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  1. Scientific evidence indicates that endothelial glycocalyx (EG) shedding contributes to the pathophysiological installation of acute respiratory distress syndrome (ARDS) after bacterial sepsis. The aim was to e...

    Authors: Maira Nilson Benatti, Alexandre Todorovic Fabro and Carlos Henrique Miranda

    Citation: Journal of Intensive Care 2020 8:72

    Content type: Research

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  2. A high rate of thrombotic complications, such as pulmonary embolism, has been linked to mortality in COVID-19, and appropriate treatment of thrombosis is important for lifesaving. Although heparin is frequentl...

    Authors: Hidesaku Asakura and Haruhiko Ogawa

    Citation: Journal of Intensive Care 2020 8:71

    Content type: Letter to the Editor

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  3. Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and...

    Authors: Samhati Mondal, Ashley L. Quintili, Kunal Karamchandani and Somnath Bose

    Citation: Journal of Intensive Care 2020 8:70

    Content type: Review

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  4. The choice of intravenous infusion products for critically ill patients has been studied extensively because it can affect prognosis. However, there has been little research on drug diluents in this context. T...

    Authors: Yukari Aoyagi, Takuo Yoshida, Shigehiko Uchino, Masanori Takinami and Shoichi Uezono

    Citation: Journal of Intensive Care 2020 8:69

    Content type: Research

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  5. The usefulness of non-invasive mechanical ventilation (NIMV) in oncohematological patients is still a matter of debate.

    Authors: Lídia Miranda Barreto, Cecilia Gómez Ravetti, Thiago Bragança Athaíde, Renan Detoffol Bragança, Nathália Costa Pinho, Lucas Vieira Chagas, Fabrício de Lima Bastos and Vandack Nobre

    Citation: Journal of Intensive Care 2020 8:68

    Content type: Research

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  6. Despite improvements in antimicrobial therapy and supportive care, sepsis is still a major public health issue. Recently, CD100 and its receptor in the immune system CD72 were shown to play a major role in imm...

    Authors: Yang Yang, Jiajun Chen, Manli Tang, Chengla Yi, Wei Gao, Xiangjun Bai, Zhanfei Li and Fan Yang

    Citation: Journal of Intensive Care 2020 8:67

    Content type: Research

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ofer Sadan, Kai Singbartl, Jacqueline Kraft, Joao McONeil Plancher, Alexander C. M. Greven, Prem Kandiah, Cederic Pimentel, C. L. Hall, Alexander Papangelou, William H. Asbury, John J. Hanfelt and Owen Samuels

    Citation: Journal of Intensive Care 2020 8:66

    Content type: Correction

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    The original article was published in Journal of Intensive Care 2020 8:32

  8. Many patients with emergent heart failure (HF) readmission have a delay between symptom onset and hospitalization. The present study aimed to characterize the interval between symptom onset and hospitalization...

    Authors: Makoto Takei, Kazumasa Harada, Yasuyuki Shiraishi, Junya Matsuda, Yoichi Iwasaki, Yoshiya Yamamoto, Kenichi Matsushita, Tetsuro Miyazaki, Takamichi Miyamoto, Kiyosi Iida, Shuzo Tanimoto, Yuji Nagatomo, Toru Hosoda, Shun Kohsaka, Takeshi Yamamoto, Ken Nagao…

    Citation: Journal of Intensive Care 2020 8:65

    Content type: Research

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  9. As extracorporeal membrane oxygenation (ECMO) has been widely used, the patient quality of life following ECMO termination has become an important issue as same as the patient’s survival. To date, the factors ...

    Authors: Hye Ju Yeo, Yun Seong Kim, Dohyung Kim and Woo Hyun Cho

    Citation: Journal of Intensive Care 2020 8:64

    Content type: Research

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  10. Influenza virus-associated encephalopathy (IAE) can lead to neurological sequela and mortality among children. Therefore, instant recognition and therapeutic intervention for IAE are crucial. In some clinical ...

    Authors: Takeshi Hatachi, Nobuaki Michihata, Muneyuki Takeuchi, Hiroki Matsui, Kiyohide Fushimi and Hideo Yasunaga

    Citation: Journal of Intensive Care 2020 8:62

    Content type: Research

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  11. Intracranial pressure control has long been recognized as an important requirement for patients with severe traumatic brain injury. Hypertonic saline has drawn attention as an alternative to mannitol in this s...

    Authors: Yukari Miyoshi, Yutaka Kondo, Hidetaka Suzuki, Tatsuma Fukuda, Hideto Yasuda and Shoji Yokobori

    Citation: Journal of Intensive Care 2020 8:61

    Content type: Research

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  12. Triage becomes necessary when demand for intensive care unit (ICU) resources exceeds supply. Without triage, there is a risk that patients will be admitted to the ICU in the sequence that they present, disadva...

    Authors: Devanand Anantham, Crystal Chai-Lim, Jamie Xuelian Zhou and Ghee Chee Phua

    Citation: Journal of Intensive Care 2020 8:59

    Content type: Review

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  13. Extracorporeal cardiopulmonary resuscitation (ECPR) with extracorporeal membrane oxygenation (ECMO) is a promising therapy for out-of-hospital cardiac arrest (OHCA) compared with conventional cardiopulmonary r...

    Authors: Maki Kitada, Tadashi Kaneko, Shu Yamada, Masahiro Harada and Takeshi Takahashi

    Citation: Journal of Intensive Care 2020 8:58

    Content type: Research

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  14. Critically ill patients are at high risk of developing neurological complications. Among all the potential aetiologies, brain hypoperfusion has been advocated as one of the potential mechanisms. Impairment of ...

    Authors: Armin Quispe Cornejo, Carla Sofía Fernandes Vilarinho, Ilaria Alice Crippa, Lorenzo Peluso, Lorenzo Calabrò, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

    Citation: Journal of Intensive Care 2020 8:57

    Content type: Research

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  15. Studies have shown the potential benefit of stress ulcer prophylaxis including histamine-2 receptor antagonists (H2RA) and proton pump inhibitors (PPI) in critically ill patients. However, the adverse effects ...

    Authors: Jun Suzuki, Yusuke Sasabuchi, Shuji Hatakeyama, Hiroki Matsui, Teppei Sasahara, Yuji Morisawa, Toshiyuki Yamada and Hideo Yasunaga

    Citation: Journal of Intensive Care 2020 8:56

    Content type: Research

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  16. We are appreciative to Dr. Jouffroy and Pr. Vivien for their responses and insights, and we agree with their words about the controversial aspect timing to antibiotic administration. Nevertheless, we stand fir...

    Authors: Johana Ascuntar, Deibie Mendoza and Fabián Jaimes

    Citation: Journal of Intensive Care 2020 8:55

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:52

  17. To treat patients with acute respiratory distress syndrome (ARDS), it is important to diagnose specific lung diseases and identify common risk factors. Our facility focuses on using bronchoalveolar lavage (BAL...

    Authors: Michihito Kyo, Koji Hosokawa, Shinichiro Ohshimo, Yoshiko Kida, Yuko Tanabe and Nobuaki Shime

    Citation: Journal of Intensive Care 2020 8:54

    Content type: Research

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  18. This is the response to the comment from Dr. Romain Jouffroy and his colleague, on the manuscript “Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients ...

    Authors: Yohei Okada, Takeyuki Kiguchi, Tetsuhisa Kitamura and Taku Iwami

    Citation: Journal of Intensive Care 2020 8:53

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:42

  19. In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we belie...

    Authors: Romain Jouffroy and Benoît Vivien

    Citation: Journal of Intensive Care 2020 8:52

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:28

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:55

  20. Postoperative respiratory failure is associated with increased perioperative complications. Our aim is to compare outcomes between non-invasive ventilation (NIV), high-flow nasal cannula (HFNC), and standard o...

    Authors: Yazan Zayed, Babikir Kheiri, Mahmoud Barbarawi, Laith Rashdan, Inderdeep Gakhal, Esra’a Ismail, Josiane Kerbage, Fatima Rizk, Saadia Shafi, Areeg Bala, Shima Sidahmed, Ghassan Bachuwa and Elfateh Seedahmed

    Citation: Journal of Intensive Care 2020 8:51

    Content type: Research

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  21. Over 5,488,000 cases of coronavirus disease-19 (COVID-19) have been reported since December 2019. We aim to explore risk factors associated with mortality in COVID-19 patients and assess the use of D-dimer as ...

    Authors: Yumeng Yao, Jiatian Cao, Qingqing Wang, Qingfeng Shi, Kai Liu, Zhe Luo, Xiang Chen, Sisi Chen, Kaihuan Yu, Zheyong Huang and Bijie Hu

    Citation: Journal of Intensive Care 2020 8:49

    Content type: Research

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  22. Patient transfer between hospitals can be one of the biases when evaluating the hospital performance in severe burn care. Optimal handling of such a population is challenging in the analysis of an inpatient da...

    Authors: Akira Endo, Atsushi Shiraishi, Kiyohide Fushimi and Yasuhiro Otomo

    Citation: Journal of Intensive Care 2020 8:48

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:47

  23. This is a critical comment on the paper by Endo et al. on the volume-outcome relationship on survival and cost benefits in severe burn injury which addresses biases related to patient transfer and burn severit...

    Authors: Akinori Osuka, Daiki Miyao and Yuichi Kuroki

    Citation: Journal of Intensive Care 2020 8:47

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2019 7:7

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:48

  24. The exacerbation of intracranial bleeding is critical in traumatic brain injury (TBI) patients. Tranexamic acid (TXA) has been used to improve outcomes in TBI patient. However, the effectiveness of TXA treatme...

    Authors: Shoji Yokobori, Tomoaki Yatabe, Yutaka Kondo and Kosaku Kinoshita

    Citation: Journal of Intensive Care 2020 8:46

    Content type: Review

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  25. Sepsis-associated encephalopathy (SAE) is related to increased short-term mortality in patients with sepsis. We aim to establish a user-friendly nomogram for individual prediction of 30-day risk of mortality i...

    Authors: Yang Yang, Shengru Liang, Jie Geng, Qiuhe Wang, Pan Wang, Yuan Cao, Rong Li, Guodong Gao and Lihong Li

    Citation: Journal of Intensive Care 2020 8:45

    Content type: Research

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  26. Diagnosing sepsis remains difficult because it is not a single disease but a syndrome with various pathogen- and host factor-associated symptoms. Sepsis-3 was established to improve risk stratification among p...

    Authors: Toshikazu Abe, Kazuma Yamakawa, Hiroshi Ogura, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Yasuhiro Otomo, Joji Kotani, Yutaka Umemura, Yuichiro Sakamoto, Junichi Sasaki, Yasukazu Shiino, Naoshi Takeyama, Takehiko Tarui, Shin-ichiro Shiraishi, Ryosuke Tsuruta…

    Citation: Journal of Intensive Care 2020 8:44

    Content type: Research

    Published on:

  27. Acute respiratory distress syndrome (ARDS) is a common and disabling disease with high rates of mortality and morbidity. The role of steroids in treating ARDS remains controversial. We aim to examine the evide...

    Authors: Yazan Zayed, Mahmoud Barbarawi, Esraa Ismail, Varun Samji, Josiane Kerbage, Fatima Rizk, Mohammad Salih, Areeg Bala, Michele Obeid, Smit Deliwala, Sherry Demian, Ibrahim Al-Sanouri and Raju Reddy

    Citation: Journal of Intensive Care 2020 8:43

    Content type: Research

    Published on:

  28. Recently, Okada et al. reported an association between low pH value before the implementation of extracorporeal cardiopulmonary resuscitation (ECPR) and 1-month unfavorable neurological outcome among out-of-ho...

    Authors: Romain Jouffroy and Benoît Vivien

    Citation: Journal of Intensive Care 2020 8:42

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:34

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:53

  29. The ROX index (ratio of pulse oximetry/FIO2 to respiratory rate) has been validated to predict high flow nasal cannula therapy (HFNC) outcomes in patients with pneumonia. We evaluated a modified ROX index incorpo...

    Authors: Ken Junyang Goh, Hui Zhong Chai, Thun How Ong, Duu Wen Sewa, Ghee Chee Phua and Qiao Li Tan

    Citation: Journal of Intensive Care 2020 8:41

    Content type: Research

    Published on:

  30. Appropriate critical care delivery for Coronavirus disease 2019 (COVID-19) is a cornerstone in saving lives. Earlier publications worldwide demonstrate higher mortality among patients receiving mechanical vent...

    Authors: Nobuaki Shime

    Citation: Journal of Intensive Care 2020 8:40

    Content type: Letter to the Editor

    Published on:

  31. Quality improvement in the administration of extracorporeal cardiopulmonary resuscitation (ECPR) over time and its association with low-flow duration (LFD) and outcomes of cardiac arrest (CA) have been insuffi...

    Authors: Akiko Higashi, Taka-aki Nakada, Taro Imaeda, Ryuzo Abe, Koichiro Shinozaki and Shigeto Oda

    Citation: Journal of Intensive Care 2020 8:39

    Content type: Research

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  32. Neuromuscular blocking agents (NMBAs) can be an effective modality to address challenges that arise daily in the intensive care unit (ICU). These medications are often used to optimize mechanical ventilation, ...

    Authors: J. Ross Renew, Robert Ratzlaff, Vivian Hernandez-Torres, Sorin J. Brull and Richard C. Prielipp

    Citation: Journal of Intensive Care 2020 8:37

    Content type: Review

    Published on:

  33. Artificial intelligence or AI has been heralded as the most transformative technology in healthcare, including critical care medicine. Globally, healthcare specialists and health ministries are being pressured...

    Authors: Euma Ishii, Daniel K. Ebner, Satoshi Kimura, Louis Agha-Mir-Salim, Ryo Uchimido and Leo A. Celi

    Citation: Journal of Intensive Care 2020 8:35

    Content type: Review

    Published on:

  34. We aimed to identify the association of pH value in blood gas assessment with neurological outcome among out-of-hospital cardiac arrest (OHCA) patients treated by extracorporeal cardiopulmonary resuscitation (...

    Authors: Yohei Okada, Takeyuki Kiguchi, Taro Irisawa, Kazuhisa Yoshiya, Tomoki Yamada, Koichi Hayakawa, Kazuo Noguchi, Tetsuro Nishimura, Takuya Ishibe, Yoshiki Yagi, Masafumi Kishimoto, Hiroshi Shintani, Yasuyuki Hayashi, Taku Sogabe, Takaya Morooka, Haruko Sakamoto…

    Citation: Journal of Intensive Care 2020 8:34

    Content type: Research

    Published on:

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:42

  35. The initial presentation of sepsis in the emergency department (ED) is difficult to distinguish from other acute illnesses based upon similar clinical presentations. A new blood parameter, a measurement of inc...

    Authors: Elliott D. Crouser, Joseph E. Parrillo, Greg S. Martin, David T. Huang, Pierre Hausfater, Ilya Grigorov, Diana Careaga, Tiffany Osborn, Mohamad Hasan and Liliana Tejidor

    Citation: Journal of Intensive Care 2020 8:33

    Content type: Research

    Published on:

  36. Recent reports have demonstrated that among patients with subarachnoid hemorrhage (SAH) treated with hypertonic NaCl, resultant hyperchloremia has been associated with the development of acute kidney injury (A...

    Authors: Ofer Sadan, Kai Singbartl, Jacqueline Kraft, Joao McONeil Plancher, Alexander C. M. Greven, Prem Kandiah, Cederic Pimentel, C. L. Hall, Alexander Papangelou, William H. Asbury, John J. Hanfelt and Owen Samuels

    Citation: Journal of Intensive Care 2020 8:32

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2020 8:66

  37. Leptospirosis is a potentially fatal zoonosis. It can cause a wide range of symptoms, including diffuse alveolar haemorrhage which occurs in a minority of cases but carries a mortality of over 70%. These patie...

    Authors: James Barnacle, Stefan Gurney, Stephane Ledot and Suveer Singh

    Citation: Journal of Intensive Care 2020 8:31

    Content type: Case report

    Published on:

  38. Candidemia is one of the most life-threatening infections among critically ill patients in the intensive care unit. However, the number of studies on the impact of host- and early treatment-related factors on ...

    Authors: Shingo Ohki, Nobuaki Shime, Tadashi Kosaka and Naohisa Fujita

    Citation: Journal of Intensive Care 2020 8:30

    Content type: Research

    Published on:

  39. The novel coronavirus disease 2019 (COVID-19) is spreading in Japan. We have collected a total of 26 patients with COVID-19 who required extracorporeal membranous oxygenation (ECMO). The available data from th...

    Authors:

    Citation: Journal of Intensive Care 2020 8:29

    Content type: Letter to the Editor

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2020 8:38

  40. Early use of antimicrobials is a critical intervention in the treatment of patients with sepsis. The exact time of initiation is controversial and its early administration may be a difficult task in crowded em...

    Authors: Johana Ascuntar, Deibie Mendoza and Fabián Jaimes

    Citation: Journal of Intensive Care 2020 8:28

    Content type: Research

    Published on:

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2020 8:52

  41. Few studies have investigated spinal cord autoregulation using near-infrared spectroscopy (NIRS). Here, we assessed spinal cord autoregulation under normal, hypovolemic, and post-fluid resuscitation conditions...

    Authors: Tadayoshi Kurita, Shingo Kawashima, Koji Morita and Yoshiki Nakajima

    Citation: Journal of Intensive Care 2020 8:27

    Content type: Research

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  42. Appropriate antimicrobial dosing is challenging because of changes in pharmacokinetics (PK) parameters and an increase in multidrug-resistant (MDR) organisms in critically ill patients. This study aimed to eva...

    Authors: Tospon Lertwattanachai, Preecha Montakantikul, Viratch Tangsujaritvijit, Pitsucha Sanguanwit, Jetjamnong Sueajai, Saranya Auparakkitanon and Pitchaya Dilokpattanamongkol

    Citation: Journal of Intensive Care 2020 8:26

    Content type: Research

    Published on:

  43. Neutrophil extracellular traps (NETs) are fibrous structures released from activated neutrophils. NET formation has been reported to be associated with acute respiratory distress syndrome (ARDS). However, ther...

    Authors: Masahiro Ojima, Norihisa Yamamoto, Tomoya Hirose, Shigeto Hamaguchi, Osamu Tasaki, Takashi Kojima, Kazunori Tomono, Hiroshi Ogura and Takeshi Shimazu

    Citation: Journal of Intensive Care 2020 8:25

    Content type: Case report

    Published on:

  44. It is estimated that 5–14% of patients presenting with hemoptysis will have life-threatening hemoptysis, with a reported mortality rate between 9 and 38%. This manuscript provides a comprehensive literature re...

    Authors: Hasmeena Kathuria, Helen M. Hollingsworth, Rajendran Vilvendhan and Christine Reardon

    Citation: Journal of Intensive Care 2020 8:23

    Content type: Review

    Published on: