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  1. During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission an...

    Authors: Thomas Daix, Robin Jeannet, Ana Catalina Hernandez Padilla, Philippe Vignon, Jean Feuillard and Bruno François

    Citation: Journal of Intensive Care 2021 9:58

    Content type: Letter to the Editor

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  2. This is a response to the issues raised in the commentary by Dr. Yifu Si et al.

    Authors: Yasutaka Hirasawa, Taka-aki Nakada and Jiro Terada

    Citation: Journal of Intensive Care 2021 9:56

    Content type: Commentary

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  3. The effect of changes to cardiopulmonary resuscitation (CPR) procedures in response to Coronavirus disease 2019 (COVID-19) on in-hospital cardiac arrest (IHCA) management and outcomes are unreported. In this m...

    Authors: Sau Ki Tong, Lowell Ling, Jack Zhenhe Zhang, Florence H. Y. Yap, Kam Leung Law and Gavin M. Joynt

    Citation: Journal of Intensive Care 2021 9:55

    Content type: Letter to the Editor

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  4. Ketamine has been shown to decrease sedative requirements in intensive care unit (ICU). Randomized trials are limited on patient-centered outcomes. We designed this pilot trial to evaluate the feasibility of a...

    Authors: Marwa Amer, Khalid Maghrabi, Mohammed Bawazeer, Kamel Alshaikh, Mohammad Shaban, Muhammad Rizwan, Rashid Amin, Edward De Vol, Mawadah Baali, Malak Altewerki, Mehreen Bano, Fawziah Alkhaldi, Sanaa Alenazi and Mohammed Hijazi

    Citation: Journal of Intensive Care 2021 9:54

    Content type: Research

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  5. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created as revised fr...

    Authors: Moritoki Egi, Hiroshi Ogura, Tomoaki Yatabe, Kazuaki Atagi, Shigeaki Inoue, Toshiaki Iba, Yasuyuki Kakihana, Tatsuya Kawasaki, Shigeki Kushimoto, Yasuhiro Kuroda, Joji Kotani, Nobuaki Shime, Takumi Taniguchi, Ryosuke Tsuruta, Kent Doi, Matsuyuki Doi…

    Citation: Journal of Intensive Care 2021 9:53

    Content type: Guideline

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  6. Our aim was to investigate the prognostic potential of circulating dipeptidyl peptidase 3 (cDPP3) to predict mortality and development of organ dysfunction in a mixed intensive care unit (ICU) population, and ...

    Authors: Attila Frigyesi, Maria Lengquist, Martin Spångfors, Martin Annborn, Tobias Cronberg, Niklas Nielsen, Helena Levin and Hans Friberg

    Citation: Journal of Intensive Care 2021 9:52

    Content type: Research

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  7. The relationship between computed tomography (CT) and prognosis of patients with COVID-19 pneumonia remains unclear. We hypothesized that the Ichikado CT score, obtained in the first 24 h of hospital admission...

    Authors: Alan Araiza, Melanie Duran, Cesar Patiño, Paul E. Marik and Joseph Varon

    Citation: Journal of Intensive Care 2021 9:51

    Content type: Research

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  8. Patient–ventilator asynchrony (PVA) is a common problem in patients undergoing invasive mechanical ventilation (MV) in the intensive care unit (ICU), and may accelerate lung injury and diaphragm mis-contractio...

    Authors: Michihito Kyo, Tatsutoshi Shimatani, Koji Hosokawa, Shunsuke Taito, Yuki Kataoka, Shinichiro Ohshimo and Nobuaki Shime

    Citation: Journal of Intensive Care 2021 9:50

    Content type: Research

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  9. Systemic inflammation relates to the initiation and progression of acute respiratory distress syndrome (ARDS). Neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW)/albumin ratio hav...

    Authors: Lijuan Yang, Chang Gao, Fengyuan Li, Ling Yang, Jiahao Chen, Shiqi Guo, Ying He and Qiang Guo

    Citation: Journal of Intensive Care 2021 9:49

    Content type: Research

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  10. Excess morbidity and mortality following critical illness is increasingly attributed to potentially avoidable complications occurring as a result of complex ICU management (Berenholtz et al., J Crit Care 17:1-...

    Authors: Issrah Jawad, Sumayyah Rashan, Chathurani Sigera, Jorge Salluh, Arjen M. Dondorp, Rashan Haniffa and Abi Beane

    Citation: Journal of Intensive Care 2021 9:48

    Content type: Research

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  11. Conservative oxygen strategy is recommended in acute illness while its benefit in ICU patients remains controversial. Therefore, we sought to conduct a systematic review and meta-analysis to examine such oxyge...

    Authors: Xiao-Li Chen, Bei-Lei Zhang, Chang Meng, Hui-Bin Huang and Bin Du

    Citation: Journal of Intensive Care 2021 9:47

    Content type: Research

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  12. Electrical cardioversion (ECV) is widely used to restore sinus rhythm in critically ill adult patients with atrial fibrillation, although its prognostic value is uncertain. This study aims to elucidate the cli...

    Authors: Nozomu Shima, Kyohei Miyamoto, Seiya Kato, Takuo Yoshida and Shigehiko Uchino

    Citation: Journal of Intensive Care 2021 9:46

    Content type: Research

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  13. The course of chronic obstructive pulmonary disease (COPD) is punctuated by exacerbations, most often of infectious origin, responsible for many intensive care unit (ICU) and intermediate care unit (IMCU) admi...

    Authors: Matthieu Amalric, Engi Ahmed, Boris Jung, Carey Suehs, Nicolas Molinari, Arnaud Bourdin and Jeremy Charriot

    Citation: Journal of Intensive Care 2021 9:45

    Content type: Research

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  14. Autotaxin (ATX) is a secreted glycoprotein that is widely present in extracellular biological fluids and has been implicated in many inflammatory and fibrotic diseases. However, the clinical impact of the rele...

    Authors: Lijuan Gao, Xiaoou Li, Hao Wang, Yue Liao, Yongfang Zhou, Ke Wang, Jun Hu, Mengxin Cheng, Zijian Zeng, Tao Wang and Fuqiang Wen

    Citation: Journal of Intensive Care 2021 9:44

    Content type: Research

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  15. Target temperature management (TTM) is suggested to reduce brain damage in the presence of global or local ischemia. Prompt TTM application may help to improve outcomes, but it is often hindered by technical p...

    Authors: Michela Masè, Alessandro Micarelli, Marika Falla, Ivo B. Regli and Giacomo Strapazzon

    Citation: Journal of Intensive Care 2021 9:43

    Content type: Review

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  16. Since the start of the coronavirus disease 2019 (COVID-19) pandemic, it has remained unknown whether conventional risk prediction tools used in intensive care units are applicable to patients with COVID-19. Th...

    Authors: Hideki Endo, Hiroyuki Ohbe, Junji Kumasawa, Shigehiko Uchino, Satoru Hashimoto, Yoshitaka Aoki, Takehiko Asaga, Eiji Hashiba, Junji Hatakeyama, Katsura Hayakawa, Nao Ichihara, Hiromasa Irie, Tatsuya Kawasaki, Hiroshi Kurosawa, Tomoyuki Nakamura, Hiroshi Okamoto…

    Citation: Journal of Intensive Care 2021 9:42

    Content type: Letter to the Editor

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  17. Airway management, including noninvasive endotracheal intubation or invasive tracheostomy, is an essential treatment strategy for patients with deep neck space abscess (DNSA) to reverse acute hypoxia, which ai...

    Authors: Yu Lin, Wenxiang Gao, Huijun Yue, Weixiong Chen, Tianrun Liu, Jin Ye, Qian Cai, Fei Ye, Long He, Xingqiang Xie, Guoping Xiong, Bin Wang, Feng Pang, Pei Li, Jianhui Wu, Bin Wang…

    Citation: Journal of Intensive Care 2021 9:41

    Content type: Research

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  18. β-blockers may protect against catecholaminergic myocardial injury in critically ill patients. Long-term β-blocker users are known to have lower lactate concentrations and favorable sepsis outcomes. However, the ...

    Authors: Ming-Jen Kuo, Ruey-Hsing Chou, Ya-Wen Lu, Jiun-Yu Guo, Yi-Lin Tsai, Cheng-Hsueh Wu, Po-Hsun Huang and Shing-Jong Lin

    Citation: Journal of Intensive Care 2021 9:40

    Content type: Research

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  19. The use of ultrashort-acting β1-blockers recently has attracted attention in septic patients with non-compensatory tachycardia. We summarized the metabolic and hemodynamic effects and the clinical evidence of ...

    Authors: Daisuke Hasegawa, Ryota Sato and Osamu Nishida

    Citation: Journal of Intensive Care 2021 9:39

    Content type: Commentary

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  20. Tracheal intubation is the gold standard for securing the airway, and it is not uncommon to encounter intubation difficulties in intensive care units and emergency rooms. Currently, there is a need for an obje...

    Authors: Tatsuya Hayasaka, Kazuharu Kawano, Kazuki Kurihara, Hiroto Suzuki, Masaki Nakane and Kaneyuki Kawamae

    Citation: Journal of Intensive Care 2021 9:38

    Content type: Research

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  21. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Intestinal mucosal barrier injury is one of the important manifestations of sepsis. Interleukin-9 (IL-9) and ...

    Authors: Jia-Kui Sun, Jing Zhou, Xin-Pei Sun, Xiao Shen, Dong-Mei Zhu, Xiang Wang, Su-Ming Zhou and Xin-Wei Mu

    Citation: Journal of Intensive Care 2021 9:37

    Content type: Research

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  22. Acute respiratory distress syndrome (ARDS) is a leading cause of morbidity and mortality in the intensive care unit. Biochemical markers of cardiac dysfunction are associated with high mortality in many respir...

    Authors: Dilip Jayasimhan, Simon Foster, Catherina L. Chang and Robert J. Hancox

    Citation: Journal of Intensive Care 2021 9:36

    Content type: Research

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  23. Heatstroke is associated with exposure to high ambient temperature (AT) and relative humidity (RH), and an increased risk of organ damage or death. Previously proposed animal models of heatstroke disregard the...

    Authors: Kazuyuki Miyamoto, Keisuke Suzuki, Hirokazu Ohtaki, Motoyasu Nakamura, Hiroki Yamaga, Masaharu Yagi, Kazuho Honda, Munetaka Hayashi and Kenji Dohi

    Citation: Journal of Intensive Care 2021 9:35

    Content type: Research

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  24. REMAP-CAP, a randomized, embedded, multifactorial adaptive platform trial for community-acquired pneumonia, is an international clinical trial that is rapidly expanding its scope and scale in response to the C...

    Authors: Kazuhiro Kamata, Kazuaki Jindai, Nao Ichihara, Hiroki Saito, Hideaki Kato, Hiroyuki Kunishima, Ayumi Shintani, Osamu Nishida and Shigeki Fujitani

    Citation: Journal of Intensive Care 2021 9:34

    Content type: Letter to the Editor

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  25. Septic patients with cardiac impairment are with high mortality. Afterload-related cardiac performance (ACP), as a new tool for diagnosing septic cardiomyopathy (SCM), still needs to be evaluated for its impac...

    Authors: Wei-yan Chen, Zhen-hui Zhang, Li-li Tao, Qi Xu, Xing Wei and Min-sheng Chen

    Citation: Journal of Intensive Care 2021 9:33

    Content type: Research

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  26. Noninvasive respiratory support devices may reduce the tracheal intubation rate compared with conventional oxygen therapy (COT). To date, few studies have compared high-flow nasal cannula (HFNC) use with nonin...

    Authors: Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Masaki Nakane and Nobuaki Shime

    Citation: Journal of Intensive Care 2021 9:32

    Content type: Research

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  27. A significant number of COVID-19 patients have been treated using invasive mechanical ventilation (IMV). The ability to evaluate functional status of COVID-19 survivors early on at ICU and hospital discharge m...

    Authors: Benjamin Musheyev, Lara Borg, Rebeca Janowicz, Michael Matarlo, Hayle Boyle, Gurinder Singh, Victoria Ende, Ioannis Babatsikos, Wei Hou and Tim Q. Duong

    Citation: Journal of Intensive Care 2021 9:31

    Content type: Research

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  28. The COVID-19 global pandemic has placed unprecedented strain on healthcare and critical care services around the world. Whilst most resources have focused on the acute phase of the disease, there is likely to ...

    Authors: Matthew Cadd and Maya Nunn

    Citation: Journal of Intensive Care 2021 9:29

    Content type: Commentary

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  29. Dynamic change of heart rate in the acute phase and clinical outcomes after intracerebral hemorrhage (ICH) remains unknown. We aimed to investigate the associations of heart rate trajectories and variability w...

    Authors: Shoujiang You, Yupin Wang, Zian Lu, Dandan Chu, Qiao Han, Jiaping Xu, Chun-Feng Liu, Yongjun Cao and Chongke Zhong

    Citation: Journal of Intensive Care 2021 9:28

    Content type: Research

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  30. The purpose of this study is to investigate the time course of syndecan-1 (Syn-1) plasma levels, the correlation between Syn-1 and organ damage development, and the associations of Syn-1 level with cumulative ...

    Authors: Yuka Kajita, Tsuguaki Terashima, Hisatake Mori, Md. Monirul Islam, Takayuki Irahara, Masanobu Tsuda, Hideki Kano and Naoshi Takeyama

    Citation: Journal of Intensive Care 2021 9:27

    Content type: Research

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  31. We comment on the study by Hirano et al. about the effect of steroids in patients with acute respiratory distress syndrome. It might be necessary to include only the existing randomized control trials and to r...

    Authors: Shodai Yoshihiro and Shunsuke Taito

    Citation: Journal of Intensive Care 2021 9:25

    Content type: Letter to the Editor

    Published on:

    The original article was published in Journal of Intensive Care 2020 8:91

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2021 9:26

  32. Physical restraint has been commonly indicated to patients with brain dysfunction in neurocritical care. The effect of physical restraints on outcomes of critically ill adults remains controversial as no rando...

    Authors: Kyoko Akiyama, Akihiko Inoue, Toru Hifumi, Kentaro Nakamura, Takuya Taira, Shun Nakagawa, Keisuke Jinno, Arisa Manabe, Sayaka Kinugasa, Hikaru Matsumura, Hajime Shishido, Shota Yokoyama, Tomoya Okazaki, Hideyuki Hamaya, Koshiro Takano, Kazutaka Kiridume…

    Citation: Journal of Intensive Care 2021 9:24

    Content type: Research

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  33. We aimed to describe the use of high-flow nasal oxygen (HFNO) in patients with COVID-19 acute respiratory failure and factors associated with a shift to invasive mechanical ventilation.

    Authors: Ricard Mellado-Artigas, Luis Eduardo Mujica, Magda Liliana Ruiz, Bruno Leonel Ferreyro, Federico Angriman, Egoitz Arruti, Antoni Torres, Enric Barbeta, Jesús Villar and Carlos Ferrando

    Citation: Journal of Intensive Care 2021 9:23

    Content type: Research

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  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

    Citation: Journal of Intensive Care 2021 9:22

    Content type: Correction

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    The original article was published in Journal of Intensive Care 2021 9:14

  35. Cellular patterns in bronchoalveolar lavage fluid (BALF) are used to distinguish or rule out particular diseases in patients with acute respiratory failure (ARF). However, whether BALF cellular patterns can pr...

    Authors: Yasutaka Hirasawa, Taka-aki Nakada, Takashi Shimazui, Mitsuhiro Abe, Yuri Isaka, Masashi Sakayori, Kenichi Suzuki, Keiichiro Yoshioka, Takeshi Kawasaki, Jiro Terada, Kenji Tsushima and Koichiro Tatsumi

    Citation: Journal of Intensive Care 2021 9:21

    Content type: Research

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  36. Coronavirus disease 2019 (COVID-19) infection is associated with a prothrombotic state. We performed a meta-analysis of proportions to estimate the weighted average incidence of pulmonary thromboembolism (PTE)...

    Authors: Jun Jie Ng, Zhen Chang Liang and Andrew M. T. L. Choong

    Citation: Journal of Intensive Care 2021 9:20

    Content type: Research

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  37. Immune and inflammatory dysfunction was reported to underpin critical COVID-19(coronavirus disease 2019). We aim to develop a machine learning model that enables accurate prediction of critical COVID-19 using ...

    Authors: Yue Gao, Lingxi Chen, Jianhua Chi, Shaoqing Zeng, Xikang Feng, Huayi Li, Dan Liu, Xinxia Feng, Siyuan Wang, Ya Wang, Ruidi Yu, Yuan Yuan, Sen Xu, Chunrui Li, Wei Zhang, Shuaicheng Li…

    Citation: Journal of Intensive Care 2021 9:19

    Content type: Research

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  38. The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model is widely used to predict mortality in Japanese intensive care units (ICUs). Although the model’s discrimination is excellent, its calibr...

    Authors: Hideki Endo, Shigehiko Uchino, Satoru Hashimoto, Yoshitaka Aoki, Eiji Hashiba, Junji Hatakeyama, Katsura Hayakawa, Nao Ichihara, Hiromasa Irie, Tatsuya Kawasaki, Junji Kumasawa, Hiroshi Kurosawa, Tomoyuki Nakamura, Hiroyuki Ohbe, Hiroshi Okamoto, Hidenobu Shigemitsu…

    Citation: Journal of Intensive Care 2021 9:18

    Content type: Research

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  39. Acute respiratory distress syndrome (ARDS) is a fatal condition with insufficiently clarified etiology. Supportive care for severe hypoxemia remains the mainstay of essential interventions for ARDS. In recent ...

    Authors: Shinichiro Ohshimo

    Citation: Journal of Intensive Care 2021 9:17

    Content type: Review

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  40. Unavailability or saturation of the intensive care unit may be associated with the fatality of COVID-19. Prioritizing the patients for hospitalization and intensive care may be critical for reducing the fatali...

    Authors: JoonNyung Heo, Deokjae Han, Hyung-Jun Kim, Daehyun Kim, Yeon-Kyeng Lee, Dosang Lim, Sung Ok Hong, Mi-Jin Park, Beomman Ha and Woong Seog

    Citation: Journal of Intensive Care 2021 9:16

    Content type: Research

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  41. Inappropriate authors’ self-citation (A-SC) is a growing mal-practice possibly boosted by the raising importance given to author’s metrics. Similarly, also excessive journals’ self-citation (J-SC) practice may...

    Authors: Filippo Sanfilippo, Stefano Tigano, Alberto Morgana, Paolo Murabito and Marinella Astuto

    Citation: Journal of Intensive Care 2021 9:15

    Content type: Commentary

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  42. The acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing p...

    Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

    Citation: Journal of Intensive Care 2021 9:14

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Intensive Care 2021 9:22

  43. Persistent apnea despite an adequate rise in arterial pressure of CO2 is an essential component of the criteria for brain death (BD) determination. Current guidelines vary regarding the utility of arterial pH cha...

    Authors: Ibrahim Migdady, Moein Amin, Aaron Shoskes, Catherine Hassett, Sung-Min Cho, Pravin George and Alexander Rae-Grant

    Citation: Journal of Intensive Care 2021 9:13

    Content type: Research

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  44. Sepsis is characterized by various hemodynamic alterations which could happen concomitantly in the heart, pulmonary and systemic circulations. A comprehensive demonstration of their interactions in the clinica...

    Authors: François Bagate, Paul Masi, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux, Genevieve Derumeaux and Armand Mekontso Dessap

    Citation: Journal of Intensive Care 2021 9:12

    Content type: Research

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  45. SARS-CoV-2 may cause acute lung injury, and secondary infections are thus relevant complications in patients with COVID-19 pneumonia. However, detailed information on community- and hospital-acquired infection...

    Authors: Kirstine K. Søgaard, Veronika Baettig, Michael Osthoff, Stephan Marsch, Karoline Leuzinger, Michael Schweitzer, Julian Meier, Stefano Bassetti, Roland Bingisser, Christian H. Nickel, Nina Khanna, Sarah Tschudin-Sutter, Maja Weisser, Manuel Battegay, Hans H. Hirsch, Hans Pargger…

    Citation: Journal of Intensive Care 2021 9:10

    Content type: Research

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  46. This systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19).

    Authors: Arief Wibowo, Raymond Pranata, Astri Astuti, Badai Bhatara Tiksnadi, Erwan Martanto, Januar Wibawa Martha, Augustine Purnomowati and Mohammad Rizki Akbar

    Citation: Journal of Intensive Care 2021 9:9

    Content type: Research

    Published on: