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  1. Although the effect of thiamine alone or in combination with vitamin C has been studied in multiple trials (RCT and interventional studies), their results are inconsistent. This meta-analysis aimed to assess i...

    Authors: Nafiseh Shokri-mashhadi, Ali Aliyari, Zahra Hajhashemy, Saeed Saadat and Mohammad Hossein Rouhani
    Citation: Journal of Intensive Care 2022 10:8
  2. Delirium in the intensive care unit (ICU) may be a preventable risk factor for cognitive impairment or psychiatric problems. We aimed to evaluate the association between the presence of delirium during hospita...

    Authors: Ryoung-Eun Ko, Danbee Kang, Hyejung Park, Juhee Cho, Gee Young Suh and Chi Ryang Chung
    Citation: Journal of Intensive Care 2022 10:7
  3. The International Guidelines for Management of Sepsis and Septic Shock 2021 and the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 share a common issue on long-term outcom...

    Authors: Yusuke Kawai and Osamu Nishida
    Citation: Journal of Intensive Care 2022 10:6
  4. This study investigated whether combination therapy with vasopressin, steroid, and epinephrine (VSE) improves in-hospital survival and return of spontaneous circulation (ROSC) during and after resuscitation in...

    Authors: Fatemeh Saghafi, Negar Bagheri, Amin Salehi-Abargouei and Adeleh Sahebnasagh
    Citation: Journal of Intensive Care 2022 10:5
  5. It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been repo...

    Authors: Toshiaki Iba, Osamu Nishida, Jerrold H. Levy and Marcel Levi
    Citation: Journal of Intensive Care 2022 10:4
  6. The significant mortality rate and prolonged ventilator days associated with invasive mechanical ventilation (IMV) in patients with severe COVID-19 have incited a debate surrounding the use of noninvasive resp...

    Authors: Zachary P. Sullivan, Luca Zazzeron, Lorenzo Berra, Dean R. Hess, Edward A. Bittner and Marvin G. Chang
    Citation: Journal of Intensive Care 2022 10:3
  7. The benefits of a high plasma-to-red blood cell (RBC) ratio on the survival of injured patients who receive massive transfusions remain unclear, especially in older patients. We aimed to investigate the intera...

    Authors: Mitsuaki Kojima, Akira Endo, Atsushi Shiraishi, Tomohisa Shoko, Yasuhiro Otomo and Raul Coimbra
    Citation: Journal of Intensive Care 2022 10:2
  8. Bedside measurements of critical closure pressure (Pcc) and mean systemic circulation filling pressure (Pmsf) were utilized to evaluate the response to esmolol in septic shock patients, in relation to the vasc...

    Authors: Zehan Liu, Chuanliang Pan, Jianping Liu, Hui Liu and Hui Xie
    Citation: Journal of Intensive Care 2022 10:1
  9. A structure and staffing model similar to that in general intensive care unit (ICUs) is applied to cardiac intensive care unit (CICUs) for patients with acute heart failure. However, there is limited evidence ...

    Authors: Hiroyuki Ohbe, Hiroki Matsui and Hideo Yasunaga
    Citation: Journal of Intensive Care 2021 9:78
  10. A recent worldwide survey indicates an international diversity in net ultrafiltration (UFNET) practices for the treatment of fluid overload in critically ill patients with acute kidney injury (AKI) requiring rena...

    Authors: Koichi Kitamura, Koichi Hayashi, Shigeki Fujitani, Raghavan Murugan and Toshihiko Suzuki
    Citation: Journal of Intensive Care 2021 9:77
  11. We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prol...

    Authors: Yumi Mitsuyama, Kazuma Yamakawa, Katsuhide Kayano, Miho Maruyama, Takeshi Wada and Satoshi Fujimi
    Citation: Journal of Intensive Care 2021 9:76
  12. Sepsis is a primary global health threat and costs a lot, requiring effective and affordable treatments. We performed this meta-analysis to explore the treatment of hydrocortisone, ascorbic acid, and thiamine ...

    Authors: Weilan Na, Huili Shen, Yichu Li and Dong Qu
    Citation: Journal of Intensive Care 2021 9:75
  13. Coronavirus disease 2019 (COVID-19) threatened human lives worldwide since first reported. The current challenge for global intensivists is to establish an effective treatment for severe COVID-19. Blood purifi...

    Authors: Hiroyuki Yamada and Shigeru Ohtsuru
    Citation: Journal of Intensive Care 2021 9:74
  14. In a recent paper, Chen et al. report the findings of a systematic review with meta-analysis concerning conservative versus conventional oxygen therapy for critically ill patients. We wish to commend the autho...

    Authors: Thomas Lass Klitgaard, Olav Lilleholt Schjørring, Frederik Mølgaard Nielsen, Christian Sylvest Meyhoff, Marija Barbateskovic, Jørn Wetterslev, Anders Perner and Bodil Steen Rasmussen
    Citation: Journal of Intensive Care 2021 9:72
  15. In patient requiring vasopressors, the radial artery pressure may underestimate the true central aortic pressure leading to unnecessary interventions. When using a femoral and a radial arterial line, this femo...

    Authors: Matthias Jacquet-Lagrèze, David Claveau, Julie Cousineau, Kun Peng Liu, Jean-Gilles Guimond, Pierre Aslanian, Yoan Lamarche, Martin Albert, Emmanuel Charbonney, Ali Hammoud, Loay Kontar and André Denault
    Citation: Journal of Intensive Care 2021 9:71
  16. Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential ass...

    Authors: Ruilian You, Hua Zheng, Lubin Xu, Tiantian Ma, Gang Chen, Peng Xia, Xiaohong Fan, Peili Ji, Li Wang and Limeng Chen
    Citation: Journal of Intensive Care 2021 9:70
  17. Previous prospective studies have suggested that spouses of patients who are admitted to the intensive care unit (ICU) have a high prevalence of mental disorders, termed post-intensive care syndrome-family (PI...

    Authors: Yuki Miyamoto, Hiroyuki Ohbe, Tadahiro Goto and Hideo Yasunaga
    Citation: Journal of Intensive Care 2021 9:69
  18. Although the associations between obesity, glucose variability (GV), and Intensive Care Unit (ICU) mortality have been studied extensively, whether age moderates these associations is not well understood.

    Authors: Lusi Lu, Yifeng Lu, Chenlu Gao and Nan Zhang
    Citation: Journal of Intensive Care 2021 9:68
  19. Little is known about the prevalence of altered CAR in anoxic brain injury and the association with patients’ outcome. We aimed at investigating CAR in cardiac arrest survivors treated by targeted temperature ...

    Authors: Ilaria Alice Crippa, Jean-Louis Vincent, Federica Zama Cavicchi, Selene Pozzebon, Filippo Annoni, Antonella Cotoia, Hassane Njimi, Nicolas Gaspard, Jacques Creteur and Fabio Silvio Taccone
    Citation: Journal of Intensive Care 2021 9:67
  20. The long-term outcome is an essential issue in critically ill patients, and the identification of early determinant is needed for risk stratification of the long-term outcome. In the present study, we investig...

    Authors: Yu-Cheng Wu, Li-Ting Wong, Chieh-Liang Wu and Wen-Cheng Chao
    Citation: Journal of Intensive Care 2021 9:66
  21. Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclea...

    Authors: Ruey-Hsing Chou, Po-Shan Wu, Shen-Chih Wang, Cheng-Hsueh Wu, Shu-Fen Lu, Ru-Yu Lien, Yi-Lin Tsai, Ya-Wen Lu, Ming-Ren Kuo, Jiun-Yu Guo, Ruey-Yi Chou, Po-Hsun Huang and Shing-Jong Lin
    Citation: Journal of Intensive Care 2021 9:65
  22. Dexamethasone improves survival of patients with COVID-19 acute respiratory distress syndrome, but might shorten the delay between the start of invasive mechanical ventilation and the occurrence of ventilator-...

    Authors: Martin Cour, Marie Simon, Laurent Argaud, Guillaume Monneret and Fabienne Venet
    Citation: Journal of Intensive Care 2021 9:64
  23. Limited data are available on the clinical significance of lactate clearance (LC) in patients with cardiogenic shock (CS). This study investigated the prognostic role of LC in CS patients.

    Authors: Ik Hyun Park, Jeong Hoon Yang, Woo Jin Jang, Woo Jung Chun, Ju Hyeon Oh, Yong Hwan Park, Young-Guk Ko, Cheol Woong Yu, Bum Sung Kim, Hyun-Joong Kim, Hyun Jong Lee, Jin-Ok Jeong and Hyeon-Cheol Gwon
    Citation: Journal of Intensive Care 2021 9:63
  24. We comment on the study by Batra et al. on the efficacy of probiotics in the prevention of ventilator-associated pneumonia in critically ill ICU patients. They also reported that probiotics administration was ...

    Authors: Kentaro Shimizu, Tomoya Hirose and Hiroshi Ogura
    Citation: Journal of Intensive Care 2021 9:62

    The Letter to the Editor to this article has been published in Journal of Intensive Care 2021 9:61

  25. Asia has more critically ill people than any other part of our planet. The aim of this article is to review the development of critical care as a specialty, critical care societies and education and research, ...

    Authors: Jason Phua, Chae-Man Lim, Mohammad Omar Faruq, Khalid Mahmood Khan Nafees, Bin Du, Charles D. Gomersall, Lowell Ling, Jigeeshu Vasishtha Divatia, Seyed Mohammad Reza Hashemian, Moritoki Egi, Aidos Konkayev, Mohd Basri Mat-Nor, Gentle Sunder Shrestha, Madiha Hashmi, Jose Emmanuel M. Palo, Yaseen M. Arabi…
    Citation: Journal of Intensive Care 2021 9:60
  26. Trans-jejunal nutrition via a post-pyloric enteral feeding tube has a low risk of aspiration or reflux; however, placement of the tube using the blind method can be difficult. Assistive devices, such as fluoro...

    Authors: Kohei Kurisawa, Masashi Yokose, Hiroyuki Tanaka, Takahiro Mihara, Shunsuke Takaki and Takahisa Goto
    Citation: Journal of Intensive Care 2021 9:59
  27. During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission an...

    Authors: Thomas Daix, Robin Jeannet, Ana Catalina Hernandez Padilla, Philippe Vignon, Jean Feuillard and Bruno François
    Citation: Journal of Intensive Care 2021 9:58
  28. This is a response to the issues raised in the commentary by Dr. Yifu Si et al.

    Authors: Yasutaka Hirasawa, Taka-aki Nakada and Jiro Terada
    Citation: Journal of Intensive Care 2021 9:56
  29. The effect of changes to cardiopulmonary resuscitation (CPR) procedures in response to Coronavirus disease 2019 (COVID-19) on in-hospital cardiac arrest (IHCA) management and outcomes are unreported. In this m...

    Authors: Sau Ki Tong, Lowell Ling, Jack Zhenhe Zhang, Florence H. Y. Yap, Kam Leung Law and Gavin M. Joynt
    Citation: Journal of Intensive Care 2021 9:55
  30. Ketamine has been shown to decrease sedative requirements in intensive care unit (ICU). Randomized trials are limited on patient-centered outcomes. We designed this pilot trial to evaluate the feasibility of a...

    Authors: Marwa Amer, Khalid Maghrabi, Mohammed Bawazeer, Kamel Alshaikh, Mohammad Shaban, Muhammad Rizwan, Rashid Amin, Edward De Vol, Mawadah Baali, Malak Altewerki, Mehreen Bano, Fawziah Alkhaldi, Sanaa Alenazi and Mohammed Hijazi
    Citation: Journal of Intensive Care 2021 9:54
  31. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created as revised fr...

    Authors: Moritoki Egi, Hiroshi Ogura, Tomoaki Yatabe, Kazuaki Atagi, Shigeaki Inoue, Toshiaki Iba, Yasuyuki Kakihana, Tatsuya Kawasaki, Shigeki Kushimoto, Yasuhiro Kuroda, Joji Kotani, Nobuaki Shime, Takumi Taniguchi, Ryosuke Tsuruta, Kent Doi, Matsuyuki Doi…
    Citation: Journal of Intensive Care 2021 9:53
  32. Our aim was to investigate the prognostic potential of circulating dipeptidyl peptidase 3 (cDPP3) to predict mortality and development of organ dysfunction in a mixed intensive care unit (ICU) population, and ...

    Authors: Attila Frigyesi, Maria Lengquist, Martin Spångfors, Martin Annborn, Tobias Cronberg, Niklas Nielsen, Helena Levin and Hans Friberg
    Citation: Journal of Intensive Care 2021 9:52
  33. The relationship between computed tomography (CT) and prognosis of patients with COVID-19 pneumonia remains unclear. We hypothesized that the Ichikado CT score, obtained in the first 24 h of hospital admission...

    Authors: Alan Araiza, Melanie Duran, Cesar Patiño, Paul E. Marik and Joseph Varon
    Citation: Journal of Intensive Care 2021 9:51
  34. Patient–ventilator asynchrony (PVA) is a common problem in patients undergoing invasive mechanical ventilation (MV) in the intensive care unit (ICU), and may accelerate lung injury and diaphragm mis-contractio...

    Authors: Michihito Kyo, Tatsutoshi Shimatani, Koji Hosokawa, Shunsuke Taito, Yuki Kataoka, Shinichiro Ohshimo and Nobuaki Shime
    Citation: Journal of Intensive Care 2021 9:50
  35. Systemic inflammation relates to the initiation and progression of acute respiratory distress syndrome (ARDS). Neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW)/albumin ratio hav...

    Authors: Lijuan Yang, Chang Gao, Fengyuan Li, Ling Yang, Jiahao Chen, Shiqi Guo, Ying He and Qiang Guo
    Citation: Journal of Intensive Care 2021 9:49
  36. Excess morbidity and mortality following critical illness is increasingly attributed to potentially avoidable complications occurring as a result of complex ICU management (Berenholtz et al., J Crit Care 17:1-...

    Authors: Issrah Jawad, Sumayyah Rashan, Chathurani Sigera, Jorge Salluh, Arjen M. Dondorp, Rashan Haniffa and Abi Beane
    Citation: Journal of Intensive Care 2021 9:48
  37. Conservative oxygen strategy is recommended in acute illness while its benefit in ICU patients remains controversial. Therefore, we sought to conduct a systematic review and meta-analysis to examine such oxyge...

    Authors: Xiao-Li Chen, Bei-Lei Zhang, Chang Meng, Hui-Bin Huang and Bin Du
    Citation: Journal of Intensive Care 2021 9:47
  38. Electrical cardioversion (ECV) is widely used to restore sinus rhythm in critically ill adult patients with atrial fibrillation, although its prognostic value is uncertain. This study aims to elucidate the cli...

    Authors: Nozomu Shima, Kyohei Miyamoto, Seiya Kato, Takuo Yoshida and Shigehiko Uchino
    Citation: Journal of Intensive Care 2021 9:46
  39. The course of chronic obstructive pulmonary disease (COPD) is punctuated by exacerbations, most often of infectious origin, responsible for many intensive care unit (ICU) and intermediate care unit (IMCU) admi...

    Authors: Matthieu Amalric, Engi Ahmed, Boris Jung, Carey Suehs, Nicolas Molinari, Arnaud Bourdin and Jeremy Charriot
    Citation: Journal of Intensive Care 2021 9:45
  40. Autotaxin (ATX) is a secreted glycoprotein that is widely present in extracellular biological fluids and has been implicated in many inflammatory and fibrotic diseases. However, the clinical impact of the rele...

    Authors: Lijuan Gao, Xiaoou Li, Hao Wang, Yue Liao, Yongfang Zhou, Ke Wang, Jun Hu, Mengxin Cheng, Zijian Zeng, Tao Wang and Fuqiang Wen
    Citation: Journal of Intensive Care 2021 9:44
  41. Target temperature management (TTM) is suggested to reduce brain damage in the presence of global or local ischemia. Prompt TTM application may help to improve outcomes, but it is often hindered by technical p...

    Authors: Michela Masè, Alessandro Micarelli, Marika Falla, Ivo B. Regli and Giacomo Strapazzon
    Citation: Journal of Intensive Care 2021 9:43
  42. Since the start of the coronavirus disease 2019 (COVID-19) pandemic, it has remained unknown whether conventional risk prediction tools used in intensive care units are applicable to patients with COVID-19. Th...

    Authors: Hideki Endo, Hiroyuki Ohbe, Junji Kumasawa, Shigehiko Uchino, Satoru Hashimoto, Yoshitaka Aoki, Takehiko Asaga, Eiji Hashiba, Junji Hatakeyama, Katsura Hayakawa, Nao Ichihara, Hiromasa Irie, Tatsuya Kawasaki, Hiroshi Kurosawa, Tomoyuki Nakamura, Hiroshi Okamoto…
    Citation: Journal of Intensive Care 2021 9:42
  43. Airway management, including noninvasive endotracheal intubation or invasive tracheostomy, is an essential treatment strategy for patients with deep neck space abscess (DNSA) to reverse acute hypoxia, which ai...

    Authors: Yu Lin, Wenxiang Gao, Huijun Yue, Weixiong Chen, Tianrun Liu, Jin Ye, Qian Cai, Fei Ye, Long He, Xingqiang Xie, Guoping Xiong, Bin Wang, Feng Pang, Pei Li, Jianhui Wu, Bin Wang…
    Citation: Journal of Intensive Care 2021 9:41
  44. β-blockers may protect against catecholaminergic myocardial injury in critically ill patients. Long-term β-blocker users are known to have lower lactate concentrations and favorable sepsis outcomes. However, the ...

    Authors: Ming-Jen Kuo, Ruey-Hsing Chou, Ya-Wen Lu, Jiun-Yu Guo, Yi-Lin Tsai, Cheng-Hsueh Wu, Po-Hsun Huang and Shing-Jong Lin
    Citation: Journal of Intensive Care 2021 9:40
  45. The use of ultrashort-acting β1-blockers recently has attracted attention in septic patients with non-compensatory tachycardia. We summarized the metabolic and hemodynamic effects and the clinical evidence of ...

    Authors: Daisuke Hasegawa, Ryota Sato and Osamu Nishida
    Citation: Journal of Intensive Care 2021 9:39
  46. Tracheal intubation is the gold standard for securing the airway, and it is not uncommon to encounter intubation difficulties in intensive care units and emergency rooms. Currently, there is a need for an obje...

    Authors: Tatsuya Hayasaka, Kazuharu Kawano, Kazuki Kurihara, Hiroto Suzuki, Masaki Nakane and Kaneyuki Kawamae
    Citation: Journal of Intensive Care 2021 9:38
  47. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Intestinal mucosal barrier injury is one of the important manifestations of sepsis. Interleukin-9 (IL-9) and ...

    Authors: Jia-Kui Sun, Jing Zhou, Xin-Pei Sun, Xiao Shen, Dong-Mei Zhu, Xiang Wang, Su-Ming Zhou and Xin-Wei Mu
    Citation: Journal of Intensive Care 2021 9:37