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  1. Here, we measured presepsins (PSPs) in four patients with acute kidney injury (AKI) or chronic kidney disease (CKD) and discuss the relationship between PSP and kidney dysfunction.

    Authors: Atsushi Kotera, Katsuyuki Sagishima, Takahiro Tashiro, Daisuke Niimori, Hidenobu Kamohara and Yoshihiro Kinoshita
    Citation: Journal of Intensive Care 2014 2:63
  2. Fresh frozen plasma transfusion is widely utilized in pediatric clinical practice to correct mild coagulopathy. Several studies on adult population have shown that transfusion of plasma cannot effectively corr...

    Authors: Esther Paula Soundar, Ronald Besandre, Sarah Kate Hartman, Jun Teruya and Shiu-Ki Rocky Hui
    Citation: Journal of Intensive Care 2014 2:64
  3. Initial distribution volume of glucose (IDVG), which is not associated with significant modification of glucose metabolism, has been proposed as an indicator of the central extracellular fluid volume status in...

    Authors: Hironori Ishihara, Eiji Hashiba, Hirobumi Okawa, Junichi Saito, Toshinori Kasai and Toshihito Tsubo
    Citation: Journal of Intensive Care 2014 2:59
  4. Redback spiders (Latrodectus hasselti) (RBSs) are venomous spiders that have recently spread to Asia from Australia. Since the first case report in 1997 (Osaka), RBS bites have been a clinical and administrative ...

    Authors: Toru Hifumi, Satoshi Fujimi, Takuya Yamagishi, Satoru Arai, Kyoko Sawabe, Akihiko Yamamoto, Manabu Ato, Keigo Shibayama, Akihiko Ginnaga, Nobuaki Kiriu, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Masanobu Kishikawa, Yuko Abe, Kenya Kawakita…
    Citation: Journal of Intensive Care 2014 2:62
  5. This is a guideline for the management of sepsis, developed by the Sepsis Registry Committee of The Japanese Society of Intensive Care Medicine (JSICM) launched in March 2007. This guideline was developed on t...

    Authors: Shigeto Oda, Mayuki Aibiki, Toshiaki Ikeda, Hitoshi Imaizumi, Shigeatsu Endo, Ryoichi Ochiai, Joji Kotani, Nobuaki Shime, Osamu Nishida, Takayuki Noguchi, Naoyuki Matsuda and Hiroyuki Hirasawa
    Citation: Journal of Intensive Care 2014 2:55
  6. Initial fluid resuscitation is an important hemodynamic therapy in patients with septic shock. The Surviving Sepsis Campaign Guidelines recommend fluid resuscitation with volume loading according to central ve...

    Authors: Takako Sasai, Hiroaki Tokioka, Tomihiro Fukushima, Takeshi Mikane, Satoru Oku, Etsu Iwasaki, Mizue Ishii, Hideyuki Mieda, Tomoki Ishikawa and Eriko Minami
    Citation: Journal of Intensive Care 2014 2:58
  7. Ventilator-induced lung injury (VILI) is associated with inflammatory responses in the lung. Thrombomodulin (TM), a component of the coagulation system, has anticoagulant and anti-inflammatory effects. We hypo...

    Authors: Yoshiaki Iwashita, Erquan Zhang, Junko Maruyama, Ayumu Yokochi, Yasuharu Yamada, Hirofumi Sawada, Yoshihide Mitani, Hiroshi Imai, Koji Suzuki and Kazuo Maruyama
    Citation: Journal of Intensive Care 2014 2:57
  8. Hemostatic resuscitation might improve the survival of severely injured trauma patients. Our objective was to establish a simplified screening system for determining the necessity of massive transfusions (MT) ...

    Authors: Tetsuya Yumoto, Atsuyoshi Iida, Takahiro Hirayama, Kohei Tsukahara, Naoki Shiba, Hideo Yamanouchi, Keiji Sato, Toyomu Ugawa, Shingo Ichiba and Yoshihito Ujike
    Citation: Journal of Intensive Care 2014 2:54
  9. A recent multicenter trial demonstrated decreased mortality when patients with acute respiratory distress syndrome were treated with prone positioning (PP). However, the optimal duration of this treatment has ...

    Authors: Kyohei Miyamoto, Yu Kawazoe, Masato Yasuda, Naoaki Shibata, Tsuyoshi Nakashima, Maki Kida and Seiya Kato
    Citation: Journal of Intensive Care 2014 2:52
  10. Rikkunshito is a traditional Japanese medicine that has been widely prescribed for patients with various gastrointestinal symptoms. Recently, the prokinetic effects of Rikkunshito in patients with a variety of...

    Authors: Mineji Hayakawa, Yuichi Ono, Takeshi Wada, Yuichiro Yanagida, Atsushi Sawamura, Hiroshi Takeda and Satoshi Gando
    Citation: Journal of Intensive Care 2014 2:53
  11. Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication in patients with autoimmune diseases who are undergoing chemotherapy or have had hematopoietic stem cell transplantation. The use of recomb...

    Authors: Raúl Carrillo Esper, Isis EspinozadelosMonteros Estrada, Teresa de la Torre León, Agustín OmarRosales Gutiérrez and Jorge ArturoNava López
    Citation: Journal of Intensive Care 2014 2:47
  12. As disseminated intravascular coagulation (DIC) causes multiple organ failure, recombinant thrombomodulin (rTM) is widely used in Japan for treating DIC. However, the optimal timing of rTM administration has n...

    Authors: Tomoaki Yatabe, Ryu Nakamura, Naoko Kumagai, Tatsuo Iiyama, Koichi Yamashita and Masataka Yokoyama
    Citation: Journal of Intensive Care 2014 2:49
  13. Idiopathic pneumonia syndrome (IPS) is a fatal non-infectious respiratory complication that develops after hematopoietic stem cell transplantation (HSCT). Because of the poor prognosis of post-HSCT patients wi...

    Authors: Toshitaka Koinuma, Shin Nunomiya, Masahiko Wada, Kansuke Koyama and Takahiro Suzuki
    Citation: Journal of Intensive Care 2014 2:48
  14. Acute kidney injury (AKI) is a common and serious condition usually detected some time after onset by changes in serum creatinine (sCr). Although stent grafting to repair aortic aneurysms is associated with AK...

    Authors: Kazuyoshi Ueta, Michiko Watanabe, Naoya Iguchi, Akinori Uchiyama, Yukitoshi Shirakawa, Toru Kuratani, Yoshiki Sawa and Yuji Fujino
    Citation: Journal of Intensive Care 2014 2:45
  15. Rhabdophis tigrinus (Yamakagashi snake) is a rear-fanged colubrid snake present throughout Russia and Asia. Its venom induces life-threatening hemorrhagic symptoms and severe disseminated intravascular coagulatio...

    Authors: Toru Hifumi, Atsushi Sakai, Akihiko Yamamoto, Masahiro Murakawa, Manabu Ato, Keigo Shibayama, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Yuko Abe, Kenya Kawakita, Masanobu Hagiike, Akihiko Ginnaga and Yasuhiro Kuroda
    Citation: Journal of Intensive Care 2014 2:44
  16. As a response to the recent article by Hifumi et al. published in the Journal of Intensive Care, the present correspondence clarifies the family-level taxonomy of the yamakagashi (Rhabdophis tigrinus). Further, t...

    Authors: Anjana Silva, Toru Hifumi, Atsushi Sakai, Akihiko Yamamoto, Masahiro Murakawa, Manabu Ato, Keigo Shibayama, Akihiko Ginnaga, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Yuko Abe, Kenya Kawakita, Masanobu Hagiike and Yasuhiro Kuroda
    Citation: Journal of Intensive Care 2014 2:43
  17. Acute kidney injury (AKI) is one of the major morbidities after surgical repair of abdominal aortic aneurysm (AAA); however, precise pathogenesis of this morbidity has not been well determined. Since prothromb...

    Authors: Yasushi Innami, Nobuyuki Katori, Katsuya Mori, Shizuko Kosugi, Takeshi Suzuki, Norihiro Sakurai, Hiromasa Nagata, Junzo Takeda and Hiroshi Morisaki
    Citation: Journal of Intensive Care 2014 2:46
  18. The objective of this case report is to describe the first case of renal actinomycosis caused by Actinomyces meyeri presenting as severe emphysematous pyelonephritis and complicated by septic shock and multi-orga...

    Authors: Alexandre Herbland, Maxime Leloup, Quentin Levrat, Frédéric Guillaume, Virginie Verrier, Philippe Bouillard, Thierry Landois, Charlie Frédéric Ouaki and Olivier Lesieur
    Citation: Journal of Intensive Care 2014 2:42
  19. Multiple scoring systems have been developed for both the intensive care unit (ICU) and the emergency department (ED) to risk stratify patients and predict mortality. However, it remains unclear whether the ad...

    Authors: Erika M Moseson, Hanjing Zhuo, Jeff Chu, John C Stein, Michael A Matthay, Kirsten N Kangelaris, Kathleen D Liu and Carolyn S Calfee
    Citation: Journal of Intensive Care 2014 2:40
  20. Although chloride is one of the major electrolytes measured routinely in dairy practice, the amount of attention chloride receives in critically ill patients is limited. There are still a few studies reporting...

    Authors: Satoshi Kimura, Shinsaku Matsumoto, Nagisa Muto, Tomoko Yamanoi, Tatsuya Higashi, Kosuke Nakamura, Mineo Miyazaki and Moritoki Egi
    Citation: Journal of Intensive Care 2014 2:39
  21. We encountered markedly elevated procalcitonin (PCT) among pediatric patients during the early postoperative period of open heart surgery. The purpose of this study is to investigate what factors are associate...

    Authors: Etsuko Minami, Shoji Ito, Takeshi Sugiura, Yoshihito Fujita, Hiroshi Sasano and Kazuya Sobue
    Citation: Journal of Intensive Care 2014 2:38
  22. Probiotics have currently been widely used in patients undergoing various types of surgeries and improved their clinical outcomes, while data in pediatric cardiac surgery have been lacking. We investigated the...

    Authors: Takako Umenai, Nobuaki Shime, Takashi Asahara, Koji Nomoto and Toshiyuki Itoi
    Citation: Journal of Intensive Care 2014 2:36
  23. This study was performed to assess the value of procalcitonin (PCT) for the differential diagnosis between infectious and non-infectious systemic inflammatory response syndrome (SIRS) after cardiac surgery.

    Authors: Dong Zhao, Jianxin Zhou, Go Haraguchi, Hirokuni Arai and Chieko Mitaka
    Citation: Journal of Intensive Care 2014 2:35
  24. To prevent endotracheal tube (ETT)-related complications during mechanical ventilation, ETT cuff pressure should be kept within proper range. In clinical settings, cuff pressure often decreases from target val...

    Authors: Shota Asai, Asuka Motoyama, Yuri Matsumoto, Hiroyuki Konami, Hideaki Imanaka and Masaji Nishimura
    Citation: Journal of Intensive Care 2014 2:34
  25. In a rural region with few medical resources, we have promoted the strategy that if an out-of-hospital cardiac arrest (OHCA) patient is likely reversible, he or she should be transported directly from the scen...

    Authors: Katsunori Mochizuki, Hiroshi Imamura, Tomomi Iwashita and Kazufumi Okamoto
    Citation: Journal of Intensive Care 2014 2:33
  26. Frantic efforts have been made up to this date to derive consensus for estimating renal function in critically ill patients, only to open the Pandora's box. This article tries to explore the various methods av...

    Authors: Sham Sunder, Rajesh Jayaraman, Himanshu Sekhar Mahapatra, Satyanand Sathi, Venkata Ramanan, Prabhu Kanchi, Anurag Gupta, Sunil Kumar Daksh and Pranit Ram
    Citation: Journal of Intensive Care 2014 2:31
  27. Thrombomodulin alfa (TM-α, recombinant thrombomodulin) significantly improved disseminated intravascular coagulation (DIC) when compared with heparin therapy in a phase III study. Post-marketing surveillance o...

    Authors: Yutaka Eguchi, Satoshi Gando, Hiroyasu Ishikura, Daizoh Saitoh, Jun Mimuro, Hoyu Takahashi, Isao Kitajima, Hajime Tsuji, Tadashi Matsushita, Ryuichi Tsujita, Osamu Nagao and Yoichi Sakata
    Citation: Journal of Intensive Care 2014 2:30
  28. This study aimed to assess the performance of the Simplified Acute Physiology Score 3 (SAPS 3) as a predictor of ICU mortality in critically ill patients of different case mixes admitted to an intensive care u...

    Authors: Aaron Mark R Hernandez and Jose Emmanuel M Palo
    Citation: Journal of Intensive Care 2014 2:29
  29. The aim of this study was to investigate effects of basic life support (BLS) training on willingness of single rescuers to make emergency calls during out-of-hospital cardiac arrests (OHCAs) with no available ...

    Authors: Keiko Hirose, Miki Enami, Hiroki Matsubara, Takahisa Kamikura, Yutaka Takei and Hideo Inaba
    Citation: Journal of Intensive Care 2014 2:28
  30. Although Acute Kidney Injury Network (AKIN) staging is widely used, it has been suggested that classification using serum creatinine levels, which fluctuate because of fluid balance, is not always appropriate ...

    Authors: Yu Horiguchi, Akinori Uchiyama, Naoya Iguchi, Kanaki Sakai, Daisuke Hiramatsu, Kazuyoshi Ueta, Noriyuki Ohta and Yuji Fujino
    Citation: Journal of Intensive Care 2014 2:26
  31. Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary ...

    Authors: Tadashi Kaneko, Yoshikatsu Kawamura, Tsuyoshi Maekawa, Takashi Tagami, Toshiaki Nakamura, Nobuyuki Saito, Yasuhide Kitazawa, Hiroyasu Ishikura, Manabu Sugita, Kazuo Okuchi, Hiroshi Rinka, Akihiro Watanabe, Yoichi Kase, Shigeki Kushimoto, Hiroo Izumino, Takashi Kanemura…
    Citation: Journal of Intensive Care 2014 2:25
  32. Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction betwe...

    Authors: Kenichiro Morisawa, Shigeki Fujitani, Yasuhiko Taira, Shigeki Kushimoto, Yasuhide Kitazawa, Kazuo Okuchi, Hiroyasu Ishikura, Teruo Sakamoto, Takashi Tagami, Junko Yamaguchi, Manabu Sugita, Yoichi Kase, Takashi Kanemura, Hiroyuki Takahashi, Yuuichi Kuroki, Hiroo Izumino…
    Citation: Journal of Intensive Care 2014 2:24
  33. Proper fluid management is crucial for the management of critically ill patients. However, there is a continuing debate about the choice of the fluid, i.e., crystalloid vs. colloid. Colloid solution is theoret...

    Authors: Daisuke Toyoda, Shigeo Shinoda and Yoshifumi Kotake
    Citation: Journal of Intensive Care 2014 2:23
  34. Disorders of the urea cycle are secondary to a defect in the system that converts ammonia into urea, resulting in accumulation of ammonia and other products. This results in encephalopathy, coma, and death if ...

    Authors: MarcelCerqueira Cesar Machado and Fabiano Pinheiro da Silva
    Citation: Journal of Intensive Care 2014 2:22
  35. Infusion fluids may be contaminated with different types of particulates that are a potential health hazard. Particulates larger than microvessels may cause an embolism by mechanical blockage and inflammation;...

    Authors: Hajime Arima, Hiroyuki Hirate, Takeshi Sugiura, Shugo Suzuki, Satoru Takahashi and Kazuya Sobue
    Citation: Journal of Intensive Care 2014 2:21
  36. Yamakagashi (Rhabdophis tigrinus) is a species of pit viper present throughout Russia and Eastern Asia. Although R. tigrinus venom is known to induce life-threatening hemorrhagic symptoms, the clinical characteri...

    Authors: Toru Hifumi, Atsushi Sakai, Akihiko Yamamoto, Masahiro Murakawa, Manabu Ato, Keigo Shibayama, Akihiko Ginnaga, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Yuko Abe, Kenya Kawakita, Masanobu Hagiike and Yasuhiro Kuroda
    Citation: Journal of Intensive Care 2014 2:19
  37. We tested the utility of the McGrath MAC® (McG) video laryngoscope during chest compression compared with the Pentax Airwayscope® (AWS). We recruited 59 participants into the simulation study. The difference in t...

    Authors: Atsushi Kotera, Hiroki Irie, Shinsuke Iwashita, Junichi Taniguchi, Shunji Kasaoka and Yoshihiro Kinoshita
    Citation: Journal of Intensive Care 2014 2:18
  38. Tracheotomy is an indispensable component in intensive care management. Doctors in charge of the intensive care unit (ICU) usually decide whether tracheotomy should be performed. However, long-term follow-up o...

    Authors: Yukihiro Ikegami, Ken Iseki, Chiaki Nemoto, Yasuhiko Tsukada, Jiro Shimada and Choichiro Tase
    Citation: Journal of Intensive Care 2014 2:17
  39. Supplemental landiolol administration (20 or 40 μg kg-1 min-1) effectively diminished harmful hemodynamic changes during bronchoscopic endotracheal suctioning compared to normal saline. However, inappropriate use...

    Authors: Toru Hifumi, Hiroshi Kato, Yuichi Koido, Kenya Kawakita and Yasuhiro Kuroda
    Citation: Journal of Intensive Care 2014 2:16
  40. Disseminated intravascular coagulation (DIC) is categorized into bleeding, organ failure, massive bleeding, and non-symptomatic types according to the sum of vectors for hypercoagulation and hyperfibrinolysis....

    Authors: Hideo Wada, Takeshi Matsumoto and Yoshiki Yamashita
    Citation: Journal of Intensive Care 2014 2:15
  41. Here, we report a case of a 41-year-old male diagnosed as septic shock with purpura fulminans (PF) infection. The causative organism was β-lactamase-negative ampicillin-resistant Hemophilus influenzae. He develop...

    Authors: Akira Endo, Atsushi Shiraishi, Junichi Aiboshi, Yoshiro Hayashi and Yasuhiro Otomo
    Citation: Journal of Intensive Care 2014 2:13
  42. Active cytomegalovirus infection is not uncommon in critically ill non-immunosuppressed patients. We conducted a preliminary observational study to determine the prevalence of active cytomegalovirus infection ...

    Authors: Haruhiko Ishioka, Masamitsu Sanui, Yusuke Tsutsumi, Fumitaka Yanase and Junji Shiotsuka
    Citation: Journal of Intensive Care 2014 2:12
  43. In Japan, the continuation of critical care at the end of life is a common practice due to the threat of legal action against physicians that may choose a palliative care approach. This is beginning to change ...

    Authors: Jun Makino, Shigeki Fujitani, Bridget Twohig, Steven Krasnica and John Oropello
    Citation: Journal of Intensive Care 2014 2:9