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  1. Letter to the Editor

    The application of anticoagulant therapy to sepsis

    Since the withdrawal of recombinant-activated protein C, the anticoagulant therapy for sepsis was taken no notice. For instance, the international sepsis guidelines did not share a space for this therapy. Howe...

    Jecko Thachil and Toshiaki Iba

    Journal of Intensive Care 2017 5:32

    Published on: 30 May 2017

  4. Research

    Acetylcholinesterase and butyrylcholinesterase in cardiosurgical patients with postoperative delirium

    Patients in intensive care units (ICU) are often diagnosed with postoperative delirium; the duration of which has a relevant negative impact on various clinical outcomes. Recent research found a potentially im...

    Mira John, E. Wesley Ely, Dorothee Halfkann, Julika Schoen, Beate Sedemund-Adib, Stefan Klotz, Finn Radtke, Sebastian Stehr and Michael Hueppe

    Journal of Intensive Care 2017 5:29

    Published on: 26 May 2017

  5. Research

    Predictors of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation: an observational cohort study

    Intracranial hemorrhage (ICH) is a recognized complication of adults treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. However, the predictors of...

    Alexander Fletcher Sandersjöö, Jiri Bartek Jr., Eric Peter Thelin, Anders Eriksson, Adrian Elmi-Terander, Mikael Broman and Bo-Michael Bellander

    Journal of Intensive Care 2017 5:27

    Published on: 22 May 2017

  6. Research

    Association between recurrence of acute kidney injury and mortality in intensive care unit patients with severe sepsis

    Acute kidney injury (AKI) occurs in more than half critically ill patients admitted in intensive care units (ICU) and increases the mortality risk. The main cause of AKI in ICU is sepsis. AKI severity and othe...

    Emilio Rodrigo, Borja Suberviola, Miguel Santibáñez, Lara Belmar, Álvaro Castellanos, Milagros Heras, Juan Carlos Rodríguez-Borregán, Angel Luis Martín de Francisco and Claudio Ronco

    Journal of Intensive Care 2017 5:28

    Published on: 22 May 2017

  8. Research

    C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients

    Endothelin 1 (ET-1) is a strong vasoconstrictor, which is involved in inflammation and reduced tissue perfusion. C-terminal proendothelin-1 (CT-proET-1) is the stable circulating precursor protein of ET-1. We ...

    Lukas Buendgens, Eray Yagmur, Jan Bruensing, Ulf Herbers, Christer Baeck, Christian Trautwein, Alexander Koch and Frank Tacke

    Journal of Intensive Care 2017 5:25

    Published on: 20 March 2017

  9. Review

    Perfusion indices revisited

    Monitoring of tissue perfusion is an essential step in the management of acute circulatory failure. The presence of cellular dysfunction has been a basic component of shock definition even in the absence of hy...

    Ahmed Hasanin, Ahmed Mukhtar and Heba Nassar

    Journal of Intensive Care 2017 5:24

    Published on: 14 March 2017

  10. Commentary

    Are you Ernest Shackleton, the polar explorer? Refining the criteria for delirium and brain dysfunction in sepsis

    The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunct...

    Frank Anthony Rasulo, Giuseppe Bellelli, Eugene Wesley Ely, Alessandro Morandi, Pratik Pandharipande and Nicola Latronico

    Journal of Intensive Care 2017 5:23

    Published on: 7 March 2017

  11. Review

    Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis

    Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki

    Journal of Intensive Care 2017 5:22

    Published on: 3 March 2017

  12. Research

    Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis

    Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key mo...

    Bernt C. Hellerud, Hilde L. Orrem, Knut Dybwik, Søren E. Pischke, Andreas Baratt-Due, Albert Castellheim, Hilde Fure, Grethe Bergseth, Dorte Christiansen, Miles A. Nunn, Terje Espevik, Corinna Lau, Petter Brandtzæg, Erik W. Nielsen and Tom E. Mollnes

    Journal of Intensive Care 2017 5:21

    Published on: 27 February 2017

  13. Research

    The relationship between cerebral regional oxygen saturation during extracorporeal cardiopulmonary resuscitation and the neurological outcome in a retrospective analysis of 16 cases

    In recent years, the measurement of cerebral regional oxygen saturation (rSO2) during resuscitation has attracted attention. The objective of this study was to clarify the relationship between the serial changes ...

    Naoki Ehara, Tomoya Hirose, Tadahiko Shiozaki, Akinori Wakai, Tetsuro Nishimura, Nobuto Mori, Mitsuo Ohnishi, Daikai Sadamitsu and Takeshi Shimazu

    Journal of Intensive Care 2017 5:20

    Published on: 23 February 2017

  14. Research

    Prolonged direct hemoperfusion using a polymyxin B immobilized fiber cartridge provides sustained circulatory stabilization in patients with septic shock: a retrospective observational before-after study

    Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridges (PMX-DHP) is widely used for septic shock in Japan and parts of Europe. Although this treatment is usually administered for 2 h, the o...

    Kyohei Miyamoto, Yu Kawazoe and Seiya Kato

    Journal of Intensive Care 2017 5:19

    Published on: 20 February 2017

  15. Research

    Long-term cognitive outcomes among unselected ventilated and non-ventilated ICU patients

    Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization. Delirium, an acute form of brai...

    José Raimundo A. de Azevedo, Widlani Sousa Montenegro, Djane Pereira Rodrigues, Suellen C. de C. Souza, Vanessa F. S. Araujo, Margareth Pereira de Paula, Patricia H. C. P. Prazeres, Adenilde da Luz Leitão and Adriana V. N. Mendonça

    Journal of Intensive Care 2017 5:18

    Published on: 17 February 2017

  18. Research

    Psychological rumination and recovery from work in intensive care professionals: associations with stress, burnout, depression and health

    The work demands of critical care can be a major cause of stress in intensive care unit (ICU) professionals and lead to poor health outcomes. In the process of recovery from work, psychological rumination is c...

    Tushna Vandevala, Louisa Pavey, Olga Chelidoni, Nai-Feng Chang, Ben Creagh-Brown and Anna Cox

    Journal of Intensive Care 2017 5:16

    Published on: 2 February 2017

  20. Review

    The impact of changes in intensive care organization on patient outcome and cost-effectiveness—a narrative review

    The mortality rate of critically ill patients is high and the cost of the intensive (ICU) department is among the highest within the health-care industry. The cost will continue to increase because of the agin...

    Alexander F. van der Sluijs, Eline R. van Slobbe-Bijlsma, Stephen E. Chick, Margreeth B. Vroom, Dave A. Dongelmans and Alexander P. J. Vlaar

    Journal of Intensive Care 2017 5:13

    Published on: 25 January 2017

  23. Review

    Tranexamic acid and trauma-induced coagulopathy

    Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa

    Journal of Intensive Care 2017 5:5

    Published on: 20 January 2017

  24. Review

    Dynamics of fibrinogen in acute phases of trauma

    Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Mineji Hayakawa

    Journal of Intensive Care 2017 5:3

    Published on: 20 January 2017

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