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  1. Heterogeneity among critically ill patients undergoing invasive mechanical ventilation (IMV) treatment could result in high mortality rates. Currently, there are no well-established indicators to help identify...

    Authors: Xiawei Shi, Yangyang Shi, Liming Fan, Jia Yang, Hao Chen, Kaiwen Ni and Junchao Yang
    Citation: Journal of Intensive Care 2023 11:59
    Content type: Research Published on:

  2. Limiting driving pressure and mechanical power is associated with reduced mortality risk in both patients with and without acute respiratory distress syndrome. However, it is still poorly understood how the in...

    Authors: Han Chen, Zhi-Zhong Chen, Shu-Rong Gong and Rong-Guo Yu
    Citation: Journal of Intensive Care 2023 11:58
    Content type: Research Published on:

  3. The effort to minimize VILI risk must be multi-pronged. The need to adequately ventilate, a key determinant of hazardous power, is reduced by judicious permissive hypercapnia, reduction of innate oxygen demand...

    Authors: Lauren T. Thornton and John J. Marini
    Citation: Journal of Intensive Care 2023 11:57
    Content type: Review Published on:

  4. This study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis was that interventions lasting over 40 min, as per the German guideline, positively affe...

    Authors: Marco Lorenz, Kristina Fuest, Bernhard Ulm, Julius J. Grunow, Linus Warner, Annika Bald, Vanessa Arsene, Michael Verfuß, Nils Daum, Manfred Blobner and Stefan J. Schaller
    Citation: Journal of Intensive Care 2023 11:56
    Content type: Research Published on:

  5. Neuromuscular blockade agents (NMBAs) can be used to facilitate mechanical ventilation in critically ill patients. Accumulating evidence has shown that NMBAs may be associated with intensive care unit (ICU)-ac...

    Authors: Chun Lin, Wen-Cheng Chao, Kai-Chih Pai, Tsung-Ying Yang, Chieh-Liang Wu and Ming-Cheng Chan
    Citation: Journal of Intensive Care 2023 11:55
    Content type: Research Published on:

  6. Unfractionated heparin (UFH) is primarily monitored using activated partial thromboplastin time (APTT). However, the recent introduction of anti-activated factor X (anti-Xa) activity testing has provided a dir...

    Authors: Tomoyo Saito, Mineji Hayakawa, Osamu Kumano, Yoshinori Honma, Mone Murashita, Jun Kato, Syouki Fukui, Masaki Takahashi, Yuki Takahashi, Takumi Tsuchida, Asumi Mizugaki, Shuhei Takauji, Mariko Hayamizu, Tomonao Yoshida, Kenichi Katabami, Takeshi Wada…
    Citation: Journal of Intensive Care 2023 11:54
    Content type: Research Published on:

  7. This review examined studies regarding the implementation and translation of patients’ advance directives (AD) in intensive care units (ICUs), focusing on practical difficulties and obstacles.

    Authors: Sira M. Baumann, Natalie J. Kruse, Paulina S. C. Kliem, Simon A. Amacher, Sabina Hunziker, Tolga D. Dittrich, Fabienne Renetseder, Pascale Grzonka and Raoul Sutter
    Citation: Journal of Intensive Care 2023 11:53
    Content type: Review Published on:

  9. The aims of this study were to evaluate the efficacy, safety, and pharmacokinetics (PK) of continuous intravenous administration of remifentanil in mechanically ventilated patients in the intensive care unit (...

    Authors: Matsuyuki Doi, Naoki Takahashi, Rumi Nojiri, Takehiko Hiraoka, Yusuke Kishimoto, Shinichi Inoue and Nobuyo Oya
    Citation: Journal of Intensive Care 2023 11:51
    Content type: Research Published on:

  10. Lacosamide is one of the anticonvulsants used in critically ill patients. This study aimed to suggest appropriate lacosamide dosing regimens in critically ill patients receiving continuous renal replacement th...

    Authors: Weerachai Chaijamorn, Sathian Phunpon, Thanompong Sathienluckana, Taniya Charoensareerat, Sutthiporn Pattharachayakul, Dhakrit Rungkitwattanakul and Nattachai Srisawat
    Citation: Journal of Intensive Care 2023 11:50
    Content type: Research Published on:

  11. This study aimed to apply the backpropagation neural network (BPNN) to develop a model for predicting multidrug-resistant organism (MDRO) infection in critically ill patients.

    Authors: Yaxi Wang, Gang Wang, Yuxiao Zhao, Cheng Wang, Chen Chen, Yaoyao Ding, Jing Lin, Jingjing You, Silong Gao and Xufeng Pang
    Citation: Journal of Intensive Care 2023 11:49
    Content type: Research Published on:

  12. The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/pharmacodynamics and specific drug properties for critically ill patients is unclear. He...

    Authors: Nozomi Takahashi, Yutaka Kondo, Kenji Kubo, Moritoki Egi, Ken-ichi Kano, Yoshiyasu Ohshima and Taka-aki Nakada
    Citation: Journal of Intensive Care 2023 11:48
    Content type: Research Published on:

  13. Providing standardized, high-quality rehabilitation for critically ill patients is a crucial issue. In 2017, the Japanese Society of Intensive Care Medicine (JSICM) promulgated the “Evidence-Based Expert Conse...

    Authors: Takeshi Unoki, Kei Hayashida, Yusuke Kawai, Shunsuke Taito, Morihide Ando, Yuki Iida, Fumihito Kasai, Tatsuya Kawasaki, Ryo Kozu, Yutaka Kondo, Masakazu Saitoh, Hideaki Sakuramoto, Nobuyuki Sasaki, Ryuichi Saura, Kensuke Nakamura, Akira Ouchi…
    Citation: Journal of Intensive Care 2023 11:47
    Content type: Guideline Published on:

  14. Previous studies have reported conflicting results regarding fresh frozen plasma (FFP)-to-red blood cell (RBC) ratio and platelet-to-RBC ratio on outcomes for massive transfusion for trauma. Moreover, nationwi...

    Authors: Hiroyuki Ohbe, Takashi Tagami, Akira Endo, Shigeki Miyata, Hiroki Matsui, Kiyohide Fushimi, Shigeki Kushimoto and Hideo Yasunaga
    Citation: Journal of Intensive Care 2023 11:46
    Content type: Research Published on:

  15. The prognosis for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is poor, and there is no established treatment. Hence, we aimed to investigate the effectiveness of a polymyxin B-immobilised fibr...

    Authors: Nobuyasu Awano, Taisuke Jo, Takehiro Izumo, Minoru Inomata, Yu Ito, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi, Hirokazu Urushiyama, Takahide Nagase and Hideo Yasunaga
    Citation: Journal of Intensive Care 2023 11:45
    Content type: Research Published on:

  16. While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in maintaining fluid homeostasis. Fluid balance regulation is a critical aspect of septic...

    Authors: Auguste Dargent, Hugo Dumargne, Marie Labruyère, Stéphane Brezillon, Sylvie Brassart-Pasco, Mathieu Blot, Pierre-Emmanuel Charles, Isabelle Fournel, Jean-Pierre Quenot and Marine Jacquier
    Citation: Journal of Intensive Care 2023 11:44
    Content type: Review Published on:

  17. Gasping during resuscitation has been reported as a favorable factor for out-of-hospital cardiac arrest. We examined whether gasping during resuscitation is independently associated with favorable neurological...

    Authors: Satoshi Nara, Naofumi Bunya, Hirofumi Ohnishi, Keigo Sawamoto, Shuji Uemura, Nobuaki Kokubu, Mamoru Hase, Eichi Narimatsu, Yasufumi Asai, Yoshio Tahara, Takahiro Atsumi, Ken Nagao, Naoto Morimura and Tetsuya Sakamoto
    Citation: Journal of Intensive Care 2023 11:43
    Content type: Research Published on:

  18. Mechanical ventilation may cause pulmonary hypertension in patients with acute lung injury (ALI), but the underlying mechanism remains elucidated.

    Authors: Yonghao Xu, Yu Zhang, Jie Zhang, Weibo Liang, Ya Wang, Zitao Zeng, Zhenting Liang, Zhaoyi Ling, Yubiao Chen, Xiumei Deng, Yongbo Huang, Xiaoqing Liu, Haibo Zhang and Yimin Li
    Citation: Journal of Intensive Care 2023 11:42
    Content type: Research Published on:

  19. This aim of study was to introduce a diaphragm-based EIT-belt placement method based on diaphragm position by ultrasound, and to evaluate the difference between diaphragm-based EIT-belt placement and conventio...

    Authors: Chaofu Yue, Huaiwu He, Longxiang Su, Jun Wang, Siyi Yuan, Yun Long and Zhanqi Zhao
    Citation: Journal of Intensive Care 2023 11:41
    Content type: Research Published on:

  20. Diaphragm dysfunction is common in critically ill patients and associated with poorer outcomes. The function of the diaphragm can be evaluated at the bedside by measuring diaphragmatic excursion using ultrason...

    Authors: Karn Suttapanit, Supawit Wongkrasunt, Sorravit Savatmongkorngul and Praphaphorn Supatanakij
    Citation: Journal of Intensive Care 2023 11:40
    Content type: Research Published on:

  21. Diaphragmatic dysfunction often occurs after adult cardiovascular surgery. The prognostic effect of diaphragmatic dysfunction on ventilatory management in patients after cardiovascular surgery is unknown. This...

    Authors: Reimi Inoue, Yusuke Nagamine, Masahide Ohtsuka and Takahisa Goto
    Citation: Journal of Intensive Care 2023 11:39
    Content type: Research Published on:

  22. The efficacy and safety of saline versus balanced crystalloid solutions in ICU-patients remains complicated by exceptionally heterogenous study population in past comparative studies. This study sought to comp...

    Authors: Jonas Gmeiner, Bernhardt Bulach, Enzo Lüsebrink, Leonhard Binzenhöfer, Danny Kupka, Thomas Stocker, Kornelia Löw, Ludwig Weckbach, Wolf-Stephan Rudi, Tobias Petzold, Stefan Kääb, Jörg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban and Clemens Scherer
    Citation: Journal of Intensive Care 2023 11:38
    Content type: Research Published on:

  23. The respiratory ECMO survival prediction (RESP) score is used to predict survival for patients managed with extracorporeal membrane oxygenation (ECMO), but its performance in patients with Coronavirus Disease ...

    Authors: Elias H. Pratt, Samantha Morrison, Cynthia L. Green and Craig R. Rackley
    Citation: Journal of Intensive Care 2023 11:37
    Content type: Letter to the Editor Published on:

  24. Previous studies show positive effect of music on reducing anxiety, pain, and medication requirement. Anxiety has become a more pertinent issue in the intensive care unit (ICU) since wakefulness is preferred a...

    Authors: Ellaha Kakar, Thomas Ottens, Susanne Stads, Sanne Wesselius, Diederik A. M. P. J. Gommers, Johannes Jeekel and Mathieu van der Jagt
    Citation: Journal of Intensive Care 2023 11:36
    Content type: Research Published on:

  25. Despite the understanding of sepsis-induced extracellular vesicles (EVs), such as exosomes, and their role in intercellular communication during sepsis, little is known about EV contents such as microRNA (miRN...

    Authors: Beomsu Shin, Jin Young Lee, Yunjoo Im, Hongseok Yoo, Junseon Park, Joo Sang Lee, Ki-Young Lee and Kyeongman Jeon
    Citation: Journal of Intensive Care 2023 11:35
    Content type: Research Published on:

  26. The efficacies of fresh frozen plasma and coagulation factor transfusion have been widely evaluated in trauma-induced coagulopathy management during the acute post-injury phase. However, the efficacy of red bl...

    Authors: Mineji Hayakawa, Takashi Tagami, Daisuke Kudo, Kota Ono, Makoto Aoki, Akira Endo, Tetsuya Yumoto, Yosuke Matsumura, Shiho Irino, Kazuhiko Sekine, Noritaka Ushio, Takayuki Ogura, Sho Nachi, Yuhei Irie, Katsura Hayakawa, Yusuke Ito…
    Citation: Journal of Intensive Care 2023 11:34
    Content type: Research Published on:

  30. Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recogni...

    Authors: Francesco Bellanti, Sławomir Kasperczyk, Aleksandra Kasperczyk, Michał Dobrakowski, Gabriella Pacilli, Giuseppina Vurchio, Alessandro Maddalena, Stefano Quiete, Aurelio Lo Buglio, Cristiano Capurso, Gaetano Serviddio and Gianluigi Vendemiale
    Citation: Journal of Intensive Care 2023 11:30
    Content type: Research Published on:

  31. A unified clinical definition of feeding intolerance (FI) is urged for better management of enteral nutrition (EN) in critically ill patients. We aimed to identify optimum clinical FI definitions based on repo...

    Authors: Jianbo Li, Lijie Wang, Huan Zhang, Tongjuan Zou, Yan Kang, Wei He, Yuan Xu and Wanhong Yin
    Citation: Journal of Intensive Care 2023 11:29
    Content type: Review Published on:

  32. Tissue Doppler-derived left ventricular systolic velocity (mitral S’) has shown excellent correlation to left ventricular ejection fraction (LVEF) in non-critically patients. However, their correlation in sept...

    Authors: Sanchit Chawla, Ryota Sato, Abhijit Duggal, Mahmoud Alwakeel, Daisuke Hasegawa, Dina Alayan, Patrick Collier, Filippo Sanfilippo, Michael Lanspa and Siddharth Dugar
    Citation: Journal of Intensive Care 2023 11:28
    Content type: Research Published on:

  33. The effects of body mass index (BMI) on mortality of sepsis remain unknown, since previous meta-analyses have reported conflicting results. Several observational studies published recently have provided new ev...

    Authors: Le Bai, Jingyi Huang, Dan Wang, Dongwei Zhu, Qi Zhao, Tingyuan Li, Xianmei Zhou and Yong Xu
    Citation: Journal of Intensive Care 2023 11:27
    Content type: Research Published on:

  34. Cardiogenic shock (CS) is caused by primary cardiac dysfunction and induced by various and heterogeneous diseases (e.g., acute impairment of cardiac performance, or acute or chronic impairment of cardiac perfo...

    Authors: Akihiro Shirakabe, Masato Matsushita, Yusaku Shibata, Shota Shighihara, Suguru Nishigoori, Tomofumi Sawatani, Kazutaka Kiuchi and Kuniya Asai
    Citation: Journal of Intensive Care 2023 11:26
    Content type: Review Published on:

  35. Post-pyloric enteral feeding reduces respiratory complications and shortens the duration of mechanical ventilation. Blind placement of post-pyloric enteral feeding tubes (EFT) in patients with critical illness...

    Authors: Masashi Yokose, Shunsuke Takaki, Yusuke Saigusa, Takahiro Mihara, Yoshinobu Ishiwata, Shingo Kato, Keiichi Horie and Takahisa Goto
    Citation: Journal of Intensive Care 2023 11:25
    Content type: Research Published on:

  36. The International Society on Thrombosis and Haemostasis (ISTH) released overt disseminated intravascular coagulation (DIC) diagnostic criteria in 2001. Since then, DIC has been understood as the end-stage cons...

    Authors: Toshiaki Iba, Julie Helms, Jean Marie Connors and Jerrold H. Levy
    Citation: Journal of Intensive Care 2023 11:24
    Content type: Review Published on:

  37. An increasing number of patients are surviving critical illness, but some experience new or worsening long-lasting impairments in physical, cognitive and/or mental health, commonly known as post-intensive care...

    Authors: Stephanie L. Hiser, Arooj Fatima, Mazin Ali and Dale M. Needham
    Citation: Journal of Intensive Care 2023 11:23
    Content type: Review Published on:

  38. Transpulmonary pressure is an essential physiologic concept as it reflects the true pressure across the alveoli, and is a more precise marker for lung stress. To calculate transpulmonary pressure, one needs an...

    Authors: Tatsutoshi Shimatani, Miyako Kyogoku, Yukie Ito, Muneyuki Takeuchi and Robinder G. Khemani
    Citation: Journal of Intensive Care 2023 11:22
    Content type: Review Published on:

  39. Long-term outcomes of patients treated with helmet noninvasive ventilation (NIV) are unknown: safety concerns regarding the risk of patient self-inflicted lung injury and delayed intubation exist when NIV is a...

    Authors: Teresa Michi, Chiara Mattana, Luca S. Menga, Maria Grazia Bocci, Melania Cesarano, Tommaso Rosà, Maria Rosaria Gualano, Jonathan Montomoli, Savino Spadaro, Matteo Tosato, Elisabetta Rota, Francesco Landi, Salvatore L. Cutuli, Eloisa S. Tanzarella, Gabriele Pintaudi, Edoardo Piervincenzi…
    Citation: Journal of Intensive Care 2023 11:21
    Content type: Research Published on:

  40. Postoperative delirium in intensive care is common and associated with mortality, cognitive impairment, prolonged hospital stays and high costs. We evaluate whether a nurse-led orientation program could reduce...

    Authors: Ryo Nakamura, Kyohei Miyamoto, Kaori Tsuji, Kana Ozaki, Hideki Kunimoto, Kentaro Honda, Yoshiharu Nishimura and Seiya Kato
    Citation: Journal of Intensive Care 2023 11:20
    Content type: Research Published on:

  42. High-flow nasal cannula (HFNC) has been proven effective in improving patients with acute hypoxemic respiratory failure (AHRF), but a discussion of its use for initial flow settings still need to be provided. ...

    Authors: Yuewen He, Xuhui Zhuang, Hao Liu and Wuhua Ma
    Citation: Journal of Intensive Care 2023 11:18
    Content type: Research Published on:

  43. Increased estimated whole blood viscosity (eWBV) predicts higher mortality in patients hospitalized for coronavirus disease 2019 (COVID-19). This study assesses whether eWBV is an early predictor of non-fatal ...

    Authors: Ori Waksman, Daein Choi, Phyu Mar, Qinzhong Chen, Daniel J. Cho, HyoungSup Kim, Robin L. Smith, Sascha N. Goonewardena and Robert S. Rosenson
    Citation: Journal of Intensive Care 2023 11:17
    Content type: Research Published on:

  44. Based on sparse evidence, the current Surviving Sepsis Campaign guideline suggests that critically ill patients with sepsis be admitted to the intensive care unit (ICU) within 6 h. However, limited ICU bed ava...

    Authors: Yoon Hae Ahn, Jinwoo Lee, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Haein Lee, Chae-Man Lim, Sang-Min Lee and Hong Yeul Lee
    Citation: Journal of Intensive Care 2023 11:16
    Content type: Research Published on:

  45. Hemolysis is associated with increased mortality in patients with sepsis, ARDS, or therapy with extracorporeal membrane oxygenation (ECMO). To quantify a critical threshold of hemolysis in patients with ARDS a...

    Authors: Victoria Bünger, Oliver Hunsicker, Alexander Krannich, Felix Balzer, Claudia D. Spies, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk and Jan A. Graw
    Citation: Journal of Intensive Care 2023 11:15
    Content type: Research Published on:

  46. Previous studies linked a high intensity of ventilation, measured as mechanical power, to mortality in patients suffering from “classic” ARDS. By contrast, mechanically ventilated patients with a diagnosis of ...

    Authors: Basit A. Azizi, Ricardo Munoz-Acuna, Aiman Suleiman, Elena Ahrens, Simone Redaelli, Tim M. Tartler, Guanqing Chen, Boris Jung, Daniel Talmor, Elias N. Baedorf-Kassis and Maximilian S. Schaefer
    Citation: Journal of Intensive Care 2023 11:14
    Content type: Research Published on:

  47. Augmented renal clearance (ARC) is associated with lower blood plasma concentrations of renally excreted drugs; however, its time course is unknown. The current study aimed to determine the onset timing/durati...

    Authors: Ryusei Mikami, Mineji Hayakawa, Shungo Imai, Mitsuru Sugawara and Yoh Takekuma
    Citation: Journal of Intensive Care 2023 11:13
    Content type: Research Published on:

  48. The public enquiry into the mass casualty incident at the Manchester Arena in the UK in which 23 people died and over 1000 were injured, identified the need for timely intramuscular administration of tranexami...

    Authors: Kazuhiko Omori and Ian Roberts
    Citation: Journal of Intensive Care 2023 11:12
    Content type: Review Published on:

  49. Acute kidney injury (AKI) is a frequent syndrome in the intensive care unit (ICU). AKI patients with kidney function recovery have better short-term and long-term prognoses compared with those with non-recover...

    Authors: Ben-Shu Qian, Hui-Miao Jia, Yi-Bing Weng, Xin-Cheng Li, Chao-Dong Chen, Fang-Xing Guo, Yu-Zhen Han, Li-Feng Huang, Yue Zheng and Wen-Xiong Li
    Citation: Journal of Intensive Care 2023 11:11
    Content type: Research Published on:
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  • ISSN: 2052-0492 (electronic)

Journal of Intensive Care

ISSN: 2052-0492