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  1. Patients with sepsis-associated encephalopathy (SAE) have higher mortality rates and longer ICU stays. Predictors of SAE are yet to be identified. We aimed to establish an effective and simple-to-use nomogram ...

    Authors: Guan Wang, Xinzhu Jiang, Yanan Fu, Yan Gao, Qin Jiang, Enyu Guo, Haoyang Huang and Xinjie Liu
    Citation: Journal of Intensive Care 2024 12:8
  2. The HACOR score for predicting treatment failure includes vital signs and acid–base balance factors, whereas the ROX index only considers the respiratory rate, oxygen saturation, and fraction of inspired oxyge...

    Authors: Hiromu Okano, Ryohei Yamamoto, Yudai Iwasaki, Daisuke Irimada, Daisuke Konno, Taku Tanaka, Takatoshi Oishi, Hiroki Nawa, Akihiko Yano, Hiroaki Taniguchi, Masayuki Otawara, Ayaka Matsuoka and Masanori Yamauchi
    Citation: Journal of Intensive Care 2024 12:7
  3. Coronavirus disease 2019 (COVID-19) has exposed critical care supply shortages worldwide. This study aimed to investigate the association between regional critical care capacity and the incidence of invasive m...

    Authors: Hiroyuki Ohbe, Satoru Hashimoto, Takayuki Ogura, Mitsuaki Nishikimi, Daisuke Kudo, Nobuaki Shime and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2024 12:6
  4. Chest computed tomography findings are helpful for understanding the pathophysiology of severe acute respiratory distress syndrome (ARDS). However, there is no large, multicenter, chest computed tomography reg...

    Authors: Mitsuaki Nishikimi, Shinichiro Ohshimo, Wataru Fukumoto, Jun Hamaguchi, Kazuki Matsumura, Kenji Fujizuka, Yoshihiro Hagiwara, Ryuichi Nakayama, Naofumi Bunya, Junichi Maruyama, Toshikazu Abe, Tatsuhiko Anzai, Yoshitaka Ogata, Hiromichi Naito, Yu Amemiya, Tokuji Ikeda…
    Citation: Journal of Intensive Care 2024 12:5
  5. Our previous study in 2011 concluded that permissive underfeeding may improve outcomes in patients receiving parenteral nutrition therapy. This conclusion was tentative, given the small sample size. We conduct...

    Authors: Han-yang Yue, Wei Peng, Jun Zeng, Yang Zhang, Yu Wang and Hua Jiang
    Citation: Journal of Intensive Care 2024 12:4
  6. The limitation of life sustaining treatments (LLST) causes ethical dilemmas even in patients faced with poor prognosis, which applies to many patients admitted to a Neurocritical Care Unit (NCCU). The effects ...

    Authors: Stefan Yu Bögli, Federica Stretti, Didar Utebay, Ladina Hitz, Caroline Hertler and Giovanna Brandi
    Citation: Journal of Intensive Care 2024 12:3
  7. Post-intensive care syndrome (PICS) is the long-lasting impairment of physical functions, cognitive functions, and mental health after intensive care. Although a long-term follow-up is essential for the succes...

    Authors: Nobuto Nakanishi, Keibun Liu, Junji Hatakeyama, Akira Kawauchi, Minoru Yoshida, Hidenori Sumita, Kyohei Miyamoto and Kensuke Nakamura
    Citation: Journal of Intensive Care 2024 12:2
  8. Patients in intensive care units (ICUs) often require quality palliative care for relief from various types of suffering. To achieve quality palliative care, specific goals need to be identified, measured, and...

    Authors: Yuta Tanaka, Kento Masukawa, Hideaki Sakuramoto, Akane Kato, Yuichiro Ishigami, Junko Tatsuno, Kaori Ito, Yoshiyuki Kizawa and Mitsunori Miyashita
    Citation: Journal of Intensive Care 2024 12:1
  9. Cardiogenic shock is a complex and diverse pathological condition characterized by reduced myocardial contractility. The goal of treatment of cardiogenic shock is to improve abnormal hemodynamics and maintain ...

    Authors: Jun Nakata, Takeshi Yamamoto, Keita Saku, Yuki Ikeda, Takashi Unoki and Kuniya Asai
    Citation: Journal of Intensive Care 2023 11:64
  10. Extra-hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), maintains vascular health, with high levels reflecting poor vitamin K status. The occurrence of extra-...

    Authors: Mark M. G. Mulder, Joep Schellens, Jan-Willem E. M. Sels, Frank van Rosmalen, Anne-Marije Hulshof, Femke de Vries, Ruud Segers, Casper Mihl, Walther N. K. A. van Mook, Aalt Bast, Henri M. H. Spronk, Yvonne M. C. Henskens, Iwan C. C. van der Horst, Hugo ten Cate, Leon J. Schurgers, Marjolein Drent…
    Citation: Journal of Intensive Care 2023 11:63
  11. Postoperative delirium is a common complication in patients after cardiac surgery, especially in older patients, and can manifest as a disturbance of attention and consciousness. It can lead to increased posto...

    Authors: Tuğce Dinç Dogan, Vera Guttenthaler, Alexa Zimmermann, Andrea Kunsorg, Merve Özlem Dinç, Niko Knuelle, Jens-Christian Schewe and Maria Wittmann
    Citation: Journal of Intensive Care 2023 11:62
  12. Japan has four types of intensive care units (ICUs) that are divided into two categories according to the management fee charged per day: ICU management fees 1 and 2 (ICU1/2) (equivalent to high-intensity staf...

    Authors: Saori Ikumi, Takuya Shiga, Takuya Ueda, Eichi Takaya, Yudai Iwasaki, Yu Kaiho, Kunio Tarasawa, Kiyohide Fushimi, Yukiko Ito, Kenji Fujimori and Masanori Yamauchi
    Citation: Journal of Intensive Care 2023 11:60
  13. Heterogeneity among critically ill patients undergoing invasive mechanical ventilation (IMV) treatment could result in high mortality rates. Currently, there are no well-established indicators to help identify...

    Authors: Xiawei Shi, Yangyang Shi, Liming Fan, Jia Yang, Hao Chen, Kaiwen Ni and Junchao Yang
    Citation: Journal of Intensive Care 2023 11:59
  14. Limiting driving pressure and mechanical power is associated with reduced mortality risk in both patients with and without acute respiratory distress syndrome. However, it is still poorly understood how the in...

    Authors: Han Chen, Zhi-Zhong Chen, Shu-Rong Gong and Rong-Guo Yu
    Citation: Journal of Intensive Care 2023 11:58
  15. The effort to minimize VILI risk must be multi-pronged. The need to adequately ventilate, a key determinant of hazardous power, is reduced by judicious permissive hypercapnia, reduction of innate oxygen demand...

    Authors: Lauren T. Thornton and John J. Marini
    Citation: Journal of Intensive Care 2023 11:57
  16. This study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis was that interventions lasting over 40 min, as per the German guideline, positively affe...

    Authors: Marco Lorenz, Kristina Fuest, Bernhard Ulm, Julius J. Grunow, Linus Warner, Annika Bald, Vanessa Arsene, Michael Verfuß, Nils Daum, Manfred Blobner and Stefan J. Schaller
    Citation: Journal of Intensive Care 2023 11:56
  17. Neuromuscular blockade agents (NMBAs) can be used to facilitate mechanical ventilation in critically ill patients. Accumulating evidence has shown that NMBAs may be associated with intensive care unit (ICU)-ac...

    Authors: Chun Lin, Wen-Cheng Chao, Kai-Chih Pai, Tsung-Ying Yang, Chieh-Liang Wu and Ming-Cheng Chan
    Citation: Journal of Intensive Care 2023 11:55
  18. Unfractionated heparin (UFH) is primarily monitored using activated partial thromboplastin time (APTT). However, the recent introduction of anti-activated factor X (anti-Xa) activity testing has provided a dir...

    Authors: Tomoyo Saito, Mineji Hayakawa, Osamu Kumano, Yoshinori Honma, Mone Murashita, Jun Kato, Syouki Fukui, Masaki Takahashi, Yuki Takahashi, Takumi Tsuchida, Asumi Mizugaki, Shuhei Takauji, Mariko Hayamizu, Tomonao Yoshida, Kenichi Katabami, Takeshi Wada…
    Citation: Journal of Intensive Care 2023 11:54
  19. This review examined studies regarding the implementation and translation of patients’ advance directives (AD) in intensive care units (ICUs), focusing on practical difficulties and obstacles.

    Authors: Sira M. Baumann, Natalie J. Kruse, Paulina S. C. Kliem, Simon A. Amacher, Sabina Hunziker, Tolga D. Dittrich, Fabienne Renetseder, Pascale Grzonka and Raoul Sutter
    Citation: Journal of Intensive Care 2023 11:53
  20. The aims of this study were to evaluate the efficacy, safety, and pharmacokinetics (PK) of continuous intravenous administration of remifentanil in mechanically ventilated patients in the intensive care unit (...

    Authors: Matsuyuki Doi, Naoki Takahashi, Rumi Nojiri, Takehiko Hiraoka, Yusuke Kishimoto, Shinichi Inoue and Nobuyo Oya
    Citation: Journal of Intensive Care 2023 11:51
  21. Lacosamide is one of the anticonvulsants used in critically ill patients. This study aimed to suggest appropriate lacosamide dosing regimens in critically ill patients receiving continuous renal replacement th...

    Authors: Weerachai Chaijamorn, Sathian Phunpon, Thanompong Sathienluckana, Taniya Charoensareerat, Sutthiporn Pattharachayakul, Dhakrit Rungkitwattanakul and Nattachai Srisawat
    Citation: Journal of Intensive Care 2023 11:50
  22. This study aimed to apply the backpropagation neural network (BPNN) to develop a model for predicting multidrug-resistant organism (MDRO) infection in critically ill patients.

    Authors: Yaxi Wang, Gang Wang, Yuxiao Zhao, Cheng Wang, Chen Chen, Yaoyao Ding, Jing Lin, Jingjing You, Silong Gao and Xufeng Pang
    Citation: Journal of Intensive Care 2023 11:49
  23. The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/pharmacodynamics and specific drug properties for critically ill patients is unclear. He...

    Authors: Nozomi Takahashi, Yutaka Kondo, Kenji Kubo, Moritoki Egi, Ken-ichi Kano, Yoshiyasu Ohshima and Taka-aki Nakada
    Citation: Journal of Intensive Care 2023 11:48
  24. Providing standardized, high-quality rehabilitation for critically ill patients is a crucial issue. In 2017, the Japanese Society of Intensive Care Medicine (JSICM) promulgated the “Evidence-Based Expert Conse...

    Authors: Takeshi Unoki, Kei Hayashida, Yusuke Kawai, Shunsuke Taito, Morihide Ando, Yuki Iida, Fumihito Kasai, Tatsuya Kawasaki, Ryo Kozu, Yutaka Kondo, Masakazu Saitoh, Hideaki Sakuramoto, Nobuyuki Sasaki, Ryuichi Saura, Kensuke Nakamura, Akira Ouchi…
    Citation: Journal of Intensive Care 2023 11:47
  25. Previous studies have reported conflicting results regarding fresh frozen plasma (FFP)-to-red blood cell (RBC) ratio and platelet-to-RBC ratio on outcomes for massive transfusion for trauma. Moreover, nationwi...

    Authors: Hiroyuki Ohbe, Takashi Tagami, Akira Endo, Shigeki Miyata, Hiroki Matsui, Kiyohide Fushimi, Shigeki Kushimoto and Hideo Yasunaga
    Citation: Journal of Intensive Care 2023 11:46
  26. The prognosis for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is poor, and there is no established treatment. Hence, we aimed to investigate the effectiveness of a polymyxin B-immobilised fibr...

    Authors: Nobuyasu Awano, Taisuke Jo, Takehiro Izumo, Minoru Inomata, Yu Ito, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi, Hirokazu Urushiyama, Takahide Nagase and Hideo Yasunaga
    Citation: Journal of Intensive Care 2023 11:45
  27. While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in maintaining fluid homeostasis. Fluid balance regulation is a critical aspect of septic...

    Authors: Auguste Dargent, Hugo Dumargne, Marie Labruyère, Stéphane Brezillon, Sylvie Brassart-Pasco, Mathieu Blot, Pierre-Emmanuel Charles, Isabelle Fournel, Jean-Pierre Quenot and Marine Jacquier
    Citation: Journal of Intensive Care 2023 11:44
  28. Gasping during resuscitation has been reported as a favorable factor for out-of-hospital cardiac arrest. We examined whether gasping during resuscitation is independently associated with favorable neurological...

    Authors: Satoshi Nara, Naofumi Bunya, Hirofumi Ohnishi, Keigo Sawamoto, Shuji Uemura, Nobuaki Kokubu, Mamoru Hase, Eichi Narimatsu, Yasufumi Asai, Yoshio Tahara, Takahiro Atsumi, Ken Nagao, Naoto Morimura and Tetsuya Sakamoto
    Citation: Journal of Intensive Care 2023 11:43
  29. Mechanical ventilation may cause pulmonary hypertension in patients with acute lung injury (ALI), but the underlying mechanism remains elucidated.

    Authors: Yonghao Xu, Yu Zhang, Jie Zhang, Weibo Liang, Ya Wang, Zitao Zeng, Zhenting Liang, Zhaoyi Ling, Yubiao Chen, Xiumei Deng, Yongbo Huang, Xiaoqing Liu, Haibo Zhang and Yimin Li
    Citation: Journal of Intensive Care 2023 11:42
  30. This aim of study was to introduce a diaphragm-based EIT-belt placement method based on diaphragm position by ultrasound, and to evaluate the difference between diaphragm-based EIT-belt placement and conventio...

    Authors: Chaofu Yue, Huaiwu He, Longxiang Su, Jun Wang, Siyi Yuan, Yun Long and Zhanqi Zhao
    Citation: Journal of Intensive Care 2023 11:41
  31. Diaphragm dysfunction is common in critically ill patients and associated with poorer outcomes. The function of the diaphragm can be evaluated at the bedside by measuring diaphragmatic excursion using ultrason...

    Authors: Karn Suttapanit, Supawit Wongkrasunt, Sorravit Savatmongkorngul and Praphaphorn Supatanakij
    Citation: Journal of Intensive Care 2023 11:40
  32. Diaphragmatic dysfunction often occurs after adult cardiovascular surgery. The prognostic effect of diaphragmatic dysfunction on ventilatory management in patients after cardiovascular surgery is unknown. This...

    Authors: Reimi Inoue, Yusuke Nagamine, Masahide Ohtsuka and Takahisa Goto
    Citation: Journal of Intensive Care 2023 11:39
  33. The efficacy and safety of saline versus balanced crystalloid solutions in ICU-patients remains complicated by exceptionally heterogenous study population in past comparative studies. This study sought to comp...

    Authors: Jonas Gmeiner, Bernhardt Bulach, Enzo Lüsebrink, Leonhard Binzenhöfer, Danny Kupka, Thomas Stocker, Kornelia Löw, Ludwig Weckbach, Wolf-Stephan Rudi, Tobias Petzold, Stefan Kääb, Jörg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban and Clemens Scherer
    Citation: Journal of Intensive Care 2023 11:38
  34. The respiratory ECMO survival prediction (RESP) score is used to predict survival for patients managed with extracorporeal membrane oxygenation (ECMO), but its performance in patients with Coronavirus Disease ...

    Authors: Elias H. Pratt, Samantha Morrison, Cynthia L. Green and Craig R. Rackley
    Citation: Journal of Intensive Care 2023 11:37
  35. Previous studies show positive effect of music on reducing anxiety, pain, and medication requirement. Anxiety has become a more pertinent issue in the intensive care unit (ICU) since wakefulness is preferred a...

    Authors: Ellaha Kakar, Thomas Ottens, Susanne Stads, Sanne Wesselius, Diederik A. M. P. J. Gommers, Johannes Jeekel and Mathieu van der Jagt
    Citation: Journal of Intensive Care 2023 11:36
  36. Despite the understanding of sepsis-induced extracellular vesicles (EVs), such as exosomes, and their role in intercellular communication during sepsis, little is known about EV contents such as microRNA (miRN...

    Authors: Beomsu Shin, Jin Young Lee, Yunjoo Im, Hongseok Yoo, Junseon Park, Joo Sang Lee, Ki-Young Lee and Kyeongman Jeon
    Citation: Journal of Intensive Care 2023 11:35
  37. The efficacies of fresh frozen plasma and coagulation factor transfusion have been widely evaluated in trauma-induced coagulopathy management during the acute post-injury phase. However, the efficacy of red bl...

    Authors: Mineji Hayakawa, Takashi Tagami, Daisuke Kudo, Kota Ono, Makoto Aoki, Akira Endo, Tetsuya Yumoto, Yosuke Matsumura, Shiho Irino, Kazuhiko Sekine, Noritaka Ushio, Takayuki Ogura, Sho Nachi, Yuhei Irie, Katsura Hayakawa, Yusuke Ito…
    Citation: Journal of Intensive Care 2023 11:34
  38. Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recogni...

    Authors: Francesco Bellanti, Sławomir Kasperczyk, Aleksandra Kasperczyk, Michał Dobrakowski, Gabriella Pacilli, Giuseppina Vurchio, Alessandro Maddalena, Stefano Quiete, Aurelio Lo Buglio, Cristiano Capurso, Gaetano Serviddio and Gianluigi Vendemiale
    Citation: Journal of Intensive Care 2023 11:30
  39. A unified clinical definition of feeding intolerance (FI) is urged for better management of enteral nutrition (EN) in critically ill patients. We aimed to identify optimum clinical FI definitions based on repo...

    Authors: Jianbo Li, Lijie Wang, Huan Zhang, Tongjuan Zou, Yan Kang, Wei He, Yuan Xu and Wanhong Yin
    Citation: Journal of Intensive Care 2023 11:29
  40. Tissue Doppler-derived left ventricular systolic velocity (mitral S’) has shown excellent correlation to left ventricular ejection fraction (LVEF) in non-critically patients. However, their correlation in sept...

    Authors: Sanchit Chawla, Ryota Sato, Abhijit Duggal, Mahmoud Alwakeel, Daisuke Hasegawa, Dina Alayan, Patrick Collier, Filippo Sanfilippo, Michael Lanspa and Siddharth Dugar
    Citation: Journal of Intensive Care 2023 11:28
  41. The effects of body mass index (BMI) on mortality of sepsis remain unknown, since previous meta-analyses have reported conflicting results. Several observational studies published recently have provided new ev...

    Authors: Le Bai, Jingyi Huang, Dan Wang, Dongwei Zhu, Qi Zhao, Tingyuan Li, Xianmei Zhou and Yong Xu
    Citation: Journal of Intensive Care 2023 11:27
  42. Cardiogenic shock (CS) is caused by primary cardiac dysfunction and induced by various and heterogeneous diseases (e.g., acute impairment of cardiac performance, or acute or chronic impairment of cardiac perfo...

    Authors: Akihiro Shirakabe, Masato Matsushita, Yusaku Shibata, Shota Shighihara, Suguru Nishigoori, Tomofumi Sawatani, Kazutaka Kiuchi and Kuniya Asai
    Citation: Journal of Intensive Care 2023 11:26
  43. Post-pyloric enteral feeding reduces respiratory complications and shortens the duration of mechanical ventilation. Blind placement of post-pyloric enteral feeding tubes (EFT) in patients with critical illness...

    Authors: Masashi Yokose, Shunsuke Takaki, Yusuke Saigusa, Takahiro Mihara, Yoshinobu Ishiwata, Shingo Kato, Keiichi Horie and Takahisa Goto
    Citation: Journal of Intensive Care 2023 11:25
  44. The International Society on Thrombosis and Haemostasis (ISTH) released overt disseminated intravascular coagulation (DIC) diagnostic criteria in 2001. Since then, DIC has been understood as the end-stage cons...

    Authors: Toshiaki Iba, Julie Helms, Jean Marie Connors and Jerrold H. Levy
    Citation: Journal of Intensive Care 2023 11:24
  45. An increasing number of patients are surviving critical illness, but some experience new or worsening long-lasting impairments in physical, cognitive and/or mental health, commonly known as post-intensive care...

    Authors: Stephanie L. Hiser, Arooj Fatima, Mazin Ali and Dale M. Needham
    Citation: Journal of Intensive Care 2023 11:23