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  1. In out-of-hospital cardiac arrest (OHCA) patients with extracorporeal cardiopulmonary resuscitation (ECPR), the association between low-flow time and outcomes in accidental hypothermia (AH) patients compared t...

    Authors: Kosuke Shoji, Hiroyuki Ohbe, Tasuku Matsuyama, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2024 12:22
  2. Patients who receive invasive mechanical ventilation (IMV) in the intensive care unit (ICU) have exhibited lower in-hospital mortality rates than those who are treated outside. However, the patient-, hospital-...

    Authors: Hiroyuki Ohbe, Nobuaki Shime, Hayato Yamana, Tadahiro Goto, Yusuke Sasabuchi, Daisuke Kudo, Hiroki Matsui, Hideo Yasunaga and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2024 12:21
  3. Previous studies have explored the association between the number of cases and patient outcomes for critical illnesses such as sepsis and trauma, as well as various surgeries, with the expectation that a highe...

    Authors: Jun Fujinaga, Takanao Otake, Takehide Umeda and Toshio Fukuoka
    Citation: Journal of Intensive Care 2024 12:20
  4. To optimize right ventricular–pulmonary coupling during veno-arterial (VA) ECMO weaning, inotropes, vasopressors and/or vasodilators are used to change right ventricular (RV) function (contractility) and pulmo...

    Authors: Kaspar F. Bachmann, Per Werner Moller, Lukas Hunziker, Marco Maggiorini and David Berger
    Citation: Journal of Intensive Care 2024 12:19
  5. Extracorporeal membrane oxygenation (ECMO) is a rescue therapy in patients with severe acute respiratory distress syndrome (ARDS) secondary to COVID-19. While bleeding and thrombosis complicate ECMO, these eve...

    Authors: Maximilian Feth, Natasha Weaver, Robert B. Fanning, Sung-Min Cho, Matthew J. Griffee, Mauro Panigada, Akram M. Zaaqoq, Ahmed Labib, Glenn J. R. Whitman, Rakesh C. Arora, Bo S. Kim, Nicole White, Jacky Y. Suen, Gianluigi Li Bassi, Giles J. Peek, Roberto Lorusso…
    Citation: Journal of Intensive Care 2024 12:18
  6. The prognostic nutritional index (PNI), integrating nutrition and inflammation markers, has been increasingly recognized as a prognostic predictor in diverse patient cohorts. Recently, its effectiveness as a p...

    Authors: Jia-Jin Chen, Tao-Han Lee, Pei-Chun Lai, Chih-Hsiang Chang, Che-Hsiung Wu and Yen-Ta Huang
    Citation: Journal of Intensive Care 2024 12:16
  7. Respiratory drive is defined as the intensity of respiratory centers output during the breath and is primarily affected by cortical and chemical feedback mechanisms. During the involuntary act of breathing, ch...

    Authors: Dimitrios Georgopoulos, Maria Bolaki, Vaia Stamatopoulou and Evangelia Akoumianaki
    Citation: Journal of Intensive Care 2024 12:15
  8. Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the benefits and harms of four target blood glucose levels (< 110, 110...

    Authors: Aiko Tanaka, Tomoaki Yatabe, Tomohiro Suhara and Moritoki Egi
    Citation: Journal of Intensive Care 2024 12:14
  9. Clinical practice guidelines on limitation of life-sustaining treatments (LST) in the intensive care unit (ICU), in the form of withholding or withdrawal of LST, state that there is no ethical difference betwe...

    Authors: Clare Fong, Wern Lunn Kueh, Sennen Jin Wen Lew, Benjamin Choon Heng Ho, Yu-Lin Wong, Yie Hui Lau, Yew Woon Chia, Hui Ling Tan, Ying Hao Christopher Seet, Wen Ting Siow, Graeme MacLaren, Rohit Agrawal, Tian Jin Lim, Shir Lynn Lim, Toon Wei Lim, Vui Kian Ho…
    Citation: Journal of Intensive Care 2024 12:13
  10. Arterial catheters (ACs) are critical for haemodynamic monitoring and blood sampling but are prone to complications. We investigated the incidence and risk factors of AC failure.

    Authors: Jessica A. Schults, Emily R. Young, Nicole Marsh, Emily Larsen, Amanda Corley, Robert S. Ware, Marghie Murgo, Evan Alexandrou, Matthew McGrail, John Gowardman, Karina R. Charles, Adrian Regli, Hideto Yasuda and Claire M. Rickard
    Citation: Journal of Intensive Care 2024 12:12
  11. As advancements in critical care medicine continue to improve Intensive Care Unit (ICU) survival rates, clinical and research attention is urgently shifting toward improving the quality of survival. Post-Inten...

    Authors: Keibun Liu, Oystein Tronstad, Dylan Flaws, Luke Churchill, Alice Y. M. Jones, Kensuke Nakamura and John F. Fraser
    Citation: Journal of Intensive Care 2024 12:11
  12. Intensive care unit-to-unit transfer due to temporary shortage of beds is increasing in Sweden. Transportation induces practical hazards, and the change of health care provider may prolong the length of stay i...

    Authors: Christian Rylander, Jesper Sternley, Max Petzold and Jonatan Oras
    Citation: Journal of Intensive Care 2024 12:10
  13. Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by a high mortality rate, the management of which relies on supportive care and a profound understanding of its pathop...

    Authors: Ling-Xi Xiao, De Liang Zhu, Juan Chen, Jing Lv, Mei-Jun Liu, Xue Dai, Dao-Xin Wang and Wang Deng
    Citation: Journal of Intensive Care 2024 12:9
  14. Patients with sepsis-associated encephalopathy (SAE) have higher mortality rates and longer ICU stays. Predictors of SAE are yet to be identified. We aimed to establish an effective and simple-to-use nomogram ...

    Authors: Guan Wang, Xinzhu Jiang, Yanan Fu, Yan Gao, Qin Jiang, Enyu Guo, Haoyang Huang and Xinjie Liu
    Citation: Journal of Intensive Care 2024 12:8
  15. The HACOR score for predicting treatment failure includes vital signs and acid–base balance factors, whereas the ROX index only considers the respiratory rate, oxygen saturation, and fraction of inspired oxyge...

    Authors: Hiromu Okano, Ryohei Yamamoto, Yudai Iwasaki, Daisuke Irimada, Daisuke Konno, Taku Tanaka, Takatoshi Oishi, Hiroki Nawa, Akihiko Yano, Hiroaki Taniguchi, Masayuki Otawara, Ayaka Matsuoka and Masanori Yamauchi
    Citation: Journal of Intensive Care 2024 12:7
  16. Coronavirus disease 2019 (COVID-19) has exposed critical care supply shortages worldwide. This study aimed to investigate the association between regional critical care capacity and the incidence of invasive m...

    Authors: Hiroyuki Ohbe, Satoru Hashimoto, Takayuki Ogura, Mitsuaki Nishikimi, Daisuke Kudo, Nobuaki Shime and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2024 12:6
  17. Chest computed tomography findings are helpful for understanding the pathophysiology of severe acute respiratory distress syndrome (ARDS). However, there is no large, multicenter, chest computed tomography reg...

    Authors: Mitsuaki Nishikimi, Shinichiro Ohshimo, Wataru Fukumoto, Jun Hamaguchi, Kazuki Matsumura, Kenji Fujizuka, Yoshihiro Hagiwara, Ryuichi Nakayama, Naofumi Bunya, Junichi Maruyama, Toshikazu Abe, Tatsuhiko Anzai, Yoshitaka Ogata, Hiromichi Naito, Yu Amemiya, Tokuji Ikeda…
    Citation: Journal of Intensive Care 2024 12:5
  18. Our previous study in 2011 concluded that permissive underfeeding may improve outcomes in patients receiving parenteral nutrition therapy. This conclusion was tentative, given the small sample size. We conduct...

    Authors: Han-yang Yue, Wei Peng, Jun Zeng, Yang Zhang, Yu Wang and Hua Jiang
    Citation: Journal of Intensive Care 2024 12:4
  19. The limitation of life sustaining treatments (LLST) causes ethical dilemmas even in patients faced with poor prognosis, which applies to many patients admitted to a Neurocritical Care Unit (NCCU). The effects ...

    Authors: Stefan Yu Bögli, Federica Stretti, Didar Utebay, Ladina Hitz, Caroline Hertler and Giovanna Brandi
    Citation: Journal of Intensive Care 2024 12:3
  20. Post-intensive care syndrome (PICS) is the long-lasting impairment of physical functions, cognitive functions, and mental health after intensive care. Although a long-term follow-up is essential for the succes...

    Authors: Nobuto Nakanishi, Keibun Liu, Junji Hatakeyama, Akira Kawauchi, Minoru Yoshida, Hidenori Sumita, Kyohei Miyamoto and Kensuke Nakamura
    Citation: Journal of Intensive Care 2024 12:2
  21. Patients in intensive care units (ICUs) often require quality palliative care for relief from various types of suffering. To achieve quality palliative care, specific goals need to be identified, measured, and...

    Authors: Yuta Tanaka, Kento Masukawa, Hideaki Sakuramoto, Akane Kato, Yuichiro Ishigami, Junko Tatsuno, Kaori Ito, Yoshiyuki Kizawa and Mitsunori Miyashita
    Citation: Journal of Intensive Care 2024 12:1
  22. Cardiogenic shock is a complex and diverse pathological condition characterized by reduced myocardial contractility. The goal of treatment of cardiogenic shock is to improve abnormal hemodynamics and maintain ...

    Authors: Jun Nakata, Takeshi Yamamoto, Keita Saku, Yuki Ikeda, Takashi Unoki and Kuniya Asai
    Citation: Journal of Intensive Care 2023 11:64
  23. Extra-hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), maintains vascular health, with high levels reflecting poor vitamin K status. The occurrence of extra-...

    Authors: Mark M. G. Mulder, Joep Schellens, Jan-Willem E. M. Sels, Frank van Rosmalen, Anne-Marije Hulshof, Femke de Vries, Ruud Segers, Casper Mihl, Walther N. K. A. van Mook, Aalt Bast, Henri M. H. Spronk, Yvonne M. C. Henskens, Iwan C. C. van der Horst, Hugo ten Cate, Leon J. Schurgers, Marjolein Drent…
    Citation: Journal of Intensive Care 2023 11:63
  24. Postoperative delirium is a common complication in patients after cardiac surgery, especially in older patients, and can manifest as a disturbance of attention and consciousness. It can lead to increased posto...

    Authors: Tuğce Dinç Dogan, Vera Guttenthaler, Alexa Zimmermann, Andrea Kunsorg, Merve Özlem Dinç, Niko Knuelle, Jens-Christian Schewe and Maria Wittmann
    Citation: Journal of Intensive Care 2023 11:62
  25. Japan has four types of intensive care units (ICUs) that are divided into two categories according to the management fee charged per day: ICU management fees 1 and 2 (ICU1/2) (equivalent to high-intensity staf...

    Authors: Saori Ikumi, Takuya Shiga, Takuya Ueda, Eichi Takaya, Yudai Iwasaki, Yu Kaiho, Kunio Tarasawa, Kiyohide Fushimi, Yukiko Ito, Kenji Fujimori and Masanori Yamauchi
    Citation: Journal of Intensive Care 2023 11:60
  26. Heterogeneity among critically ill patients undergoing invasive mechanical ventilation (IMV) treatment could result in high mortality rates. Currently, there are no well-established indicators to help identify...

    Authors: Xiawei Shi, Yangyang Shi, Liming Fan, Jia Yang, Hao Chen, Kaiwen Ni and Junchao Yang
    Citation: Journal of Intensive Care 2023 11:59
  27. Limiting driving pressure and mechanical power is associated with reduced mortality risk in both patients with and without acute respiratory distress syndrome. However, it is still poorly understood how the in...

    Authors: Han Chen, Zhi-Zhong Chen, Shu-Rong Gong and Rong-Guo Yu
    Citation: Journal of Intensive Care 2023 11:58
  28. The effort to minimize VILI risk must be multi-pronged. The need to adequately ventilate, a key determinant of hazardous power, is reduced by judicious permissive hypercapnia, reduction of innate oxygen demand...

    Authors: Lauren T. Thornton and John J. Marini
    Citation: Journal of Intensive Care 2023 11:57
  29. This study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis was that interventions lasting over 40 min, as per the German guideline, positively affe...

    Authors: Marco Lorenz, Kristina Fuest, Bernhard Ulm, Julius J. Grunow, Linus Warner, Annika Bald, Vanessa Arsene, Michael Verfuß, Nils Daum, Manfred Blobner and Stefan J. Schaller
    Citation: Journal of Intensive Care 2023 11:56
  30. Neuromuscular blockade agents (NMBAs) can be used to facilitate mechanical ventilation in critically ill patients. Accumulating evidence has shown that NMBAs may be associated with intensive care unit (ICU)-ac...

    Authors: Chun Lin, Wen-Cheng Chao, Kai-Chih Pai, Tsung-Ying Yang, Chieh-Liang Wu and Ming-Cheng Chan
    Citation: Journal of Intensive Care 2023 11:55
  31. Unfractionated heparin (UFH) is primarily monitored using activated partial thromboplastin time (APTT). However, the recent introduction of anti-activated factor X (anti-Xa) activity testing has provided a dir...

    Authors: Tomoyo Saito, Mineji Hayakawa, Osamu Kumano, Yoshinori Honma, Mone Murashita, Jun Kato, Syouki Fukui, Masaki Takahashi, Yuki Takahashi, Takumi Tsuchida, Asumi Mizugaki, Shuhei Takauji, Mariko Hayamizu, Tomonao Yoshida, Kenichi Katabami, Takeshi Wada…
    Citation: Journal of Intensive Care 2023 11:54
  32. This review examined studies regarding the implementation and translation of patients’ advance directives (AD) in intensive care units (ICUs), focusing on practical difficulties and obstacles.

    Authors: Sira M. Baumann, Natalie J. Kruse, Paulina S. C. Kliem, Simon A. Amacher, Sabina Hunziker, Tolga D. Dittrich, Fabienne Renetseder, Pascale Grzonka and Raoul Sutter
    Citation: Journal of Intensive Care 2023 11:53
  33. The aims of this study were to evaluate the efficacy, safety, and pharmacokinetics (PK) of continuous intravenous administration of remifentanil in mechanically ventilated patients in the intensive care unit (...

    Authors: Matsuyuki Doi, Naoki Takahashi, Rumi Nojiri, Takehiko Hiraoka, Yusuke Kishimoto, Shinichi Inoue and Nobuyo Oya
    Citation: Journal of Intensive Care 2023 11:51
  34. Lacosamide is one of the anticonvulsants used in critically ill patients. This study aimed to suggest appropriate lacosamide dosing regimens in critically ill patients receiving continuous renal replacement th...

    Authors: Weerachai Chaijamorn, Sathian Phunpon, Thanompong Sathienluckana, Taniya Charoensareerat, Sutthiporn Pattharachayakul, Dhakrit Rungkitwattanakul and Nattachai Srisawat
    Citation: Journal of Intensive Care 2023 11:50
  35. This study aimed to apply the backpropagation neural network (BPNN) to develop a model for predicting multidrug-resistant organism (MDRO) infection in critically ill patients.

    Authors: Yaxi Wang, Gang Wang, Yuxiao Zhao, Cheng Wang, Chen Chen, Yaoyao Ding, Jing Lin, Jingjing You, Silong Gao and Xufeng Pang
    Citation: Journal of Intensive Care 2023 11:49
  36. The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/pharmacodynamics and specific drug properties for critically ill patients is unclear. He...

    Authors: Nozomi Takahashi, Yutaka Kondo, Kenji Kubo, Moritoki Egi, Ken-ichi Kano, Yoshiyasu Ohshima and Taka-aki Nakada
    Citation: Journal of Intensive Care 2023 11:48
  37. Providing standardized, high-quality rehabilitation for critically ill patients is a crucial issue. In 2017, the Japanese Society of Intensive Care Medicine (JSICM) promulgated the “Evidence-Based Expert Conse...

    Authors: Takeshi Unoki, Kei Hayashida, Yusuke Kawai, Shunsuke Taito, Morihide Ando, Yuki Iida, Fumihito Kasai, Tatsuya Kawasaki, Ryo Kozu, Yutaka Kondo, Masakazu Saitoh, Hideaki Sakuramoto, Nobuyuki Sasaki, Ryuichi Saura, Kensuke Nakamura, Akira Ouchi…
    Citation: Journal of Intensive Care 2023 11:47
  38. Previous studies have reported conflicting results regarding fresh frozen plasma (FFP)-to-red blood cell (RBC) ratio and platelet-to-RBC ratio on outcomes for massive transfusion for trauma. Moreover, nationwi...

    Authors: Hiroyuki Ohbe, Takashi Tagami, Akira Endo, Shigeki Miyata, Hiroki Matsui, Kiyohide Fushimi, Shigeki Kushimoto and Hideo Yasunaga
    Citation: Journal of Intensive Care 2023 11:46
  39. The prognosis for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is poor, and there is no established treatment. Hence, we aimed to investigate the effectiveness of a polymyxin B-immobilised fibr...

    Authors: Nobuyasu Awano, Taisuke Jo, Takehiro Izumo, Minoru Inomata, Yu Ito, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi, Hirokazu Urushiyama, Takahide Nagase and Hideo Yasunaga
    Citation: Journal of Intensive Care 2023 11:45
  40. While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in maintaining fluid homeostasis. Fluid balance regulation is a critical aspect of septic...

    Authors: Auguste Dargent, Hugo Dumargne, Marie Labruyère, Stéphane Brezillon, Sylvie Brassart-Pasco, Mathieu Blot, Pierre-Emmanuel Charles, Isabelle Fournel, Jean-Pierre Quenot and Marine Jacquier
    Citation: Journal of Intensive Care 2023 11:44
  41. Gasping during resuscitation has been reported as a favorable factor for out-of-hospital cardiac arrest. We examined whether gasping during resuscitation is independently associated with favorable neurological...

    Authors: Satoshi Nara, Naofumi Bunya, Hirofumi Ohnishi, Keigo Sawamoto, Shuji Uemura, Nobuaki Kokubu, Mamoru Hase, Eichi Narimatsu, Yasufumi Asai, Yoshio Tahara, Takahiro Atsumi, Ken Nagao, Naoto Morimura and Tetsuya Sakamoto
    Citation: Journal of Intensive Care 2023 11:43
  42. Mechanical ventilation may cause pulmonary hypertension in patients with acute lung injury (ALI), but the underlying mechanism remains elucidated.

    Authors: Yonghao Xu, Yu Zhang, Jie Zhang, Weibo Liang, Ya Wang, Zitao Zeng, Zhenting Liang, Zhaoyi Ling, Yubiao Chen, Xiumei Deng, Yongbo Huang, Xiaoqing Liu, Haibo Zhang and Yimin Li
    Citation: Journal of Intensive Care 2023 11:42
  43. This aim of study was to introduce a diaphragm-based EIT-belt placement method based on diaphragm position by ultrasound, and to evaluate the difference between diaphragm-based EIT-belt placement and conventio...

    Authors: Chaofu Yue, Huaiwu He, Longxiang Su, Jun Wang, Siyi Yuan, Yun Long and Zhanqi Zhao
    Citation: Journal of Intensive Care 2023 11:41
  44. Diaphragm dysfunction is common in critically ill patients and associated with poorer outcomes. The function of the diaphragm can be evaluated at the bedside by measuring diaphragmatic excursion using ultrason...

    Authors: Karn Suttapanit, Supawit Wongkrasunt, Sorravit Savatmongkorngul and Praphaphorn Supatanakij
    Citation: Journal of Intensive Care 2023 11:40
  45. Diaphragmatic dysfunction often occurs after adult cardiovascular surgery. The prognostic effect of diaphragmatic dysfunction on ventilatory management in patients after cardiovascular surgery is unknown. This...

    Authors: Reimi Inoue, Yusuke Nagamine, Masahide Ohtsuka and Takahisa Goto
    Citation: Journal of Intensive Care 2023 11:39
  46. The efficacy and safety of saline versus balanced crystalloid solutions in ICU-patients remains complicated by exceptionally heterogenous study population in past comparative studies. This study sought to comp...

    Authors: Jonas Gmeiner, Bernhardt Bulach, Enzo Lüsebrink, Leonhard Binzenhöfer, Danny Kupka, Thomas Stocker, Kornelia Löw, Ludwig Weckbach, Wolf-Stephan Rudi, Tobias Petzold, Stefan Kääb, Jörg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban and Clemens Scherer
    Citation: Journal of Intensive Care 2023 11:38
  47. The respiratory ECMO survival prediction (RESP) score is used to predict survival for patients managed with extracorporeal membrane oxygenation (ECMO), but its performance in patients with Coronavirus Disease ...

    Authors: Elias H. Pratt, Samantha Morrison, Cynthia L. Green and Craig R. Rackley
    Citation: Journal of Intensive Care 2023 11:37