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  1. Content type: Review

    Perioperative hypovolemia and fluid overload have effects on both complications following surgery and on patient survival. Therefore, the administration of intravenous fluids before, during, and after surgery ...

    Authors: Anders Winther Voldby and Birgitte Brandstrup

    Citation: Journal of Intensive Care 2016 4:27

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  2. Content type: Case report

    Patient-ventilator asynchrony is a major cause of difficult weaning from mechanical ventilation. Neurally adjusted ventilatory assist (NAVA) is reported useful to improve the synchrony in patients with sustain...

    Authors: Yuya Goto, Shinshu Katayama, Atsuko Shono, Yosuke Mori, Yuya Miyazaki, Yoko Sato, Makoto Ozaki and Toru Kotani

    Citation: Journal of Intensive Care 2016 4:26

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  3. Content type: Research

    The early prediction of neurological outcomes in postcardiac arrest patients treated with therapeutic hypothermia (TH) remains challenging. Amplitude-integrated electroencephalography (aEEG) is a type of quant...

    Authors: Kazuhiro Sugiyama, Masahiro Kashiura, Akiko Akashi, Takahiro Tanabe and Yuichi Hamabe

    Citation: Journal of Intensive Care 2016 4:25

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  4. Content type: Review

    Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategie...

    Authors: Alexandre Mebazaa, Pierre François Laterre, James A. Russell, Andreas Bergmann, Luciano Gattinoni, Etienne Gayat, Michael O. Harhay, Oliver Hartmann, Frauke Hein, Anne Louise Kjolbye, Matthieu Legrand, Roger J. Lewis, John C. Marshall, Gernot Marx, Peter Radermacher, Mathias Schroedter…

    Citation: Journal of Intensive Care 2016 4:24

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  5. Content type: Review

    Sepsis is aggravated by an inappropriate immune response to invading microorganisms, which occasionally leads to multiple organ failure. Several lines of evidence suggest that the ventricular myocardium is dep...

    Authors: Yasuyuki Kakihana, Takashi Ito, Mayumi Nakahara, Keiji Yamaguchi and Tomotsugu Yasuda

    Citation: Journal of Intensive Care 2016 4:22

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  6. Content type: Review

    The term sepsis-associated encephalopathy (SAE) has been applied to animal models, postmortem studies in patients, and severe cases of sepsis. SAE is considered to include all types of brain dysfunction, inclu...

    Authors: Ryosuke Tsuruta and Yasutaka Oda

    Citation: Journal of Intensive Care 2016 4:18

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  7. Content type: Review

    Sepsis is frequently complicated by coagulopathy and, in about 35 % of severe cases, by disseminated intravascular coagulation (DIC). In Japan, aggressive treatment of septic DIC is encouraged using antithromb...

    Authors: Kohji Okamoto, Toshihisa Tamura and Yusuke Sawatsubashi

    Citation: Journal of Intensive Care 2016 4:23

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  8. Content type: Review

    Kidney injury, including acute kidney injury (AKI) and chronic kidney disease (CKD), has become very common in critically ill patients treated in ICUs. Many epidemiological studies have revealed significant as...

    Authors: Kent Doi

    Citation: Journal of Intensive Care 2016 4:17

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  9. Content type: Review

    Microcirculatory alterations are frequently observed in critically ill patients undergoing major surgery and those who suffer from trauma or sepsis. Despite the need for adequate fluid administration to restor...

    Authors: Tsuneo Tatara

    Citation: Journal of Intensive Care 2016 4:20

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  10. Content type: Review

    The availability of direct oral anticoagulants (DOACs) has caused a paradigm shift in thrombosis management. DOAC profiles do not differ greatly, though they are quite different from that of warfarin, whereas ...

    Authors: Masahiro Ieko, Sumiyoshi Naitoh, Mika Yoshida and Nobuhiko Takahashi

    Citation: Journal of Intensive Care 2016 4:19

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  11. Content type: Research

    Intensive care unit (ICU) scoring systems or prediction models evolved to meet the desire of clinical and administrative leaders to assess the quality of care provided by their ICUs. The Critical Care Informat...

    Authors: Raymond Kao, Fran Priestap and Allan Donner

    Citation: Journal of Intensive Care 2016 4:16

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  12. Content type: Review

    The type of medical review before an adverse event influences patient outcome. Delays in the up-transfer of patients requiring intensive care are associated with higher mortality rates. Timely detection and re...

    Authors: Krishnaswamy Sundararajan, Arthas Flabouris and Campbell Thompson

    Citation: Journal of Intensive Care 2016 4:15

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  13. Content type: Research

    The components of nucleosomes, which contain DNA and histones, are released into the circulation from damaged cells and can promote inflammation. We studied whether the on-admission levels of circulating nucle...

    Authors: Anne K. Penttilä, Ari Rouhiainen, Leena Kylänpää, Harri Mustonen, Pauli Puolakkainen, Heikki Rauvala and Heikki Repo

    Citation: Journal of Intensive Care 2016 4:14

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  14. Content type: Research

    Based on the proven efficacy of lactate in predicting mortality and morbidity in sepsis when measured early in the resuscitative protocol, our group hypothesized that this utility extends later in the course o...

    Authors: Jason Chertoff, Michael Chisum, Lauren Simmons, Brent King, Michael Walker and Jorge Lascano

    Citation: Journal of Intensive Care 2016 4:13

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  15. Content type: Research

    Physiological abnormalities are often observed in patients prior to cardiac arrest. A modified early warning score (MEWS) system was introduced, which aims to detect early abnormalities by grading vital signs,...

    Authors: Isao Nishijima, Shouhei Oyadomari, Shuuto Maedomari, Risa Toma, Chisato Igei, Shinya Kobata, Jyun Koyama, Ryuichiro Tomori, Natsuki Kawamitsu, Yoshiki Yamamoto, Masafumi Tsuchida, Yoshihiro Tokeshi, Ryo Ikemura, Kazufumi Miyagi, Koichi Okiyama and Kiyoshi Iha

    Citation: Journal of Intensive Care 2016 4:12

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  16. Content type: Research

    We established a multi-center, prospective cohort that could provide appropriate therapeutic strategies such as criteria for the introduction and the effectiveness of in-hospital advanced treatments, including...

    Authors: Tomoki Yamada, Tetsuhisa Kitamura, Koichi Hayakawa, Kazuhisa Yoshiya, Taro Irisawa, Yoshio Abe, Megumi Ishiro, Toshifumi Uejima, Yasuo Ohishi, Kazuhisa Kaneda, Takeyuki Kiguchi, Masashi Kishi, Masafumi Kishimoto, Shota Nakao, Tetsuro Nishimura, Yasuyuki Hayashi…

    Citation: Journal of Intensive Care 2016 4:10

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  17. Content type: Research

    The clinical impact of arrhythmias on the continuum of critical illness is unclear, and data in medical intensive care units (ICU) is lacking. In this study, we distinguish between different types of arrhythmi...

    Authors: Rodrigo J. Valderrábano, Alejandro Blanco, Eduardo J. Santiago-Rodriguez, Christine Miranda, José Rivera-del Rio del Rio, Juan Ruiz and Robert Hunter

    Citation: Journal of Intensive Care 2016 4:9

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  18. Content type: Research

    We often administer adrenaline to improve hypotension of patients undergoing systemic inflammation that is not treated with volume resuscitation. The effects of adrenaline on injured lungs during shock status ...

    Authors: Shuhei Ota, Takuya Yazawa, Kentaro Tojo, Yasuko Baba, Munehito Uchiyama, Takahisa Goto and Kiyoyasu Kurahashi

    Citation: Journal of Intensive Care 2016 4:8

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  19. Content type: Research

    Community-acquired pneumonia (CAP) mortality exceeds 20 % in critical care patients despite appropriate antibiotic therapy. Regional tissue oxygen saturation index (rSO2) measured with near-infrared spectrosco...

    Authors: Laura Claverias, Michael Marí, Judith Marín-Corral, Mónica Magret, Sandra Trefler, María Bodí, Antonio García-España, Juan Carlos Yébenes, Sergi Pascual, Joaquim Gea and Alejandro Rodríguez

    Citation: Journal of Intensive Care 2016 4:7

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  20. Content type: Research

    The management of tracheal tube cuff pressure in patients receiving mechanical ventilation is important for the prevention of ventilator-associated pneumonia. Currently, cuff pressure is intermittently monitor...

    Authors: Junichi Michikoshi, Shigekiyo Matsumoto, Hiroshi Miyawaki, Harushi Niu, Katsuhiro Seo, Makoto Yamamoto, Shu-ichi Tokunaga and Takaaki Kitano

    Citation: Journal of Intensive Care 2016 4:4

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  21. Content type: Research

    Intravenously administered iodine-containing contrast medium (CM) is associated with the development of contrast-induced nephropathy (CIN). Data on the effectiveness of sodium bicarbonate therapy in the preven...

    Authors: Nicole Lefel, Loes Janssen, Jos le Noble and Norbert Foudraine

    Citation: Journal of Intensive Care 2016 4:5

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  22. Content type: Research

    The purposes of the study were to compare serum total cortisol (STC), salivary cortisol (SaC) and calculated free cortisol (cFC) levels at baseline and after the adrenocorticotrophic hormone (ACTH) stimulation...

    Authors: Gulsah Elbuken, Zuleyha Karaca, Fatih Tanriverdi, Kursad Unluhizarci, Murat Sungur, Mehmet Doganay and Fahrettin Kelestimur

    Citation: Journal of Intensive Care 2016 4:3

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  23. Content type: Research

    Severity of illness is an important consideration in making the decision to transfuse as it is the sicker patient that often needs a red cell transfusion. Red blood cell (RBC) transfusions could potentially ha...

    Authors: Surender Rajasekaran, Eric Kort, Richard Hackbarth, Alan T. Davis, Dominic Sanfilippo, Robert Fitzgerald, Sandra Zuiderveen, Akunne N. Ndika, Hilary Beauchamp, Anthony Olivero and Nabil Hassan

    Citation: Journal of Intensive Care 2016 4:2

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  24. Content type: Letter to the Editor

    We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated prote...

    Authors: Subrina Jesmin, Satoshi Gando, Takeshi Wada, Mineji Hayakawa and Atsushi Sawamura

    Citation: Journal of Intensive Care 2016 4:1

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  25. Content type: Research

    Determination of a patient’s volume status remains challenging. Ultrasound assessments of the inferior vena cava and lung parenchyma have been shown to reflect fluid status when compared to the more traditiona...

    Authors: Nawal Salahuddin, Iqbal Hussain, Hakam Alsaidi, Quratulain Shaikh, Mini Joseph, Hassan Hawa and Khalid Maghrabi

    Citation: Journal of Intensive Care 2015 3:55

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  26. Content type: Review

    Intensive care unit (ICU)-acquired infections are a challenging health problem worldwide, especially when caused by multidrug-resistant (MDR) pathogens. In ICUs, inanimate surfaces and equipment (e.g., bedrail...

    Authors: Vincenzo Russotto, Andrea Cortegiani, Santi Maurizio Raineri and Antonino Giarratano

    Citation: Journal of Intensive Care 2015 3:54

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  27. Content type: Research

    Delirium in intensive care units increases morbidity and mortality risk. The incidence and risk factors of delirium vary among studies. This study therefore aimed to determine the incidence and risk factors of...

    Authors: Tanyong Pipanmekaporn, Kaweesak Chittawatanarat, Onuma Chaiwat, Thammasak Thawitsri, Petch Wacharasint and Suneerat Kongsayreepong

    Citation: Journal of Intensive Care 2015 3:53

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  28. Content type: Research

    Delirium occurs in the intensive care unit and identification is often performed using a validated assessment tool such as the Confusion Assessment Method for Intensive Care Unit (CAM-ICU) patients. The CAM-IC...

    Authors: Kimberly J. Terry, Kevin E. Anger and Paul M. Szumita

    Citation: Journal of Intensive Care 2015 3:52

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  29. Content type: Research

    Molecular amplification techniques are suggested to be a useful adjunct in early detection of pathogens in septic patients. The aim was to study the feasibility of a polymerase chain reaction (PCR) assay compa...

    Authors: Runa Plettig, Andreas Nowak, Veronika Balau, Klaus Hahnenkamp and Taras Usichenko

    Citation: Journal of Intensive Care 2015 3:51

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  30. Content type: Review

    Although fluid resuscitation of patients having acute circulatory failure is essential, avoiding unnecessary administration of fluids in these patients is also important. Fluid responsiveness (FR) is defined a...

    Authors: Ahmed Hasanin

    Citation: Journal of Intensive Care 2015 3:50

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  31. Content type: Research

    Sepsis is a potentially fatal syndrome mediated by an early [e.g., tumor necrosis factor-alpha (TNF-α)] and late [high mobility group box-1 (HMGB-1)] proinflammatory cytokine response to infection. Sepsis-indu...

    Authors: Mari Ishida, Masaaki Ueki, Jun Morishita, Masaki Ueno, Shunichi Shiozawa and Nobuhiro Maekawa

    Citation: Journal of Intensive Care 2015 3:49

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  32. Content type: Review

    Sepsis-induced cardiomyopathy is a reversible myocardial dysfunction that typically resolves in 7–10 days. It is characterized by left ventricular dilatation and depressed ejection fraction. However, many unce...

    Authors: Ryota Sato and Michitaka Nasu

    Citation: Journal of Intensive Care 2015 3:48

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  33. Content type: Case report

    Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse reaction characterized by acute sterile pustular eruptions, mostly induced by medications. Antibiotics are the most commonly implic...

    Authors: Sagger Mawri, Tarun Jain, Jainil Shah, Gina Hurst and Jennifer Swiderek

    Citation: Journal of Intensive Care 2015 3:47

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  34. Content type: Research

    Traumatic brain injury (TBI) is a major public health problem and a leading cause of death worldwide. A paucity of literature exists on risk factors for mortality in isolated severe TBI, a condition that is di...

    Authors: Vijay Krishnamoorthy, Monica S. Vavilala, Brianna Mills and Ali Rowhani-Rahbar

    Citation: Journal of Intensive Care 2015 3:46

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  35. Content type: Letter to the Editor

    Although neurological evaluation using the Glasgow Coma Scale motor score is mandatory for post-cardiac arrest patients, further study is required to determine if this score can be used as an indicator for mil...

    Authors: Toru Hifumi, Kenya Kawakita, Tomoya Okazaki, Satoshi Egawa, Yutaka Kondo, Tomoaki Natsukawa and Hirotaka Sawano

    Citation: Journal of Intensive Care 2015 3:45

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  36. Content type: Research

    Device-associated healthcare-associated infections (DA-HAIs) are a major problem in pediatric intensive care units (PICUs). However, there are no data available regarding the incidences of DA-HAIs in PICUs in ...

    Authors: Takeshi Hatachi, Kazuya Tachibana and Muneyuki Takeuchi

    Citation: Journal of Intensive Care 2015 3:44

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  37. Content type: Case report

    We firstly report a postoperative hemodialysis patient who was co-administered with amiodarone and dexmedetomidine and developed severe bradycardia followed by cardiac arrest. A 79-year-old male patient underw...

    Authors: Takafumi Ohmori, Nobuhiro Shiota, Akihiro Haramo, Takahiro Masuda, Fumi Maruyama, Kenji Wakabayashi, Yushi U. Adachi and Koichi Nakazawa

    Citation: Journal of Intensive Care 2015 3:43

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  38. Content type: Research

    The urinary albumin/creatinine ratio (ACR) is a significant neurologic prognostic predictor in patients with aneurysmal subarachnoid hemorrhage (SAH). B-type natriuretic peptide (BNP) plays an important role i...

    Authors: Yoshiaki Terao, Makito Oji, Tomomi Toyoda, Haruka Inoue, Makoto Fukusaki and Tetsuya Hara

    Citation: Journal of Intensive Care 2015 3:42

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  39. Content type: Research

    Contemporary critical care research necessitates involvement of multiple centers, preferably from many countries. Adult and pediatric research networks have produced outstanding data; however, their involvemen...

    Authors: Sandeep Tripathi, Harsheen Kaur, Rahul Kashyap, Yue Dong, Ognjen Gajic and Srinivas Murthy

    Citation: Journal of Intensive Care 2015 3:40

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  40. Content type: Review

    Over the last two decades, there have been vast improvements in sepsis-related outcomes, largely resulting from the widespread adoption of aggressive fluid resuscitation and infection control. With increased u...

    Authors: Jason Chertoff, Michael Chisum, Bryan Garcia and Jorge Lascano

    Citation: Journal of Intensive Care 2015 3:39

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  41. Content type: Research

    Appropriate patient selection is very important when initiating mild therapeutic hypothermia (MTH) for patients following out-of-hospital cardiac arrest, and the extent of unconsciousness at implementation mus...

    Authors: Tomoaki Natsukawa, Hirotaka Sawano, Mai Natsukawa, Yuichi Yoshinaga, Shuho Sato, Yusuke Ito, Takayuki Otani, Jiro Ohba, Yasuyuki Hayashi and Tatsuro Kai

    Citation: Journal of Intensive Care 2015 3:38

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  42. Content type: Research

    Abnormalities in potassium levels can lead to several clinical difficulties in trauma patients admitted to the ICU. However, the significance of potassium abnormalities soon after admission in trauma patients ...

    Authors: Takaaki Ookuma, Koji Miyasho, Nobuhiro Kashitani, Nobuhiko Beika, Naoki Ishibashi, Takahiro Yamashita and Yoshihito Ujike

    Citation: Journal of Intensive Care 2015 3:37

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  43. Content type: Research

    Regional citrate anticoagulation (RCA) is being increasingly used during continuous renal replacement therapy (CRRT) in intensive care units as an alternative to systemic heparin anticoagulation. However, due ...

    Authors: Sebastian Hafner, Wolfgang Stahl, Theresa Fels, Karl Träger, Michael Georgieff and Martin Wepler

    Citation: Journal of Intensive Care 2015 3:35

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  44. Content type: Research

    Since hyperglycemia-induced cellular dysfunction could be associated with alterations of the immune system, we tested the hypothesis that hyperglycemia augments the aberrant immune responses such as inflammati...

    Authors: Katsuya Mori, Takeshi Suzuki, Toru Igarashi, Kei Inoue, Takashi Asahara, Koji Nomoto, Hiroyuki Seki, Takashige Yamada, Shizuka Minamishima, Shizuko Kosugi, Nobuyuki Katori and Hiroshi Morisaki

    Citation: Journal of Intensive Care 2015 3:34

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  45. Content type: Research

    Extracorporeal cardiopulmonary resuscitation (ECPR) is being used increasingly in the emergency and critical care field in Japan. A major complication of ECPR is bleeding; however, the optimal initial heparin ...

    Authors: Yoshiaki Iwashita, Mashiro Yukimitsu, Masaki Matsuduki, Akitaka Yamamoto, Ken Ishikura and Hiroshi Imai

    Citation: Journal of Intensive Care 2015 3:33

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