Fig. 3
Individual patient data on two primary study outcomes and major determinants of right ventricular function. a Primary outcome no. 1, the right-to-left ventricular end-diastolic area ratio (RVEDA/LVEDA). b Primary outcome no. 2, the end-diastolic eccentricity index. c Determinant of right ventricular function no. 1, the arterial carbon dioxide tension (PaCO2). d Determinant of right ventricular function no. 2, the mean airway pressure. CV1 first period of conventional ventilation, HFO high-frequency oscillation, TGI tracheal gas insufflation, CV2 second period of conventional ventilation (see also “Methods” and Fig. 1). Numbers (from 1 to 17) just above the colored lines that connect the data points (triangles) indicate patient no.; the color of each “data-point-connecting line” is unique for each one of the patients. Horizontal black bars correspond to mean values. For each ventilatory strategy, summary data are also reported as mean ± SD. “Effect of Strategy” corresponds to the level of significance of the effect of the fixed, within-subjects factor (i.e., ventilatory strategy) in linear mixed-model analysis (see also the “Statistical Analysis” subsection); additional mixed-model data: a Percent variation explained 87, calculated as 100 × R2 value of bivariate linear regression between observed and mixed model-predicted values; b percent variation explained, 72; c percent variation explained, 74. *p < 0.05 versus CV1. †p < 0.05 versus 4-Hz HFO. ‡p < 0.05 versus 4-Hz HFO-TGI. §p < 0.05 versus 7-Hz HFO. Actual p values of pairwise comparisons are reported in Additional file 2