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  1. Patients with water intoxication may develop rhabdomyolysis. Existing studies suggest a relationship between the serum sodium correction rate and rhabdomyolysis. The aim of the present study was to determine t...

    Authors: Masahiro Kashiura, Kazuhiro Sugiyama and Yuichi Hamabe
    Citation: Journal of Intensive Care 2017 5:37
  2. Swift and adequate fluid loading is a cornerstone of septic shock therapy. Yet, careful assessment of volume responsiveness and volume amount during the resuscitation process is a prerequisite. Both overzealou...

    Authors: Patrick M. Honore and Herbert D. Spapen
    Citation: Journal of Intensive Care 2017 5:36
  3. Reintubation after pediatric cardiac surgery is associated with a high rate of mortality. Therefore, adequate respiratory support for postextubation acute respiratory failure (ARF) is important. However, littl...

    Authors: Naohiro Shioji, Tatsuo Iwasaki, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tomohiko Suemori, Kentaro Sugimoto, Yasutoshi Kuroe and Hiroshi Morimatsu
    Citation: Journal of Intensive Care 2017 5:35
  4. A crucial step in the transition from mechanical ventilation to extubation is the successful performance of a spontaneous breathing trial (SBT). The American College of Chest Physicians (ACCP) Guidelines recom...

    Authors: Chuan Jiang, Antonio Esquinas and Bushra Mina
    Citation: Journal of Intensive Care 2017 5:33
  5. Since the withdrawal of recombinant-activated protein C, the anticoagulant therapy for sepsis was taken no notice. For instance, the international sepsis guidelines did not share a space for this therapy. Howe...

    Authors: Jecko Thachil and Toshiaki Iba
    Citation: Journal of Intensive Care 2017 5:32
  6. Patients in intensive care units (ICU) are often diagnosed with postoperative delirium; the duration of which has a relevant negative impact on various clinical outcomes. Recent research found a potentially im...

    Authors: Mira John, E. Wesley Ely, Dorothee Halfkann, Julika Schoen, Beate Sedemund-Adib, Stefan Klotz, Finn Radtke, Sebastian Stehr and Michael Hueppe
    Citation: Journal of Intensive Care 2017 5:29
  7. Acute kidney injury (AKI) occurs in more than half critically ill patients admitted in intensive care units (ICU) and increases the mortality risk. The main cause of AKI in ICU is sepsis. AKI severity and othe...

    Authors: Emilio Rodrigo, Borja Suberviola, Miguel Santibáñez, Lara Belmar, Álvaro Castellanos, Milagros Heras, Juan Carlos Rodríguez-Borregán, Angel Luis Martín de Francisco and Claudio Ronco
    Citation: Journal of Intensive Care 2017 5:28
  8. Intracranial hemorrhage (ICH) is a recognized complication of adults treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. However, the predictors of...

    Authors: Alexander Fletcher Sandersjöö, Jiri Bartek Jr., Eric Peter Thelin, Anders Eriksson, Adrian Elmi-Terander, Mikael Broman and Bo-Michael Bellander
    Citation: Journal of Intensive Care 2017 5:27

    The Correction to this article has been published in Journal of Intensive Care 2020 8:2

  9. This prospective study compared clinical characteristics and prognosis between primary (P) and secondary (S) acute gastrointestinal injury (AGI) (P-AGI)/(S-AGI) in critically ill patients.

    Authors: Dong Zhang, Rao Fu, Yanhua Li, Hongyan Li, Yuting Li and Hongxiang Li
    Citation: Journal of Intensive Care 2017 5:26
  10. Endothelin 1 (ET-1) is a strong vasoconstrictor, which is involved in inflammation and reduced tissue perfusion. C-terminal proendothelin-1 (CT-proET-1) is the stable circulating precursor protein of ET-1. We ...

    Authors: Lukas Buendgens, Eray Yagmur, Jan Bruensing, Ulf Herbers, Christer Baeck, Christian Trautwein, Alexander Koch and Frank Tacke
    Citation: Journal of Intensive Care 2017 5:25
  11. Monitoring of tissue perfusion is an essential step in the management of acute circulatory failure. The presence of cellular dysfunction has been a basic component of shock definition even in the absence of hy...

    Authors: Ahmed Hasanin, Ahmed Mukhtar and Heba Nassar
    Citation: Journal of Intensive Care 2017 5:24
  12. The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunct...

    Authors: Frank Anthony Rasulo, Giuseppe Bellelli, Eugene Wesley Ely, Alessandro Morandi, Pratik Pandharipande and Nicola Latronico
    Citation: Journal of Intensive Care 2017 5:23
  13. Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Authors: Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki
    Citation: Journal of Intensive Care 2017 5:22
  14. Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key mo...

    Authors: Bernt C. Hellerud, Hilde L. Orrem, Knut Dybwik, Søren E. Pischke, Andreas Baratt-Due, Albert Castellheim, Hilde Fure, Grethe Bergseth, Dorte Christiansen, Miles A. Nunn, Terje Espevik, Corinna Lau, Petter Brandtzæg, Erik W. Nielsen and Tom E. Mollnes
    Citation: Journal of Intensive Care 2017 5:21
  15. In recent years, the measurement of cerebral regional oxygen saturation (rSO2) during resuscitation has attracted attention. The objective of this study was to clarify the relationship between the serial changes ...

    Authors: Naoki Ehara, Tomoya Hirose, Tadahiko Shiozaki, Akinori Wakai, Tetsuro Nishimura, Nobuto Mori, Mitsuo Ohnishi, Daikai Sadamitsu and Takeshi Shimazu
    Citation: Journal of Intensive Care 2017 5:20
  16. Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridges (PMX-DHP) is widely used for septic shock in Japan and parts of Europe. Although this treatment is usually administered for 2 h, the o...

    Authors: Kyohei Miyamoto, Yu Kawazoe and Seiya Kato
    Citation: Journal of Intensive Care 2017 5:19
  17. Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization. Delirium, an acute form of brai...

    Authors: José Raimundo A. de Azevedo, Widlani Sousa Montenegro, Djane Pereira Rodrigues, Suellen C. de C. Souza, Vanessa F. S. Araujo, Margareth Pereira de Paula, Patricia H. C. P. Prazeres, Adenilde da Luz Leitão and Adriana V. N. Mendonça
    Citation: Journal of Intensive Care 2017 5:18
  18. Pain assessment is highly recommended in patients receiving mechanical ventilation. However, pain intensity and its impact on outcomes in these patients remain obscure. We collected the results of routine pain...

    Authors: Ayahiro Yamashita, Masaki Yamasaki, Hiroki Matsuyama and Fumimasa Amaya
    Citation: Journal of Intensive Care 2017 5:17

    The Commentary to this article has been published in Journal of Intensive Care 2017 5:73

  19. The work demands of critical care can be a major cause of stress in intensive care unit (ICU) professionals and lead to poor health outcomes. In the process of recovery from work, psychological rumination is c...

    Authors: Tushna Vandevala, Louisa Pavey, Olga Chelidoni, Nai-Feng Chang, Ben Creagh-Brown and Anna Cox
    Citation: Journal of Intensive Care 2017 5:16
  20. The mortality rate of critically ill patients is high and the cost of the intensive (ICU) department is among the highest within the health-care industry. The cost will continue to increase because of the agin...

    Authors: Alexander F. van der Sluijs, Eline R. van Slobbe-Bijlsma, Stephen E. Chick, Margreeth B. Vroom, Dave A. Dongelmans and Alexander P. J. Vlaar
    Citation: Journal of Intensive Care 2017 5:13
  21. Sepsis and septic shock are major healthcare problems, affecting millions of individuals around the world each year. Pathophysiologically, septic multiple organ dysfunction (MOD) is a life-threatening conditio...

    Authors: Sascha David, Kristina Thamm, Bernhard M. W. Schmidt, Christine S. Falk and Jan T. Kielstein
    Citation: Journal of Intensive Care 2017 5:12
  22. Achieving a balance between organ perfusion and hemostasis is critical for optimal fluid resuscitation in patients with severe trauma. The concept of “permissive hypotension” refers to managing trauma patients...

    Authors: Daisuke Kudo, Yoshitaro Yoshida and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2017 5:11
  23. Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Authors: Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa
    Citation: Journal of Intensive Care 2017 5:5
  24. Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Authors: Mineji Hayakawa
    Citation: Journal of Intensive Care 2017 5:3
  25. Tracheal ultrasound can be an alternative diagnostic tool in airway management, besides traditional confirmatory methods such as capnography and auscultation. The standard image is a hyperechoic air–mucosa (A–...

    Authors: Wan-Ching Lien
    Citation: Journal of Intensive Care 2017 5:10

    The original article was published in Journal of Intensive Care 2016 4:52

  26. Deep vein thrombosis (DVT) is a major complication in critical care. There are various methods of prophylaxis, but none of them fully prevent DVT, and each method has adverse effects. Electrical muscle stimula...

    Authors: Masahiro Ojima, Ryosuke Takegawa, Tomoya Hirose, Mitsuo Ohnishi, Tadahiko Shiozaki and Takeshi Shimazu
    Citation: Journal of Intensive Care 2017 5:9
  27. Older patients account for the majority of patients with sepsis. The objective of this study was to determine if decreased skeletal muscle mass is associated with outcomes in elderly patients with sepsis.

    Authors: Keita Shibahashi, Kazuhiro Sugiyama, Masahiro Kashiura and Yuichi Hamabe
    Citation: Journal of Intensive Care 2017 5:8
  28. Severe heat stroke tends to be complicated with rhabdomyolysis, especially in patients with exertional heat stroke. Rhabdomyolysis usually occurs in the acute phase of heat stroke. We herein report a case of h...

    Authors: Toshihiko Yoshizawa, Kazuhiko Omori, Ikuto Takeuchi, Yuto Miyoshi, Hiroshi Kido, Etsuhisa Takahashi, Kei Jitsuiki, Kouhei Ishikawa, Hiromichi Ohsaka, Manabu Sugita and Youichi Yanagawa
    Citation: Journal of Intensive Care 2016 4:71
  29. Recent studies have shown acute respiratory distress syndrome (ARDS) to be underdiagnosed and inadequately treated, as evidenced by underutilization of low-tidal volume ventilation. Despite a proven survival b...

    Authors: Jason Chertoff
    Citation: Journal of Intensive Care 2016 4:70
  30. Active smokers are prevalent within the intensive care setting and place a significant burden on healthcare systems. Nicotine withdrawal due to forced abstinence on admission may contribute to increased agitat...

    Authors: Melanie Kowalski, Andrew A. Udy, Hayden J. McRobbie and Michael J. Dooley
    Citation: Journal of Intensive Care 2016 4:69
  31. Critically ill patients admitted to intensive care unit (ICU) may suffer from different painful stimuli, but the assessment of pain is difficult because most of them are almost sedated and unable to self-repor...

    Authors: Paolo Severgnini, Paolo Pelosi, Elena Contino, Elisa Serafinelli, Raffaele Novario and Maurizio Chiaranda
    Citation: Journal of Intensive Care 2016 4:68
  32. Critical care is a complex field of medicine, especially because of its diversity and unpredictability. Mortality rates of the diseases are usually high and patients are critically ill, admitted in emergency, ...

    Authors: Bruno François, Marc Clavel, Philippe Vignon and Pierre-François Laterre
    Citation: Journal of Intensive Care 2016 4:67
  33. We conducted an internet survey targeting healthcare providers in intensive care units (ICUs) in Japan and received 318 responses. Eighteen percent of respondents replied that full-time physical therapists (PT...

    Authors: Shunsuke Taito, Masamitsu Sanui, Hideto Yasuda, Nobuaki Shime and Alan Kawarai Lefor
    Citation: Journal of Intensive Care 2016 4:66
  34. The Richmond Agitation-Sedation Scale (RASS) is a single tool that is intuitive, is easy to use, and includes both agitation and sedation. The RASS has never been formally validated for pediatric populations. ...

    Authors: Abigail Glicksman Kerson, Rebecca DeMaria, Elizabeth Mauer, Christine Joyce, Linda M. Gerber, Bruce M. Greenwald, Gabrielle Silver and Chani Traube
    Citation: Journal of Intensive Care 2016 4:65
  35. Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estima...

    Authors: Hiroyuki Yamada, Tatsuo Tsukamoto, Hiromichi Narumiya, Kazumasa Oda, Satoshi Higaki, Ryoji Iizuka, Motoko Yanagita and Masako Deguchi
    Citation: Journal of Intensive Care 2016 4:64
  36. Passive leg raising (PLR) is a so called self-volume challenge used to test for fluid responsiveness. Changes in cardiac output (CO) or stroke volume (SV) measured during PLR are used to predict the need for s...

    Authors: Anton Krige, Martin Bland and Thomas Fanshawe
    Citation: Journal of Intensive Care 2016 4:63
  37. Augmented renal clearance (ARC) of circulating solutes and drugs has been recently often reported in intensive care unit (ICU) patients. However, only few studies on ARC have been reported in Japan. The aims o...

    Authors: Yasumasa Kawano, Shinichi Morimoto, Yoshito Izutani, Kentaro Muranishi, Hironari Kaneyama, Kota Hoshino, Takeshi Nishida and Hiroyasu Ishikura
    Citation: Journal of Intensive Care 2016 4:62
  38. Vascular hyperpermeability is a frequent intractable feature involved in a wide range of diseases in the intensive care unit. The glycocalyx (GCX) seemingly plays a key role to control vascular permeability. T...

    Authors: Akira Ushiyama, Hanae Kataoka and Takehiko Iijima
    Citation: Journal of Intensive Care 2016 4:59