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  1. This prospective study compared clinical characteristics and prognosis between primary (P) and secondary (S) acute gastrointestinal injury (AGI) (P-AGI)/(S-AGI) in critically ill patients.

    Authors: Dong Zhang, Rao Fu, Yanhua Li, Hongyan Li, Yuting Li and Hongxiang Li
    Citation: Journal of Intensive Care 2017 5:26
  2. Endothelin 1 (ET-1) is a strong vasoconstrictor, which is involved in inflammation and reduced tissue perfusion. C-terminal proendothelin-1 (CT-proET-1) is the stable circulating precursor protein of ET-1. We ...

    Authors: Lukas Buendgens, Eray Yagmur, Jan Bruensing, Ulf Herbers, Christer Baeck, Christian Trautwein, Alexander Koch and Frank Tacke
    Citation: Journal of Intensive Care 2017 5:25
  3. Monitoring of tissue perfusion is an essential step in the management of acute circulatory failure. The presence of cellular dysfunction has been a basic component of shock definition even in the absence of hy...

    Authors: Ahmed Hasanin, Ahmed Mukhtar and Heba Nassar
    Citation: Journal of Intensive Care 2017 5:24
  4. The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunct...

    Authors: Frank Anthony Rasulo, Giuseppe Bellelli, Eugene Wesley Ely, Alessandro Morandi, Pratik Pandharipande and Nicola Latronico
    Citation: Journal of Intensive Care 2017 5:23
  5. Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Authors: Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki
    Citation: Journal of Intensive Care 2017 5:22
  6. Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key mo...

    Authors: Bernt C. Hellerud, Hilde L. Orrem, Knut Dybwik, Søren E. Pischke, Andreas Baratt-Due, Albert Castellheim, Hilde Fure, Grethe Bergseth, Dorte Christiansen, Miles A. Nunn, Terje Espevik, Corinna Lau, Petter Brandtzæg, Erik W. Nielsen and Tom E. Mollnes
    Citation: Journal of Intensive Care 2017 5:21
  7. In recent years, the measurement of cerebral regional oxygen saturation (rSO2) during resuscitation has attracted attention. The objective of this study was to clarify the relationship between the serial changes ...

    Authors: Naoki Ehara, Tomoya Hirose, Tadahiko Shiozaki, Akinori Wakai, Tetsuro Nishimura, Nobuto Mori, Mitsuo Ohnishi, Daikai Sadamitsu and Takeshi Shimazu
    Citation: Journal of Intensive Care 2017 5:20
  8. Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridges (PMX-DHP) is widely used for septic shock in Japan and parts of Europe. Although this treatment is usually administered for 2 h, the o...

    Authors: Kyohei Miyamoto, Yu Kawazoe and Seiya Kato
    Citation: Journal of Intensive Care 2017 5:19
  9. Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization. Delirium, an acute form of brai...

    Authors: José Raimundo A. de Azevedo, Widlani Sousa Montenegro, Djane Pereira Rodrigues, Suellen C. de C. Souza, Vanessa F. S. Araujo, Margareth Pereira de Paula, Patricia H. C. P. Prazeres, Adenilde da Luz Leitão and Adriana V. N. Mendonça
    Citation: Journal of Intensive Care 2017 5:18
  10. Pain assessment is highly recommended in patients receiving mechanical ventilation. However, pain intensity and its impact on outcomes in these patients remain obscure. We collected the results of routine pain...

    Authors: Ayahiro Yamashita, Masaki Yamasaki, Hiroki Matsuyama and Fumimasa Amaya
    Citation: Journal of Intensive Care 2017 5:17

    The Commentary to this article has been published in Journal of Intensive Care 2017 5:73

  11. The work demands of critical care can be a major cause of stress in intensive care unit (ICU) professionals and lead to poor health outcomes. In the process of recovery from work, psychological rumination is c...

    Authors: Tushna Vandevala, Louisa Pavey, Olga Chelidoni, Nai-Feng Chang, Ben Creagh-Brown and Anna Cox
    Citation: Journal of Intensive Care 2017 5:16
  12. The mortality rate of critically ill patients is high and the cost of the intensive (ICU) department is among the highest within the health-care industry. The cost will continue to increase because of the agin...

    Authors: Alexander F. van der Sluijs, Eline R. van Slobbe-Bijlsma, Stephen E. Chick, Margreeth B. Vroom, Dave A. Dongelmans and Alexander P. J. Vlaar
    Citation: Journal of Intensive Care 2017 5:13
  13. Sepsis and septic shock are major healthcare problems, affecting millions of individuals around the world each year. Pathophysiologically, septic multiple organ dysfunction (MOD) is a life-threatening conditio...

    Authors: Sascha David, Kristina Thamm, Bernhard M. W. Schmidt, Christine S. Falk and Jan T. Kielstein
    Citation: Journal of Intensive Care 2017 5:12
  14. Achieving a balance between organ perfusion and hemostasis is critical for optimal fluid resuscitation in patients with severe trauma. The concept of “permissive hypotension” refers to managing trauma patients...

    Authors: Daisuke Kudo, Yoshitaro Yoshida and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2017 5:11
  15. Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Authors: Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa
    Citation: Journal of Intensive Care 2017 5:5
  16. Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Authors: Mineji Hayakawa
    Citation: Journal of Intensive Care 2017 5:3
  17. Tracheal ultrasound can be an alternative diagnostic tool in airway management, besides traditional confirmatory methods such as capnography and auscultation. The standard image is a hyperechoic air–mucosa (A–...

    Authors: Wan-Ching Lien
    Citation: Journal of Intensive Care 2017 5:10

    The original article was published in Journal of Intensive Care 2016 4:52

  18. Deep vein thrombosis (DVT) is a major complication in critical care. There are various methods of prophylaxis, but none of them fully prevent DVT, and each method has adverse effects. Electrical muscle stimula...

    Authors: Masahiro Ojima, Ryosuke Takegawa, Tomoya Hirose, Mitsuo Ohnishi, Tadahiko Shiozaki and Takeshi Shimazu
    Citation: Journal of Intensive Care 2017 5:9
  19. Older patients account for the majority of patients with sepsis. The objective of this study was to determine if decreased skeletal muscle mass is associated with outcomes in elderly patients with sepsis.

    Authors: Keita Shibahashi, Kazuhiro Sugiyama, Masahiro Kashiura and Yuichi Hamabe
    Citation: Journal of Intensive Care 2017 5:8
  20. Severe heat stroke tends to be complicated with rhabdomyolysis, especially in patients with exertional heat stroke. Rhabdomyolysis usually occurs in the acute phase of heat stroke. We herein report a case of h...

    Authors: Toshihiko Yoshizawa, Kazuhiko Omori, Ikuto Takeuchi, Yuto Miyoshi, Hiroshi Kido, Etsuhisa Takahashi, Kei Jitsuiki, Kouhei Ishikawa, Hiromichi Ohsaka, Manabu Sugita and Youichi Yanagawa
    Citation: Journal of Intensive Care 2016 4:71
  21. Recent studies have shown acute respiratory distress syndrome (ARDS) to be underdiagnosed and inadequately treated, as evidenced by underutilization of low-tidal volume ventilation. Despite a proven survival b...

    Authors: Jason Chertoff
    Citation: Journal of Intensive Care 2016 4:70
  22. Active smokers are prevalent within the intensive care setting and place a significant burden on healthcare systems. Nicotine withdrawal due to forced abstinence on admission may contribute to increased agitat...

    Authors: Melanie Kowalski, Andrew A. Udy, Hayden J. McRobbie and Michael J. Dooley
    Citation: Journal of Intensive Care 2016 4:69
  23. Critically ill patients admitted to intensive care unit (ICU) may suffer from different painful stimuli, but the assessment of pain is difficult because most of them are almost sedated and unable to self-repor...

    Authors: Paolo Severgnini, Paolo Pelosi, Elena Contino, Elisa Serafinelli, Raffaele Novario and Maurizio Chiaranda
    Citation: Journal of Intensive Care 2016 4:68
  24. Critical care is a complex field of medicine, especially because of its diversity and unpredictability. Mortality rates of the diseases are usually high and patients are critically ill, admitted in emergency, ...

    Authors: Bruno François, Marc Clavel, Philippe Vignon and Pierre-François Laterre
    Citation: Journal of Intensive Care 2016 4:67
  25. We conducted an internet survey targeting healthcare providers in intensive care units (ICUs) in Japan and received 318 responses. Eighteen percent of respondents replied that full-time physical therapists (PT...

    Authors: Shunsuke Taito, Masamitsu Sanui, Hideto Yasuda, Nobuaki Shime and Alan Kawarai Lefor
    Citation: Journal of Intensive Care 2016 4:66
  26. The Richmond Agitation-Sedation Scale (RASS) is a single tool that is intuitive, is easy to use, and includes both agitation and sedation. The RASS has never been formally validated for pediatric populations. ...

    Authors: Abigail Glicksman Kerson, Rebecca DeMaria, Elizabeth Mauer, Christine Joyce, Linda M. Gerber, Bruce M. Greenwald, Gabrielle Silver and Chani Traube
    Citation: Journal of Intensive Care 2016 4:65
  27. Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estima...

    Authors: Hiroyuki Yamada, Tatsuo Tsukamoto, Hiromichi Narumiya, Kazumasa Oda, Satoshi Higaki, Ryoji Iizuka, Motoko Yanagita and Masako Deguchi
    Citation: Journal of Intensive Care 2016 4:64
  28. Passive leg raising (PLR) is a so called self-volume challenge used to test for fluid responsiveness. Changes in cardiac output (CO) or stroke volume (SV) measured during PLR are used to predict the need for s...

    Authors: Anton Krige, Martin Bland and Thomas Fanshawe
    Citation: Journal of Intensive Care 2016 4:63
  29. Augmented renal clearance (ARC) of circulating solutes and drugs has been recently often reported in intensive care unit (ICU) patients. However, only few studies on ARC have been reported in Japan. The aims o...

    Authors: Yasumasa Kawano, Shinichi Morimoto, Yoshito Izutani, Kentaro Muranishi, Hironari Kaneyama, Kota Hoshino, Takeshi Nishida and Hiroyasu Ishikura
    Citation: Journal of Intensive Care 2016 4:62
  30. Vascular hyperpermeability is a frequent intractable feature involved in a wide range of diseases in the intensive care unit. The glycocalyx (GCX) seemingly plays a key role to control vascular permeability. T...

    Authors: Akira Ushiyama, Hanae Kataoka and Takehiko Iijima
    Citation: Journal of Intensive Care 2016 4:59
  31. Because treatment modalities for carbon monoxide (CO) poisoning, especially normobaric oxygen and hyperbaric oxygen therapies, have limited effects and hyperbaric oxygen is not available at the scene where tre...

    Authors: Taku Tanaka, Takeshi Kashimura, Marii Ise, Brandon D. Lohman and Yasuhiko Taira
    Citation: Journal of Intensive Care 2016 4:58
  32. The skin, soft tissue, and most parts of the musculoskeletal system are relatively superficial anatomical structures and ideal targets for ultrasound examination in the emergency departments. Soft tissue and m...

    Authors: Kuo-Chih Chen, Aming Chor-Ming Lin, Chee-Fah Chong and Tzong-Luen Wang
    Citation: Journal of Intensive Care 2016 4:55
  33. Rapid and accurate diagnosis and treatment are paramount in the management of the critically ill. Critical care ultrasound has been widely used as an adjunct to standard clinical examination, an invaluable ext...

    Authors: Young-Rock Ha and Hong-Chuen Toh
    Citation: Journal of Intensive Care 2016 4:54
  34. Upper airway ultrasound is a valuable, non-invasive, simple, and portable point of care ultrasound (POCUS) for evaluation of airway management even in anatomy distorted by pathology or trauma. Ultrasound enabl...

    Authors: Adi Osman and Kok Meng Sum
    Citation: Journal of Intensive Care 2016 4:52

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2017 5:10

  35. The long-term economic and quality-of-life outcomes of patients admitted to intensive care unit (ICU) with acute respiratory distress syndrome are not well understood. In this study, we investigate 1-year cost...

    Authors: Joachim Marti, Peter Hall, Patrick Hamilton, Sarah Lamb, Chris McCabe, Ranjit Lall, Julie Darbyshire, Duncan Young and Claire Hulme
    Citation: Journal of Intensive Care 2016 4:56
  36. The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NET...

    Authors: Yasuyo Shimomura, Mika Suga, Naohide Kuriyama, Tomoyuki Nakamura, Toshikazu Sakai, Yu Kato, Yoshitaka Hara, Chizuru Yamashita, Hiroshi Nagasaki, Masao Kaneki and Osamu Nishida
    Citation: Journal of Intensive Care 2016 4:48