Skip to main content

Fluid therapy in the perioperative setting—a clinical review



Perioperative hypovolemia and fluid overload have effects on both complications following surgery and on patient survival. Therefore, the administration of intravenous fluids before, during, and after surgery at the right time and in the right amounts is of great importance. This review aims to analyze the literature concerning perioperative fluid therapy in abdominal surgery and to provide evidence-based recommendations for clinical practice.


Preoperative oral or intravenous administration of carbohydrate containing fluids has been shown to improve postoperative well-being and muscular strength and to reduce insulin resistance. Hence, the intake of fluid (preferably containing carbohydrates) should be encouraged up to 2 h prior to surgery in order to avoid dehydration. Excessive intravenous fluid administration adds to tissue inflammation and edema formation, thereby compromising tissue healing.

During major abdominal surgery a “zero-balance” intraoperative fluid strategy aims at avoiding fluid overload (and comparable to the so-called restrictive approach) as well as goal-directed fluid therapy (GDT). Both proved to significantly reduce postoperative complications when compared to “standard fluid therapy”. Trials comparing “restrictive” or zero-balance and GDT have shown equal results, as long as fluid overload is avoided in the GDT group as well (categorized as “zero-balance GDT”).

It is possible that high-risk surgical patients, such as those undergoing acute surgery, may benefit from the continuous monitoring of circulatory status that the GDT provides. Data on this group of patients is not available at present, but trials are ongoing.


In elective surgery, the zero-balance approach has shown to reduce postoperative complications and is easily applied for most patients. It is less expensive and simpler than the zero-balance GDT approach and therefore recommended in this review. In outpatient surgery, 1–2 L of balanced crystalloids reduces postoperative nausea and vomiting and improves well-being.


Intravenous fluid therapy is an integrated and lifesaving part of the treatment of patients undergoing surgery. Hypovolemia leads to insufficient circulation with decreased oxygen delivery to organs and peripheral tissues causing organ dysfunction and shock. Fluid overload, on the other hand, leads to interstitial edema and local inflammation and impairs the regeneration of collagen, thereby weakening the tissue healing with increased risk of postoperative wound infections, wound rupture, and anastomotic leakage. Moreover, it causes impaired cardiopulmonary function [114]. It is therefore imperative to administer fluid therapy individually, when needed, and in the right amounts [15, 16].

The goal of perioperative intravenous fluid therapy is to maintain or restore circulation with an adequate fluid and electrolyte balance, thereby creating the preconditions for a favorable outcome for the patient. Hence, the goals of perioperative fluid therapy can be summarized as follows:

  • Maintain or correct fluid balance (dehydration, hypovolemia)

  • Maintain or correct plasma constitution (electrolytes)

  • Secure sufficient circulation (in combination with vasoactive and/or cardioactive substances)

  • Secure sufficient oxygen delivery to organs (in combination with oxygen therapy)

In daily clinical practice, fluid therapy is guided by knowledge of basic physiological needs and simple cardiovascular measurements as well as the monitoring of the renal function by urine output. However, parameters such as mean arterial pressure (MAP), heart rate (HR), and diuresis are affected by variables not related to the circulatory status, including pain, body temperature, and physiological and psychological stress, as well as anesthetic and analgesic drugs, etc. These parameters are therefore imprecise in the measurement of intravascular status. The blood volume has to decrease by approximately 20 % before hypovolemia is detected, and fluid overload does not change blood pressure or HR at all in patients without heart failure. Therefore, using these parameters, fluid overload is invisible for the treating clinician giving intravenous fluid therapy to surgical patients, and its deleterious effects only become apparent in clinical trials avoiding fluid overload.

Consequently, the use of central cardiovascular measurements such as stroke volume or functional parameters (arterial wave form analysis, stroke volume variation, etc.) is recommended for the monitoring of circulatory status (goal-directed fluid therapy—GDT) to secure sufficient circulation and avoid fluid overload, with or without the simultaneous use of “zero-balance” or “restricted” fluid therapy.

The aim of this review is to analyze the literature concerning perioperative fluid therapy in abdominal surgery and to provide evidence-based recommendations for clinical practice.


Fluid therapy preoperative

Fasting prior to surgery is mandatory to avoid aspiration of stomach content to the lungs. Six hours fasting from food and 2 h from liquids is generally recommended, and the patient should be encouraged to minimize the fasting period, thus avoiding dehydration [17].

Carbohydrates given orally or intravenously have been shown to improve postoperative well-being and muscular strength and to attenuate insulin resistance, the latter being correlated to prolonged length of hospital stay [1820]. For this reason, this practice is indorsed, even when no effect on postoperative complications and mortality has been shown.

Jacob et al. show that a prolonged fasting period is unlikely to affect cardiopulmonary function and cause hypovolemia in healthy patients [21]. Thus, fasting deficit is not extensive for a patient who has been drinking up to 2 h prior to surgery. The loss is the combined fluid loss through diuresis and insensible perspiration and therefore primarily a loss of water which, if needed, should be compensated with glucose-containing fluids.

Mechanical bowel preparation prior to surgery has been argued to reduce postoperative leakage and infection. However, the benefit of the procedure has not been shown despite systematic review of the literature in a Cochrane review [22]. In addition, bowel preparation has been shown to induce functional hypovolemia affecting cardiovascular capacity and to cause preoperative dehydration [23]. Therefore, mechanical bowel preparation is no longer a standard recommendation.

Fluid loss and replacement in the perioperative patient

Loss of fluid and electrolytes occurs continuously and has to be replaced to maintain homoeostasis. However, replacement regimes vary considerably within studies and unclear categorizations of perioperative fluid therapy as restrictive, conventional, or liberal creates confusion. In the earliest original papers testing the so-called restricted fluid therapy, the fluid regimen was in fact aiming at zero-balance measured as zero body-weight gain, thus, avoiding fluid overload. Therefore, the more descriptive term zero-balance is used in more recent papers from the same authors, as well as in this article. To ensure an optimal and adequate fluid replacement therapy, knowledge of physiological fluid turnover is fundamental.

Perspiration and diuresis

Several investigators have measured insensible perspiration (evaporation from the skin and the airways—the only loss of pure water from the body) in different circumstances. In 1977, Lamke et al. used a special chamber to measure the water content in the air layer immediately adjacent to the skin in four different zones of the body of adult healthy volunteers. They found insensible perspiration to be approximately 0.3 mL/kg/h [24]. Reithner et al. documented the same result for patients during abdominal surgery, but moreover showed that water loss from respiration was approximately 0.2 mL/kg/h. Thus, daily insensible perspiration amounts to approximately 0.5 mL/kg/h or 10 mL/kg/day [2527]. During fever, insensible perspiration loss increases due to the rise of respiratory frequency. Reithner measured an increase in water loss from the respiratory tract of approximately 110 mL/day (0.06 mL/kg/h) in patients with fever above 39 °C [28]. However, taking into account that patients during surgery are ventilated with moist air, the insensible perspiration is only 0.3 mL/kg/h.

Sensible perspiration is visible sweat consisting of salt and water. The volume varies considerably depending on the surrounding temperature and physiological stress. Lamke et al. estimated visible sweat in patients with a rectal temperature above 39.5 °C to account for 600 mL/day (0.3 mL/kg/h). However, fever and sweating were occasional and only present for 6 h/day [29]. In a clinical setting, sensible perspiration is not generally considered, but may be significant for a patient with severe sepsis.

Diuresis is affected by a variety of factors including blood pressure, fluid intake, stress response (and other hormonal changes), surgical trauma, and anesthesia. Thus, diuresis reflects many other things than the renal ability to secrete fluid and osmotic components. Urinary output is therefore unreliable as a marker for intravascular fluid status and does not show the adequacy of the fluid therapy in the perioperative setting [30].

The expected diuresis for postsurgical patients varies in different countries, but a diuresis of 0.5–1.0 mL/kg/h is generally recommended. In several studies, the allowance of perioperative diuresis of 0.5 mL/kg/h in combination with a judicious fluid therapy has been shown to reduce postoperative morbidity [1, 5, 30].

When healthy individuals experience considerable thirst, the kidneys can concentrate urine to approximately 1200 mOsm/L and sodium in an amount of 300 mmol/L urine [31]. The clinical implication of this is illustrated in an average patient weighing 75 kg, not capable of drinking, and given 2 L 0.9 % saline as the only fluid therapy for a day. It is estimated that 750 mL of the water is lost as insensible perspiration, leaving 1250 mL to excrete 308 mmol sodium, hence bringing the kidneys close to their limit of sodium excretion. Age and diseases reduce the renal ability to concentrate diuresis, and infusion of large amounts of sodium is likely to cause unnecessary harm [32].

Intraoperative fluid losses and their replacement

Lamke et al. have measured the evaporation from the surgical wound. They used a chamber to cover the wound and the exteriorized viscera and found an evaporative loss correlating to the size of incision ranging from 2.1 g/h in minor wounds with slightly exposed viscera, up to 32 g/h in major wounds with completely exposed viscera [33]. An additional reduction by 87 % has been shown in a study on rabbits, using a plastic envelope covering the exposed viscera and irrigating the abdominal cavity with warmed crystalloids after replacement of the viscera to the abdominal cavity [34].

The evaporative fluid loss during laparoscopic surgery is considered small, yet dry air is insufflated into the abdomen with an unknown turnover. At present, evaporative loss during laparoscopic surgery is completely unknown.

The third space loss and the effects of intraoperative edema formation

It has been argued that surgical trauma leads to a shift of fluid volume between the fluid compartments of the body, creating a loss of extracellular fluid to a nonanatomical compartment named “the third space”.

This has led to the recommendation of giving up to 15 mL/kg/h the first hour of surgery and thereafter declining amounts of fluid in accordance with algorithms.

However, having reviewed the literature, this hypothesis is based on few studies using one specific but flawed method of measurement of the extracellular volume. More recent studies using sounder methods cannot demonstrate any such fluid loss. The entire concept of a loss to the third space should therefore be abandoned [35, 36].

Surgical trauma, however, does create an edema in the traumatized tissue as demonstrated by Chan et al. in 1983. They showed that the formation of a small bowel anastomosis in rabbits caused an increase in tissue weight of 5–10 %, due to fluid accumulation. Supplementary intravenous crystalloid infusion of 5 mL/kg/h doubled the edema and destabilized the anastomosis [37].

Transferring these findings to a clinical setting, a hypothetic manipulation of the entire colon (approximately 3 kg) results in water accumulation in the tissue of about 150–300 mL. Substituting this volume, additional edema formation appears, compromising the healing of anastomosis and increasing the risk of leakage [3, 10]. Moreover, the estimated maximal volume loss of 300 mL is very small and hardly causes a need for replacement [35].

Noblett et al. randomized 108 patients undergoing colorectal resection to intraoperative GDT compared to standard fluid therapy (3638 mL vs. 3834 mL) and showed that GDT significantly reduced interleukin 6 levels. This indicates that through securing splanchnic circulation by GDT, a reduction of the systemic inflammatory response due to surgical trauma was achieved [16]. In addition, in a study by Kulemann et al., excessive intraoperative intravenous administration of crystalloids was shown to promote inflammation and accelerated collagenolysis in rats [3]. These findings suggest that unrestrained administration of intravenous crystalloids induces adverse inflammatory responses and compromises wound healing.

The balance between sustaining intravascular volume and avoiding extravascular fluid accumulation is delicate. Lobo et al. infused 1 L saline and demonstrated that 68 % had escaped from the intravascular space 1 h after the infusion, compared to 16 % after the infusion of 1 L colloid [38]. Likewise, patients with moderate hypovolemia receiving rapid infusion of 1 L Ringers solution do not increase the intravascular volume compared to rapid infusion of 1 L hydroxyethyl starch 6 % (HES), which significantly improved blood expansion and cardiac output [39]. This suggests that crystalloids leave the intravascular volume fast and induce interstitial edema.

Acetated or lactated Ringers solutions are originally developed from the plasma of amphibians, but are closer to the composition of human plasma than saline. It contains less chloride than saline (100 mmol vs. 154 mmol) but still 140 mmol of sodium. Even though chloride causes hyperchloremic acidosis if given in excess amounts, the importance of sodium in the development of postoperative edema is unknown.

The use of colloids for stroke volume optimizing regimes has been shown to reduce postoperative complications [13, 4042]. However, a recent study showed significant coagulopathy and adverse kidney effects using HES to stabilize patients with sepsis at intensive care units [43] and calls for caution using colloids for resuscitation. At the same time, a recent systematic review found no association between the use of starch solutions and acute kidney injury in surgical patients [44]. Therefore, the use of colloids in the perioperative setting seems safe.

Interstitial edema following intravenous fluid administration is formed and sustained as a result of osmotic forces and caused by the diffusion of osmotic active components, primarily excessive sodium and chloride infusion. This means that interstitial edema is not caused by excess of water (hydra = water) but “excess of salt” and should be treated as such. It is important to keep in mind that excess sodium is excreted slower than water [9, 32].

Oxygenation of organs is essential to preserve tissue function and avoid negative implications for wound healing and further complications. The correlation between oxygenation and sufficient circulation is subtle, since fluid optimization causes hemodilution and increases interstitial oedema, thereby compromising oxygen supply [45, 46]. Many methods have been tested to improve tissue oxygenation, but the invasive techniques limit clinical use [47, 48]. However, it is worth noting that in a randomized study by Jhanji et al., a significant increase in microcirculation and oxygenation of tissue was observed in patients receiving postoperative stroke volume-guided fluid therapy in combination with dopexamine. However, no difference in overall complications, a decrease in length of hospital stay (LOS) or inflammatory markers, was seen [49].

Liberal-, restricted-, or goal-directed approach

Belief in the existence of a third space loss and the fear of hypovolemia has led to a perioperative fluid practice of giving a large volume of intravenous fluid. However, observational studies show that a postoperative weight gain had deleterious side effects [2, 12, 50, 51] and formed the hypothesis behind the so-called restrictive fluid therapy, simply meaning avoiding fluid overload.

In a study of 141 patients undergoing colorectal surgery, Brandstrup et al. showed a beneficial effect of a more restrictive vs. a standard (liberal) fluid regimen (2740 mL vs. 5388 mL), reducing overall, major and minor postoperative complications and confirming that fluid overload caused poor tissue healing and cardiopulmonary complications [1]. This restrictive regimen aimed at zero-balance, measured as no more than 1 kg of body weight increase, and is also described as zero-balance fluid therapy. Similarly, Nisanevich et al. randomized 152 patients undergoing elective intraabdominal surgery to a restrictive vs. a standard (liberal) fluid regimen (1230 mL vs. 3670 mL), showing reduced complications, length of hospital stay, and faster bowel movement in the restrictive group [6]. Several subsequent trials have confirmed these results, all showing the benefits of a zero-balance perioperative fluid approach [25, 8, 9].

However, the fear of occult hypovolemia caused by a too restrictive fluid regimen [15] and the difficulty of handling the goal of zero-balance in unstable patients has led to the request for a hemodynamic goal. Different hemodynamic goals to direct the fluid therapy have been suggested, for example, arterial wave form analysis, central venous pressure, or lactate. In this review, GDT refers to studies using dynamic parameters such as stroke volume or pulse pressure variation analysis as goals during fluid optimization. The GDT approach has in several studies shown to improve outcome and reduce LOS and overall complications [16, 41, 42, 5255]. The randomized trials of GDT in abdominal surgery are shown in Table 1 [14, 16, 41, 42, 5259].

Table 1 Trials of “goal-directed fluid therapy” (GDT) in abdominal surgery versus “standard therapy”

A common factor to the trials on fluid therapy is that blinding is difficult since edema and diuresis is evident for all parts of treating patients. In addition, in all research concerning the surgical patient, many variables affect outcome and are difficult to standardize. Small sample sizes in the presented GDT trials challenge the results potentially affected by confounders. Furthermore, primary outcomes are dominated by LOS, which is a weak parameter influenced by local traditions and doctor and patient preferences and expectations.

Lopes et al. randomized 33 patients undergoing high-risk surgery to GDT vs. standard care (4618 mL vs. 1694 mL), perceiving the benefit of GDT with significant reduction in LOS, fewer patients developing complications, and shorter duration of mechanical ventilation [52]. In a study by Gan et al., patients receiving GDT were shown to reduce LOS compared to standard operative care (5420 mL vs. 4775 mL) [55].

However, not all trials showed a benefit [5962]. In a study of 179 elective colorectal surgical patients subdivided into aerobically fit or unfit groups, Challand et al. demonstrated an impaired outcome with prolonged LOS and increased number of intensive care unit (ICU) admissions in the GDT group compared to standard care (5309 mL vs. 4010 mL) [59]. In a recent ambitious multicenter trial of 734 high-risk patients undergoing major gastrointestinal surgery, Pearse et al. randomized patients to a GDT algorithm using intravenous fluids and dopexamine vs. usual care (4190 mL vs. 4024 mL). They showed no significant improvement in the composite primary outcome consisting of 30-day mortality and complications [14]. However, an updated meta-analysis of randomized clinical trials testing GDT in abdominal surgery shows a significant reduction of patients developing complications when using a GDT approach (see Fig. 1).

Fig. 1

Meta-analysis of number of patients developing complications after abdominal surgery in studies using GDT. Some studies do not provide information on complications and are therefore excluded in the meta-analysis. Test for heterogeneity is significant, and the results should be interpreted with caution. Size of data marker corresponds to weighting of each study and RR with 95 % CI. Diamonds sum up the overall effect estimate. RR <1 favors GDT. Heterogeneity: tau2 = 0.04; chi2 = 20.41; df = 11 (p = 0.04); I 2 = 46 %. Test for overall effect: z = 4.56 (p < 0.0001)

It is important to note that diverse methodology, different patient categories, and the use of supplemental crystalloids in both the GDT and the reference group challenge comparison between studies and might explain the heterogeneity in results. Overall beneficial outcomes to GDT appear to be related to patient risk stratification, being more beneficial in groups with higher mortality rates and more comorbidities [63].

The GDT approach is usually applied in addition to “the standard fluid therapy”, compromising the ability of GDT to limit excessive fluid administration, allowing continuous intravenous crystalloid infusion alongside GDT optimization. Crystalloid infusion seems to have an insignificant effect on GDT measurements. This is in accordance with the findings by Lobo et al. and McIlroy and Kharasch, who showed a lower effect of crystalloids on the circulating volume and cardiac output. Hence, “the standard fluid therapy” or “maintenance regimen” should only replace physiological fluid turnover and pathological fluid losses with fluids resembling the loss in quantity as well as quality. The physiological loss is no more than 1–1.5 mL/kg/h substituting diuresis and insensible perspiration and is more than replaced by the fluid given with the different anesthetic and antibiotic medication.

Interestingly, recent studies comparing restrictive or zero-balance fluid therapy with GDT based on a zero-balance maintenance regime (categorized as “zero-balance GDT”) have shown no difference in outcome between the two approaches (see Table 2) [6062, 64].

Table 2 Trials of “goal-directed fluid therapy” (GDT) in abdominal surgery versus “zero-balance fluid therapy” (restricted)

Brandstrup et al. randomized 151 patients to zero-balance GDT compared to a zero-balance fluid approach (1876 mL vs. 1491 mL) and showed no difference in mortality and postoperative complications, despite a significant increase in SV in the GDT group. Likewise, Srinivasa et al. randomized 85 patients undergoing colectomy to GDT vs. a restrictive regime (1994 mL vs. 1614 mL) and found superior cardiac indices in the GDT group, but no difference in surgical recovery, LOS, and complications per patient. In the same way, Phan et al. showed improved stroke volume index but no difference in LOS in a study of 100 patients randomized to GDT vs. restrictive therapy (1500 mL vs. 1400 mL). Thus, zero-balance or restrictive fluid approach seems equal compared to the zero-balance GDT approach during elective abdominal surgery with a RR, 1.06 (95 % CI, 0.85–1.33) (see Fig. 1).

Trials of outpatient surgery

The trials of outpatient abdominal surgery are shown in Table 3 [6571].

Table 3 Trials of outpatient abdominal surgery

In 1986, Keane and Murray investigated fluid therapy in outpatient surgery and showed reduced thirst, drowsiness, headache, and dizziness in the group receiving 1 L of Hartmann’s solution and 1 L 5 % dextrose preoperative compared to patients without fluids [65]. In comparison, McCaul et al. demonstrated no difference in postoperative nausea and vomiting (PONV) between 108 patients undergoing gynecologic laparoscopy randomized into three groups receiving no fluid, 1.5 mL/kg/fasting hour of compound sodium lactate (CSL) or 1.5 mL/kg/fasting hour CSL with an additional 0.5 g/kg of dextrose [71]. In contrast to this finding, Magner et al. randomized 141 patients undergoing gynecologic laparoscopy and found reduced nausea and vomiting in the group receiving 30 mL/kg of CSL compared to 10 mL/kg CSL [68]. Despite the discrepancy, a tendency towards reduced PONV, dizziness, and drowsiness seems related to intravenous infusion of 1–2 L of crystalloids in outpatient surgery, an amount comparable to the fasting deficit.

One trial by Holte et al. stands out, being the only one showing a beneficial outcome in the group receiving 2928 mL compared to 998 mL (40 mL/kg vs. 15 mL/kg) for patients undergoing laparoscopic cholecystectomy. Patients showed an improvement in postoperative nausea and vomiting, performance on a treadmill, and balance test in the group receiving the most fluid [69]. However, a significantly increased administration of postoperative opioids in the restricted group most likely affected the outcome parameters.


Oral fluid intake should be encouraged up to 2 h prior to surgery, thereby minimizing the need for intravenous compensation. Preferably, carbohydrate-containing fluids should be given due to patients’ proven reduction of postoperative insulin resistance and improved well-being.

Perioperative fluid turnover accounts for no more than 1–1.5 mL/kg/h consisting of diuresis, insensible perspiration, evaporation from the wound, and accumulation in the traumatized tissue and should be compensated by carbohydrate-containing (hypotonic) fluids unless counter indications are present. Sensible perspiration varies considerably and is recommended replaced by balanced crystalloids. The assumption that elective surgery causes a fluid loss to the third space is based on flawed methodology and the replacement of a “loss to third space” worsens the postoperative outcome, due to derived fluid overload. Hence, this practice should be abandoned. A delicately balanced fluid therapy is recommended to avoid adverse effects of unnecessary excessive fluid administration as edema, inflammation, and compromised tissue healing.

The intraoperative zero-balance fluid approach based on measurement of lost blood and fluid and postoperatively on body weight is easily implemented and has been shown to reduce postoperative major and minor complications. Therefore, a zero-balance fluid approach is recommended in the elective perioperative setting. A GDT approach likewise has shown to improve postoperative outcome, and guidelines recommending GDT seem well supported. However, the GDT practice is not documented to be superior to the zero-balance fluid approach. Nevertheless, high-risk surgery with multimorbid patients might benefit from the dynamic GDT approach. Evidence regarding urgent surgery is lacking, leaving a gap for future studies to explore.

In relation to outpatient surgery, 1–2 L balanced crystalloids reduces PONV and improves well-being.



compound sodium lactate


goal-directed fluid therapy


hydroxyethyl starch 6 %


intensive care unit


length of hospital stay


postoperative nausea and vomiting


  1. 1.

    Brandstrup B, Tønnesen H, Beier-Holgersen R, et al. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg. 2003;238(5):641–8. doi:10.1097/01.sla.0000094387.50865.23.

    Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    de Aguilar-Nascimento JE, Diniz BN, do Carmo AV, Silveira EAO, Silva RM. Clinical benefits after the implementation of a protocol of restricted perioperative intravenous crystalloid fluids in major abdominal operations. World J Surg. 2009;33(5):925–30. doi:10.1007/s00268-009-9944-2.

    Article  PubMed  Google Scholar 

  3. 3.

    Kulemann B, Timme S, Seifert G, et al. Intraoperative crystalloid overload leads to substantial inflammatory infiltration of intestinal anastomoses—a histomorphological analysis. Surg (United States). 2013;154(3):596–603. doi:10.1016/j.surg.2013.04.010.

    Google Scholar 

  4. 4.

    Wuethrich PY, Burkhard FC, Thalmann GN, Stueber F, Studer UE. Restrictive deferred hydration combined with preemptive norepinephrine infusion during radical cystectomy reduces postoperative complications and hospitalization time. Anesthesiology. 2014;120(2):365–77. doi:10.1097/ALN.0b013e3182a44440.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Neal JM, Wilcox RT, Allen HW, Low DE. Near-total esophagectomy: the influence of standardized multimodal management and intraoperative fluid restriction. Reg Anesth Pain Med. 2003;28(4):328–34. doi:10.1016/S1098-7339(03)00197-4.

    PubMed  Google Scholar 

  6. 6.

    Nisanevich V, Felsenstein I, Almogy G, Weissman C, Einav S, Matot I. Effect of intraoperative fluid management on outcome after intraabdominal surgery. Anesthesiology. 2005;103(1):25–32. doi:10.1177/153100350601800129.

    Article  PubMed  Google Scholar 

  7. 7.

    National Heart and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network L. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564–75.

    Article  Google Scholar 

  8. 8.

    McArdle GT, McAuley DF, McKinley A, Blair P, Hoper M, Harkin DW. Preliminary results of a prospective randomized trial of restrictive versus standard fluid regime in elective open abdominal aortic aneurysm repair. Ann Surg. 2009;250(1):28–34. doi:10.1097/SLA.0b013e3181ad61c8.

    Article  PubMed  Google Scholar 

  9. 9.

    Lobo DN, Bostock KA, Neal KR, Perkins AC, Rowlands BJ, Allison SP. Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial. Lancet. 2002;359:1812–8. doi:10.1016/S0140-6736(02)08711-1.

    Article  PubMed  Google Scholar 

  10. 10.

    Marjanovic G, Villain C, Juettner E, et al. Impact of different crystalloid volume regimes on intestinal anastomotic stability. Ann Surg. 2009;249(2):181–5. doi:10.1097/SLA.0b013e31818b73dc.

    Article  PubMed  Google Scholar 

  11. 11.

    Klein MB, Hayden D, Elson C, et al. The association between fluid administration and outcome following major burn. Ann Surg. 2007;245(4):622–8. doi:10.1097/01.sla.0000252572.50684.49.

    Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    WenKui Y, Ning L, JianFeng G, et al. Restricted peri-operative fluid administration adjusted by serum lactate level improved outcome after major elective surgery for gastrointestinal malignancy. Surgery. 2010;147(4):542–52. doi:10.1016/j.surg.2009.10.036.

    Article  PubMed  Google Scholar 

  13. 13.

    Mythen MG, Webb AR. Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg. 1995;130(4):423–9.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Pearse RM, Harrison DA, MacDonald N, et al. Supplementary: effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery. JAMA. 2014;311(21):2181. doi:10.1001/jama.2014.5305.

    CAS  Article  PubMed  Google Scholar 

  15. 15.

    Varadhan KK, Lobo DN. A meta-analysis of randomised controlled trials of intravenous fluid therapy in major elective open abdominal surgery: getting the balance right. Proc Nutr Soc. 2010;69(4):488–98. doi:10.1017/S0029665110001734.

    Article  PubMed  Google Scholar 

  16. 16.

    Noblett SE, Snowden CP, Shenton BK, Horgan AF. Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection. Br J Surg. 2006;93(9):1069–76. doi:10.1002/bjs.5454.

    CAS  Article  PubMed  Google Scholar 

  17. 17.

    Smith I, Kranke P, Murat I, et al. Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2011;28(8):556–69. doi:10.1097/EJA.0b013e3283495ba1.

    Article  PubMed  Google Scholar 

  18. 18.

    Henriksen MG, Hessov I, Dela F, Hansen HV, Haraldsted V, Rodt SA. Effects of preoperative oral carbohydrates and peptides on postoperative endocrine response, mobilization, nutrition and muscle function in abdominal surgery. Acta Anaesthesiol Scand. 2003;47(2):191–9. doi:10.1034/j.1399-6576.2003.00047.x.

    CAS  Article  PubMed  Google Scholar 

  19. 19.

    Soop M, Nygren J, Myrenfors P, Thorell A, Ljungqvist O. Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance. Am J Physiol Endocrinol Metab. 2001;280(4):E576–83.

    CAS  PubMed  Google Scholar 

  20. 20.

    Hausel J, Nygren J, Lagerkranser M, et al. A carbohydrate-rich drink reduces preoperative discomfort in elective surgery patients. Anesth Analg. 2001;93(5):1344–50. doi:10.1097/00132586-200304000-00042.

    CAS  Article  PubMed  Google Scholar 

  21. 21.

    Jacob M, Chappell D, Conzen P, Finsterer U, Rehm M. Blood volume is normal after pre-operative overnight fasting. Acta Anaesthesiol Scand. 2008;52(4):522–9. doi:10.1111/j.1399-6576.2008.01587.x.

    CAS  Article  PubMed  Google Scholar 

  22. 22.

    Güenaga KF, Matos D, Wille-Jørgensen P. Mechanical bowel preparation for elective colorectal surgery. Cochrane Database Syst Rev. 2011;9:CD001544. doi:10.1002/14651858.CD001544.pub4.

    PubMed  Google Scholar 

  23. 23.

    Holte K. Pathophysiology and clinical implications of peroperative fluid management in elective surgery. Dan Med Bull. 2010;57(7):B4156.

    PubMed  Google Scholar 

  24. 24.

    Lamke LO, Nilsson GE, Reithner HL. Insensible perspiration from the skin under standardized environmental conditions. Scand J Clin Lab Invest. 1977;37(4):325–31.

    CAS  Article  PubMed  Google Scholar 

  25. 25.

    Reithner L, Johansson H, Strouth L. Insensible perspiration during anaesthesia and surgery. Acta Anaesthesiol Scand. 1980;24(5):362–6.

    CAS  Article  PubMed  Google Scholar 

  26. 26.

    Jacob M, Chappell D, Hofmann-Kiefer K, Conzen P, Peter K, Rehm M. Determinanten des insensiblen Flüssigkeitsverlustes. Anaesthesist. 2007;56(8):747–64. doi:10.1007/s00101-007-1235-4.

    CAS  Article  PubMed  Google Scholar 

  27. 27.

    Cox P. Insensible water loss and its assessment in adult patients: a review. Acta Anaesthesiol Scand. 1987;31(8):771–6.

    CAS  Article  PubMed  Google Scholar 

  28. 28.

    Reithner L. Insensible water loss from the respiratory tract in patients with fever. Acta Chir Scand. 1981;147(3):163–7.

    CAS  PubMed  Google Scholar 

  29. 29.

    Lamke LO, Nilsson G, Reithner L. The influence of elevated body temperature on skin perspiration. Acta Chir Scand. 1980;146(2):81–4.

    CAS  PubMed  Google Scholar 

  30. 30.

    Alpert RA, Roizen MF, Hamilton WK, et al. Intraoperative urinary output does not predict postoperative renal function in patients undergoing abdominal aortic revascularization. Surgery. 1984;95(6):707–11.

    CAS  PubMed  Google Scholar 

  31. 31.

    Engquist A, Brandstrup B. Rationel Vaeske-, Elektrolytbehandling Og Ernaering.; 2015.

  32. 32.

    Lobo DN, Stanga Z, Simpson JA, Anderson JA, Rowlands BJ, Allison SP. Dilution and redistribution effects of rapid 2-litre infusions of 0.9 % (w/v) saline and 5 % (w/v) dextrose on haematological parameters and serum biochemistry in normal subjects: a double-blind crossover study. Clin Sci (Lond). 2001;101(2):173–9. doi:10.1042/CS20000316.

    CAS  Article  Google Scholar 

  33. 33.

    Lamke LO, Nilsson GE, Reithner HL. Water loss by evaporation from the abdominal cavity during surgery. Acta Chir Scand. 1977;143(5):279–84.

    CAS  PubMed  Google Scholar 

  34. 34.

    Roe CF. Effect of bowel exposure on body temperature during surgical operations. Am J Surg. 1971;122(1):13–5. doi:10.1016/0002-9610(71)90338-2.

    CAS  Article  PubMed  Google Scholar 

  35. 35.

    Jacob M, Chappell D, Rehm M. The “third space”—fact or fiction? Best Pract Res Clin Anaesthesiol. 2009;23(2):145–57. doi:10.1016/j.bpa.2009.05.001.

    Article  PubMed  Google Scholar 

  36. 36.

    Brandstrup B, Svensen C, Engquist A. Hemorrhage and operation cause a contraction of the extracellular space needing replacement—evidence and implications? A systematic review. Surgery. 2006;139(3):419–32. doi:10.1016/j.surg.2005.07.035.

    Article  PubMed  Google Scholar 

  37. 37.

    Chan ST, Kapadia CR, Johnson AW, Radcliffe AG, Dudley HA. Extracellular fluid volume expansion and third space sequestration at the site of small bowel anastomoses. Br J Surg. 1983;70(1):36–9.

    CAS  Article  PubMed  Google Scholar 

  38. 38.

    Lobo DN, Stanga Z, Aloysius MM, et al. Effect of volume loading with 1 liter intravenous infusions of 0.9 % saline, 4 % succinylated gelatine (Gelofusine) and 6 % hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteers. Crit Care Med. 2010;38(2):464–70. doi:10.1097/CCM.0b013e3181bc80f1.

    CAS  Article  PubMed  Google Scholar 

  39. 39.

    McIlroy DR, Kharasch ED. Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia. Anesth Analg. 2003;96(6):1572–7. doi:10.1213/01.ANE.0000061460.59320.B0.

    Article  PubMed  Google Scholar 

  40. 40.

    Sinclair S, James S, Singer M. Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. BMJ. 1997;315(7113):909–12. doi:10.1136/bmj.315.7113.909.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  41. 41.

    Mayer J, Boldt J, Mengistu AM, Röhm KD, Suttner S. Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial. Crit Care. 2010;14(1):R18. doi:10.1186/cc8875.

    Article  PubMed  PubMed Central  Google Scholar 

  42. 42.

    Wakeling HG, McFall MR, Jenkins CS, et al. Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery. Br J Anaesth. 2005;95(5):634–42. doi:10.1093/bja/aei223.

    CAS  Article  PubMed  Google Scholar 

  43. 43.

    Perner A, Haase N, Guttormsen AB, et al. Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med. 2012;367(2):124–34. doi:10.1056/NEJMoa1204242.

    CAS  Article  PubMed  Google Scholar 

  44. 44.

    Gillies MA, Habicher M, Jhanji S, et al. Incidence of postoperative death and acute kidney injury associated with i.v. 6 % hydroxyethyl starch use: systematic review and meta-analysis. Br J Anaesth. 2014;112(1):25–34. doi:10.1093/bja/aet303.

    CAS  Article  PubMed  Google Scholar 

  45. 45.

    Jonsson K, Jensen JA, Goodson WH, et al. Tissue oxygenation, anemia, and perfusion in relation to wound healing in surgical patients. Ann Surg. 1991;214(5):605–13. doi:10.1097/00000658-199111000-00011.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  46. 46.

    Heughan C, Ninikoski J, Hunt TK. Effect of excessive infusion of saline solution on tissue oxygen transport. Surg Gynecol Obstet. 1972;135(2):257–60.

    CAS  PubMed  Google Scholar 

  47. 47.

    Bundgaard-Nielsen M, Ruhnau B, Secher NH, Kehlet H. Flow-related techniques for preoperative goal-directed fluid optimization. Br J Anaesth. 2007;98(1):38–44. doi:10.1093/bja/ael287.

    CAS  Article  PubMed  Google Scholar 

  48. 48.

    Hopf HW, Hunt TK, West JM, et al. Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch Surg. 1997;132(9):997–1004. discussion 1005

    CAS  Article  PubMed  Google Scholar 

  49. 49.

    Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM. Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial. Crit Care. 2010;14(4):R151. doi:10.1186/cc9220.

    Article  PubMed  PubMed Central  Google Scholar 

  50. 50.

    Adesanya A, Rosero E, Timaran C, Clagett P, Johnston WE. Intraoperative fluid restriction predicts improved outcomes in major vascular surgery. Vasc Endovascular Surg. 2015;42(6):531–6. doi:10.1177/1538574408318474.

    Article  Google Scholar 

  51. 51.

    Booi DI. Perioperative fluid overload increases anastomosis thrombosis in the free TRAM flap used for breast reconstruction. Eur J Plast Surg. 2011;34(2):81–6. doi:10.1007/s00238-010-0466-9.

    Article  PubMed  PubMed Central  Google Scholar 

  52. 52.

    Lopes MR, Oliveira MA, Pereira VOS, Lemos IPB, Auler JOC, Michard F. Goal-directed fluid management based on pulse pressure variation monitoring during high-risk surgery: a pilot randomized controlled trial. Crit Care. 2007;11(5):R100. doi:10.1186/cc6117.

    Article  PubMed  PubMed Central  Google Scholar 

  53. 53.

    Salzwedel C, Puig J, Carstens A, et al. Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces postoperative complications after major abdominal surgery: a multi-center, prospective, randomized study. Crit Care. 2013;17(5):R191. doi:10.1186/cc12885.

    Article  PubMed  PubMed Central  Google Scholar 

  54. 54.

    Benes J, Chytra I, Altmann P, et al. Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study. Crit Care. 2010;14:R118. doi:10.1186/cc9070.

    Article  PubMed  PubMed Central  Google Scholar 

  55. 55.

    Gan TJ, Soppitt A, Maroof M, et al. Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology. 2002;97(4):820–6. doi:10.1097/00000542-200210000-00012.

    Article  PubMed  Google Scholar 

  56. 56.

    Conway DH, Mayall R, Abdul-Latif MS, Gilligan S, Tackaberry C. Randomised controlled trial investigating the influence of intravenous fluid titration using oesophageal Doppler monitoring during bowel surgery. Anaesthesia. 2002;57(9):845–9. doi:10.1046/j.1365-2044.2002.02708.x.

    CAS  Article  PubMed  Google Scholar 

  57. 57.

    Buettner M, Schummer W, Huettemann E, Schenke S, Van Hout N, Sakka SG. Influence of systolic-pressure-variation-guided intraoperative fluid management on organ function and oxygen transport. Br J Anaesth. 2008;101(2):194–9. doi:10.1093/bja/aen126.

    CAS  Article  PubMed  Google Scholar 

  58. 58.

    Forget P, Lois F, de Kock M. Goal-directed fluid management based on the pulse oximeter-derived pleth variability index reduces lactate levels and improves fluid management. Anesth Analg. 2010;111(4):1. doi:10.1213/ANE.0b013e3181eb624f.

    Article  Google Scholar 

  59. 59.

    Challand C, Struthers R, Sneyd JR, et al. Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery. Br J Anaesth. 2012;108(1):53–62. doi:10.1093/bja/aer273.

    CAS  Article  PubMed  Google Scholar 

  60. 60.

    Phan TD, D’Souza B, Rattray MJ, Johnston MJ, Cowie BS. A randomised controlled trial of fluid restriction compared to oesophageal Doppler-guided goal-directed fluid therapy in elective major colorectal surgery within an Enhanced Recovery After Surgery program. Anaesth Intensive Care. 2014;42(6):752–60. doi:10.1016/S0040-4020(01)98697-1.

    CAS  PubMed  Google Scholar 

  61. 61.

    Srinivasa S, Taylor MHG, Singh PP, Yu TC, Soop M, Hill AG. Randomized clinical trial of goal-directed fluid therapy within an enhanced recovery protocol for elective colectomy. Br J Surg. 2013;100(1):66–74. doi:10.1002/bjs.8940.

    CAS  Article  PubMed  Google Scholar 

  62. 62.

    Brandstrup B, Svendsen PE, Rasmussen M, et al. Which goal for fluid therapy during colorectal surgery is followed by the best outcome: near-maximal stroke volume or zero fluid balance? Br J Anaesth. 2012;109(June):191–9. doi:10.1093/bja/aes163.

    CAS  Article  PubMed  Google Scholar 

  63. 63.

    Cecconi M, Corredor C, Arulkumaran N, et al. Clinical review: goal-directed therapy—what is the evidence in surgical patients? The effect on different risk groups. Crit Care. 2013;17:209. doi:10.1186/cc11823.

    Article  PubMed  PubMed Central  Google Scholar 

  64. 64.

    Zhang J, Qiao H, He Z, Wang Y, Che X, Liang W. Intraoperative fluid management in open gastrointestinal surgery: goal-directed versus restrictive. Clinics. 2012;67(10):1149–55. doi:10.6061/clinics/2012(10)06.

    Article  PubMed  PubMed Central  Google Scholar 

  65. 65.

    Keane PW, Murray PF. Intravenous fluids in minor surgery. Their effect on recovery from anaesthesia. Anaesthesia. 1986;41(6):635–7.

    CAS  Article  PubMed  Google Scholar 

  66. 66.

    Spencer EM. Intravenous fluids in minor gynaecological surgery. Their effect on postoperative morbidity. Anaesthesia. 1988;43(12):1050–1.

    CAS  Article  PubMed  Google Scholar 

  67. 67.

    COOK R, ANDERSON S, RISEBOROUGH M, BLOGG CE. Intravenous fluid load and recovery. A double-blind comparison in gynaecological patients who had day-case laparoscopy. Anaesthesia. 1990;45(10):826–30. doi:10.1111/j.1365-2044.1990.tb14563.x.

    CAS  Article  PubMed  Google Scholar 

  68. 68.

    Magner JJ, McCaul C, Carton E, Gardiner J, Buggy D. Effect of intraoperative intravenous crystalloid infusion on postoperative nausea and vomiting after gynaecological laparoscopy: comparison of 30 and 10 ml kg (−1). Br J Anaesth. 2004;93(3):381–5. doi:10.1093/bja/aeh219.

    CAS  Article  PubMed  Google Scholar 

  69. 69.

    Holte K, Klarskov B, Christensen DS, et al. Liberal versus restrictive fluid administration to improve recovery after laparoscopic cholecystectomy: a randomized, double-blind study. Ann Surg. 2004;240(5):892–9. doi:10.1097/01.sla.0000143269.96649.3b.

    Article  PubMed  PubMed Central  Google Scholar 

  70. 70.

    Yogendran S, Asokumar B, Cheng DC, Chung F. A prospective randomized double-blinded study of the effect of intravenous fluid therapy on adverse outcomes on outpatient surgery. Anesth Analg. 1995;80(4):682–6.

    CAS  PubMed  Google Scholar 

  71. 71.

    McCaul C, Moran C, O’Cronin D, et al. Intravenous fluid loading with or without supplementary dextrose does not prevent nausea, vomiting and pain after laparoscopy. Can J Anaesth. 2003;50(5):440–4. doi:10.1007/BF03021053.

    Article  PubMed  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Anders Winther Voldby.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

BB searched the literature, selected the papers in agreement with AV, extracted the data, interpreted the data, critically revised the draft, and approved the final manuscript. AV in addition searched the literature, selected the papers in agreement with BB, extracted the data from the papers, performed the analysis, interpreted the data, drafted the manuscript, and approved the final version to be published.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Voldby, A.W., Brandstrup, B. Fluid therapy in the perioperative setting—a clinical review. j intensive care 4, 27 (2016).

Download citation


  • Fluid therapy
  • Restricted
  • Goal-directed fluid therapy
  • Postoperative complications
  • Outcome of surgery
  • Third space
  • Third space loss