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  1. Predicting mortality in the intensive care unit (ICU) is one of the biggest challenges in critical care medicine. Several studies have linked the presence of eosinopenia with adverse outcomes in different popu...

    Authors: Emmanuel Jesús Escobar-Valdivia, Julio Edgardo González-Aguirre, Eunice Rebeca Carrillo-Cisneros, Karla Carolina Guerra-Leza and Roberto Mercado-Longoría

    Citation: Journal of Intensive Care 2015 3:27

    Content type: Research Article

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  2. Dexmedetomidine (Dex) provides sedation and analgesia by acting on central alpha-2 receptors and is suitable for use after extubation because it has little respiratory depression. Considering the sympathoinhib...

    Authors: Ayuka Narisawa, Masaki Nakane, Takako Kano, Nozomi Momose, Yu Onodera, Ryo Akimoto, Tadahiro Kobayashi, Masahiro Iwabuchi, Masayuki Okada, Yoshihide Miura and Kaneyuki Kawamae

    Citation: Journal of Intensive Care 2015 3:26

    Content type: Research

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  3. In this study, the effects of an enteral diet enriched with eicosapentaenoic acid (EPA), γ-linolenic acid (GLA), and antioxidants were compared with a standard enteral diet in critically ill patients with seps...

    Authors: Kunihiro Shirai, Shozo Yoshida, Naoki Matsumaru, Izumi Toyoda and Shinji Ogura

    Citation: Journal of Intensive Care 2015 3:24

    Content type: Research

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  4. The aim of this study was to establish the pharmacokinetics of levofloxacin (LVFX) and determine the optimal dose of this drug in critically ill patients receiving continuous hemodiafiltration (CHDF). The resu...

    Authors: Takeshi Wada, Masaki Kobayashi, Yuichi Ono, Asumi Mizugaki, Kenichi Katabami, Kunihiko Maekawa, Daisuke Miyamoto, Yuichiro Yanagida, Mineji Hayakawa, Atsushi Sawamura, Ken Iseki and Satoshi Gando

    Citation: Journal of Intensive Care 2015 3:22

    Content type: Letter to the Editor

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  5. Organophosphate poisoning (OP) results in various poisoning symptoms due to its strong inhibitory effect on cholinesterase. One of the occasional complications of OP is pancreatitis.

    Authors: Shozo Yoshida, Hideshi Okada, Shiho Nakano, Kunihiro Shirai, Toshiyuki Yuhara, Hiromasa Kojima, Tomoaki Doi, Hisaaki Kato, Kodai Suzuki, Kentaro Morishita, Eiji Murakami, Hiroaki Ushikoshi, Izumi Toyoda and Shinji Ogura

    Citation: Journal of Intensive Care 2015 3:21

    Content type: Case report

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  6. Atrial fibrillation (AF) is a common arrhythmia in the ICU. The aim of this review is to summarize relevant information on new-onset AF in non-cardiac critical illness with respect to epidemiology, prevention,...

    Authors: Takuo Yoshida, Tomoko Fujii, Shigehiko Uchino and Masanori Takinami

    Citation: Journal of Intensive Care 2015 3:19

    Content type: Research

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  7. Snake bites are life-threatening injuries that can require intensive care. The diagnosis and treatment of venomous snake bites is sometimes difficult for clinicians because sufficient information has not been ...

    Authors: Toru Hifumi, Atsushi Sakai, Yutaka Kondo, Akihiko Yamamoto, Nobuya Morine, Manabu Ato, Keigo Shibayama, Kazuo Umezawa, Nobuaki Kiriu, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Kenya Kawakita and Yasuhiro Kuroda

    Citation: Journal of Intensive Care 2015 3:16

    Content type: Review

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  8. High-flow nasal cannula (HFNC) oxygen therapy comprises an air/oxygen blender, an active humidifier, a single heated circuit, and a nasal cannula. It delivers adequately heated and humidified medical gas at up...

    Authors: Masaji Nishimura

    Citation: Journal of Intensive Care 2015 3:15

    Content type: Review

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  9. Polymyxin B-immobilized fiber column hemoperfusion (PMX) has been reported to be effective for patients with septic shock. It remains unclear, however, how the efficacy of PMX varies according to the character...

    Authors: Makiko Sugiura, Chieko Mitaka, Go Haraguchi, Makoto Tomita and Naohiko Inase

    Citation: Journal of Intensive Care 2015 3:14

    Content type: Research

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  10. Direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) has been widely used for patients with septic shock around the world, but the prognostic factors have not been fully understood. We conducted a...

    Authors: Satoshi Matsukuma, Kazuhiko Sakamoto, Mitsuo Nishiyama, Takao Tamesa, Shigefumi Yoshino, Shoichi Hazama, Rumi Oshibuchi, Norimasa Matsuda, Satoshi Matsumoto, Hiroya Wakamatsu, Ryosuke Tsuruta, Mishiya Matsumoto and Masaaki Oka

    Citation: Journal of Intensive Care 2015 3:13

    Content type: Research

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  11. Methyl bromide (CH3Br) is a colorless and odorless volatile gas, used as an insecticide, fire extinguisher, fumigant, and refrigerant. Although forbidden since 1987 for domestic use, it is still used in indust...

    Authors: Sylvain Lecailtel, Céline Broucqsault-Dedrie, Clément Vanbaelinghem, Martine Nyunga, Delphine Colling and Patrick Herbecq

    Citation: Journal of Intensive Care 2015 3:12

    Content type: Case report

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  12. Journal of Intensive Care is very grateful for the generously-provided time and constructive, insightful reports provided by the journal’s highly-qualified reviewers. We would like to show our a...

    Authors: Satoshi Gando

    Citation: Journal of Intensive Care 2015 3:11

    Content type: Reviewer acknowledgement

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  13. Diffuse alveolar hemorrhage (DAH) from systemic lupus erythematosus (SLE) is a rare but potentially life-threatening condition. We report the case of a 14-year-old female with SLE who developed hypoxia and sho...

    Authors: Dai Kimura, Samir Shah, Mario Briceno-Medina, Shyam Sathanandam, Brent Haberman, Jie Zhang, Linda Myers, TK Susheel Kumar and Christopher Knott-Craig

    Citation: Journal of Intensive Care 2015 3:10

    Content type: Case report

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  14. Ventilator-associated pneumonia (VAP) caused by drug-resistant Acinetobacter baumannii is associated with high mortality in critically ill patients. We identified the prognostic factors of 30-day mortality in pat...

    Authors: Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Atikun Limsukon, Weerayut Khositsakulchai and Chalerm Liwsrisakun

    Citation: Journal of Intensive Care 2015 3:9

    Content type: Research

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  15. In autumn 2014, with great effort by the Ministry of Health, Labour and Welfare, the research group will obtain several vials of redback spider (RBS) antivenom for emergency use. However, these small amounts o...

    Authors: Toru Hifumi, Hisashi Taki, Akihiko Yamamoto, Manabu Ato, Yuichi Koido and Yasuhiro Kuroda

    Citation: Journal of Intensive Care 2015 3:7

    Content type: Letter to the Editor

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  16. Up to 40% of infants with persistent pulmonary hypertension (PPHN) remains refractory to conventional therapies, and extracorporeal membrane oxygenation (ECMO) is offered as an effective support for this group...

    Authors: Sule Doymaz, Marcia Zinger and Todd Sweberg

    Citation: Journal of Intensive Care 2015 3:6

    Content type: Research

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  17. Peripheral venoarterial extracorporeal membranous oxygenation (ECMO) support is effective in patients with cardiogenic shock or fatal arrhythmia due to fulminant myocarditis. The clinical courses of fulminant ...

    Authors: Tomohiro Nakamura, Kohki Ishida, Yousuke Taniguchi, Tomu Nakagawa, Masaru Seguchi, Hiroshi Wada, Yoshitaka Sugawara, Hiroshi Funayama, Takeshi Mitsuhashi and Shin-ichi Momomura

    Citation: Journal of Intensive Care 2015 3:5

    Content type: Research

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  18. Increasing incidence of resistance of gram-negative bacteria against even newer antibiotic including carbapenem has generated interest in the old antibiotic colistin, which are being used as salvage therapy in...

    Authors: Mohan Gurjar

    Citation: Journal of Intensive Care 2015 3:3

    Content type: Review

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  19. Microparticles (MPs) are small membrane vesicles that are released from many different cell types by exocytic budding of the plasma membrane in response to cellular activation or apoptosis. MPs may also be inv...

    Authors: Shosaku Nomura and Michiomi Shimizu

    Citation: Journal of Intensive Care 2015 3:2

    Content type: Review

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  20. There are few reports detailing the importance of extracorporeal membrane oxygenation (ECMO) for pediatric cardiac arrest in Japan. We investigated the status and issues surrounding extracorporeal cardiopulmon...

    Authors: Kohei Tsukahara, Chiaki Toida and Takashi Muguruma

    Citation: Journal of Intensive Care 2014 2:68

    Content type: Research

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  21. Neutrophil elastase plays an important role in the development and progression of acute respiratory distress syndrome (ARDS). Although the selective elastase inhibitor, sivelestat, is widely used in Japan for ...

    Authors: Takashi Tagami, Ryoichi Tosa, Mariko Omura, Hidetada Fukushima, Tadashi Kaneko, Tomoyuki Endo, Hiroshi Rinka, Akira Murai, Junko Yamaguchi, Kazuhide Yoshikawa, Nobuyuki Saito, Hideaki Uzu, Yoichi Kase, Makoto Takatori, Hiroo Izumino, Toshiaki Nakamura…

    Citation: Journal of Intensive Care 2014 2:67

    Content type: Research

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  22. Antithrombin (AT) is known as an important physiological anticoagulant. AT inactivates thrombin and multiple other coagulation factors, thereby strongly inhibiting the over-activation of the coagulation system...

    Authors: Toshiaki Iba and Daizoh Saitoh

    Citation: Journal of Intensive Care 2014 2:66

    Content type: Review

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  23. Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role...

    Authors: Takashi Ito

    Citation: Journal of Intensive Care 2014 2:65

    Content type: Review

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  24. Here, we measured presepsins (PSPs) in four patients with acute kidney injury (AKI) or chronic kidney disease (CKD) and discuss the relationship between PSP and kidney dysfunction.

    Authors: Atsushi Kotera, Katsuyuki Sagishima, Takahiro Tashiro, Daisuke Niimori, Hidenobu Kamohara and Yoshihiro Kinoshita

    Citation: Journal of Intensive Care 2014 2:63

    Content type: Letter to the Editor

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  25. Fresh frozen plasma transfusion is widely utilized in pediatric clinical practice to correct mild coagulopathy. Several studies on adult population have shown that transfusion of plasma cannot effectively corr...

    Authors: Esther Paula Soundar, Ronald Besandre, Sarah Kate Hartman, Jun Teruya and Shiu-Ki Rocky Hui

    Citation: Journal of Intensive Care 2014 2:64

    Content type: Research

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  26. Initial distribution volume of glucose (IDVG), which is not associated with significant modification of glucose metabolism, has been proposed as an indicator of the central extracellular fluid volume status in...

    Authors: Hironori Ishihara, Eiji Hashiba, Hirobumi Okawa, Junichi Saito, Toshinori Kasai and Toshihito Tsubo

    Citation: Journal of Intensive Care 2014 2:59

    Content type: Research

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  27. Redback spiders (Latrodectus hasselti) (RBSs) are venomous spiders that have recently spread to Asia from Australia. Since the first case report in 1997 (Osaka), RBS bites have been a clinical and administrative ...

    Authors: Toru Hifumi, Satoshi Fujimi, Takuya Yamagishi, Satoru Arai, Kyoko Sawabe, Akihiko Yamamoto, Manabu Ato, Keigo Shibayama, Akihiko Ginnaga, Nobuaki Kiriu, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Masanobu Kishikawa, Yuko Abe, Kenya Kawakita…

    Citation: Journal of Intensive Care 2014 2:62

    Content type: Research

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  28. This is a guideline for the management of sepsis, developed by the Sepsis Registry Committee of The Japanese Society of Intensive Care Medicine (JSICM) launched in March 2007. This guideline was developed on t...

    Authors: Shigeto Oda, Mayuki Aibiki, Toshiaki Ikeda, Hitoshi Imaizumi, Shigeatsu Endo, Ryoichi Ochiai, Joji Kotani, Nobuaki Shime, Osamu Nishida, Takayuki Noguchi, Naoyuki Matsuda and Hiroyuki Hirasawa

    Citation: Journal of Intensive Care 2014 2:55

    Content type: Guideline

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  29. Initial fluid resuscitation is an important hemodynamic therapy in patients with septic shock. The Surviving Sepsis Campaign Guidelines recommend fluid resuscitation with volume loading according to central ve...

    Authors: Takako Sasai, Hiroaki Tokioka, Tomihiro Fukushima, Takeshi Mikane, Satoru Oku, Etsu Iwasaki, Mizue Ishii, Hideyuki Mieda, Tomoki Ishikawa and Eriko Minami

    Citation: Journal of Intensive Care 2014 2:58

    Content type: Research

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  30. Ventilator-induced lung injury (VILI) is associated with inflammatory responses in the lung. Thrombomodulin (TM), a component of the coagulation system, has anticoagulant and anti-inflammatory effects. We hypo...

    Authors: Yoshiaki Iwashita, Erquan Zhang, Junko Maruyama, Ayumu Yokochi, Yasuharu Yamada, Hirofumi Sawada, Yoshihide Mitani, Hiroshi Imai, Koji Suzuki and Kazuo Maruyama

    Citation: Journal of Intensive Care 2014 2:57

    Content type: Research

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  31. Hemostatic resuscitation might improve the survival of severely injured trauma patients. Our objective was to establish a simplified screening system for determining the necessity of massive transfusions (MT) ...

    Authors: Tetsuya Yumoto, Atsuyoshi Iida, Takahiro Hirayama, Kohei Tsukahara, Naoki Shiba, Hideo Yamanouchi, Keiji Sato, Toyomu Ugawa, Shingo Ichiba and Yoshihito Ujike

    Citation: Journal of Intensive Care 2014 2:54

    Content type: Research

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  32. A recent multicenter trial demonstrated decreased mortality when patients with acute respiratory distress syndrome were treated with prone positioning (PP). However, the optimal duration of this treatment has ...

    Authors: Kyohei Miyamoto, Yu Kawazoe, Masato Yasuda, Naoaki Shibata, Tsuyoshi Nakashima, Maki Kida and Seiya Kato

    Citation: Journal of Intensive Care 2014 2:52

    Content type: Research

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  33. Rikkunshito is a traditional Japanese medicine that has been widely prescribed for patients with various gastrointestinal symptoms. Recently, the prokinetic effects of Rikkunshito in patients with a variety of...

    Authors: Mineji Hayakawa, Yuichi Ono, Takeshi Wada, Yuichiro Yanagida, Atsushi Sawamura, Hiroshi Takeda and Satoshi Gando

    Citation: Journal of Intensive Care 2014 2:53

    Content type: Research

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  34. Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication in patients with autoimmune diseases who are undergoing chemotherapy or have had hematopoietic stem cell transplantation. The use of recomb...

    Authors: Raúl Carrillo Esper, Isis EspinozadelosMonteros Estrada, Teresa de la Torre León, Agustín OmarRosales Gutiérrez and Jorge ArturoNava López

    Citation: Journal of Intensive Care 2014 2:47

    Content type: Case report

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  35. As disseminated intravascular coagulation (DIC) causes multiple organ failure, recombinant thrombomodulin (rTM) is widely used in Japan for treating DIC. However, the optimal timing of rTM administration has n...

    Authors: Tomoaki Yatabe, Ryu Nakamura, Naoko Kumagai, Tatsuo Iiyama, Koichi Yamashita and Masataka Yokoyama

    Citation: Journal of Intensive Care 2014 2:49

    Content type: Research

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  36. Idiopathic pneumonia syndrome (IPS) is a fatal non-infectious respiratory complication that develops after hematopoietic stem cell transplantation (HSCT). Because of the poor prognosis of post-HSCT patients wi...

    Authors: Toshitaka Koinuma, Shin Nunomiya, Masahiko Wada, Kansuke Koyama and Takahiro Suzuki

    Citation: Journal of Intensive Care 2014 2:48

    Content type: Case report

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  37. Acute kidney injury (AKI) is a common and serious condition usually detected some time after onset by changes in serum creatinine (sCr). Although stent grafting to repair aortic aneurysms is associated with AK...

    Authors: Kazuyoshi Ueta, Michiko Watanabe, Naoya Iguchi, Akinori Uchiyama, Yukitoshi Shirakawa, Toru Kuratani, Yoshiki Sawa and Yuji Fujino

    Citation: Journal of Intensive Care 2014 2:45

    Content type: Research

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  38. Rhabdophis tigrinus (Yamakagashi snake) is a rear-fanged colubrid snake present throughout Russia and Asia. Its venom induces life-threatening hemorrhagic symptoms and severe disseminated intravascular coagulatio...

    Authors: Toru Hifumi, Atsushi Sakai, Akihiko Yamamoto, Masahiro Murakawa, Manabu Ato, Keigo Shibayama, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Yuko Abe, Kenya Kawakita, Masanobu Hagiike, Akihiko Ginnaga and Yasuhiro Kuroda

    Citation: Journal of Intensive Care 2014 2:44

    Content type: Research

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  39. As a response to the recent article by Hifumi et al. published in the Journal of Intensive Care, the present correspondence clarifies the family-level taxonomy of the yamakagashi (Rhabdophis tigrinus). Further, t...

    Authors: Anjana Silva, Toru Hifumi, Atsushi Sakai, Akihiko Yamamoto, Masahiro Murakawa, Manabu Ato, Keigo Shibayama, Akihiko Ginnaga, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Yuko Abe, Kenya Kawakita, Masanobu Hagiike and Yasuhiro Kuroda

    Citation: Journal of Intensive Care 2014 2:43

    Content type: Letter to the Editor

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  40. Acute kidney injury (AKI) is one of the major morbidities after surgical repair of abdominal aortic aneurysm (AAA); however, precise pathogenesis of this morbidity has not been well determined. Since prothromb...

    Authors: Yasushi Innami, Nobuyuki Katori, Katsuya Mori, Shizuko Kosugi, Takeshi Suzuki, Norihiro Sakurai, Hiromasa Nagata, Junzo Takeda and Hiroshi Morisaki

    Citation: Journal of Intensive Care 2014 2:46

    Content type: Research

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  41. The objective of this case report is to describe the first case of renal actinomycosis caused by Actinomyces meyeri presenting as severe emphysematous pyelonephritis and complicated by septic shock and multi-orga...

    Authors: Alexandre Herbland, Maxime Leloup, Quentin Levrat, Frédéric Guillaume, Virginie Verrier, Philippe Bouillard, Thierry Landois, Charlie Frédéric Ouaki and Olivier Lesieur

    Citation: Journal of Intensive Care 2014 2:42

    Content type: Case report

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