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  1. A recombinant form of antithrombin (AT), called AT gamma, is being developed as an alternative to AT derived from human plasma. To compare the efficacy and safety of AT gamma to plasma-derived AT (pAT), we con...

    Authors: Shigeatsu Endo and Ryutaro Shimazaki
    Citation: Journal of Intensive Care 2018 6:75
  2. It is not clear whether vasopressin versus norepinephrine changed mortality in clinical practice in the Vasopressin and Septic Shock Trial (VASST) coordinating center hospital after VASST was published. We tes...

    Authors: James A. Russell, Hugh Wellman and Keith R. Walley
    Citation: Journal of Intensive Care 2018 6:73
  3. Sepsis biomarker panels that provide diagnostic and prognostic discrimination in sepsis patients would be transformative to patient care. We assessed the mortality prediction and diagnostic discriminatory accu...

    Authors: Christopher Duplessis, Michael Gregory, Kenneth Frey, Matthew Bell, Luu Truong, Kevin Schully, James Lawler, Raymond J. Langley, Stephen F. Kingsmore, Christopher W. Woods, Emanuel P. Rivers, Anja K. Jaehne, Eugenia B. Quackenbush, Vance G. Fowler, Ephraim L. Tsalik and Danielle Clark
    Citation: Journal of Intensive Care 2018 6:72
  4. Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first repor...

    Authors: Andrea Cortegiani, Giovanni Misseri, Teresa Fasciana, Anna Giammanco, Antonino Giarratano and Anuradha Chowdhary
    Citation: Journal of Intensive Care 2018 6:69
  5. Patients who require a prolonged weaning process comprise a highly heterogeneous group of patients amongst whom the outcome differs significantly. The present study aimed to identify the factors that predict w...

    Authors: Friederike Sophie Magnet, Hannah Bleichroth, Sophie Emilia Huttmann, Jens Callegari, Sarah Bettina Schwarz, Claudia Schmoor, Wolfram Windisch and Jan Hendrik Storre
    Citation: Journal of Intensive Care 2018 6:67
  6. Pneumonia complicated by septic shock is associated with significant morbidity and mortality. Classification and regression tree methodology is an intuitive method for predicting clinical outcomes using binary...

    Authors: Jaime L Speiser, Constantine J Karvellas, Geoffery Shumilak, Wendy I Sligl, Yazdan Mirzanejad, Dave Gurka, Aseem Kumar and Anand Kumar
    Citation: Journal of Intensive Care 2018 6:66
  7. Several advanced and developing countries are now entering a superaged society, in which the percentage of elderly people exceeds 20% of the total population. In such an aging society, the number of age-relate...

    Authors: Shigeaki Inoue, Masafumi Saito and Joji Kotani
    Citation: Journal of Intensive Care 2018 6:65
  8. Community-acquired gram-negative bacillary meningitis is rare to occur without preexisting conditions like trauma, organ dysfunction, and immunocompromised state, and very few case reports with Escherichia coli h...

    Authors: Rajesh Kasimahanti, Sai Kandraju Satish and Mridu Anand
    Citation: Journal of Intensive Care 2018 6:63
  9. Analgosedation is a cornerstone therapy for mechanically ventilated patients in intensive care units (ICU). To avoid inadequate sedation and its complications, monitoring of analgosedation is of great importan...

    Authors: Richard J. Nies, Carsten Müller, Roman Pfister, Philipp S. Binder, Nicole Nosseir, Felix S. Nettersheim, Kathrin Kuhr, Martin H. J. Wiesen, Matthias Kochanek and Guido Michels
    Citation: Journal of Intensive Care 2018 6:62
  10. Cefepime can be removed by continuous renal replacement therapy (CRRT) due to its pharmacokinetics. The purpose of this study is to define the optimal cefepime dosing regimens for critically ill patients recei...

    Authors: Weerachai Chaijamorn, Taniya Charoensareerat, Nattachai Srisawat, Sutthiporn Pattharachayakul and Apinya Boonpeng
    Citation: Journal of Intensive Care 2018 6:61
  11. Both anaemia and red blood cell (RBC) transfusion are common and associated with adverse outcomes in patients admitted to the intensive care unit (ICU). The aim of this study was to determine whether serum hep...

    Authors: Edward Litton, Stuart Baker, Wendy Erber, Shannon Farmer, Janet Ferrier, Craig French, Joel Gummer, David Hawkins, Alisa Higgins, Axel Hofmann, Bart De Keulenaer, Julie McMorrow, John K. Olynyk, Toby Richards, Simon Towler, Robert Trengove…
    Citation: Journal of Intensive Care 2018 6:60
  12. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly used in the treatment of depression. While most intoxications with SSRI’s have favorable outcomes and do not require interventions other t...

    Authors: Jan Albert Nicolaas Groot, Leonore ten Bokum and Hubertus Laurentius Antonius van den Oever
    Citation: Journal of Intensive Care 2018 6:59
  13. Recent, large trials of high-frequency oscillation (HFO) versus conventional ventilation (CV) in acute respiratory distress syndrome (ARDS) reported negative results. This could be explained by an HFO-induced ...

    Authors: Spyros D. Mentzelopoulos, Hector Anninos, Sotirios Malachias and Spyros G. Zakynthinos
    Citation: Journal of Intensive Care 2018 6:58
  14. The aim of this study is to investigate the association between treatment in a closed ICU and survival at discharge in patients with sepsis.

    Authors: Takayuki Ogura, Yoshihiko Nakamura, Kunihiko Takahashi, Kazuki Nishida, Daisuke Kobashi and Shigeyuki Matsui
    Citation: Journal of Intensive Care 2018 6:57
  15. We aimed to determine predictors of, and outcomes after, veno-arterial extracorporeal membrane oxygenation instituted within 48 h after cardiac surgery (early ECMO) in young infants.

    Authors: Gabriela A. Kuraim, Daniel Garros, Lindsay Ryerson, Fahimeh Moradi, Irina A. Dinu, Gonzalo Garcia Guerra, Diane Moddemann, Gwen Y. Bond, Charlene M. T. Robertson and Ari R. Joffe
    Citation: Journal of Intensive Care 2018 6:56
  16. Intravenous glycerol treatment, usually administered in the form of a 5% fructose solution, can be used to reduce intracranial pressure. The administered fructose theoretically influences blood lactate levels,...

    Authors: Shinshu Katayama, Ken Tonai, Yuya Goto, Kansuke Koyama, Toshitaka Koinuma, Jun Shima, Masahiko Wada and Shin Nunomiya
    Citation: Journal of Intensive Care 2018 6:55
  17. Although chest compression is a standard technique in cardiopulmonary resuscitation, it is well recognized that manual chest compression causes various internal injuries, of which major injuries are often fata...

    Authors: Shigeaki Aoyagi, Tomokazu Kosuga, Kumiko Wada, Shin-ichi Nata and Hiroshi Yasunaga
    Citation: Journal of Intensive Care 2018 6:54
  18. An updated meta-analysis incorporating nine randomized trials (n = 816) investigating low-to-moderate dose prolonged glucocorticoid treatment in acute respiratory distress syndrome (ARDS) show moderate-to-high qu...

    Authors: Gianfranco Umberto Meduri, Reed A. C. Siemieniuk, Rachel A. Ness and Samuel J. Seyler
    Citation: Journal of Intensive Care 2018 6:53
  19. Fluid responsiveness prediction with continuously available monitoring is an unsettled matter for the vast majority of critically ill patients, and development of new and reliable methods is desired. We hypoth...

    Authors: Simon Tilma Vistisen, Martin Buhl Krog, Thomas Elkmann, Mikael Fink Vallentin, Thomas W. L. Scheeren and Christoffer Sølling
    Citation: Journal of Intensive Care 2018 6:52
  20. Intravenous fluids are one of the most used medical therapy for patients, especially critically ill patients. We conducted a meta-analysis comparing between balanced crystalloids and normal saline in criticall...

    Authors: Yazan Z. M. Zayed, Ahmed M. Y. Aburahma, Mahmoud O. Barbarawi, Kewan Hamid, Momen R. N. Banifadel, Laith Rashdan and Ghassan I. Bachuwa
    Citation: Journal of Intensive Care 2018 6:51
  21. Echocardiography is often used to guide septic shock resuscitation, but without evidence for efficacy. We conducted an intensive care unit (ICU)-based randomized controlled feasibility trial comparing echocard...

    Authors: Michael J. Lanspa, Rebecca E. Burk, Emily L. Wilson, Eliotte L. Hirshberg, Colin K. Grissom and Samuel M. Brown
    Citation: Journal of Intensive Care 2018 6:50
  22. Endotracheal intubation in critically ill is a high-risk procedure requiring significant expertise in airway handling as well as understanding of pathophysiology of the disease process.

    Authors: Armin Ahmed and Afzal Azim
    Citation: Journal of Intensive Care 2018 6:49
  23. Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early d...

    Authors: Kent Doi, Osamu Nishida, Takashi Shigematsu, Tomohito Sadahiro, Noritomo Itami, Kunitoshi Iseki, Yukio Yuzawa, Hirokazu Okada, Daisuke Koya, Hideyasu Kiyomoto, Yugo Shibagaki, Kenichi Matsuda, Akihiko Kato, Terumasa Hayashi, Tomonari Ogawa, Tatsuo Tsukamoto…
    Citation: Journal of Intensive Care 2018 6:48
  24. The main problem of hospitalized patients in intensive care units is feeding, and if the patient does not receive the daily caloric intake required to his body, he will have malnutrition and problems related t...

    Authors: Farzad Momenfar, Alireza Abdi, Nader Salari, Ali Soroush and Behzad Hemmatpour
    Citation: Journal of Intensive Care 2018 6:47
  25. Quick Sepsis-related Organ Failure Assessment (qSOFA) is a new screening system for sepsis. The prognostic performance of qSOFA for patients with suspected infections outside the intensive care unit (ICU) is s...

    Authors: Fumiaki Tokioka, Hiroshi Okamoto, Akio Yamazaki, Akihiro Itou and Tadashi Ishida
    Citation: Journal of Intensive Care 2018 6:46
  26. Extubation failure is associated with mortality and morbidity in the intensive care unit. Ventilator weaning protocols have been introduced, and extubation is conducted based on the results of a spontaneous br...

    Authors: Yugo Okabe, Takehiko Asaga, Sayuri Bekku, Hiromi Suzuki, Kanae Kanda, Takeshi Yoda, Tomohiro Hirao and Gotaro Shirakami
    Citation: Journal of Intensive Care 2018 6:44
  27. New-onset refractory status epilepticus (NORSE) is a newly defined critical disease entity characterized by prolonged periods of refractory epileptic seizure with no readily identifiable cause in otherwise hea...

    Authors: Satoshi Kodama, Noritoshi Arai, Akiyoshi Hagiwara, Akio Kimura and Sousuke Takeuchi
    Citation: Journal of Intensive Care 2018 6:43
  28. Every day in the ICU, legal issues arise while treating sedated, unconscious, and legally incapacitated patients. Whenever a life-saving treatment cannot be discussed in a timely manner with an unconscious pat...

    Authors: Doreen Stark, Ruth Stiller, Min Xie, Damian Weber, Marco Maggiorini and Matthias Peter Hilty
    Citation: Journal of Intensive Care 2018 6:40
  29. Continuous electroencephalogram (CEEG) monitoring is increasingly being used for brain monitoring in neurocritical care setting. This is because of the proven effectiveness of CEEG in diagnosing nonconvulsive ...

    Authors: Yuichi Kubota, Hidetoshi Nakamoto, Satoshi Egawa and Takakazu Kawamata
    Citation: Journal of Intensive Care 2018 6:39
  30. Since the 2009 pandemic influenza, we have nationally established a committee of the extracorporeal membrane oxygenation (ECMO) project. This project involves adequate respiratory management for severe respira...

    Authors: Shinichiro Ohshimo, Nobuaki Shime, Satoshi Nakagawa, Osamu Nishida and Shinhiro Takeda
    Citation: Journal of Intensive Care 2018 6:38
  31. C1 inhibitor (C1-INH), which belongs to the superfamily of serine protease inhibitors, regulates the complement system and also the plasma kallikrein-kinin, fibrinolytic, and coagulation systems. The biologic ...

    Authors: Tomoya Hirose, Hiroshi Ogura, Hiroki Takahashi, Masahiro Ojima, Kang Jinkoo, Youhei Nakamura, Takashi Kojima and Takeshi Shimazu
    Citation: Journal of Intensive Care 2018 6:37
  32. While outcome improvement with extracorporeal CO2 removal (ECCO2R) is not demonstrated, a strong pathophysiological rational supports its use in the setting of acute respiratory distress syndrome (ARDS) and COPD ...

    Authors: Hadrien Winiszewski, François Aptel, François Belon, Nicolas Belin, Claire Chaignat, Cyrille Patry, Cecilia Clermont, Elise David, Jean-Christophe Navellou, Guylaine Labro, Gaël Piton and Gilles Capellier
    Citation: Journal of Intensive Care 2018 6:36
  33. Clinical benefits of recruitment maneuver in ARDS patients are controversial. A number of previous studies showed possible benefits; a large recent study reported that recruitment maneuver and PEEP titration m...

    Authors: Sulagna Bhattacharjee, Kapil D. Soni and Souvik Maitra
    Citation: Journal of Intensive Care 2018 6:35
  34. Serum lactate level can predict clinical outcomes in some critical cases. In the clinical setting, we noted that patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) and with poor serum lact...

    Authors: Takashi Mizutani, Norio Umemoto, Toshio Taniguchi, Hideki Ishii, Yuri Hiramatsu, Koji Arata, Horagaito Takuya, Sho Inoue, Tsuyoshi Sugiura, Toru Asai, Michiharu Yamada, Toyoaki Murohara and Kiyokazu Shimizu
    Citation: Journal of Intensive Care 2018 6:33

    The Correction to this article has been published in Journal of Intensive Care 2019 7:18

  35. In the original publication of this article [1], one author’s name was misspelling.

    Authors: Ken Parhar, Victoria Millar, Vasileios Zochios, Emilia Bruton, Catherine Jaworski, Nick West and Alain Vuylsteke
    Citation: Journal of Intensive Care 2018 6:32

    The original article was published in Journal of Intensive Care 2018 6:5

  36. Heat stroke is a life-threatening injury requiring neurocritical care; however, heat stroke has not been completely examined due to several possible reasons, such as no universally accepted definition or class...

    Authors: Toru Hifumi, Yutaka Kondo, Keiki Shimizu and Yasufumi Miyake
    Citation: Journal of Intensive Care 2018 6:30
  37. Protracted treatment on intensive care unit (ICU) sets the patients at increased risk for the development of chronic critical illness (CCI). Muscular and cardio-respiratory deconditioning are common long-term ...

    Authors: Gloria-Beatrice Wintermann, Jenny Rosendahl, Kerstin Weidner, Bernhard Strauß, Andreas Hinz and Katja Petrowski
    Citation: Journal of Intensive Care 2018 6:27
  38. Early brain CT is one of the most useful tools for estimating the prognosis in patients with post-cardiac arrest syndrome (PCAS) at the emergency department (ED). The aim of this study was to evaluate the prog...

    Authors: Mitsuaki Nishikimi, Takayuki Ogura, Kota Matsui, Kunihiko Takahashi, Kenji Fukaya, Keibun Liu, Hideo Morita, Mitsunobu Nakamura, Shigeyuki Matsui and Naoyuki Matsuda
    Citation: Journal of Intensive Care 2018 6:26
  39. The original article [1] contained an error. The caption of Fig. 4 should be changed. The correct caption can be found below.

    Authors: Pattarin Pirompanich and Sasithon Romsaiyut
    Citation: Journal of Intensive Care 2018 6:25

    The original article was published in Journal of Intensive Care 2018 6:6