Hemilä H, Chalker E. Vitamin C can shorten the length of stay in the ICU: a meta-analysis. Nutrients. 2019;11:708. https://doi.org/10.3390/nu11040708.
Article
CAS
PubMed Central
Google Scholar
Long CL, Maull KI, Krishnan RS, Laws HL, Geiger JW, Borghesi L, Franks W, Lawson TC, Sauberlich HE. Ascorbic acid dynamics in the seriously ill and injured. J Surg Res. 2003;109:144–8. https://doi.org/10.1016/S0022-4804(02)00083-5.
Article
CAS
PubMed
Google Scholar
Rümelin A, Jaehde U, Kerz T, Roth W, Krämer M, Fauth U. Early postoperative substitution procedure of the antioxidant ascorbic acid. J Nutr Biochem. 2005;16:104–8. https://doi.org/10.1016/j.jnutbio.2004.10.005.
Article
CAS
PubMed
Google Scholar
Rümelin A, Humbert T, Lühker O, Drescher A, Fauth U. Metabolic clearance of the antioxidant ascorbic acid in surgical patients. J Surg Res. 2005;129:46–51. https://doi.org/10.1016/j.jss.2005.03.017.
Article
CAS
PubMed
Google Scholar
De Grooth HJ, Manubulu-Choo WP, Zandvliet AS, Spoelstra-de Man AME, Girbes AR, Swart EL, Oudemans-van Straaten HM. Vitamin C pharmacokinetics in critically ill patients: a randomized trial of four iv regimens. Chest. 2018;153:1368–77. https://doi.org/10.1016/j.chest.2018.02.025.
Article
PubMed
Google Scholar
Schorah CJ, Downing C, Piripitsi A, Gallivan L, Al-Hazaa AH, Sanderson MJ, Bodenham A. Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients. Am J Clin Nutr. 1996;63:760–7. https://doi.org/10.1093/ajcn/63.5.760.
Article
CAS
PubMed
Google Scholar
Galley HF, Davies MJ, Webster NR. Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading. Free Radic Biol Med. 1996;20:139–43. https://doi.org/10.1016/0891-5849(95)02022-5.
Article
CAS
PubMed
Google Scholar
Evans-Olders R, Eintracht S, Hoffer LJ. Metabolic origin of hypovitaminosis C in acutely hospitalized patients. Nutrition. 2010;26:1070–4. https://doi.org/10.1016/j.nut.2009.08.015.
Article
CAS
PubMed
Google Scholar
Rodemeister S, Duquesne M, Adolph M, Nohr D, Biesalski HK, Unertl K. Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation. Nutrition. 2014;30:673–8. https://doi.org/10.1016/j.nut.2013.10.026.
Article
CAS
PubMed
Google Scholar
Carr AC, Rosengrave PC, Bayer S, Chambers S, Mehrtens J, Shaw GM. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care. 2017;21:300. https://doi.org/10.1186/s13054-017-1891-y.
Article
PubMed
PubMed Central
Google Scholar
Bjordahl PM, Helmer SD, Gosnell DJ, Wemmer GE, O’Hara WW, Milfeld DJ. Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients. Am J Surg. 2012;204:862–7. https://doi.org/10.1016/j.amjsurg.2012.03.012.
Article
CAS
PubMed
Google Scholar
Amini S, Robabi HN, Tashnizi MA, Vakili V. Selenium, vitamin C and N-acetylcysteine do not reduce the risk of acute kidney injury after off-pump CABG: a randomized clinical trial. Braz J Cardiovasc Surg. 2018;33:129–34. https://doi.org/10.21470/1678-9741-2017-0071.
Article
PubMed
PubMed Central
Google Scholar
Dehghani MR, Madjidi N, Rahmani A, Asgari B, Rezaei Y. Effect of oral vitamin C on atrial fibrillation development after isolated coronary artery bypass grafting surgery: a prospective randomized clinical trial. Cardiol J. 2014;21:492–9. https://doi.org/10.5603/CJ.a2013.0154.
Article
PubMed
Google Scholar
Habib TN, Ahmed I. Early adjuvant intravenous vitamin C treatment in septic shock may resolve the vasopressor dependence. Int J Microbiol Adv Immunol. 2017;5:77–81. https://doi.org/10.19070/2329-9967-1700015.
Article
Google Scholar
Safaei N, Babaei H, Azarfarin R, Jodati AR, Yaghoubi A, Sheikhalizadeh MA. Comparative effect of grape seed extract (vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery. Ann Cardiac Anaesth 2017;20:45–51. https://doi.org/10.4103/0971-9784.197834.
Article
PubMed
PubMed Central
Google Scholar
Ebade A, Taha WS, Saleh RH, Fawzy A. Ascorbic acid versus magnesium for the prevention of atrial fibrillation after coronary artery bypass grafting surgery. Egypt J Cardiothorac Anesth. 2014;8:59–65. https://doi.org/10.4103/1687-9090.143259.
Article
Google Scholar
Tanaka H, Matsuda T, Miyagantani Y, Yukioka T, Matsuda H, Shimazaki S. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized prospective study. Arch Surg. 2000;135:326–31. https://doi.org/10.1001/archsurg.135.3.326.
Article
CAS
PubMed
Google Scholar
Zabet MH, Mohammadi M, Ramezani M, Khalili H. Effect of high-dose ascorbic acid on vasopressor’s requirement in septic shock. J Res Pharm Pract. 2016;5:94–100. https://doi.org/10.4103/2279-042X.179569.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sadeghpour A, Alizadehasl A, Kyavar M, Sadeghi T, Moludi J, Gholizadeh F, Totonchi Z, Ghadrdoost B. Impact of vitamin C supplementation on post-cardiac surgery ICU and hospital length of stay. Anesth Pain Med. 2015;5:e25337. https://doi.org/10.5812/aapm.25337.
Article
PubMed
PubMed Central
Google Scholar
Fowler AA 3rd, Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, Farthing CA, Larus TL, Martin E, Brophy DF, Gupta S, Medical Respiratory Intensive Care Unit Nursing, Fisher BJ, Natarajan R. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med. 2014;12:32. https://doi.org/10.1186/1479-5876-12-32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fowler AA 3rd, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, Fisher B, Thacker LR 2nd, Natarajan R, Brophy DF, Sculthorpe R, Nanchal R, Syed A, Sturgill J, Martin GS, Sevransky J, Kashiouris M, Hamman S, Egan KF, Hastings A, Spencer W, Tench S, Mehkri O, Bindas J, Duggal A, Graf J, Zellner S, Yanny L, McPolin C, Hollrith T, Kramer D, Ojielo C, Damm T, Cassity E, Wieliczko A, Halquist M. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA. 2019;322:1261–70. https://doi.org/10.1001/jama.2019.11825.
Article
PubMed
PubMed Central
Google Scholar
Friedrich JO, Adhikari NK, Beyene J. Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods. J Clin Epidemiol. 2011;64:556–64. https://doi.org/10.1016/j.jclinepi.2010.09.016.
Article
PubMed
Google Scholar
Hemilä H. Many continuous variables such as the duration of the common cold should be analyzed using the relative scale. J Clin Epidemiol. 2016;78:128–9. https://doi.org/10.1016/j.jclinepi.2016.03.020.
Article
PubMed
Google Scholar
Hemilä H. Duration of the common cold and similar continuous outcomes should be analyzed on the relative scale: a case study of two zinc lozenge trials. BMC Med Res Methodol. 2017;17:82. https://doi.org/10.1186/s12874-017-0356-y.
Article
PubMed
PubMed Central
Google Scholar
R Core Team. R Project for Statistical Computing, (2019). https://www.r-project.org Accessed 5 Jan 2020.
Google Scholar
Schwarzer G. meta: an R package for meta-analysis. R News. 2009;7:40–5 https://cran.r-project.org/doc/Rnews/Rnews_2007-3.pdf Accessed 5 Jan 2020.
Google Scholar
Schwarzer G, Carpenter JR, Rucker G. Meta-analysis with R. London: Springer. https://doi.org/10.1007/978-3-319-21416-0.
Book
Google Scholar
Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analysis. BMJ. 2003;327:557–60. https://doi.org/10.1136/bmj.327.7414.557.
Article
PubMed
PubMed Central
Google Scholar
Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, Radella F, Garcia I, Maier RV. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg. 2002;236:814–22. https://doi.org/10.1097/00000658-200212000-00014.
Article
PubMed
PubMed Central
Google Scholar
Crimi E, Liguori A, Condorelli M, Cioffi M, Astuto M, Bontempo P, Pignalosa O, Vietri MT, Molinari AM, Sica V, Della Corte F, Napoli C. The beneficial effects of antioxidant supplementation in enteral feeding in critically ill patients: a prospective, randomized, double-blind, placebo-controlled trial. Anesth Analg. 2004;99:857–63. https://doi.org/10.1213/01.ANE.0000133144.60584.F6.
Article
CAS
PubMed
Google Scholar
Howe KP, Clochesy JM, Goldstein LS, Owen H. Mechanical ventilation antioxidant trial. Am J Crit Care. 2015;24:440–5. https://www.ncbi.nlm.nih.gov/pubmed/26330437
Article
PubMed
Google Scholar
Campbell GD Jr, Steinberg MH, Bower JD. Ascorbic acid-induced hemolysis in G-6-PD deficiency. Ann Intern Med. 1975;82:810. https://doi.org/10.7326/0003-4819-82-6-810_1.
Article
PubMed
Google Scholar
Buehner M, Pamplin J, Studer L, Hughes RL, King BT, Graybill JC, Chung KK. Oxalate nephropathy after continuous infusion of high-dose vitamin C as an adjunct to burn resuscitation. J Burn Care Res. 2016;37:e374–9. https://doi.org/10.1097/BCR.0000000000000233.
Article
PubMed
Google Scholar
Hemilä H. Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis. BMJ Open 2013;3:e002416. doi: https://doi.org/10.1136/bmjopen-2012-002416
Article
PubMed
PubMed Central
Google Scholar
Bucca C, Rolla G, Arossa W, Caria E, Elia C, Nebiolo F, Baldi S. Effect of ascorbic acid on increased bronchial responsiveness during upper airway infection. Respiration. 1989;55:214–9. https://doi.org/10.1159/000195737.
Article
CAS
PubMed
Google Scholar
Hemilä H. Vitamin C and common cold-induced asthma: a systematic review and statistical analysis. Allergy Asthma Clin Immunol. 2013;9:46. https://doi.org/10.1186/1710-1492-9-46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sharma MK, Buettner GR. Interaction of vitamin C and vitamin E during free radical stress in plasma: an ESR study. Free Rad Biol Med. 1993;15:649–53. https://doi.org/10.1016/0891-5849(93)90146-L.
Article
Google Scholar
Huang J, May JM. Ascorbic acid spares alpha-tocopherol and prevents lipid peroxidation in cultured H4IIE liver cells. Mol Cell Biochem. 2003;247:171–6. https://doi.org/10.1023/a:1024167731074.
Article
CAS
PubMed
Google Scholar
Hill KE, Montine TJ, Motley AK, Li X, May JM, Burk RF. Combined deficiency of vitamins E and C causes paralysis and death in Guinea pigs. Am J Clin Nutr. 2003;77:1484–8. https://doi.org/10.1093/ajcn/77.6.1484.
Article
CAS
PubMed
Google Scholar
Bruno RS, Leonard SW, Atkinson J, Montine TJ, Ramakrishnan R, Bray TM, Traber MG. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med. 2006;40:689–97. https://doi.org/10.1016/j.freeradbiomed.2005.10.051.
Article
CAS
PubMed
Google Scholar
Hemilä H, Kaprio J. Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C. Am J Epidemiol. 2009;169:946–53. https://doi.org/10.1093/aje/kwn413.
Article
PubMed
PubMed Central
Google Scholar
Panagiotou OA, Contopoulos-Ioannidis DG, Ioannidis JP. Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment. BMJ. 2013;346:f707. https://doi.org/10.1136/bmj.f707.
Article
PubMed
PubMed Central
Google Scholar
Hemilä H, Suonsyrjä T. Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2017;17:49. https://doi.org/10.1186/s12872-017-0478-5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Langlois PL, Manzanares W, Adhikari NKJ, Lamontagne F, Stoppe C, Hill A, Heyland DK. Vitamin C administration to the critically ill: a systematic review and meta-analysis. JPEN J Parenter Enteral Nutr. 2019;43:335–46. https://doi.org/10.1002/jpen.1471.
Article
CAS
PubMed
Google Scholar
Putzu A, Daems AM, Lopez-Delgado JC, Giordano VF, Landoni G. The effect of vitamin C on clinical outcome in critically ill patients: a systematic review with meta-analysis of randomized controlled trials. Crit Care Med. 2019;47:774–83. https://doi.org/10.1097/CCM.0000000000003700.
Article
PubMed
Google Scholar
Li J. Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis. Crit Care. 2018;22:258. https://doi.org/10.1186/s13054-018-2191-x.
Article
PubMed
PubMed Central
Google Scholar
Hemilä H. Misleading meta-analysis on vitamin C and critically ill patients. PubPeer. https://pubpeer.com/publications/D661E94CBDF6C6A9C04B8ACCD32DFC Accessed 5 Jan 2020.
Hemilä H. Statistical problems in a meta-analysis on vitamin C and critically ill patients. PubPeer. https://pubpeer.com/publications/31E6DF677EC5A16CFBD1908ADACD15#1 Accessed 5 Jan 2020.
Hemilä H. Misleading meta-analysis on vitamin C for sepsis patients. PubPeer. https://pubpeer.com/publications/2D26F22CEA264D1B84910D89AD26D7 Accessed 5 Jan 2020.
Hill A. Clasen KC. Wendt S. Majoros ÁG. Stoppe C. Adhikari NKJ. Heyland DK. Benstoem C. Effects of vitamin C on organ function in cardiac surgery patients: a systematic review and meta-analysis. Nutrients. 2019;11:2103. doi: https://doi.org/10.3390/nu11092103.
Article
PubMed Central
Google Scholar
Hemilä H, Chalker E. Vitamin C for cardiac surgery patients: several errors in a published meta-analysis. Comment on “Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis. Nutrients 2019, 11, 2103” [Comment]. Nutrients. 2020 (in press). https://www.mv.helsinki.fi/home/hemila/hill. Accessed 22 Jan 2020.
Hrobjartsson A, Gøtzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med. 2001;344:1594–602. https://doi.org/10.1056/NEJM200105243442106.
Article
CAS
PubMed
Google Scholar