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  1. Content type: Letter to the Editor

    Since the withdrawal of recombinant-activated protein C, the anticoagulant therapy for sepsis was taken no notice. For instance, the international sepsis guidelines did not share a space for this therapy. Howe...

    Authors: Jecko Thachil and Toshiaki Iba

    Citation: Journal of Intensive Care 2017 5:32

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  2. Content type: Research

    Patients in intensive care units (ICU) are often diagnosed with postoperative delirium; the duration of which has a relevant negative impact on various clinical outcomes. Recent research found a potentially im...

    Authors: Mira John, E. Wesley Ely, Dorothee Halfkann, Julika Schoen, Beate Sedemund-Adib, Stefan Klotz, Finn Radtke, Sebastian Stehr and Michael Hueppe

    Citation: Journal of Intensive Care 2017 5:29

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  3. Content type: Research

    Acute kidney injury (AKI) occurs in more than half critically ill patients admitted in intensive care units (ICU) and increases the mortality risk. The main cause of AKI in ICU is sepsis. AKI severity and othe...

    Authors: Emilio Rodrigo, Borja Suberviola, Miguel Santibáñez, Lara Belmar, Álvaro Castellanos, Milagros Heras, Juan Carlos Rodríguez-Borregán, Angel Luis Martín de Francisco and Claudio Ronco

    Citation: Journal of Intensive Care 2017 5:28

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  4. Content type: Research

    Intracranial hemorrhage (ICH) is a recognized complication of adults treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. However, the predictors of...

    Authors: Alexander Fletcher Sandersjöö, Jiri Bartek Jr., Eric Peter Thelin, Anders Eriksson, Adrian Elmi-Terander, Mikael Broman and Bo-Michael Bellander

    Citation: Journal of Intensive Care 2017 5:27

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  5. Content type: Research

    This prospective study compared clinical characteristics and prognosis between primary (P) and secondary (S) acute gastrointestinal injury (AGI) (P-AGI)/(S-AGI) in critically ill patients.

    Authors: Dong Zhang, Rao Fu, Yanhua Li, Hongyan Li, Yuting Li and Hongxiang Li

    Citation: Journal of Intensive Care 2017 5:26

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  6. Content type: Research

    Endothelin 1 (ET-1) is a strong vasoconstrictor, which is involved in inflammation and reduced tissue perfusion. C-terminal proendothelin-1 (CT-proET-1) is the stable circulating precursor protein of ET-1. We ...

    Authors: Lukas Buendgens, Eray Yagmur, Jan Bruensing, Ulf Herbers, Christer Baeck, Christian Trautwein, Alexander Koch and Frank Tacke

    Citation: Journal of Intensive Care 2017 5:25

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  7. Content type: Review

    Monitoring of tissue perfusion is an essential step in the management of acute circulatory failure. The presence of cellular dysfunction has been a basic component of shock definition even in the absence of hy...

    Authors: Ahmed Hasanin, Ahmed Mukhtar and Heba Nassar

    Citation: Journal of Intensive Care 2017 5:24

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  8. Content type: Commentary

    The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunct...

    Authors: Frank Anthony Rasulo, Giuseppe Bellelli, Eugene Wesley Ely, Alessandro Morandi, Pratik Pandharipande and Nicola Latronico

    Citation: Journal of Intensive Care 2017 5:23

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  9. Content type: Review

    Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Authors: Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki

    Citation: Journal of Intensive Care 2017 5:22

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  10. Content type: Research

    Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key mo...

    Authors: Bernt C. Hellerud, Hilde L. Orrem, Knut Dybwik, Søren E. Pischke, Andreas Baratt-Due, Albert Castellheim, Hilde Fure, Grethe Bergseth, Dorte Christiansen, Miles A. Nunn, Terje Espevik, Corinna Lau, Petter Brandtzæg, Erik W. Nielsen and Tom E. Mollnes

    Citation: Journal of Intensive Care 2017 5:21

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  11. Content type: Research

    In recent years, the measurement of cerebral regional oxygen saturation (rSO2) during resuscitation has attracted attention. The objective of this study was to clarify the relationship between the serial changes ...

    Authors: Naoki Ehara, Tomoya Hirose, Tadahiko Shiozaki, Akinori Wakai, Tetsuro Nishimura, Nobuto Mori, Mitsuo Ohnishi, Daikai Sadamitsu and Takeshi Shimazu

    Citation: Journal of Intensive Care 2017 5:20

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  12. Content type: Research

    Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridges (PMX-DHP) is widely used for septic shock in Japan and parts of Europe. Although this treatment is usually administered for 2 h, the o...

    Authors: Kyohei Miyamoto, Yu Kawazoe and Seiya Kato

    Citation: Journal of Intensive Care 2017 5:19

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  13. Content type: Research

    Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization. Delirium, an acute form of brai...

    Authors: José Raimundo A. de Azevedo, Widlani Sousa Montenegro, Djane Pereira Rodrigues, Suellen C. de C. Souza, Vanessa F. S. Araujo, Margareth Pereira de Paula, Patricia H. C. P. Prazeres, Adenilde da Luz Leitão and Adriana V. N. Mendonça

    Citation: Journal of Intensive Care 2017 5:18

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  14. Content type: Research

    Pain assessment is highly recommended in patients receiving mechanical ventilation. However, pain intensity and its impact on outcomes in these patients remain obscure. We collected the results of routine pain...

    Authors: Ayahiro Yamashita, Masaki Yamasaki, Hiroki Matsuyama and Fumimasa Amaya

    Citation: Journal of Intensive Care 2017 5:17

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    The Commentary to this article has been published in Journal of Intensive Care 2017 5:73

  15. Content type: Research

    The work demands of critical care can be a major cause of stress in intensive care unit (ICU) professionals and lead to poor health outcomes. In the process of recovery from work, psychological rumination is c...

    Authors: Tushna Vandevala, Louisa Pavey, Olga Chelidoni, Nai-Feng Chang, Ben Creagh-Brown and Anna Cox

    Citation: Journal of Intensive Care 2017 5:16

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  16. Content type: Review

    The mortality rate of critically ill patients is high and the cost of the intensive (ICU) department is among the highest within the health-care industry. The cost will continue to increase because of the agin...

    Authors: Alexander F. van der Sluijs, Eline R. van Slobbe-Bijlsma, Stephen E. Chick, Margreeth B. Vroom, Dave A. Dongelmans and Alexander P. J. Vlaar

    Citation: Journal of Intensive Care 2017 5:13

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  17. Content type: Case report

    Sepsis and septic shock are major healthcare problems, affecting millions of individuals around the world each year. Pathophysiologically, septic multiple organ dysfunction (MOD) is a life-threatening conditio...

    Authors: Sascha David, Kristina Thamm, Bernhard M. W. Schmidt, Christine S. Falk and Jan T. Kielstein

    Citation: Journal of Intensive Care 2017 5:12

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  18. Content type: Review

    Achieving a balance between organ perfusion and hemostasis is critical for optimal fluid resuscitation in patients with severe trauma. The concept of “permissive hypotension” refers to managing trauma patients...

    Authors: Daisuke Kudo, Yoshitaro Yoshida and Shigeki Kushimoto

    Citation: Journal of Intensive Care 2017 5:11

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  19. Content type: Review

    Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Authors: Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa

    Citation: Journal of Intensive Care 2017 5:5

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  20. Content type: Review

    Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Authors: Mineji Hayakawa

    Citation: Journal of Intensive Care 2017 5:3

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  21. Content type: Letter to the Editor

    Tracheal ultrasound can be an alternative diagnostic tool in airway management, besides traditional confirmatory methods such as capnography and auscultation. The standard image is a hyperechoic air–mucosa (A–...

    Authors: Wan-Ching Lien

    Citation: Journal of Intensive Care 2017 5:10

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    The original article was published in Journal of Intensive Care 2016 4:52

  22. Content type: Research

    Deep vein thrombosis (DVT) is a major complication in critical care. There are various methods of prophylaxis, but none of them fully prevent DVT, and each method has adverse effects. Electrical muscle stimula...

    Authors: Masahiro Ojima, Ryosuke Takegawa, Tomoya Hirose, Mitsuo Ohnishi, Tadahiko Shiozaki and Takeshi Shimazu

    Citation: Journal of Intensive Care 2017 5:9

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  23. Content type: Research

    Older patients account for the majority of patients with sepsis. The objective of this study was to determine if decreased skeletal muscle mass is associated with outcomes in elderly patients with sepsis.

    Authors: Keita Shibahashi, Kazuhiro Sugiyama, Masahiro Kashiura and Yuichi Hamabe

    Citation: Journal of Intensive Care 2017 5:8

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  24. Content type: Case report

    Severe heat stroke tends to be complicated with rhabdomyolysis, especially in patients with exertional heat stroke. Rhabdomyolysis usually occurs in the acute phase of heat stroke. We herein report a case of h...

    Authors: Toshihiko Yoshizawa, Kazuhiko Omori, Ikuto Takeuchi, Yuto Miyoshi, Hiroshi Kido, Etsuhisa Takahashi, Kei Jitsuiki, Kouhei Ishikawa, Hiromichi Ohsaka, Manabu Sugita and Youichi Yanagawa

    Citation: Journal of Intensive Care 2016 4:71

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  25. Content type: Commentary

    Recent studies have shown acute respiratory distress syndrome (ARDS) to be underdiagnosed and inadequately treated, as evidenced by underutilization of low-tidal volume ventilation. Despite a proven survival b...

    Authors: Jason Chertoff

    Citation: Journal of Intensive Care 2016 4:70

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  26. Content type: Research

    Active smokers are prevalent within the intensive care setting and place a significant burden on healthcare systems. Nicotine withdrawal due to forced abstinence on admission may contribute to increased agitat...

    Authors: Melanie Kowalski, Andrew A. Udy, Hayden J. McRobbie and Michael J. Dooley

    Citation: Journal of Intensive Care 2016 4:69

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  27. Content type: Research

    Critically ill patients admitted to intensive care unit (ICU) may suffer from different painful stimuli, but the assessment of pain is difficult because most of them are almost sedated and unable to self-repor...

    Authors: Paolo Severgnini, Paolo Pelosi, Elena Contino, Elisa Serafinelli, Raffaele Novario and Maurizio Chiaranda

    Citation: Journal of Intensive Care 2016 4:68

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  28. Content type: Review

    Critical care is a complex field of medicine, especially because of its diversity and unpredictability. Mortality rates of the diseases are usually high and patients are critically ill, admitted in emergency, ...

    Authors: Bruno François, Marc Clavel, Philippe Vignon and Pierre-François Laterre

    Citation: Journal of Intensive Care 2016 4:67

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  29. Content type: Letter to the Editor

    We conducted an internet survey targeting healthcare providers in intensive care units (ICUs) in Japan and received 318 responses. Eighteen percent of respondents replied that full-time physical therapists (PT...

    Authors: Shunsuke Taito, Masamitsu Sanui, Hideto Yasuda, Nobuaki Shime and Alan Kawarai Lefor

    Citation: Journal of Intensive Care 2016 4:66

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  30. Content type: Research

    The Richmond Agitation-Sedation Scale (RASS) is a single tool that is intuitive, is easy to use, and includes both agitation and sedation. The RASS has never been formally validated for pediatric populations. ...

    Authors: Abigail Glicksman Kerson, Rebecca DeMaria, Elizabeth Mauer, Christine Joyce, Linda M. Gerber, Bruce M. Greenwald, Gabrielle Silver and Chani Traube

    Citation: Journal of Intensive Care 2016 4:65

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  31. Content type: Research

    Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estima...

    Authors: Hiroyuki Yamada, Tatsuo Tsukamoto, Hiromichi Narumiya, Kazumasa Oda, Satoshi Higaki, Ryoji Iizuka, Motoko Yanagita and Masako Deguchi

    Citation: Journal of Intensive Care 2016 4:64

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  32. Content type: Research

    Passive leg raising (PLR) is a so called self-volume challenge used to test for fluid responsiveness. Changes in cardiac output (CO) or stroke volume (SV) measured during PLR are used to predict the need for s...

    Authors: Anton Krige, Martin Bland and Thomas Fanshawe

    Citation: Journal of Intensive Care 2016 4:63

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  33. Content type: Research

    Augmented renal clearance (ARC) of circulating solutes and drugs has been recently often reported in intensive care unit (ICU) patients. However, only few studies on ARC have been reported in Japan. The aims o...

    Authors: Yasumasa Kawano, Shinichi Morimoto, Yoshito Izutani, Kentaro Muranishi, Hironari Kaneyama, Kota Hoshino, Takeshi Nishida and Hiroyasu Ishikura

    Citation: Journal of Intensive Care 2016 4:62

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  34. Content type: Review

    Vascular hyperpermeability is a frequent intractable feature involved in a wide range of diseases in the intensive care unit. The glycocalyx (GCX) seemingly plays a key role to control vascular permeability. T...

    Authors: Akira Ushiyama, Hanae Kataoka and Takehiko Iijima

    Citation: Journal of Intensive Care 2016 4:59

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  35. Content type: Research

    Because treatment modalities for carbon monoxide (CO) poisoning, especially normobaric oxygen and hyperbaric oxygen therapies, have limited effects and hyperbaric oxygen is not available at the scene where tre...

    Authors: Taku Tanaka, Takeshi Kashimura, Marii Ise, Brandon D. Lohman and Yasuhiko Taira

    Citation: Journal of Intensive Care 2016 4:58

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  36. Content type: Review

    The skin, soft tissue, and most parts of the musculoskeletal system are relatively superficial anatomical structures and ideal targets for ultrasound examination in the emergency departments. Soft tissue and m...

    Authors: Kuo-Chih Chen, Aming Chor-Ming Lin, Chee-Fah Chong and Tzong-Luen Wang

    Citation: Journal of Intensive Care 2016 4:55

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  37. Content type: Review

    Rapid and accurate diagnosis and treatment are paramount in the management of the critically ill. Critical care ultrasound has been widely used as an adjunct to standard clinical examination, an invaluable ext...

    Authors: Young-Rock Ha and Hong-Chuen Toh

    Citation: Journal of Intensive Care 2016 4:54

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  38. Content type: Review

    Upper airway ultrasound is a valuable, non-invasive, simple, and portable point of care ultrasound (POCUS) for evaluation of airway management even in anatomy distorted by pathology or trauma. Ultrasound enabl...

    Authors: Adi Osman and Kok Meng Sum

    Citation: Journal of Intensive Care 2016 4:52

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    The Letter to the Editor to this article has been published in Journal of Intensive Care 2017 5:10