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  1. Achieving a balance between organ perfusion and hemostasis is critical for optimal fluid resuscitation in patients with severe trauma. The concept of “permissive hypotension” refers to managing trauma patients...

    Authors: Daisuke Kudo, Yoshitaro Yoshida and Shigeki Kushimoto
    Citation: Journal of Intensive Care 2017 5:11
  2. Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Authors: Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa
    Citation: Journal of Intensive Care 2017 5:5
  3. Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Authors: Mineji Hayakawa
    Citation: Journal of Intensive Care 2017 5:3
  4. Tracheal ultrasound can be an alternative diagnostic tool in airway management, besides traditional confirmatory methods such as capnography and auscultation. The standard image is a hyperechoic air–mucosa (A–...

    Authors: Wan-Ching Lien
    Citation: Journal of Intensive Care 2017 5:10

    The original article was published in Journal of Intensive Care 2016 4:52

  5. Deep vein thrombosis (DVT) is a major complication in critical care. There are various methods of prophylaxis, but none of them fully prevent DVT, and each method has adverse effects. Electrical muscle stimula...

    Authors: Masahiro Ojima, Ryosuke Takegawa, Tomoya Hirose, Mitsuo Ohnishi, Tadahiko Shiozaki and Takeshi Shimazu
    Citation: Journal of Intensive Care 2017 5:9
  6. Older patients account for the majority of patients with sepsis. The objective of this study was to determine if decreased skeletal muscle mass is associated with outcomes in elderly patients with sepsis.

    Authors: Keita Shibahashi, Kazuhiro Sugiyama, Masahiro Kashiura and Yuichi Hamabe
    Citation: Journal of Intensive Care 2017 5:8
  7. Severe heat stroke tends to be complicated with rhabdomyolysis, especially in patients with exertional heat stroke. Rhabdomyolysis usually occurs in the acute phase of heat stroke. We herein report a case of h...

    Authors: Toshihiko Yoshizawa, Kazuhiko Omori, Ikuto Takeuchi, Yuto Miyoshi, Hiroshi Kido, Etsuhisa Takahashi, Kei Jitsuiki, Kouhei Ishikawa, Hiromichi Ohsaka, Manabu Sugita and Youichi Yanagawa
    Citation: Journal of Intensive Care 2016 4:71
  8. Recent studies have shown acute respiratory distress syndrome (ARDS) to be underdiagnosed and inadequately treated, as evidenced by underutilization of low-tidal volume ventilation. Despite a proven survival b...

    Authors: Jason Chertoff
    Citation: Journal of Intensive Care 2016 4:70
  9. Active smokers are prevalent within the intensive care setting and place a significant burden on healthcare systems. Nicotine withdrawal due to forced abstinence on admission may contribute to increased agitat...

    Authors: Melanie Kowalski, Andrew A. Udy, Hayden J. McRobbie and Michael J. Dooley
    Citation: Journal of Intensive Care 2016 4:69
  10. Critically ill patients admitted to intensive care unit (ICU) may suffer from different painful stimuli, but the assessment of pain is difficult because most of them are almost sedated and unable to self-repor...

    Authors: Paolo Severgnini, Paolo Pelosi, Elena Contino, Elisa Serafinelli, Raffaele Novario and Maurizio Chiaranda
    Citation: Journal of Intensive Care 2016 4:68
  11. Critical care is a complex field of medicine, especially because of its diversity and unpredictability. Mortality rates of the diseases are usually high and patients are critically ill, admitted in emergency, ...

    Authors: Bruno François, Marc Clavel, Philippe Vignon and Pierre-François Laterre
    Citation: Journal of Intensive Care 2016 4:67
  12. We conducted an internet survey targeting healthcare providers in intensive care units (ICUs) in Japan and received 318 responses. Eighteen percent of respondents replied that full-time physical therapists (PT...

    Authors: Shunsuke Taito, Masamitsu Sanui, Hideto Yasuda, Nobuaki Shime and Alan Kawarai Lefor
    Citation: Journal of Intensive Care 2016 4:66
  13. The Richmond Agitation-Sedation Scale (RASS) is a single tool that is intuitive, is easy to use, and includes both agitation and sedation. The RASS has never been formally validated for pediatric populations. ...

    Authors: Abigail Glicksman Kerson, Rebecca DeMaria, Elizabeth Mauer, Christine Joyce, Linda M. Gerber, Bruce M. Greenwald, Gabrielle Silver and Chani Traube
    Citation: Journal of Intensive Care 2016 4:65
  14. Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estima...

    Authors: Hiroyuki Yamada, Tatsuo Tsukamoto, Hiromichi Narumiya, Kazumasa Oda, Satoshi Higaki, Ryoji Iizuka, Motoko Yanagita and Masako Deguchi
    Citation: Journal of Intensive Care 2016 4:64
  15. Passive leg raising (PLR) is a so called self-volume challenge used to test for fluid responsiveness. Changes in cardiac output (CO) or stroke volume (SV) measured during PLR are used to predict the need for s...

    Authors: Anton Krige, Martin Bland and Thomas Fanshawe
    Citation: Journal of Intensive Care 2016 4:63
  16. Augmented renal clearance (ARC) of circulating solutes and drugs has been recently often reported in intensive care unit (ICU) patients. However, only few studies on ARC have been reported in Japan. The aims o...

    Authors: Yasumasa Kawano, Shinichi Morimoto, Yoshito Izutani, Kentaro Muranishi, Hironari Kaneyama, Kota Hoshino, Takeshi Nishida and Hiroyasu Ishikura
    Citation: Journal of Intensive Care 2016 4:62
  17. Vascular hyperpermeability is a frequent intractable feature involved in a wide range of diseases in the intensive care unit. The glycocalyx (GCX) seemingly plays a key role to control vascular permeability. T...

    Authors: Akira Ushiyama, Hanae Kataoka and Takehiko Iijima
    Citation: Journal of Intensive Care 2016 4:59
  18. Because treatment modalities for carbon monoxide (CO) poisoning, especially normobaric oxygen and hyperbaric oxygen therapies, have limited effects and hyperbaric oxygen is not available at the scene where tre...

    Authors: Taku Tanaka, Takeshi Kashimura, Marii Ise, Brandon D. Lohman and Yasuhiko Taira
    Citation: Journal of Intensive Care 2016 4:58
  19. The skin, soft tissue, and most parts of the musculoskeletal system are relatively superficial anatomical structures and ideal targets for ultrasound examination in the emergency departments. Soft tissue and m...

    Authors: Kuo-Chih Chen, Aming Chor-Ming Lin, Chee-Fah Chong and Tzong-Luen Wang
    Citation: Journal of Intensive Care 2016 4:55
  20. Rapid and accurate diagnosis and treatment are paramount in the management of the critically ill. Critical care ultrasound has been widely used as an adjunct to standard clinical examination, an invaluable ext...

    Authors: Young-Rock Ha and Hong-Chuen Toh
    Citation: Journal of Intensive Care 2016 4:54
  21. Upper airway ultrasound is a valuable, non-invasive, simple, and portable point of care ultrasound (POCUS) for evaluation of airway management even in anatomy distorted by pathology or trauma. Ultrasound enabl...

    Authors: Adi Osman and Kok Meng Sum
    Citation: Journal of Intensive Care 2016 4:52

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2017 5:10

  22. The long-term economic and quality-of-life outcomes of patients admitted to intensive care unit (ICU) with acute respiratory distress syndrome are not well understood. In this study, we investigate 1-year cost...

    Authors: Joachim Marti, Peter Hall, Patrick Hamilton, Sarah Lamb, Chris McCabe, Ranjit Lall, Julie Darbyshire, Duncan Young and Claire Hulme
    Citation: Journal of Intensive Care 2016 4:56
  23. The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NET...

    Authors: Yasuyo Shimomura, Mika Suga, Naohide Kuriyama, Tomoyuki Nakamura, Toshikazu Sakai, Yu Kato, Yoshitaka Hara, Chizuru Yamashita, Hiroshi Nagasaki, Masao Kaneki and Osamu Nishida
    Citation: Journal of Intensive Care 2016 4:48
  24. Families of cancer patients in the ICU often experience severe stress. Understanding their experience is important for providing family-centered care during this difficult period. Little is known about the exp...

    Authors: Miyuki H. Komachi and Kiyoko Kamibeppu
    Citation: Journal of Intensive Care 2016 4:47
  25. In a previous retrospective work, it has been postulated that early enteral nutrition was a protective factor against late defecation and its subsequent consequences in critically ill patients. We raise concer...

    Authors: Dominique Prat and Benjamin Sztrymf
    Citation: Journal of Intensive Care 2016 4:46

    The Erratum to this article has been published in Journal of Intensive Care 2016 4:60

    The original article was published in Journal of Intensive Care 2016 4:33

  26. The presence of acid-base disturbances, especially metabolic acidosis may negatively affect the outcome of critically ill patients. Lactic acidosis is the most frequent etiology and has largest impact on the p...

    Authors: Yoshifumi Kotake
    Citation: Journal of Intensive Care 2016 4:45

    The original article was published in Journal of Intensive Care 2016 4:43

  27. Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sep...

    Authors: Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Kazuma Yamakawa, Daisuke Kudo, Yusuke Iizuka, Masamitsu Sanui, Kohei Takimoto, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Katsura Hayakawa, Tsuyoshi Nakashima, Takayuki Ogura, Eiichiro Noda…
    Citation: Journal of Intensive Care 2016 4:44
  28. This cohort study compared the prognostic significance of strong ion gap (SIG) with other acid-base markers in the critically ill.

    Authors: Kwok M. Ho, Norris S. H. Lan, Teresa A. Williams, Yusra Harahsheh, Andrew R. Chapman, Geoffrey J. Dobb and Sheldon Magder
    Citation: Journal of Intensive Care 2016 4:43

    The Commentary to this article has been published in Journal of Intensive Care 2016 4:45

  29. The mortality rate from septic shock has been declining. Cerebral hypoxia, measured non-invasively with cerebral oximetry, has been correlated with neurologic and non-neurologic sequelae. Whether cerebral desa...

    Authors: Duane J. Funk, Anand Kumar and Gregory Klar
    Citation: Journal of Intensive Care 2016 4:42
  30. Acute kidney injury (AKI) is a serious complication after cardiac surgery, being associated with a high mortality. We assessed three urinary biomarkers, L-type fatty acid-binding protein (L-FABP), neutrophil g...

    Authors: Takahiro Moriyama, Shintaro Hagihara, Toko Shiramomo, Misaki Nagaoka, Shohei Iwakawa and Yuichi Kanmura
    Citation: Journal of Intensive Care 2016 4:41
  31. The Deyo-Charlson Comorbidity Index (DCCI) has low predictive value in the intensive care unit (ICU). Our goal was to determine whether addition of 25-hydroxyvitamin D (25OHD) levels to the DCCI improved 90-da...

    Authors: Bisundev Mahato, Tiffany M. N. Otero, Carrie A. Holland, Patrick T. Giguere, Ednan K. Bajwa, Carlos A. Camargo Jr. and Sadeq A. Quraishi
    Citation: Journal of Intensive Care 2016 4:40
  32. Macrophage migration inhibitory factor (MIF) is known to amplify the immune response in septic animal models. Few clinical data support this pro-inflammatory role in septic patients. Renal replacement therapy ...

    Authors: Julia Pohl, Maria Papathanasiou, Martin Heisler, Pia Stock, Malte Kelm, Ulrike B. Hendgen-Cotta, Tienush Rassaf and Peter Luedike
    Citation: Journal of Intensive Care 2016 4:39
  33. The right heart often receives less attention during echocardiography. The situation is no different in septic shock. We prospectively investigated the echocardiographic indices of the right heart in septic sh...

    Authors: Ratender Kumar Singh, Sudeep Kumar, Sreevatsa Nadig, Arvind Kumar Baronia, Banani Poddar, Afzal Azim and Mohan Gurjar
    Citation: Journal of Intensive Care 2016 4:38
  34. Alarmins, including high-mobility group box 1 (HMGB-1), can be released from damaged tissues and activated cells as inflammatory mediators. We aimed to evaluate HMGB-1 and mitochondrial DNA dynamics and estima...

    Authors: Taku Omura, Shigeki Kushimoto, Satoshi Yamanouchi, Daisuke Kudo and Noriko Miyagawa
    Citation: Journal of Intensive Care 2016 4:37
  35. This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temper...

    Authors: Yasuhiro Kuroda
    Citation: Journal of Intensive Care 2016 4:36

    The Erratum to this article has been published in Journal of Intensive Care 2016 4:49

  36. Quality benchmarks are increasingly being used to compare the delivery of healthcare, and may affect reimbursement in the future. The University Health Consortium (UHC) expected probability of mortality (EPM) ...

    Authors: Angela K. M. Lipshutz, John R. Feiner, Barbara Grimes and Michael A. Gropper
    Citation: Journal of Intensive Care 2016 4:35
  37. Sepsis is associated with coagulation abnormalities, and a high content of intravascular tissue factor (TF) may contribute to the development of multisystem organ failure. Circulating microvesicles (MVs) are i...

    Authors: Carolin Trepesch, Ramona Nitzsche, Aenne Glass, Bernd Kreikemeyer, Jochen K. Schubert and Sonja Oehmcke-Hecht
    Citation: Journal of Intensive Care 2016 4:34
  38. Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecati...

    Authors: Shinya Fukuda, Takashi Miyauchi, Motoki Fujita, Yasutaka Oda, Masaki Todani, Yoshikatsu Kawamura, Kotaro Kaneda and Ryosuke Tsuruta
    Citation: Journal of Intensive Care 2016 4:33

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2016 4:46