Li, Dan Liu, Xinxia Feng, Siyuan Wang, Ya Wang, Ruidi Yu, Yuan Yuan, Sen Xu, Chunrui Li, Wei Zhang, Shuaicheng Li…

    Citation: Journal of Intensive Care 2021 9:19

    Content type: Research

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  24. The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model is widely used to predict mortality in Japanese intensive care units (ICUs). Although the model’s discrimination is excellent, its calibr...

    Authors: Hideki Endo, Shigehiko Uchino, Satoru Hashimoto, Yoshitaka Aoki, Eiji Hashiba, Junji Hatakeyama, Katsura Hayakawa, Nao Ichihara, Hiromasa Irie, Tatsuya Kawasaki, Junji Kumasawa, Hiroshi Kurosawa, Tomoyuki Nakamura, Hiroyuki Ohbe, Hiroshi Okamoto, Hidenobu Shigemitsu…

    Citation: Journal of Intensive Care 2021 9:18

    Content type: Research

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  25. Acute respiratory distress syndrome (ARDS) is a fatal condition with insufficiently clarified etiology. Supportive care for severe hypoxemia remains the mainstay of essential interventions for ARDS. In recent ...

    Authors: Shinichiro Ohshimo

    Citation: Journal of Intensive Care 2021 9:17

    Content type: Review

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  26. Unavailability or saturation of the intensive care unit may be associated with the fatality of COVID-19. Prioritizing the patients for hospitalization and intensive care may be critical for reducing the fatali...

    Authors: JoonNyung Heo, Deokjae Han, Hyung-Jun Kim, Daehyun Kim, Yeon-Kyeng Lee, Dosang Lim, Sung Ok Hong, Mi-Jin Park, Beomman Ha and Woong Seog

    Citation: Journal of Intensive Care 2021 9:16

    Content type: Research

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  27. Inappropriate authors’ self-citation (A-SC) is a growing mal-practice possibly boosted by the raising importance given to author’s metrics. Similarly, also excessive journals’ self-citation (J-SC) practice may...

    Authors: Filippo Sanfilippo, Stefano Tigano, Alberto Morgana, Paolo Murabito and Marinella Astuto

    Citation: Journal of Intensive Care 2021 9:15

    Content type: Commentary

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  28. The acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing p...

    Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

    Citation: Journal of Intensive Care 2021 9:14

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2021 9:22

  29. Persistent apnea despite an adequate rise in arterial pressure of CO2 is an essential component of the criteria for brain death (BD) determination. Current guidelines vary regarding the utility of arterial pH cha...

    Authors: Ibrahim Migdady, Moein Amin, Aaron Shoskes, Catherine Hassett, Sung-Min Cho, Pravin George and Alexander Rae-Grant

    Citation: Journal of Intensive Care 2021 9:13

    Content type: Research

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  30. Sepsis is characterized by various hemodynamic alterations which could happen concomitantly in the heart, pulmonary and systemic circulations. A comprehensive demonstration of their interactions in the clinica...

    Authors: François Bagate, Paul Masi, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux, Genevieve Derumeaux and Armand Mekontso Dessap

    Citation: Journal of Intensive Care 2021 9:12

    Content type: Research

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  31. SARS-CoV-2 may cause acute lung injury, and secondary infections are thus relevant complications in patients with COVID-19 pneumonia. However, detailed information on community- and hospital-acquired infection...

    Authors: Kirstine K. Søgaard, Veronika Baettig, Michael Osthoff, Stephan Marsch, Karoline Leuzinger, Michael Schweitzer, Julian Meier, Stefano Bassetti, Roland Bingisser, Christian H. Nickel, Nina Khanna, Sarah Tschudin-Sutter, Maja Weisser, Manuel Battegay, Hans H. Hirsch, Hans Pargger…

    Citation: Journal of Intensive Care 2021 9:10

    Content type: Research

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  32. This systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19).

    Authors: Arief Wibowo, Raymond Pranata, Astri Astuti, Badai Bhatara Tiksnadi, Erwan Martanto, Januar Wibawa Martha, Augustine Purnomowati and Mohammad Rizki Akbar

    Citation: Journal of Intensive Care 2021 9:9

    Content type: Research

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  33. The use of indirect calorimetry is strongly recommended to guide nutrition therapy in critically ill patients, preventing the detrimental effects of under- and overfeeding. However, the course of energy expend...

    Authors: Hanneke Pierre Franciscus Xaverius Moonen, Karin Josephina Hubertina Beckers and Arthur Raymond Hubert van Zanten

    Citation: Journal of Intensive Care 2021 9:8

    Content type: Review

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  34. To demonstrate feasibility of a music medicine intervention trial in pediatric intensive care and to obtain information on sedation and analgesia dose variation to plan a larger trial.

    Authors: Gonzalo Garcia Guerra, Ari R. Joffe, Cathy Sheppard, Krista Hewson, Irina A. Dinu, Morteza Hajihosseini, Allan deCaen, Hsing Jou, Lisa Hartling and Sunita Vohra

    Citation: Journal of Intensive Care 2021 9:7

    Content type: Research

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  35. Accidental hypothermia is a critical condition with high risks of fatal arrhythmia, multiple organ failure, and mortality; however, there is no established model to predict the mortality. The present study aim...

    Authors: Yohei Okada, Tasuku Matsuyama, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Ryoji Iiduka and Shigeru Ohtsuru

    Citation: Journal of Intensive Care 2021 9:6

    Content type: Research

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  36. During COVID-19 pandemic, visits have been prohibited in most French ICUs. Psychological effects, for reference persons (RPs), of remote-only communication have been assessed.

    Authors: Jessy Cattelan, Sara Castellano, Hamid Merdji, Jean Audusseau, Baptiste Claude, Léa Feuillassier, Sibylle Cunat, Marc Astrié, Camille Aquin, Guillaume Buis, Edgar Gehant, Amandine Granier, Hassiba Kercha, Camille Le Guillou, Guillaume Martin, Kevin Roulot…

    Citation: Journal of Intensive Care 2021 9:5

    Content type: Research

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  37. Improving neurological outcomes after cardiac arrest (CA) is the most important patient-oriented outcome for CA research. Near-infrared spectroscopy (NIRS) enables a non-invasive, real-time measurement of regi...

    Authors: Ryosuke Takegawa, Kei Hayashida, Rishabh Choudhary, Daniel M. Rolston and Lance B. Becker

    Citation: Journal of Intensive Care 2021 9:4

    Content type: Letter to the Editor

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  38. The lack of precise information on the epidemiology of peripheral intravascular catheter (PIVC)-related phlebitis and complications in critically ill patients results in the absence of appropriate preventive m...

    Authors: Hideto Yasuda, Ryohei Yamamoto, Yoshiro Hayashi, Yuki Kotani, Yuki Kishihara, Natsuki Kondo, Kosuke Sekine, Nobuaki Shime, Keita Morikane, Takayuki Abe, Toru Takebayashi, Mikihiro Maeda, Takuya Shiga, Taku Furukawa, Mototaka Inaba, Sachito Fukuda…

    Citation: Journal of Intensive Care 2021 9:3

    Content type: Research

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  39. Globally, mortality rates of patients admitted to the intensive care unit (ICU) have decreased over the last two decades. However, evaluations of the temporal trends in the characteristics and outcomes of ICU ...

    Authors: Lowell Ling, Chun Ming Ho, Pauline Yeung Ng, King Chung Kenny Chan, Hoi Ping Shum, Cheuk Yan Chan, Alwin Wai Tak Yeung, Wai Tat Wong, Shek Yin Au, Kit Hung Anne Leung, Jacky Ka Hing Chan, Chi Keung Ching, Oi Yan Tam, Hin Hung Tsang, Ting Liong, Kin Ip Law…

    Citation: Journal of Intensive Care 2021 9:2

    Content type: Research

    Published on:

  40. Aggressive fluid administration is recommended in the resuscitation of septic patients. However, the delivery of a rapid fluid bolus might cause harm by inducing degradation of the endothelial glycocalyx. This...

    Authors: Jutamas Saoraya, Lipda Wongsamita, Nattachai Srisawat and Khrongwong Musikatavorn

    Citation: Journal of Intensive Care 2021 9:1

    Content type: Research

    Published on:

  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lorenzo Gamberini, Tommaso Tonetti, Savino Spadaro, Gianluca Zani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Alberto Fogagnolo, Maurizio Fusari…

    Citation: Journal of Intensive Care 2020 8:96

    Content type: Correction

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:80

  42. Clinical evidence showing the effectiveness of recombinant human soluble thrombomodulin (rhTM) for treating sepsis-induced disseminated intravascular coagulation (DIC) and organ dysfunction (particularly renal...

    Authors: Masayuki Akatsuka, Yoshiki Masuda, Hiroomi Tatsumi and Tomoko Sonoda

    Citation: Journal of Intensive Care 2020 8:94

    Content type: Research

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  43. Focused cardiac ultrasound (FoCUS) is a valuable skill for rapid assessment of cardiac function and volume status. Despite recent widespread adoption among physicians, there is limited data on the optimal trai...

    Authors: Lauren E. Gibson, Gabrielle A. White-Dzuro, Patrick J. Lindsay, Sheri M. Berg, Edward A. Bittner and Marvin G. Chang

    Citation: Journal of Intensive Care 2020 8:93

    Content type: Review

    Published on:

  44. Current evidence supporting the utility of electromagnetic (EM)-guided method as the preferred technique for post-pyloric feeding tube placement is limited. We conducted a meta-analysis to compare the performa...

    Authors: Yaping Wei, Zheng Jin, Ying Zhu and Wei Hu

    Citation: Journal of Intensive Care 2020 8:92

    Content type: Research

    Published on:

  45. The effect of corticosteroid treatment on survival outcome in early acute respiratory distress syndrome (ARDS) is still debated. We conducted a systematic review and meta-analysis of randomized controlled tria...

    Authors: Yohei Hirano, Shunsuke Madokoro, Yutaka Kondo, Ken Okamoto and Hiroshi Tanaka

    Citation: Journal of Intensive Care 2020 8:91

    Content type: Research

    Published on:

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2021 9:25

  46. This study aimed to identify the association between total visitation restriction because of the coronavirus 2019 (COVID-19) pandemic and the incidence of delirium for emergency inpatients.

    Authors: Kenji Kandori, Yohei Okada, Wataru Ishii, Hiromichi Narumiya, Yoshiro Maebayashi and Ryoji Iizuka

    Citation: Journal of Intensive Care 2020 8:90

    Content type: Research

    Published on: