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  1. Content type: Letter to the Editor

    Abdominal X-rays, the diagnostic method for enteral feeding tube (EFT) positioning, are a source of irradiation for the patients and carry a potential risk of adverse effects. Data related to ultrasound (US)-g...

    Authors: Wagner Luis Nedel, Mariana Nunes Ferreira Jost and João Wilney Franco Filho

    Citation: Journal of Intensive Care 2017 5:55

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  2. Content type: Case report

    Nonconvulsive status epilepticus (NCSE) is a diagnosis that is often challenging and one that may progress to refractory NCSE. Ketamine is a noncompetitive N-methyl-d-aspartate antagonist that increasingly has be...

    Authors: Michael A. Pizzi, Prasuna Kamireddi, William O. Tatum, Jerry J. Shih, Daniel A. Jackson and William D. Freeman

    Citation: Journal of Intensive Care 2017 5:54

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  3. Content type: Research

    Interruption of enteral nutrition (EN) in the intensive care unit (ICU) occurs frequently for various reasons including feeding intolerance and the conduct of diagnostic and therapeutic procedures. However, fe...

    Authors: Midori Uozumi, Masamitsu Sanui, Tetsuya Komuro, Yusuke Iizuka, Tadashi Kamio, Hiroshi Koyama, Hideyuki Mouri, Tomoyuki Masuyama, Kazuyuki Ono and Alan Kawarai Lefor

    Citation: Journal of Intensive Care 2017 5:52

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  4. Content type: Review

    Sepsis is a global healthcare problem, characterized by whole body inflammation in response to microbial infection, which leads to organ dysfunction. It is becoming a frequent complication in hospitalized pati...

    Authors: Ashitha L. Vijayan, Vanimaya, Shilpa Ravindran, R. Saikant, S. Lakshmi, R. Kartik and Manoj. G

    Citation: Journal of Intensive Care 2017 5:51

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  5. Content type: Guideline

    The Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine provide here a clinical practice guideline for the management of adult patients with ARDS in the ICU.

    Authors: Satoru Hashimoto, Masamitsu Sanui, Moritoki Egi, Shinichiro Ohshimo, Junji Shiotsuka, Ryutaro Seo, Ryoma Tanaka, Yu Tanaka, Yasuhiro Norisue, Yoshiro Hayashi and Eishu Nango

    Citation: Journal of Intensive Care 2017 5:50

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  6. Content type: Review

    Brain-dead donor organ transplantation has been available to children in Japan since the 2010 revision of the Organ Transplant Law. Of the 50–60 brain-dead donor organ transplants performed annually in Japan, ...

    Authors: Nao Nishimura, Mureo Kasahara, Kenji Ishikura and Satoshi Nakagawa

    Citation: Journal of Intensive Care 2017 5:48

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  7. Content type: Review

    Sepsis is one of the leading causes of mortality among children worldwide. Unfortunately, however, reliable evidence was insufficient in pediatric sepsis and many aspects in clinical practice actually depend o...

    Authors: Tatsuya Kawasaki

    Citation: Journal of Intensive Care 2017 5:47

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  8. Content type: Review

    Acute kidney injury (AKI) after cardiac surgery in children with congenital heart disease is a common complication. AKI is also associated with high morbidity and mortality. The Kidney Diseases Improving Globa...

    Authors: Yuichiro Toda and Kentaro Sugimoto

    Citation: Journal of Intensive Care 2017 5:49

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  9. Content type: Research

    In Japan, nafamostat mesylate (NM) is frequently used as an anticoagulant during continuous renal replacement therapy (CRRT). The dialyzer membrane AN69ST has been reported to adsorb NM and affect the manageme...

    Authors: Takahiro Hirayama, Nobuyuki Nosaka, Yasumasa Okawa, Soichiro Ushio, Yoshihisa Kitamura, Toshiaki Sendo, Toyomu Ugawa and Atsunori Nakao

    Citation: Journal of Intensive Care 2017 5:46

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  10. Content type: Research

    Sepsis is a prevalent disease worldwide and still exhibits high rates of mortality. In the last years, many interventions aiming a positive impact on sepsis evolution have been studied. One of the main is the ...

    Authors: F. Teles, W. G. Rodrigues, M. G. T. C. Alves, C. F. T. Albuquerque, S. M. O. Bastos, M. F. A. Mota, E. S. Mota and F. J. L. Silva

    Citation: Journal of Intensive Care 2017 5:45

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  11. Content type: Research

    The perfusion of splanchnic organs is deeply altered in patients with septic shock. The aim of the study is to identify the predictive factors of septic shock-induced increase of serum lipase and amylase and t...

    Authors: Anis Chaari, Karim Abdel Hakim, Nevine Rashed, Kamel Bousselmi, Vipin Kauts, Mahmoud Etman and William Francis Casey

    Citation: Journal of Intensive Care 2017 5:44

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  12. Content type: Research

    Patients with severe sepsis generally respond well to initial therapy administered in the emergency department (ED), but a subset later decompensate and require unexpected transfer to the intensive care unit (...

    Authors: Gabriel Wardi, Arvin R. Wali, Julian Villar, Vaishal Tolia, Christian Tomaszewski, Christian Sloane, Peter Fedullo, Jeremy R. Beitler, Matthew Nolan, Daniel Lasoff and Rebecca E. Sell

    Citation: Journal of Intensive Care 2017 5:43

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  13. Content type: Research

    Sepsis is one of the most significant causes of mortality in intensive care units. It indicates crosstalk between inflammation and coagulation. In this study, we aimed to identify prognostic markers among seps...

    Authors: Kota Hoshino, Taisuke Kitamura, Yoshihiko Nakamura, Yuhei Irie, Norihiko Matsumoto, Yasumasa Kawano and Hiroyasu Ishikura

    Citation: Journal of Intensive Care 2017 5:42

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  14. Content type: Research

    The intensive care unit (ICU) environment exposes patients to noise levels that may result in substantial sleep disruption. There is a need to accurately describe the intensity pattern and source of noise in t...

    Authors: Lori J. Delaney, Marian J. Currie, Hsin-Chia Carol Huang, Violeta Lopez, Edward Litton and Frank Van Haren

    Citation: Journal of Intensive Care 2017 5:41

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  15. Content type: Letter to the Editor

    The efficacy of polymyxin B-immobilized (PMX) fiber column on septic shock is still under debate. Recently, the result from “Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of ...

    Authors: Toshiaki Iba and Lucy Fowler

    Citation: Journal of Intensive Care 2017 5:40

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  16. Content type: Case report

    Extracorporeal membrane oxygenation (ECMO) have become more frequently used in daily ICU practice, heparin-induced thrombocytopenia (HIT) is a rare but life-threatening complication while on extracorporeal mem...

    Authors: Alain Rougé, Felix Pelen, Michel Durand and Carole Schwebel

    Citation: Journal of Intensive Care 2017 5:39

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  17. Content type: Review

    Decannulation is an essential step towards liberating tracheostomized patients from mechanical ventilation. However, despite its perceived importance, there is no universally accepted protocol for this vital t...

    Authors: Ratender Kumar Singh, Sai Saran and Arvind K. Baronia

    Citation: Journal of Intensive Care 2017 5:38

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  18. Content type: Research

    Patients with water intoxication may develop rhabdomyolysis. Existing studies suggest a relationship between the serum sodium correction rate and rhabdomyolysis. The aim of the present study was to determine t...

    Authors: Masahiro Kashiura, Kazuhiro Sugiyama and Yuichi Hamabe

    Citation: Journal of Intensive Care 2017 5:37

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  19. Content type: Commentary

    Swift and adequate fluid loading is a cornerstone of septic shock therapy. Yet, careful assessment of volume responsiveness and volume amount during the resuscitation process is a prerequisite. Both overzealou...

    Authors: Patrick M. Honore and Herbert D. Spapen

    Citation: Journal of Intensive Care 2017 5:36

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  20. Content type: Research

    Reintubation after pediatric cardiac surgery is associated with a high rate of mortality. Therefore, adequate respiratory support for postextubation acute respiratory failure (ARF) is important. However, littl...

    Authors: Naohiro Shioji, Tatsuo Iwasaki, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tomohiko Suemori, Kentaro Sugimoto, Yasutoshi Kuroe and Hiroshi Morimatsu

    Citation: Journal of Intensive Care 2017 5:35

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  21. Content type: Review

    A crucial step in the transition from mechanical ventilation to extubation is the successful performance of a spontaneous breathing trial (SBT). The American College of Chest Physicians (ACCP) Guidelines recom...

    Authors: Chuan Jiang, Antonio Esquinas and Bushra Mina

    Citation: Journal of Intensive Care 2017 5:33

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  22. Content type: Letter to the Editor

    Since the withdrawal of recombinant-activated protein C, the anticoagulant therapy for sepsis was taken no notice. For instance, the international sepsis guidelines did not share a space for this therapy. Howe...

    Authors: Jecko Thachil and Toshiaki Iba

    Citation: Journal of Intensive Care 2017 5:32

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  23. Content type: Research

    Patients in intensive care units (ICU) are often diagnosed with postoperative delirium; the duration of which has a relevant negative impact on various clinical outcomes. Recent research found a potentially im...

    Authors: Mira John, E. Wesley Ely, Dorothee Halfkann, Julika Schoen, Beate Sedemund-Adib, Stefan Klotz, Finn Radtke, Sebastian Stehr and Michael Hueppe

    Citation: Journal of Intensive Care 2017 5:29

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  24. Content type: Research

    Intracranial hemorrhage (ICH) is a recognized complication of adults treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. However, the predictors of...

    Authors: Alexander Fletcher Sandersjöö, Jiri Bartek Jr., Eric Peter Thelin, Anders Eriksson, Adrian Elmi-Terander, Mikael Broman and Bo-Michael Bellander

    Citation: Journal of Intensive Care 2017 5:27

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  25. Content type: Research

    Acute kidney injury (AKI) occurs in more than half critically ill patients admitted in intensive care units (ICU) and increases the mortality risk. The main cause of AKI in ICU is sepsis. AKI severity and othe...

    Authors: Emilio Rodrigo, Borja Suberviola, Miguel Santibáñez, Lara Belmar, Álvaro Castellanos, Milagros Heras, Juan Carlos Rodríguez-Borregán, Angel Luis Martín de Francisco and Claudio Ronco

    Citation: Journal of Intensive Care 2017 5:28

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  26. Content type: Research

    This prospective study compared clinical characteristics and prognosis between primary (P) and secondary (S) acute gastrointestinal injury (AGI) (P-AGI)/(S-AGI) in critically ill patients.

    Authors: Dong Zhang, Rao Fu, Yanhua Li, Hongyan Li, Yuting Li and Hongxiang Li

    Citation: Journal of Intensive Care 2017 5:26

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  27. Content type: Research

    Endothelin 1 (ET-1) is a strong vasoconstrictor, which is involved in inflammation and reduced tissue perfusion. C-terminal proendothelin-1 (CT-proET-1) is the stable circulating precursor protein of ET-1. We ...

    Authors: Lukas Buendgens, Eray Yagmur, Jan Bruensing, Ulf Herbers, Christer Baeck, Christian Trautwein, Alexander Koch and Frank Tacke

    Citation: Journal of Intensive Care 2017 5:25

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  28. Content type: Review

    Monitoring of tissue perfusion is an essential step in the management of acute circulatory failure. The presence of cellular dysfunction has been a basic component of shock definition even in the absence of hy...

    Authors: Ahmed Hasanin, Ahmed Mukhtar and Heba Nassar

    Citation: Journal of Intensive Care 2017 5:24

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  29. Content type: Commentary

    The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunct...

    Authors: Frank Anthony Rasulo, Giuseppe Bellelli, Eugene Wesley Ely, Alessandro Morandi, Pratik Pandharipande and Nicola Latronico

    Citation: Journal of Intensive Care 2017 5:23

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  30. Content type: Review

    Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Authors: Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki

    Citation: Journal of Intensive Care 2017 5:22

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  31. Content type: Research

    Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key mo...

    Authors: Bernt C. Hellerud, Hilde L. Orrem, Knut Dybwik, Søren E. Pischke, Andreas Baratt-Due, Albert Castellheim, Hilde Fure, Grethe Bergseth, Dorte Christiansen, Miles A. Nunn, Terje Espevik, Corinna Lau, Petter Brandtzæg, Erik W. Nielsen and Tom E. Mollnes

    Citation: Journal of Intensive Care 2017 5:21

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  32. Content type: Research

    In recent years, the measurement of cerebral regional oxygen saturation (rSO2) during resuscitation has attracted attention. The objective of this study was to clarify the relationship between the serial changes ...

    Authors: Naoki Ehara, Tomoya Hirose, Tadahiko Shiozaki, Akinori Wakai, Tetsuro Nishimura, Nobuto Mori, Mitsuo Ohnishi, Daikai Sadamitsu and Takeshi Shimazu

    Citation: Journal of Intensive Care 2017 5:20

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  33. Content type: Research

    Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridges (PMX-DHP) is widely used for septic shock in Japan and parts of Europe. Although this treatment is usually administered for 2 h, the o...

    Authors: Kyohei Miyamoto, Yu Kawazoe and Seiya Kato

    Citation: Journal of Intensive Care 2017 5:19

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  34. Content type: Research

    Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization. Delirium, an acute form of brai...

    Authors: José Raimundo A. de Azevedo, Widlani Sousa Montenegro, Djane Pereira Rodrigues, Suellen C. de C. Souza, Vanessa F. S. Araujo, Margareth Pereira de Paula, Patricia H. C. P. Prazeres, Adenilde da Luz Leitão and Adriana V. N. Mendonça

    Citation: Journal of Intensive Care 2017 5:18

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  35. Content type: Research

    Pain assessment is highly recommended in patients receiving mechanical ventilation. However, pain intensity and its impact on outcomes in these patients remain obscure. We collected the results of routine pain...

    Authors: Ayahiro Yamashita, Masaki Yamasaki, Hiroki Matsuyama and Fumimasa Amaya

    Citation: Journal of Intensive Care 2017 5:17

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    The Commentary to this article has been published in Journal of Intensive Care 2017 5:73

  36. Content type: Research

    The work demands of critical care can be a major cause of stress in intensive care unit (ICU) professionals and lead to poor health outcomes. In the process of recovery from work, psychological rumination is c...

    Authors: Tushna Vandevala, Louisa Pavey, Olga Chelidoni, Nai-Feng Chang, Ben Creagh-Brown and Anna Cox

    Citation: Journal of Intensive Care 2017 5:16

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  37. Content type: Review

    The mortality rate of critically ill patients is high and the cost of the intensive (ICU) department is among the highest within the health-care industry. The cost will continue to increase because of the agin...

    Authors: Alexander F. van der Sluijs, Eline R. van Slobbe-Bijlsma, Stephen E. Chick, Margreeth B. Vroom, Dave A. Dongelmans and Alexander P. J. Vlaar

    Citation: Journal of Intensive Care 2017 5:13

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  38. Content type: Case report

    Sepsis and septic shock are major healthcare problems, affecting millions of individuals around the world each year. Pathophysiologically, septic multiple organ dysfunction (MOD) is a life-threatening conditio...

    Authors: Sascha David, Kristina Thamm, Bernhard M. W. Schmidt, Christine S. Falk and Jan T. Kielstein

    Citation: Journal of Intensive Care 2017 5:12

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  39. Content type: Review

    Achieving a balance between organ perfusion and hemostasis is critical for optimal fluid resuscitation in patients with severe trauma. The concept of “permissive hypotension” refers to managing trauma patients...

    Authors: Daisuke Kudo, Yoshitaro Yoshida and Shigeki Kushimoto

    Citation: Journal of Intensive Care 2017 5:11

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  40. Content type: Review

    Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

    Authors: Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa

    Citation: Journal of Intensive Care 2017 5:5

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  41. Content type: Review

    Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

    Authors: Mineji Hayakawa

    Citation: Journal of Intensive Care 2017 5:3

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