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  1. Critically ill traumatic brain injury (TBI) patients experience extensive muscle damage during their stay in the intensive care unit. Neuromuscular electrical stimulation (NMES) has been considered a promising...

    Authors: Paulo Eugênio Silva, Rita de Cássia Marqueti, Karina Livino-de-Carvalho, Amaro Eduardo Tavares de Araujo, Joana Castro, Vinicius Maldaner da Silva, Luciana Vieira, Vinicius Carolino Souza, Lucas Ogura Dantas, Gerson Cipriano Jr, Otávio Tolêdo Nóbrega, Nicolas Babault and Joao Luiz Quagliotti Durigan

    Citation: Journal of Intensive Care 2019 7:59

    Content type: Research

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  2. Serial lactate measurement is found to predict mortality in septic shock. Majority of patients with perforation peritonitis for emergency laparotomy are in sepsis and mortality rate is substantial. However, la...

    Authors: S. P. Jobin, Souvik Maitra, Dalim Kumar Baidya, Rajeshwari Subramaniam, Ganga Prasad and Vathulru Seenu

    Citation: Journal of Intensive Care 2019 7:58

    Content type: Research

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  3. This systematic review and meta-analysis of randomized clinical trials aimed to investigate the efficacy of early mobilization among critically ill adult patients.

    Authors: Yohei Okada, Takeshi Unoki, Yujiro Matsuishi, Yuko Egawa, Kei Hayashida and Shigeaki Inoue

    Citation: Journal of Intensive Care 2019 7:57

    Content type: Research

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  4. Diaphragm atrophy is observed in mechanically ventilated patients. However, the atrophy is not investigated in other respiratory muscles. Therefore, we conducted a two-center prospective observational study to...

    Authors: Nobuto Nakanishi, Jun Oto, Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki and Masaji Nishimura

    Citation: Journal of Intensive Care 2019 7:56

    Content type: Research

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  5. The burden of sepsis is highest in low- and middle-income countries, though the management of sepsis in these settings is poorly characterized. Therefore, the objective of this study was to assess the early ma...

    Authors: Kristina E. Rudd, Viriya Hantrakun, Ranjani Somayaji, Suchart Booraphun, Chaiyaporn Boonsri, Annette L. Fitzpatrick, Nicholas P. J. Day, Prapit Teparrukkul, Direk Limmathurotsakul and T. Eoin West

    Citation: Journal of Intensive Care 2019 7:55

    Content type: Research

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  6. A spontaneous breathing trial (SBT) is a major diagnostic tool to predict successfully extubation in patients. Several factors may lead to weaning failure, including the degree of lung aeration loss and diaphr...

    Authors: Jing Xia, Chuan-Yun Qian, Li Yang, Mei-Ju Li, Xiao-Xue Liu, Ting Yang and Qin Lu

    Citation: Journal of Intensive Care 2019 7:54

    Content type: Research

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  7. Gait independence is one of the most important factors related to returning home from the hospital for patients treated in the intensive care unit (ICU), but the factors affecting gait independence have not be...

    Authors: Shinichi Watanabe, Toru Kotani, Shunsuke Taito, Kohei Ota, Kenzo Ishii, Mika Ono, Hajime Katsukawa, Ryo Kozu, Yasunari Morita, Ritsuro Arakawa and Shuichi Suzuki

    Citation: Journal of Intensive Care 2019 7:53

    Content type: Research

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  8. Traditional capillary refill time (CRT) is a manual measurement that is commonly used by clinicians to identify deterioration in peripheral perfusion status. Our study compared a novel method of measuring peri...

    Authors: Koichiro Shinozaki, Lee S. Jacobson, Kota Saeki, Hideaki Hirahara, Naoki Kobayashi, Steve Weisner, Julianne M. Falotico, Timmy Li, Junhwan Kim and Lance B. Becker

    Citation: Journal of Intensive Care 2019 7:52

    Content type: Research

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  9. The majority of patients with hemorrhagic stroke experience enhanced renal clearance or augmented renal clearance (ARC). The purpose of this study was to determine the impact of enhanced renal clearance or ARC...

    Authors: Kathryn A. Morbitzer, Denise H. Rhoney, Kelly A. Dehne and J. Dedrick Jordan

    Citation: Journal of Intensive Care 2019 7:51

    Content type: Research

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  10. Ventilator weaning protocols have been shown to reduce the duration of mechanical ventilation (MV), intensive care unit length of stay, and resource use. However, weaning protocols have not significantly affec...

    Authors: Kenichi Nitta, Kazufumi Okamoto, Hiroshi Imamura, Katsunori Mochizuki, Hiroshi Takayama, Hiroshi Kamijo, Mayumi Okada, Kanako Takeshige, Yuichiro Kashima and Takahisa Satou

    Citation: Journal of Intensive Care 2019 7:50

    Content type: Research

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  11. Alcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding i...

    Authors: Ekaterina R. Yavarovich, Maythawee Bintvihok, Justin C. McCarty, Janis L. Breeze and Peter LaCamera

    Citation: Journal of Intensive Care 2019 7:49

    Content type: Research

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  12. Frailty status is recognized as an important parameter in critically ill elderly patients, but nothing is known about outcomes in non-frail patients regarding the development of frailty or frailty and death af...

    Authors: Yoann Launey, Hervé Jacquet, Matthieu Arnouat, Chloe Rousseau, Nicolas Nesseler and Philippe Seguin

    Citation: Journal of Intensive Care 2019 7:48

    Content type: Research

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  13. Serum lactate and central venous oxygen saturation (ScvO2) are commonly used and commonly recommended as markers of tissue oxygenation in shock states. Medical literature has both explicitly stated and implied th...

    Authors: Roshan Bisarya, Deena Shaath, Arman Pirzad, Lewis Satterwhite, Jianghua He and Steven Q. Simpson

    Citation: Journal of Intensive Care 2019 7:47

    Content type: Research

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  14. Early recognition of sepsis is challenging, and diagnostic criteria have changed repeatedly. We assessed the robustness of sepsis-3 criteria in intensive care unit (ICU) patients.

    Authors: Diana M. Verboom, Jos F. Frencken, David S. Y. Ong, Janneke Horn, Tom van der Poll, Marc J. M. Bonten, Olaf L. Cremer and Peter M. C. Klein Klouwenberg

    Citation: Journal of Intensive Care 2019 7:46

    Content type: Research

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  15. Extracorporeal carbon dioxide removal (ECCO2R) is a promising technique for the management of acute respiratory failure, but with a limited level of evidence to support its use outside clinical trials and/or data...

    Authors: J. L. Augy, N. Aissaoui, C. Richard, E. Maury, M. Fartoukh, A. Mekontso-Dessap, R. Paulet, N. Anguel, C. Blayau, Y. Cohen, J. D. Chiche, S. Gaudry, S. Voicu, A. Demoule, A. Combes, B. Megarbane…

    Citation: Journal of Intensive Care 2019 7:45

    Content type: Research

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  16. We investigated if early intensive care unit (ICU) scoring with the Simplified Acute Physiology Score (SAPS 3) could be improved using artificial neural networks (ANNs).

    Authors: Gustav Holmgren, Peder Andersson, Andreas Jakobsson and Attila Frigyesi

    Citation: Journal of Intensive Care 2019 7:44

    Content type: Research

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  17. An error occurred during the publication of a number of articles in Journal of Intensive Care. Several articles were published in volume 7 with a duplicate citation number.

    Authors:

    Citation: Journal of Intensive Care 2019 7:43

    Content type: Publisher Correction

    Published on:

    The original article was published in Journal of Intensive Care 2019 7:35

    The original article was published in Journal of Intensive Care 2019 7:34

  18. Fluid infusion represents one of the cornerstones of resuscitation therapies in order to increase oxygen delivery during septic shock. Fluid overload as a consequence of excessive fluid administration seems to...

    Authors: Xavier Chapalain, Véronique Vermeersch, Pierre-Yves Egreteau, Gwenael Prat, Zarrin Alavi, Eric Vicaut and Olivier Huet

    Citation: Journal of Intensive Care 2019 7:42

    Content type: Research

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  19. With Sepsis-3, the increase in sequential organ failure assessment (SOFA) as a clinical score for the identification of patients with sepsis and quickSOFA (qSOFA) for the identification of patients at risk of ...

    Authors: Lucie Probst, Enrico Schalk, Tobias Liebregts, Vanja Zeremski, Asterios Tzalavras, Michael von Bergwelt-Baildon, Nina Hesse, Johanna Prinz, Jörg Janne Vehreschild, Alexander Shimabukuro-Vornhagen, Dennis A. Eichenauer, Jorge Garcia Borrega, Matthias Kochanek and Boris Böll

    Citation: Journal of Intensive Care 2019 7:41

    Content type: Research

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  20. In the original publication of this article [1], the content of Authors’ contributions needs to be revised as below:

    Authors: Hendrik Gussen, Philipp Hohlstein, Matthias Bartneck, Klaudia Theresa Warzecha, Lukas Buendgens, Tom Luedde, Christian Trautwein, Alexander Koch and Frank Tacke

    Citation: Journal of Intensive Care 2019 7:40

    Content type: Correction

    Published on:

    The original article was published in Journal of Intensive Care 2019 7:26

  21. Commencement of a new academic cycle is presumed to be associated with poor patient outcomes. However, supportive evidence is limited for trauma patients treated in under-resourced hospitals, especially those ...

    Authors: Yuko Ono, Takeyasu Kakamu, Tokiya Ishida, Tetsu Sasaki, Shigeaki Inoue, Joji Kotani and Kazuaki Shinohara

    Citation: Journal of Intensive Care 2019 7:39

    Content type: Research

    Published on:

  22. The length of stay (LOS) in intensive care units (ICUs) has been used as a good indicator not only for resource consumption but also for health outcomes of patients. However, data regarding pediatric LOS in Ja...

    Authors: Emily Knaup, Nobuyuki Nosaka, Takashi Yorifuji, Kohei Tsukahara, Hiromichi Naito, Hirokazu Tsukahara and Atsunori Nakao

    Citation: Journal of Intensive Care 2019 7:38

    Content type: Research

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  23. Appropriate use of antimicrobials is essential to improve outcomes in sepsis. The aim of this study was to determine whether the use of a rapid molecular blood test—SeptiFast (SF) reduces the antibiotic consumpti...

    Authors: Cristhieni Rodrigues, Rinaldo Focaccia Siciliano, Helio Caiaffa Filho, Cecília Eugenia Charbel, Luciane de Carvalho Sarahyba da Silva, Martina Baiardo Redaelli, Ana Paula de Paula Rosa Passetti, Maria Renata Gomes Franco, Flávia Rossi, Rogerio Zeigler, Daniel De Backer, Rafael Alves Franco, Juliano Pinheiro de Almeida, Stéphanie Itala Rizk, Julia Tizue Fukushima, Giovanni Landoni…

    Citation: Journal of Intensive Care 2019 7:37

    Content type: Research

    Published on:

  24. The objective of this study was to determine the main risk factors of Pseudomonas aeruginosa mutation as well as the mechanisms of acquired resistance.

    Authors: Stéphanie Druge, Stéphanie Ruiz, Fanny Vardon-Bounes, Marion Grare, François Labaste, Thierry Seguin, Olivier Fourcade, Vincent Minville, Jean-Marie Conil and Bernard Georges

    Citation: Journal of Intensive Care 2019 7:36

    Content type: Research

    Published on:

  25. We examined whether high lactate level in septic patients was associated with 90-day mortality based on the patients’ disseminated intravascular coagulation (DIC) status.

    Authors: Daisuke Hasegawa, Kazuki Nishida, Yoshitaka Hara, Takahiro Kawaji, Kazuhiro Moriyama, Yasuyo Shimomura, Daisuke Niimi, Hidefumi Komura and Osamu Nishida

    Citation: Journal of Intensive Care 2019 7:35

    Content type: Research

    Published on:

    The Publisher Correction to this article has been published in Journal of Intensive Care 2019 7:43

  26. In the original publication of this article [1], the figure legends of Fig. 2 and Fig. 3 are wrong and should be changed as below:

    Authors: Yohei Okada, Tasuku Matsuyama, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Shungo Yamamoto, Ryoji Iiduka…

    Citation: Journal of Intensive Care 2019 7:34

    Content type: Correction

    Published on:

    The Publisher Correction to this article has been published in Journal of Intensive Care 2019 7:43

    The original article was published in Journal of Intensive Care 2019 7:27

  27. Disseminated intravascular coagulation (DIC) is a common complication in sepsis. Since DIC not only promotes organ dysfunction but also is a strong prognostic factor, its diagnosis at the earliest possible tim...

    Authors: Toshiaki Iba, Eizo Watanabe, Yutaka Umemura, Takeshi Wada, Kei Hayashida, Shigeki Kushimoto and Hideo Wada

    Citation: Journal of Intensive Care 2019 7:32

    Content type: Review

    Published on:

  28. Enteral nutrition (EN) can maintain the structure and function of the gastrointestinal mucosa better than parenteral nutrition. In critically ill patients, EN must be discontinued or interrupted, if gastrointe...

    Authors: Hiroomi Tatsumi

    Citation: Journal of Intensive Care 2019 7:30

    Content type: Review

    Published on:

  29. Outcomes in emergent patients with suspected infection depend on how quickly clinicians evaluate the patients and start treatment. This study was performed to compare the predictive ability of the quantitative...

    Authors: Oi Yasufumi, Naoto Morimura, Aya Shirasawa, Hiroshi Honzawa, Yutaro Oyama, Shoko Niida, Takeru Abe, Shouhei Imaki and Ichiro Takeuchi

    Citation: Journal of Intensive Care 2019 7:29

    Content type: Research

    Published on:

  30. Accurate and early identification of infection sites might help to drive crucial decisions regarding the treatment of sepsis. We aimed to determine the clinical and etiological features of infection according ...

    Authors: Toshikazu Abe, Hiroshi Ogura, Shigeki Kushimoto, Atsushi Shiraishi, Takehiro Sugiyama, Gautam A. Deshpande, Masatoshi Uchida, Isao Nagata, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Toru Hifumi, Yasukazu Shiino, Taka-aki Nakada, Takehiko Tarui, Yasuhiro Otomo…

    Citation: Journal of Intensive Care 2019 7:28

    Content type: Research

    Published on:

  31. Accidental hypothermia is a serious condition that requires immediate and accurate assessment to determine severity and treatment. Currently, accidental hypothermia is evaluated using the Swiss grading system ...

    Authors: Yohei Okada, Tasuku Matsuyama, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Shungo Yamamoto, Ryoji Iiduka…

    Citation: Journal of Intensive Care 2019 7:27

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2019 7:34

  32. Circulating levels of soluble urokinase plasminogen activation receptor (suPAR) have been proposed as a prognostic biomarker in patients with critical illness and sepsis. However, the origin of suPAR in sepsis...

    Authors: Hendrik Gussen, Philipp Hohlstein, Matthias Bartneck, Klaudia Theresa Warzecha, Lukas Buendgens, Tom Luedde, Christian Trautwein, Alexander Koch and Frank Tacke

    Citation: Journal of Intensive Care 2019 7:26

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2019 7:40

  33. While understanding of critical illness and delirium continue to evolve, the impact on clinical practice is often unknown and delayed. Our purpose was to provide insight into practice changes by characterizing...

    Authors: Gary D. Owen, Joanna L. Stollings, Shayan Rakhit, Li Wang, Chang Yu, Morgan A. Hosay, James W. Stewart, Fernando Frutos-Vivar, Oscar Peñuelas, Andres Esteban, Antonio R. Anzueto, Konstantinos Raymondos, Fernando Rios, Arnaud W. Thille, Marco González, Bin Du…

    Citation: Journal of Intensive Care 2019 7:25

    Content type: Research

    Published on:

  34. The study by Ogura et al. investigated the association between the structures of intensive care units (ICUs) affecting patient outcomes. A major limitation of this study is that the types of ICUs had not clear...

    Authors: Nobuaki Shime

    Citation: Journal of Intensive Care 2019 7:24

    Content type: Letter to the Editor

    Published on:

  35. Sphingosine 1-phosphate (S1P) is a signaling lipid essential in regulating processes involved in sepsis pathophysiology, including endothelial permeability and vascular tone. Serum S1P is progressively reduced...

    Authors: Martin Sebastian Winkler, Konstantin B. Märtz, Axel Nierhaus, Günter Daum, Edzard Schwedhelm, Stefan Kluge and Markus H. Gräler

    Citation: Journal of Intensive Care 2019 7:23

    Content type: Research

    Published on:

  36. Early and accurate diagnosis of sepsis is challenging. Although procalcitonin and presepsin have been identified as potential biomarkers to differentiate between sepsis and other non-infectious causes of syste...

    Authors: Yutaka Kondo, Yutaka Umemura, Kei Hayashida, Yoshitaka Hara, Morio Aihara and Kazuma Yamakawa

    Citation: Journal of Intensive Care 2019 7:22

    Content type: Research

    Published on:

  37. Cardiac output measurements may inform diagnosis and provide guidance of therapeutic interventions in patients with hemodynamic instability. The FloTrac™ algorithm uses uncalibrated arterial pressure waveform ...

    Authors: Thomas Kaufmann, Ramon P. Clement, Bart Hiemstra, Jaap Jan Vos, Thomas W. L. Scheeren, Frederik Keus and Iwan C. C. van der Horst

    Citation: Journal of Intensive Care 2019 7:21

    Content type: Research

    Published on:

  38. Currently, the appropriate method of management of patients with refractory septic shock remains unclear. This study aimed to evaluate the factors associated with response to epinephrine in norepinephrine-refr...

    Authors: Daisuke Kasugai, Mitsuaki Nishikimi, Kazuki Nishida, Michiko Higashi, Takanori Yamamoto, Atsushi Numaguchi, Kunihiko Takahashi, Shigeyuki Matsui and Naoyuki Matsuda

    Citation: Journal of Intensive Care 2019 7:20

    Content type: Research

    Published on:

  39. Red blood cell (RBC) transfusions are common procedures performed in the intensive care unit (ICU). However, conservative transfusion approaches have been recommended to avoid RBC transfusions that are not cli...

    Authors: Lesley J. J. Soril, Tom W. Noseworthy, Henry T. Stelfox, David A. Zygun and Fiona M. Clement

    Citation: Journal of Intensive Care 2019 7:19

    Content type: Research

    Published on:

  40. In the original publication of this article [1], the values of PH in the Table 4 are wrong.

    Authors: Takashi Mizutani, Norio Umemoto, Toshio Taniguchi, Hideki Ishii, Yuri Hiramatsu, Koji Arata, Horagaito Takuya, Sho Inoue, Tsuyoshi Sugiura, Toru Asai, Michiharu Yamada, Toyoaki Murohara and Kiyokazu Shimizu

    Citation: Journal of Intensive Care 2019 7:18

    Content type: Correction

    Published on:

    The original article was published in Journal of Intensive Care 2018 6:33

  41. The gut is hypothesized to be the “motor” of critical illness. Under basal conditions, the gut plays a crucial role in the maintenance of health. However, in critical illness, all elements of the gut are injur...

    Authors: Shunsuke Otani and Craig M. Coopersmith

    Citation: Journal of Intensive Care 2019 7:17

    Content type: Review

    Published on:

  42. Differentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentati...

    Authors: Bert K. Lopansri, Russell R. Miller III, John P. Burke, Mitchell Levy, Steven Opal, Richard E. Rothman, Franco R. D’Alessio, Venkataramana K. Sidhaye, Robert Balk, Jared A. Greenberg, Mark Yoder, Gourang P. Patel, Emily Gilbert, Majid Afshar, Jorge P. Parada, Greg S. Martin…

    Citation: Journal of Intensive Care 2019 7:13

    Content type: Research

    Published on:

  43. Guidelines for grading diastolic dysfunction poorly categorize septic patients. We compared how well the American Society of Echocardiography (ASE) 2009 and 2016 definitions and a simplified definition categor...

    Authors: Michael J. Lanspa, Troy D. Olsen, Emily L. Wilson, Mary Louise Leguyader, Eliotte L. Hirshberg, Jeffrey L. Anderson, Samuel M. Brown and Colin K. Grissom

    Citation: Journal of Intensive Care 2019 7:14

    Content type: Research

    Published on:

  44. One of the main pathophysiological manifestations during the acute phase of sepsis is massive production of proinflammatory mediators. Clinical trials involving direct suppression of inflammatory mediators to ...

    Authors: Ken Kuwajima, Kyungho Chang, Ai Furuta, Masahiko Bougaki, Kanji Uchida, Shigehito Sawamura and Yoshitsugu Yamada

    Citation: Journal of Intensive Care 2019 7:12

    Content type: Research

    Published on:

  45. For patients treated with extracorporeal membrane oxygenation (ECMO), employing a well-coordinated, multidisciplinary team specializing in ECMO has reportedly been effective in delivering better clinical outco...

    Authors: Atthasit Komindr, Ryuzo Abe, Yoshihisa Tateishi, Yuka Takahashi, Jun Goto, Keita Wada, Yutaka Furukawa, Atsushi Sugiura, Taro Imaeda, Natsumi Suga, Noriyuki Hattori and Shigeto Oda

    Citation: Journal of Intensive Care 2019 7:11

    Content type: Research

    Published on:

  46. This review is a “Pro-Con” discussion about the optimal fluid volume in critically ill patients in the intensive care unit (ICU). This article argues that fluids should be aggressively managed in critically il...

    Authors: Katsura Hayakawa

    Citation: Journal of Intensive Care 2019 7:9

    Content type: Commentary

    Published on: