Articles

Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis

Noninvasive respiratory support devices may reduce the tracheal intubation rate compared with conventional oxygen therapy (COT). To date, few studies have compared high-flow nasal cannula (HFNC) use with nonin...

Authors: Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Masaki Nakane and Nobuaki Shime

Functional status of mechanically ventilated COVID-19 survivors at ICU and hospital discharge

A significant number of COVID-19 patients have been treated using invasive mechanical ventilation (IMV). The ability to evaluate functional status of COVID-19 survivors early on at ICU and hospital discharge m...

Authors: Benjamin Musheyev, Lara Borg, Rebeca Janowicz, Michael Matarlo, Hayle Boyle, Gurinder Singh, Victoria Ende, Ioannis Babatsikos, Wei Hou and Tim Q. Duong

What place for virtual reality in the intensive care unit during medical procedures?

In the intensive care unit, patients are subject to discomforts and pain. Their management is essentially based on pharmacologic approaches. Immersive virtual reality could represent an adjunctive non-invasive...

Authors: Floriane Puel, Vincent Minville and Fanny Vardon-Bounes

An A-E assessment of post-ICU COVID-19 recovery

The COVID-19 global pandemic has placed unprecedented strain on healthcare and critical care services around the world. Whilst most resources have focused on the acute phase of the disease, there is likely to ...

Authors: Matthew Cadd and Maya Nunn

Dynamic change of heart rate in the acute phase and clinical outcomes after intracerebral hemorrhage: a cohort study

Dynamic change of heart rate in the acute phase and clinical outcomes after intracerebral hemorrhage (ICH) remains unknown. We aimed to investigate the associations of heart rate trajectories and variability w...

Authors: Shoujiang You, Yupin Wang, Zian Lu, Dandan Chu, Qiao Han, Jiaping Xu, Chun-Feng Liu, Yongjun Cao and Chongke Zhong

A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock: a preliminary study

The purpose of this study is to investigate the time course of syndecan-1 (Syn-1) plasma levels, the correlation between Syn-1 and organ damage development, and the associations of Syn-1 level with cumulative ...

Authors: Yuka Kajita, Tsuguaki Terashima, Hisatake Mori, Md. Monirul Islam, Takayuki Irahara, Masanobu Tsuda, Hideki Kano and Naoshi Takeyama

The author’s response

Authors: Yohei Hirano, Shunsuke Madokoro, Yutaka Kondo, Ken Okamoto and Hiroshi Tanaka

A reassessment about included studies and certainty of evidence on a systematic review and meta-analysis of steroid for patients with acute respiratory distress syndrome

We comment on the study by Hirano et al. about the effect of steroids in patients with acute respiratory distress syndrome. It might be necessary to include only the existing randomized control trials and to r...

Authors: Shodai Yoshihiro and Shunsuke Taito

Association between physical restraint requirement and unfavorable neurologic outcomes in subarachnoid hemorrhage

Physical restraint has been commonly indicated to patients with brain dysfunction in neurocritical care. The effect of physical restraints on outcomes of critically ill adults remains controversial as no rando...

Authors: Kyoko Akiyama, Akihiko Inoue, Toru Hifumi, Kentaro Nakamura, Takuya Taira, Shun Nakagawa, Keisuke Jinno, Arisa Manabe, Sayaka Kinugasa, Hikaru Matsumura, Hajime Shishido, Shota Yokoyama, Tomoya Okazaki, Hideyuki Hamaya, Koshiro Takano, Kazutaka Kiridume…

Predictors of failure with high-flow nasal oxygen therapy in COVID-19 patients with acute respiratory failure: a multicenter observational study

We aimed to describe the use of high-flow nasal oxygen (HFNO) in patients with COVID-19 acute respiratory failure and factors associated with a shift to invasive mechanical ventilation.

Authors: Ricard Mellado-Artigas, Luis Eduardo Mujica, Magda Liliana Ruiz, Bruno Leonel Ferreyro, Federico Angriman, Egoitz Arruti, Antoni Torres, Enric Barbeta, Jesús Villar and Carlos Ferrando

Correction to: The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?

An amendment to this paper has been published and can be accessed via the original article.

Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

Prognostic value of lymphocyte counts in bronchoalveolar lavage fluid in patients with acute respiratory failure: a retrospective cohort study

Cellular patterns in bronchoalveolar lavage fluid (BALF) are used to distinguish or rule out particular diseases in patients with acute respiratory failure (ARF). However, whether BALF cellular patterns can pr...

Authors: Yasutaka Hirasawa, Taka-aki Nakada, Takashi Shimazui, Mitsuhiro Abe, Yuri Isaka, Masashi Sakayori, Kenichi Suzuki, Keiichiro Yoshioka, Takeshi Kawasaki, Jiro Terada, Kenji Tsushima and Koichiro Tatsumi

The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit: a meta-analysis and meta-regression of observational studies

Coronavirus disease 2019 (COVID-19) infection is associated with a prothrombotic state. We performed a meta-analysis of proportions to estimate the weighted average incidence of pulmonary thromboembolism (PTE)...

Authors: Jun Jie Ng, Zhen Chang Liang and Andrew M. T. L. Choong

Development and validation of an online model to predict critical COVID-19 with immune-inflammatory parameters

Immune and inflammatory dysfunction was reported to underpin critical COVID-19(coronavirus disease 2019). We aim to develop a machine learning model that enables accurate prediction of critical COVID-19 using ...

Authors: Yue Gao, Lingxi Chen, Jianhua Chi, Shaoqing Zeng, Xikang Feng, Huayi Li, Dan Liu, Xinxia Feng, Siyuan Wang, Ya Wang, Ruidi Yu, Yuan Yuan, Sen Xu, Chunrui Li, Wei Zhang, Shuaicheng Li…

Development and validation of the predictive risk of death model for adult patients admitted to intensive care units in Japan: an approach to improve the accuracy of healthcare quality measures

The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model is widely used to predict mortality in Japanese intensive care units (ICUs). Although the model’s discrimination is excellent, its calibr...

Authors: Hideki Endo, Shigehiko Uchino, Satoru Hashimoto, Yoshitaka Aoki, Eiji Hashiba, Junji Hatakeyama, Katsura Hayakawa, Nao Ichihara, Hiromasa Irie, Tatsuya Kawasaki, Junji Kumasawa, Hiroshi Kurosawa, Tomoyuki Nakamura, Hiroyuki Ohbe, Hiroshi Okamoto, Hidenobu Shigemitsu…

Oxygen administration for patients with ARDS

Acute respiratory distress syndrome (ARDS) is a fatal condition with insufficiently clarified etiology. Supportive care for severe hypoxemia remains the mainstay of essential interventions for ARDS. In recent ...

Authors: Shinichiro Ohshimo

Prediction of patients requiring intensive care for COVID-19: development and validation of an integer-based score using data from Centers for Disease Control and Prevention of South Korea

Unavailability or saturation of the intensive care unit may be associated with the fatality of COVID-19. Prioritizing the patients for hospitalization and intensive care may be critical for reducing the fatali...

Authors: JoonNyung Heo, Deokjae Han, Hyung-Jun Kim, Daehyun Kim, Yeon-Kyeng Lee, Dosang Lim, Sung Ok Hong, Mi-Jin Park, Beomman Ha and Woong Seog

Self-citation policies and journal self-citation rate among Critical Care Medicine journals

Inappropriate authors’ self-citation (A-SC) is a growing mal-practice possibly boosted by the raising importance given to author’s metrics. Similarly, also excessive journals’ self-citation (J-SC) practice may...

Authors: Filippo Sanfilippo, Stefano Tigano, Alberto Morgana, Paolo Murabito and Marinella Astuto

The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?

The acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing p...

Authors: Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen and John Fraser

The effect of incorporating an arterial pH target during apnea test for brain death determination

Persistent apnea despite an adequate rise in arterial pressure of CO₂ is an essential component of the criteria for brain death (BD) determination. Current guidelines vary regarding the utility of arterial pH cha...

Authors: Ibrahim Migdady, Moein Amin, Aaron Shoskes, Catherine Hassett, Sung-Min Cho, Pravin George and Alexander Rae-Grant

Advanced echocardiographic phenotyping of critically ill patients with coronavirus-19 sepsis: a prospective cohort study

Sepsis is characterized by various hemodynamic alterations which could happen concomitantly in the heart, pulmonary and systemic circulations. A comprehensive demonstration of their interactions in the clinica...

Authors: François Bagate, Paul Masi, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux, Genevieve Derumeaux and Armand Mekontso Dessap

The effect of vitamin K on prothrombin time in critically ill patients: an observational registry study

Previous studies have indicated that vitamin K deficiency is common in non-bleeding critically ill patients with slightly prolonged prothrombin time-international normalized ratio (PT-INR). It has never been i...

Authors: Sofia Dahlberg, Ulf Schött and Thomas Kander

Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia

SARS-CoV-2 may cause acute lung injury, and secondary infections are thus relevant complications in patients with COVID-19 pneumonia. However, detailed information on community- and hospital-acquired infection...

Authors: Kirstine K. Søgaard, Veronika Baettig, Michael Osthoff, Stephan Marsch, Karoline Leuzinger, Michael Schweitzer, Julian Meier, Stefano Bassetti, Roland Bingisser, Christian H. Nickel, Nina Khanna, Sarah Tschudin-Sutter, Maja Weisser, Manuel Battegay, Hans H. Hirsch, Hans Pargger…

Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis

This systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19).

Authors: Arief Wibowo, Raymond Pranata, Astri Astuti, Badai Bhatara Tiksnadi, Erwan Martanto, Januar Wibawa Martha, Augustine Purnomowati and Mohammad Rizki Akbar

Energy expenditure and indirect calorimetry in critical illness and convalescence: current evidence and practical considerations

The use of indirect calorimetry is strongly recommended to guide nutrition therapy in critically ill patients, preventing the detrimental effects of under- and overfeeding. However, the course of energy expend...

Authors: Hanneke Pierre Franciscus Xaverius Moonen, Karin Josephina Hubertina Beckers and Arthur Raymond Hubert van Zanten

Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial

To demonstrate feasibility of a music medicine intervention trial in pediatric intensive care and to obtain information on sedation and analgesia dose variation to plan a larger trial.

Authors: Gonzalo Garcia Guerra, Ari R. Joffe, Cathy Sheppard, Krista Hewson, Irina A. Dinu, Morteza Hajihosseini, Allan deCaen, Hsing Jou, Lisa Hartling and Sunita Vohra

Machine learning-based prediction models for accidental hypothermia patients

Accidental hypothermia is a critical condition with high risks of fatal arrhythmia, multiple organ failure, and mortality; however, there is no established model to predict the mortality. The present study aim...

Authors: Yohei Okada, Tasuku Matsuyama, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Ryoji Iiduka and Shigeru Ohtsuru

Psychological effects of remote-only communication among reference persons of ICU patients during COVID-19 pandemic

During COVID-19 pandemic, visits have been prohibited in most French ICUs. Psychological effects, for reference persons (RPs), of remote-only communication have been assessed.

Authors: Jessy Cattelan, Sara Castellano, Hamid Merdji, Jean Audusseau, Baptiste Claude, Léa Feuillassier, Sibylle Cunat, Marc Astrié, Camille Aquin, Guillaume Buis, Edgar Gehant, Amandine Granier, Hassiba Kercha, Camille Le Guillou, Guillaume Martin, Kevin Roulot…

Brain monitoring using near-infrared spectroscopy to predict outcome after cardiac arrest: a novel phenotype in a rat model of cardiac arrest

Improving neurological outcomes after cardiac arrest (CA) is the most important patient-oriented outcome for CA research. Near-infrared spectroscopy (NIRS) enables a non-invasive, real-time measurement of regi...

Authors: Ryosuke Takegawa, Kei Hayashida, Rishabh Choudhary, Daniel M. Rolston and Lance B. Becker

Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study)

The lack of precise information on the epidemiology of peripheral intravascular catheter (PIVC)-related phlebitis and complications in critically ill patients results in the absence of appropriate preventive m...

Authors: Hideto Yasuda, Ryohei Yamamoto, Yoshiro Hayashi, Yuki Kotani, Yuki Kishihara, Natsuki Kondo, Kosuke Sekine, Nobuaki Shime, Keita Morikane, Takayuki Abe, Toru Takebayashi, Mikihiro Maeda, Takuya Shiga, Taku Furukawa, Mototaka Inaba, Sachito Fukuda…

Characteristics and outcomes of patients admitted to adult intensive care units in Hong Kong: a population retrospective cohort study from 2008 to 2018

Globally, mortality rates of patients admitted to the intensive care unit (ICU) have decreased over the last two decades. However, evaluations of the temporal trends in the characteristics and outcomes of ICU ...

Authors: Lowell Ling, Chun Ming Ho, Pauline Yeung Ng, King Chung Kenny Chan, Hoi Ping Shum, Cheuk Yan Chan, Alwin Wai Tak Yeung, Wai Tat Wong, Shek Yin Au, Kit Hung Anne Leung, Jacky Ka Hing Chan, Chi Keung Ching, Oi Yan Tam, Hin Hung Tsang, Ting Liong, Kin Ip Law…

The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial

Aggressive fluid administration is recommended in the resuscitation of septic patients. However, the delivery of a rapid fluid bolus might cause harm by inducing degradation of the endothelial glycocalyx. This...

Authors: Jutamas Saoraya, Lipda Wongsamita, Nattachai Srisawat and Khrongwong Musikatavorn

Correction to: Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs

An amendment to this paper has been published and can be accessed via the original article.

Authors: Lorenzo Gamberini, Tommaso Tonetti, Savino Spadaro, Gianluca Zani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Alberto Fogagnolo, Maurizio Fusari…

Biological effects of the oxygen molecule in critically ill patients

The medical use of oxygen has been widely and frequently proposed for patients, especially those under critical care; however, its benefit and drawbacks remain controversial for certain conditions. The inducti...

Authors: Masaki Nakane

The effect of recombinant human soluble thrombomodulin on renal function and mortality in septic disseminated intravascular coagulation patients with acute kidney injury: a retrospective study

Clinical evidence showing the effectiveness of recombinant human soluble thrombomodulin (rhTM) for treating sepsis-induced disseminated intravascular coagulation (DIC) and organ dysfunction (particularly renal...

Authors: Masayuki Akatsuka, Yoshiki Masuda, Hiroomi Tatsumi and Tomoko Sonoda

Ensuring competency in focused cardiac ultrasound: a systematic review of training programs

Focused cardiac ultrasound (FoCUS) is a valuable skill for rapid assessment of cardiac function and volume status. Despite recent widespread adoption among physicians, there is limited data on the optimal trai...

Authors: Lauren E. Gibson, Gabrielle A. White-Dzuro, Patrick J. Lindsay, Sheri M. Berg, Edward A. Bittner and Marvin G. Chang

Electromagnetic-guided versus endoscopic placement of post-pyloric feeding tubes: a systematic review and meta-analysis of randomised controlled trials

Current evidence supporting the utility of electromagnetic (EM)-guided method as the preferred technique for post-pyloric feeding tube placement is limited. We conducted a meta-analysis to compare the performa...

Authors: Yaping Wei, Zheng Jin, Ying Zhu and Wei Hu

Corticosteroid treatment for early acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials

The effect of corticosteroid treatment on survival outcome in early acute respiratory distress syndrome (ARDS) is still debated. We conducted a systematic review and meta-analysis of randomized controlled tria...

Authors: Yohei Hirano, Shunsuke Madokoro, Yutaka Kondo, Ken Okamoto and Hiroshi Tanaka

Association between visitation restriction during the COVID-19 pandemic and delirium incidence among emergency admission patients: a single-center retrospective observational cohort study in Japan

This study aimed to identify the association between total visitation restriction because of the coronavirus 2019 (COVID-19) pandemic and the incidence of delirium for emergency inpatients.

Authors: Kenji Kandori, Yohei Okada, Wataru Ishii, Hiromichi Narumiya, Yoshiro Maebayashi and Ryoji Iizuka

Ginsenoside ameliorated ventilator-induced lung injury in rats

Ginsenosides have antioxidant and anti-inflammatory features. This study aimed to evaluate the biologic effects of ginsenoside Rb2 pretreatment on ventilator-induced lung injury (VILI) in rats.

Authors: Woo Hyun Cho, Yun Hak Kim, Hye Jin Heo, Dohyung Kim, Tae Won Kwak, Kwang Ho Kim and Hye Ju Yeo

Prevalence and prognostic value of elevated troponins in patients hospitalised for coronavirus disease 2019: a systematic review and meta-analysis

The clinical significance of cardiac troponin measurement in patients hospitalised for coronavirus disease 2019 (covid-19) is uncertain. We investigated the prevalence of elevated troponins in these patients a...

Authors: Bing-Cheng Zhao, Wei-Feng Liu, Shao-Hui Lei, Bo-Wei Zhou, Xiao Yang, Tong-Yi Huang, Qi-Wen Deng, Miao Xu, Cai Li and Ke-Xuan Liu

Upper limb muscle atrophy associated with in-hospital mortality and physical function impairments in mechanically ventilated critically ill adults: a two-center prospective observational study

Lower limb muscle atrophy is often observed in critically ill patients. Although upper limb muscles can undergo atrophy, it remains unclear how this atrophy is associated with clinical outcomes. We hypothesize...

Authors: Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Yusuke Akimoto, Yuki Nakano and Masaji Nishimura

The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome

Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but breakpoints of target attainment are mostly based on expert opinions. Studies that show a correlation between target attainment and...

Authors: Christina Scharf, Uwe Liebchen, Michael Paal, Max Taubert, Michael Vogeser, Michael Irlbeck, Michael Zoller and Ines Schroeder

Glycoprotein IIb/IIIa inhibitors for cardiogenic shock complicating acute myocardial infarction: a systematic review, meta-analysis, and meta-regression

Cardiogenic shock complicates 5–10% of myocardial infarction (MI) cases. Data about the benefit of glycoprotein IIb/IIIa inhibitors (GPI) in these patients is sparse and conflicting.

Authors: Carolina Saleiro, Rogério Teixeira, Diana De Campos, João Lopes, Bárbara Oliveiros, Marco Costa and Lino Gonçalves

Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis

The aim of this study was to systematically assess the accuracy of circulating microRNAs (miRNAs) as a promising biomarker for sepsis via a meta-analysis.

Authors: Xiaomin Shen, Jiajie Zhang, Yicheng Huang, Jiepeng Tong, Li Zhang, Zhijuan Zhang, Wei Yu and Yunqing Qiu

Non-catecholamine vasopressors in the treatment of adult patients with septic shock—evidence from meta-analysis and trial sequential analysis of randomized clinical trials

Norepinephrine (NE) has currently been the first-choice vasopressor in treating septic shock despite generally insufficient for patients with refractory septic shock. The aim of this update meta-analysis was t...

Authors: Lei Zhong, Xiao-Wei Ji, Hai-Li Wang, Guang-Ming Zhao, Qing Zhou and Bo Xie

The mortality of critically ill patients was not associated with inter-hospital transfer due to a shortage of ICU beds - a single-centre retrospective analysis

Patients in the intensive care unit (ICU) are increasingly being transferred between ICUs due to a shortage of ICU beds, although this practice is potentially harmful. However, in tertiary units, the transfer ...

Authors: Jonatan Oras, Marko Strube and Christian Rylander

Efficacy of probiotics in the prevention of VAP in critically ill ICU patients: an updated systematic review and meta-analysis of randomized control trials

Ventilator-associated pneumonia (VAP) is reported as the second most common nosocomial infection among critically ill patients with the incidence ranging from 2 to 16 episodes per 1000 ventilator days. The use...

Authors: Priyam Batra, Kapil Dev Soni and Purva Mathur

Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs

A large proportion of patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure requiring admission to the intensive care unit (ICU) and about 80% of them need mechanical ventilation...

Authors: Lorenzo Gamberini, Tommaso Tonetti, Savino Spadaro, Gianluca Zani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Alberto Fogagnolo, Maurizio Fusari…

Oxygen administration for postoperative surgical patients: a narrative review

Most postoperative surgical patients routinely receive supplemental oxygen therapy to prevent the potential development of hypoxemia due to incomplete lung re-expansion, reduced chest wall, and diaphragmatic a...

Authors: Satoshi Suzuki