- Open Access
Response to commentary
Journal of Intensive Care volume 9, Article number: 56 (2021)
This is a response to the issues raised in the commentary by Dr. Yifu Si et al.
We would like to thank Editor-in-Chief for the opportunity to respond to the issues raised in the commentary by Dr. Yifu Si et al. We also greatly appreciate their interest in our paper.
Following are the two concerns raised by them:
First, acute respiratory failure (ARF) is heterogenous and the predictive ability of lymphocytes in bronchoalveolar lavage fluid (BALF) can be different in each disease.
The etiology of ARF varies and is complicated; hence, comprehensive diagnostic investigation including BALF is required. We agree that it is important to conduct further study in order to confirm our result with an adequate number of subjects. However, in critically ill patients with ARF, confirming a differential diagnosis in sufficient numbers is challenging. Therefore, our findings may include important aspects present in the real-world clinical settings.
Second, Dr. Yifu Si et al. suggest the possibility that decreased mortality in interstitial lung disease (ILD) patients could be biased in our study; the difference between our results and a report of a larger multicenter observational study with four different cohorts indicates that interstitial lung abnormalities (ILA) are associated with a higher risk of all-cause mortality . In this point, we partly agree with the concerns of Dr. Yifu Si et al. that our study may be biased due to its small sample size.
However, ILA, defined as the incidental computed tomography (CT) findings, is a larger and more biased concept than ILD, which is detailed in our study . Indeed, in ILA, the usual interstitial pneumonia (UIP) pattern obtained using chest CT imaging significantly associated with increased mortality . Idiopathic pulmonary fibrosis (IPF) is one of the major ILDs with UIP pattern that is known to have poor prognosis. In our study, acute exacerbation of IPF has been diagnosed using the definition in international working group report, which was not necessary BALF since 2016 . The increased risk of mortality with ILA may in part be related to the poor prognosis of IPF. Because of this, the comparison between ILA and ILD in the context of our study is problematic as the mortality rates vary considerably.
Availability of data and materials
Acute respiratory failure
Bronchoalveolar lavage fluid
Interstitial lung abnormalities
Interstitial lung disease
Idiopathic pulmonary fibrosis
Usual interstitial pneumonia
Putman RK, Hatabu H, Araki T, Gudmundsson G, Gao W, Nishino M, et al. Association between interstitial lung abnormalities and all-cause mortality. JAMA. 2016;315:672–81.
Hata A, Schiebler ML, Lynch DA, Hatabu H. Interstitial lung abnormalities: state of the art. Radiology. 2021.
Putman RK, Gudmundsson G, Axelsson GT, Hida T, Honda O, Araki T, et al. Imaging patterns are associated with interstitial lung abnormality progression and mortality. Am J Respir Crit Care Med. 2019;200:175–83.
Collard HR, Ryerson CJ, Corte TJ, Jenkins G, Kondoh Y, Lederer DJ, et al. Acute exacerbation of idiopathic pulmonary fibrosis. An international working group report. Am J Respir Crit Care Med. 2016;194:265–75.
The authors would like to thank Enago (www.enago.jp) for the English language review.
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article refers to the article available online at https://doi.org/10.1186/s40560-021-00568-2
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Hirasawa, Y., Nakada, Ta. & Terada, J. Response to commentary. j intensive care 9, 56 (2021). https://doi.org/10.1186/s40560-021-00572-6