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  1. Content type: Research

    The long-term economic and quality-of-life outcomes of patients admitted to intensive care unit (ICU) with acute respiratory distress syndrome are not well understood. In this study, we investigate 1-year cost...

    Authors: Joachim Marti, Peter Hall, Patrick Hamilton, Sarah Lamb, Chris McCabe, Ranjit Lall, Julie Darbyshire, Duncan Young and Claire Hulme

    Citation: Journal of Intensive Care 2016 4:56

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  2. Content type: Letter to the Editor

    The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NET...

    Authors: Yasuyo Shimomura, Mika Suga, Naohide Kuriyama, Tomoyuki Nakamura, Toshikazu Sakai, Yu Kato, Yoshitaka Hara, Chizuru Yamashita, Hiroshi Nagasaki, Masao Kaneki and Osamu Nishida

    Citation: Journal of Intensive Care 2016 4:48

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  3. Content type: Research

    Families of cancer patients in the ICU often experience severe stress. Understanding their experience is important for providing family-centered care during this difficult period. Little is known about the exp...

    Authors: Miyuki H. Komachi and Kiyoko Kamibeppu

    Citation: Journal of Intensive Care 2016 4:47

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  4. Content type: Letter to the Editor

    In a previous retrospective work, it has been postulated that early enteral nutrition was a protective factor against late defecation and its subsequent consequences in critically ill patients. We raise concer...

    Authors: Dominique Prat and Benjamin Sztrymf

    Citation: Journal of Intensive Care 2016 4:46

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    The Erratum to this article has been published in Journal of Intensive Care 2016 4:60

    The original article was published in Journal of Intensive Care 2016 4:33

  5. Content type: Commentary

    The presence of acid-base disturbances, especially metabolic acidosis may negatively affect the outcome of critically ill patients. Lactic acidosis is the most frequent etiology and has largest impact on the p...

    Authors: Yoshifumi Kotake

    Citation: Journal of Intensive Care 2016 4:45

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    The original article was published in Journal of Intensive Care 2016 4:43

  6. Content type: Letter to the Editor

    Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sep...

    Authors: Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Kazuma Yamakawa, Daisuke Kudo, Yusuke Iizuka, Masamitsu Sanui, Kohei Takimoto, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Katsura Hayakawa, Tsuyoshi Nakashima, Takayuki Ogura, Eiichiro Noda…

    Citation: Journal of Intensive Care 2016 4:44

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  7. Content type: Research

    This cohort study compared the prognostic significance of strong ion gap (SIG) with other acid-base markers in the critically ill.

    Authors: Kwok M. Ho, Norris S. H. Lan, Teresa A. Williams, Yusra Harahsheh, Andrew R. Chapman, Geoffrey J. Dobb and Sheldon Magder

    Citation: Journal of Intensive Care 2016 4:43

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    The Commentary to this article has been published in Journal of Intensive Care 2016 4:45

  8. Content type: Research

    The mortality rate from septic shock has been declining. Cerebral hypoxia, measured non-invasively with cerebral oximetry, has been correlated with neurologic and non-neurologic sequelae. Whether cerebral desa...

    Authors: Duane J. Funk, Anand Kumar and Gregory Klar

    Citation: Journal of Intensive Care 2016 4:42

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  9. Content type: Research

    Acute kidney injury (AKI) is a serious complication after cardiac surgery, being associated with a high mortality. We assessed three urinary biomarkers, L-type fatty acid-binding protein (L-FABP), neutrophil g...

    Authors: Takahiro Moriyama, Shintaro Hagihara, Toko Shiramomo, Misaki Nagaoka, Shohei Iwakawa and Yuichi Kanmura

    Citation: Journal of Intensive Care 2016 4:41

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  10. Content type: Research

    The Deyo-Charlson Comorbidity Index (DCCI) has low predictive value in the intensive care unit (ICU). Our goal was to determine whether addition of 25-hydroxyvitamin D (25OHD) levels to the DCCI improved 90-da...

    Authors: Bisundev Mahato, Tiffany M. N. Otero, Carrie A. Holland, Patrick T. Giguere, Ednan K. Bajwa, Carlos A. Camargo Jr. and Sadeq A. Quraishi

    Citation: Journal of Intensive Care 2016 4:40

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  11. Content type: Research

    Macrophage migration inhibitory factor (MIF) is known to amplify the immune response in septic animal models. Few clinical data support this pro-inflammatory role in septic patients. Renal replacement therapy ...

    Authors: Julia Pohl, Maria Papathanasiou, Martin Heisler, Pia Stock, Malte Kelm, Ulrike B. Hendgen-Cotta, Tienush Rassaf and Peter Luedike

    Citation: Journal of Intensive Care 2016 4:39

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  12. Content type: Research

    The right heart often receives less attention during echocardiography. The situation is no different in septic shock. We prospectively investigated the echocardiographic indices of the right heart in septic sh...

    Authors: Ratender Kumar Singh, Sudeep Kumar, Sreevatsa Nadig, Arvind Kumar Baronia, Banani Poddar, Afzal Azim and Mohan Gurjar

    Citation: Journal of Intensive Care 2016 4:38

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  13. Content type: Research

    Alarmins, including high-mobility group box 1 (HMGB-1), can be released from damaged tissues and activated cells as inflammatory mediators. We aimed to evaluate HMGB-1 and mitochondrial DNA dynamics and estima...

    Authors: Taku Omura, Shigeki Kushimoto, Satoshi Yamanouchi, Daisuke Kudo and Noriko Miyagawa

    Citation: Journal of Intensive Care 2016 4:37

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  14. Content type: Review

    This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temper...

    Authors: Yasuhiro Kuroda

    Citation: Journal of Intensive Care 2016 4:36

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    The Erratum to this article has been published in Journal of Intensive Care 2016 4:49

  15. Content type: Research

    Quality benchmarks are increasingly being used to compare the delivery of healthcare, and may affect reimbursement in the future. The University Health Consortium (UHC) expected probability of mortality (EPM) ...

    Authors: Angela K. M. Lipshutz, John R. Feiner, Barbara Grimes and Michael A. Gropper

    Citation: Journal of Intensive Care 2016 4:35

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  16. Content type: Research

    Sepsis is associated with coagulation abnormalities, and a high content of intravascular tissue factor (TF) may contribute to the development of multisystem organ failure. Circulating microvesicles (MVs) are i...

    Authors: Carolin Trepesch, Ramona Nitzsche, Aenne Glass, Bernd Kreikemeyer, Jochen K. Schubert and Sonja Oehmcke-Hecht

    Citation: Journal of Intensive Care 2016 4:34

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  17. Content type: Research

    Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecati...

    Authors: Shinya Fukuda, Takashi Miyauchi, Motoki Fujita, Yasutaka Oda, Masaki Todani, Yoshikatsu Kawamura, Kotaro Kaneda and Ryosuke Tsuruta

    Citation: Journal of Intensive Care 2016 4:33

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    The Letter to the Editor to this article has been published in Journal of Intensive Care 2016 4:46

  18. Content type: Research

    Protein deficiency is a major problem in critically ill patients. Egg white powder recently became a standard additive for protein supplementation in our unit. However, clinical data are not available to suppo...

    Authors: Rungsun Bhurayanontachai and Sunatee Sa-nguansai

    Citation: Journal of Intensive Care 2016 4:32

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  19. Content type: Review

    Cardiac arrest induces the cessation of cerebral blood flow, which can result in brain damage. The primary intervention to salvage the brain unde...

    Authors: Hiroyuki Uchino, Yukihiko Ogihara, Hidekimi Fukui, Miyuki Chijiiwa, Shusuke Sekine, Naomi Hara and Eskil Elmér

    Citation: Journal of Intensive Care 2016 4:31

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    The Retraction Note to this article has been published in Journal of Intensive Care 2016 4:61

  20. Content type: Review

    Traumatic brain injury (TBI) is recognized as the significant cause of mortality and morbidity in the world. To reduce unfavorable outcome in TBI patients, many researches have made much efforts for the innova...

    Authors: Shoji Yokobori and Hiroyuki Yokota

    Citation: Journal of Intensive Care 2016 4:28

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  21. Content type: Review

    Perioperative hypovolemia and fluid overload have effects on both complications following surgery and on patient survival. Therefore, the administration of intravenous fluids before, during, and after surgery ...

    Authors: Anders Winther Voldby and Birgitte Brandstrup

    Citation: Journal of Intensive Care 2016 4:27

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  22. Content type: Case report

    Patient-ventilator asynchrony is a major cause of difficult weaning from mechanical ventilation. Neurally adjusted ventilatory assist (NAVA) is reported useful to improve the synchrony in patients with sustain...

    Authors: Yuya Goto, Shinshu Katayama, Atsuko Shono, Yosuke Mori, Yuya Miyazaki, Yoko Sato, Makoto Ozaki and Toru Kotani

    Citation: Journal of Intensive Care 2016 4:26

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  23. Content type: Research

    The early prediction of neurological outcomes in postcardiac arrest patients treated with therapeutic hypothermia (TH) remains challenging. Amplitude-integrated electroencephalography (aEEG) is a type of quant...

    Authors: Kazuhiro Sugiyama, Masahiro Kashiura, Akiko Akashi, Takahiro Tanabe and Yuichi Hamabe

    Citation: Journal of Intensive Care 2016 4:25

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  24. Content type: Review

    Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategie...

    Authors: Alexandre Mebazaa, Pierre François Laterre, James A. Russell, Andreas Bergmann, Luciano Gattinoni, Etienne Gayat, Michael O. Harhay, Oliver Hartmann, Frauke Hein, Anne Louise Kjolbye, Matthieu Legrand, Roger J. Lewis, John C. Marshall, Gernot Marx, Peter Radermacher, Mathias Schroedter…

    Citation: Journal of Intensive Care 2016 4:24

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  25. Content type: Review

    Sepsis is frequently complicated by coagulopathy and, in about 35 % of severe cases, by disseminated intravascular coagulation (DIC). In Japan, aggressive treatment of septic DIC is encouraged using antithromb...

    Authors: Kohji Okamoto, Toshihisa Tamura and Yusuke Sawatsubashi

    Citation: Journal of Intensive Care 2016 4:23

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  26. Content type: Review

    Sepsis is aggravated by an inappropriate immune response to invading microorganisms, which occasionally leads to multiple organ failure. Several lines of evidence suggest that the ventricular myocardium is dep...

    Authors: Yasuyuki Kakihana, Takashi Ito, Mayumi Nakahara, Keiji Yamaguchi and Tomotsugu Yasuda

    Citation: Journal of Intensive Care 2016 4:22

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  27. Content type: Review

    The term sepsis-associated encephalopathy (SAE) has been applied to animal models, postmortem studies in patients, and severe cases of sepsis. SAE is considered to include all types of brain dysfunction, inclu...

    Authors: Ryosuke Tsuruta and Yasutaka Oda

    Citation: Journal of Intensive Care 2016 4:18

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  28. Content type: Review

    Kidney injury, including acute kidney injury (AKI) and chronic kidney disease (CKD), has become very common in critically ill patients treated in ICUs. Many epidemiological studies have revealed significant as...

    Authors: Kent Doi

    Citation: Journal of Intensive Care 2016 4:17

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  29. Content type: Review

    Microcirculatory alterations are frequently observed in critically ill patients undergoing major surgery and those who suffer from trauma or sepsis. Despite the need for adequate fluid administration to restor...

    Authors: Tsuneo Tatara

    Citation: Journal of Intensive Care 2016 4:20

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  30. Content type: Review

    The availability of direct oral anticoagulants (DOACs) has caused a paradigm shift in thrombosis management. DOAC profiles do not differ greatly, though they are quite different from that of warfarin, whereas ...

    Authors: Masahiro Ieko, Sumiyoshi Naitoh, Mika Yoshida and Nobuhiko Takahashi

    Citation: Journal of Intensive Care 2016 4:19

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  31. Content type: Research

    Intensive care unit (ICU) scoring systems or prediction models evolved to meet the desire of clinical and administrative leaders to assess the quality of care provided by their ICUs. The Critical Care Informat...

    Authors: Raymond Kao, Fran Priestap and Allan Donner

    Citation: Journal of Intensive Care 2016 4:16

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  32. Content type: Review

    The type of medical review before an adverse event influences patient outcome. Delays in the up-transfer of patients requiring intensive care are associated with higher mortality rates. Timely detection and re...

    Authors: Krishnaswamy Sundararajan, Arthas Flabouris and Campbell Thompson

    Citation: Journal of Intensive Care 2016 4:15

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  33. Content type: Research

    The components of nucleosomes, which contain DNA and histones, are released into the circulation from damaged cells and can promote inflammation. We studied whether the on-admission levels of circulating nucle...

    Authors: Anne K. Penttilä, Ari Rouhiainen, Leena Kylänpää, Harri Mustonen, Pauli Puolakkainen, Heikki Rauvala and Heikki Repo

    Citation: Journal of Intensive Care 2016 4:14

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  34. Content type: Research

    Based on the proven efficacy of lactate in predicting mortality and morbidity in sepsis when measured early in the resuscitative protocol, our group hypothesized that this utility extends later in the course o...

    Authors: Jason Chertoff, Michael Chisum, Lauren Simmons, Brent King, Michael Walker and Jorge Lascano

    Citation: Journal of Intensive Care 2016 4:13

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  35. Content type: Research

    Physiological abnormalities are often observed in patients prior to cardiac arrest. A modified early warning score (MEWS) system was introduced, which aims to detect early abnormalities by grading vital signs,...

    Authors: Isao Nishijima, Shouhei Oyadomari, Shuuto Maedomari, Risa Toma, Chisato Igei, Shinya Kobata, Jyun Koyama, Ryuichiro Tomori, Natsuki Kawamitsu, Yoshiki Yamamoto, Masafumi Tsuchida, Yoshihiro Tokeshi, Ryo Ikemura, Kazufumi Miyagi, Koichi Okiyama and Kiyoshi Iha

    Citation: Journal of Intensive Care 2016 4:12

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  36. Content type: Research

    We established a multi-center, prospective cohort that could provide appropriate therapeutic strategies such as criteria for the introduction and the effectiveness of in-hospital advanced treatments, including...

    Authors: Tomoki Yamada, Tetsuhisa Kitamura, Koichi Hayakawa, Kazuhisa Yoshiya, Taro Irisawa, Yoshio Abe, Megumi Ishiro, Toshifumi Uejima, Yasuo Ohishi, Kazuhisa Kaneda, Takeyuki Kiguchi, Masashi Kishi, Masafumi Kishimoto, Shota Nakao, Tetsuro Nishimura, Yasuyuki Hayashi…

    Citation: Journal of Intensive Care 2016 4:10

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  37. Content type: Research

    The clinical impact of arrhythmias on the continuum of critical illness is unclear, and data in medical intensive care units (ICU) is lacking. In this study, we distinguish between different types of arrhythmi...

    Authors: Rodrigo J. Valderrábano, Alejandro Blanco, Eduardo J. Santiago-Rodriguez, Christine Miranda, José Rivera-del Rio del Rio, Juan Ruiz and Robert Hunter

    Citation: Journal of Intensive Care 2016 4:9

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  38. Content type: Research

    We often administer adrenaline to improve hypotension of patients undergoing systemic inflammation that is not treated with volume resuscitation. The effects of adrenaline on injured lungs during shock status ...

    Authors: Shuhei Ota, Takuya Yazawa, Kentaro Tojo, Yasuko Baba, Munehito Uchiyama, Takahisa Goto and Kiyoyasu Kurahashi

    Citation: Journal of Intensive Care 2016 4:8

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  39. Content type: Research

    Community-acquired pneumonia (CAP) mortality exceeds 20 % in critical care patients despite appropriate antibiotic therapy. Regional tissue oxygen saturation index (rSO2) measured with near-infrared spectrosco...

    Authors: Laura Claverias, Michael Marí, Judith Marín-Corral, Mónica Magret, Sandra Trefler, María Bodí, Antonio García-España, Juan Carlos Yébenes, Sergi Pascual, Joaquim Gea and Alejandro Rodríguez

    Citation: Journal of Intensive Care 2016 4:7

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  40. Content type: Research

    Intravenously administered iodine-containing contrast medium (CM) is associated with the development of contrast-induced nephropathy (CIN). Data on the effectiveness of sodium bicarbonate therapy in the preven...

    Authors: Nicole Lefel, Loes Janssen, Jos le Noble and Norbert Foudraine

    Citation: Journal of Intensive Care 2016 4:5

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  41. Content type: Research

    The management of tracheal tube cuff pressure in patients receiving mechanical ventilation is important for the prevention of ventilator-associated pneumonia. Currently, cuff pressure is intermittently monitor...

    Authors: Junichi Michikoshi, Shigekiyo Matsumoto, Hiroshi Miyawaki, Harushi Niu, Katsuhiro Seo, Makoto Yamamoto, Shu-ichi Tokunaga and Takaaki Kitano

    Citation: Journal of Intensive Care 2016 4:4

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  42. Content type: Research

    The purposes of the study were to compare serum total cortisol (STC), salivary cortisol (SaC) and calculated free cortisol (cFC) levels at baseline and after the adrenocorticotrophic hormone (ACTH) stimulation...

    Authors: Gulsah Elbuken, Zuleyha Karaca, Fatih Tanriverdi, Kursad Unluhizarci, Murat Sungur, Mehmet Doganay and Fahrettin Kelestimur

    Citation: Journal of Intensive Care 2016 4:3

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