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  1. Active smokers are prevalent within the intensive care setting and place a significant burden on healthcare systems. Nicotine withdrawal due to forced abstinence on admission may contribute to increased agitat...

    Authors: Melanie Kowalski, Andrew A. Udy, Hayden J. McRobbie and Michael J. Dooley

    Citation: Journal of Intensive Care 2016 4:69

    Content type: Research

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  2. Critically ill patients admitted to intensive care unit (ICU) may suffer from different painful stimuli, but the assessment of pain is difficult because most of them are almost sedated and unable to self-repor...

    Authors: Paolo Severgnini, Paolo Pelosi, Elena Contino, Elisa Serafinelli, Raffaele Novario and Maurizio Chiaranda

    Citation: Journal of Intensive Care 2016 4:68

    Content type: Research

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  3. Critical care is a complex field of medicine, especially because of its diversity and unpredictability. Mortality rates of the diseases are usually high and patients are critically ill, admitted in emergency, ...

    Authors: Bruno François, Marc Clavel, Philippe Vignon and Pierre-François Laterre

    Citation: Journal of Intensive Care 2016 4:67

    Content type: Review

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  4. We conducted an internet survey targeting healthcare providers in intensive care units (ICUs) in Japan and received 318 responses. Eighteen percent of respondents replied that full-time physical therapists (PT...

    Authors: Shunsuke Taito, Masamitsu Sanui, Hideto Yasuda, Nobuaki Shime and Alan Kawarai Lefor

    Citation: Journal of Intensive Care 2016 4:66

    Content type: Letter to the Editor

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  5. The Richmond Agitation-Sedation Scale (RASS) is a single tool that is intuitive, is easy to use, and includes both agitation and sedation. The RASS has never been formally validated for pediatric populations. ...

    Authors: Abigail Glicksman Kerson, Rebecca DeMaria, Elizabeth Mauer, Christine Joyce, Linda M. Gerber, Bruce M. Greenwald, Gabrielle Silver and Chani Traube

    Citation: Journal of Intensive Care 2016 4:65

    Content type: Research

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  6. Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estima...

    Authors: Hiroyuki Yamada, Tatsuo Tsukamoto, Hiromichi Narumiya, Kazumasa Oda, Satoshi Higaki, Ryoji Iizuka, Motoko Yanagita and Masako Deguchi

    Citation: Journal of Intensive Care 2016 4:64

    Content type: Research

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  7. Passive leg raising (PLR) is a so called self-volume challenge used to test for fluid responsiveness. Changes in cardiac output (CO) or stroke volume (SV) measured during PLR are used to predict the need for s...

    Authors: Anton Krige, Martin Bland and Thomas Fanshawe

    Citation: Journal of Intensive Care 2016 4:63

    Content type: Research

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  8. Augmented renal clearance (ARC) of circulating solutes and drugs has been recently often reported in intensive care unit (ICU) patients. However, only few studies on ARC have been reported in Japan. The aims o...

    Authors: Yasumasa Kawano, Shinichi Morimoto, Yoshito Izutani, Kentaro Muranishi, Hironari Kaneyama, Kota Hoshino, Takeshi Nishida and Hiroyasu Ishikura

    Citation: Journal of Intensive Care 2016 4:62

    Content type: Research

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  9. Vascular hyperpermeability is a frequent intractable feature involved in a wide range of diseases in the intensive care unit. The glycocalyx (GCX) seemingly plays a key role to control vascular permeability. T...

    Authors: Akira Ushiyama, Hanae Kataoka and Takehiko Iijima

    Citation: Journal of Intensive Care 2016 4:59

    Content type: Review

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  10. Because treatment modalities for carbon monoxide (CO) poisoning, especially normobaric oxygen and hyperbaric oxygen therapies, have limited effects and hyperbaric oxygen is not available at the scene where tre...

    Authors: Taku Tanaka, Takeshi Kashimura, Marii Ise, Brandon D. Lohman and Yasuhiko Taira

    Citation: Journal of Intensive Care 2016 4:58

    Content type: Research

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  11. The skin, soft tissue, and most parts of the musculoskeletal system are relatively superficial anatomical structures and ideal targets for ultrasound examination in the emergency departments. Soft tissue and m...

    Authors: Kuo-Chih Chen, Aming Chor-Ming Lin, Chee-Fah Chong and Tzong-Luen Wang

    Citation: Journal of Intensive Care 2016 4:55

    Content type: Review

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  12. Rapid and accurate diagnosis and treatment are paramount in the management of the critically ill. Critical care ultrasound has been widely used as an adjunct to standard clinical examination, an invaluable ext...

    Authors: Young-Rock Ha and Hong-Chuen Toh

    Citation: Journal of Intensive Care 2016 4:54

    Content type: Review

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  13. Upper airway ultrasound is a valuable, non-invasive, simple, and portable point of care ultrasound (POCUS) for evaluation of airway management even in anatomy distorted by pathology or trauma. Ultrasound enabl...

    Authors: Adi Osman and Kok Meng Sum

    Citation: Journal of Intensive Care 2016 4:52

    Content type: Review

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    The Letter to the Editor to this article has been published in Journal of Intensive Care 2017 5:10

  14. The long-term economic and quality-of-life outcomes of patients admitted to intensive care unit (ICU) with acute respiratory distress syndrome are not well understood. In this study, we investigate 1-year cost...

    Authors: Joachim Marti, Peter Hall, Patrick Hamilton, Sarah Lamb, Chris McCabe, Ranjit Lall, Julie Darbyshire, Duncan Young and Claire Hulme

    Citation: Journal of Intensive Care 2016 4:56

    Content type: Research

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  15. The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NET...

    Authors: Yasuyo Shimomura, Mika Suga, Naohide Kuriyama, Tomoyuki Nakamura, Toshikazu Sakai, Yu Kato, Yoshitaka Hara, Chizuru Yamashita, Hiroshi Nagasaki, Masao Kaneki and Osamu Nishida

    Citation: Journal of Intensive Care 2016 4:48

    Content type: Letter to the Editor

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  16. Families of cancer patients in the ICU often experience severe stress. Understanding their experience is important for providing family-centered care during this difficult period. Little is known about the exp...

    Authors: Miyuki H. Komachi and Kiyoko Kamibeppu

    Citation: Journal of Intensive Care 2016 4:47

    Content type: Research

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  17. In a previous retrospective work, it has been postulated that early enteral nutrition was a protective factor against late defecation and its subsequent consequences in critically ill patients. We raise concer...

    Authors: Dominique Prat and Benjamin Sztrymf

    Citation: Journal of Intensive Care 2016 4:46

    Content type: Letter to the Editor

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    The Erratum to this article has been published in Journal of Intensive Care 2016 4:60

    The original article was published in Journal of Intensive Care 2016 4:33

  18. The presence of acid-base disturbances, especially metabolic acidosis may negatively affect the outcome of critically ill patients. Lactic acidosis is the most frequent etiology and has largest impact on the p...

    Authors: Yoshifumi Kotake

    Citation: Journal of Intensive Care 2016 4:45

    Content type: Commentary

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    The original article was published in Journal of Intensive Care 2016 4:43

  19. Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sep...

    Authors: Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Kazuma Yamakawa, Daisuke Kudo, Yusuke Iizuka, Masamitsu Sanui, Kohei Takimoto, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Katsura Hayakawa, Tsuyoshi Nakashima, Takayuki Ogura, Eiichiro Noda…

    Citation: Journal of Intensive Care 2016 4:44

    Content type: Letter to the Editor

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  20. This cohort study compared the prognostic significance of strong ion gap (SIG) with other acid-base markers in the critically ill.

    Authors: Kwok M. Ho, Norris S. H. Lan, Teresa A. Williams, Yusra Harahsheh, Andrew R. Chapman, Geoffrey J. Dobb and Sheldon Magder

    Citation: Journal of Intensive Care 2016 4:43

    Content type: Research

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    The Commentary to this article has been published in Journal of Intensive Care 2016 4:45

  21. The mortality rate from septic shock has been declining. Cerebral hypoxia, measured non-invasively with cerebral oximetry, has been correlated with neurologic and non-neurologic sequelae. Whether cerebral desa...

    Authors: Duane J. Funk, Anand Kumar and Gregory Klar

    Citation: Journal of Intensive Care 2016 4:42

    Content type: Research

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  22. Acute kidney injury (AKI) is a serious complication after cardiac surgery, being associated with a high mortality. We assessed three urinary biomarkers, L-type fatty acid-binding protein (L-FABP), neutrophil g...

    Authors: Takahiro Moriyama, Shintaro Hagihara, Toko Shiramomo, Misaki Nagaoka, Shohei Iwakawa and Yuichi Kanmura

    Citation: Journal of Intensive Care 2016 4:41

    Content type: Research

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  23. The Deyo-Charlson Comorbidity Index (DCCI) has low predictive value in the intensive care unit (ICU). Our goal was to determine whether addition of 25-hydroxyvitamin D (25OHD) levels to the DCCI improved 90-da...

    Authors: Bisundev Mahato, Tiffany M. N. Otero, Carrie A. Holland, Patrick T. Giguere, Ednan K. Bajwa, Carlos A. Camargo Jr. and Sadeq A. Quraishi

    Citation: Journal of Intensive Care 2016 4:40

    Content type: Research

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  24. Macrophage migration inhibitory factor (MIF) is known to amplify the immune response in septic animal models. Few clinical data support this pro-inflammatory role in septic patients. Renal replacement therapy ...

    Authors: Julia Pohl, Maria Papathanasiou, Martin Heisler, Pia Stock, Malte Kelm, Ulrike B. Hendgen-Cotta, Tienush Rassaf and Peter Luedike

    Citation: Journal of Intensive Care 2016 4:39

    Content type: Research

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  25. The right heart often receives less attention during echocardiography. The situation is no different in septic shock. We prospectively investigated the echocardiographic indices of the right heart in septic sh...

    Authors: Ratender Kumar Singh, Sudeep Kumar, Sreevatsa Nadig, Arvind Kumar Baronia, Banani Poddar, Afzal Azim and Mohan Gurjar

    Citation: Journal of Intensive Care 2016 4:38

    Content type: Research

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  26. Alarmins, including high-mobility group box 1 (HMGB-1), can be released from damaged tissues and activated cells as inflammatory mediators. We aimed to evaluate HMGB-1 and mitochondrial DNA dynamics and estima...

    Authors: Taku Omura, Shigeki Kushimoto, Satoshi Yamanouchi, Daisuke Kudo and Noriko Miyagawa

    Citation: Journal of Intensive Care 2016 4:37

    Content type: Research

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  27. This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temper...

    Authors: Yasuhiro Kuroda

    Citation: Journal of Intensive Care 2016 4:36

    Content type: Review

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    The Erratum to this article has been published in Journal of Intensive Care 2016 4:49

  28. Quality benchmarks are increasingly being used to compare the delivery of healthcare, and may affect reimbursement in the future. The University Health Consortium (UHC) expected probability of mortality (EPM) ...

    Authors: Angela K. M. Lipshutz, John R. Feiner, Barbara Grimes and Michael A. Gropper

    Citation: Journal of Intensive Care 2016 4:35

    Content type: Research

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  29. Sepsis is associated with coagulation abnormalities, and a high content of intravascular tissue factor (TF) may contribute to the development of multisystem organ failure. Circulating microvesicles (MVs) are i...

    Authors: Carolin Trepesch, Ramona Nitzsche, Aenne Glass, Bernd Kreikemeyer, Jochen K. Schubert and Sonja Oehmcke-Hecht

    Citation: Journal of Intensive Care 2016 4:34

    Content type: Research

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  30. Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecati...

    Authors: Shinya Fukuda, Takashi Miyauchi, Motoki Fujita, Yasutaka Oda, Masaki Todani, Yoshikatsu Kawamura, Kotaro Kaneda and Ryosuke Tsuruta

    Citation: Journal of Intensive Care 2016 4:33

    Content type: Research

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    The Letter to the Editor to this article has been published in Journal of Intensive Care 2016 4:46

  31. Protein deficiency is a major problem in critically ill patients. Egg white powder recently became a standard additive for protein supplementation in our unit. However, clinical data are not available to suppo...

    Authors: Rungsun Bhurayanontachai and Sunatee Sa-nguansai

    Citation: Journal of Intensive Care 2016 4:32

    Content type: Research

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  32. Cardiac arrest induces the cessation of cerebral blood flow, which can result in brain damage. The primary intervention to salvage the brain unde...

    Authors: Hiroyuki Uchino, Yukihiko Ogihara, Hidekimi Fukui, Miyuki Chijiiwa, Shusuke Sekine, Naomi Hara and Eskil Elmér

    Citation: Journal of Intensive Care 2016 4:31

    Content type: Review

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    The Retraction Note to this article has been published in Journal of Intensive Care 2016 4:61

  33. Traumatic brain injury (TBI) is recognized as the significant cause of mortality and morbidity in the world. To reduce unfavorable outcome in TBI patients, many researches have made much efforts for the innova...

    Authors: Shoji Yokobori and Hiroyuki Yokota

    Citation: Journal of Intensive Care 2016 4:28

    Content type: Review

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  34. Perioperative hypovolemia and fluid overload have effects on both complications following surgery and on patient survival. Therefore, the administration of intravenous fluids before, during, and after surgery ...

    Authors: Anders Winther Voldby and Birgitte Brandstrup

    Citation: Journal of Intensive Care 2016 4:27

    Content type: Review

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  35. Patient-ventilator asynchrony is a major cause of difficult weaning from mechanical ventilation. Neurally adjusted ventilatory assist (NAVA) is reported useful to improve the synchrony in patients with sustain...

    Authors: Yuya Goto, Shinshu Katayama, Atsuko Shono, Yosuke Mori, Yuya Miyazaki, Yoko Sato, Makoto Ozaki and Toru Kotani

    Citation: Journal of Intensive Care 2016 4:26

    Content type: Case report

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  36. The early prediction of neurological outcomes in postcardiac arrest patients treated with therapeutic hypothermia (TH) remains challenging. Amplitude-integrated electroencephalography (aEEG) is a type of quant...

    Authors: Kazuhiro Sugiyama, Masahiro Kashiura, Akiko Akashi, Takahiro Tanabe and Yuichi Hamabe

    Citation: Journal of Intensive Care 2016 4:25

    Content type: Research

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  37. Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategie...

    Authors: Alexandre Mebazaa, Pierre François Laterre, James A. Russell, Andreas Bergmann, Luciano Gattinoni, Etienne Gayat, Michael O. Harhay, Oliver Hartmann, Frauke Hein, Anne Louise Kjolbye, Matthieu Legrand, Roger J. Lewis, John C. Marshall, Gernot Marx, Peter Radermacher, Mathias Schroedter…

    Citation: Journal of Intensive Care 2016 4:24

    Content type: Review

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  38. Sepsis is frequently complicated by coagulopathy and, in about 35 % of severe cases, by disseminated intravascular coagulation (DIC). In Japan, aggressive treatment of septic DIC is encouraged using antithromb...

    Authors: Kohji Okamoto, Toshihisa Tamura and Yusuke Sawatsubashi

    Citation: Journal of Intensive Care 2016 4:23

    Content type: Review

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  39. The term sepsis-associated encephalopathy (SAE) has been applied to animal models, postmortem studies in patients, and severe cases of sepsis. SAE is considered to include all types of brain dysfunction, inclu...

    Authors: Ryosuke Tsuruta and Yasutaka Oda

    Citation: Journal of Intensive Care 2016 4:18

    Content type: Review

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  40. Kidney injury, including acute kidney injury (AKI) and chronic kidney disease (CKD), has become very common in critically ill patients treated in ICUs. Many epidemiological studies have revealed significant as...

    Authors: Kent Doi

    Citation: Journal of Intensive Care 2016 4:17

    Content type: Review

    Published on: