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  1. Regional citrate anticoagulation (RCA) is being increasingly used during continuous renal replacement therapy (CRRT) in intensive care units as an alternative to systemic heparin anticoagulation. However, due ...

    Authors: Sebastian Hafner, Wolfgang Stahl, Theresa Fels, Karl Träger, Michael Georgieff and Martin Wepler
    Citation: Journal of Intensive Care 2015 3:35
  2. Since hyperglycemia-induced cellular dysfunction could be associated with alterations of the immune system, we tested the hypothesis that hyperglycemia augments the aberrant immune responses such as inflammati...

    Authors: Katsuya Mori, Takeshi Suzuki, Toru Igarashi, Kei Inoue, Takashi Asahara, Koji Nomoto, Hiroyuki Seki, Takashige Yamada, Shizuka Minamishima, Shizuko Kosugi, Nobuyuki Katori and Hiroshi Morisaki
    Citation: Journal of Intensive Care 2015 3:34
  3. Extracorporeal cardiopulmonary resuscitation (ECPR) is being used increasingly in the emergency and critical care field in Japan. A major complication of ECPR is bleeding; however, the optimal initial heparin ...

    Authors: Yoshiaki Iwashita, Mashiro Yukimitsu, Masaki Matsuduki, Akitaka Yamamoto, Ken Ishikura and Hiroshi Imai
    Citation: Journal of Intensive Care 2015 3:33
  4. It has been recommended that all survivors of out-of-hospital cardiac arrest (OHCA) have immediate coronary angiography (CAG), even though it has been reported that half of the survivors have normal coronary a...

    Authors: Toshikazu Abe, Shigeyuki Watanabe, Atsushi Mizuno, Masahiro Toyama, Vicken Y. Totten and Yasuharu Tokuda
    Citation: Journal of Intensive Care 2015 3:32
  5. In critically ill patients, Candida spp. can often be identified in pulmonary samples. The impact of prompt antifungal therapy in these patients is unknown.

    Authors: Simone Lindau, Manuel Nadermann, Hanns Ackermann, Tobias Michael Bingold, Christoph Stephan, Volkhard A. J. Kempf, Pia Herzberger, Andres Beiras-Fernandez, Kai Zacharowski and Patrick Meybohm
    Citation: Journal of Intensive Care 2015 3:31
  6. To determine if the effects of epinephrine administration on the outcome of out-of-hospital cardiac arrest (OHCA), patients are associated with the duration of cardiopulmonary resuscitation (CPR) performed by ...

    Authors: Yuichi Ono, Mineji Hayakawa, Takeshi Wada, Atsushi Sawamura and Satoshi Gando
    Citation: Journal of Intensive Care 2015 3:29
  7. Therapeutic hypothermia (TH) is a standard strategy to reduce brain damage in post-cardiac arrest syndrome (PCAS) patients. However, it is unknown whether the target temperature should be adjusted for PCAS pat...

    Authors: Tadashi Kaneko, Shunji Kasaoka, Takashi Nakahara, Hirotaka Sawano, Yoshio Tahara, Mamoru Hase, Kenji Nishioka, Shinichi Shirai, Hiroshi Hazui, Hideki Arimoto, Kazunori Kashiwase, Tomokazu Motomura, Yasuhiro Kuroda, Yuji Yasuga, Naohiro Yonemoto, Hiroyuki Yokoyama…
    Citation: Journal of Intensive Care 2015 3:28
  8. Predicting mortality in the intensive care unit (ICU) is one of the biggest challenges in critical care medicine. Several studies have linked the presence of eosinopenia with adverse outcomes in different popu...

    Authors: Emmanuel Jesús Escobar-Valdivia, Julio Edgardo González-Aguirre, Eunice Rebeca Carrillo-Cisneros, Karla Carolina Guerra-Leza and Roberto Mercado-Longoría
    Citation: Journal of Intensive Care 2015 3:27
  9. Dexmedetomidine (Dex) provides sedation and analgesia by acting on central alpha-2 receptors and is suitable for use after extubation because it has little respiratory depression. Considering the sympathoinhib...

    Authors: Ayuka Narisawa, Masaki Nakane, Takako Kano, Nozomi Momose, Yu Onodera, Ryo Akimoto, Tadahiro Kobayashi, Masahiro Iwabuchi, Masayuki Okada, Yoshihide Miura and Kaneyuki Kawamae
    Citation: Journal of Intensive Care 2015 3:26
  10. In this study, the effects of an enteral diet enriched with eicosapentaenoic acid (EPA), γ-linolenic acid (GLA), and antioxidants were compared with a standard enteral diet in critically ill patients with seps...

    Authors: Kunihiro Shirai, Shozo Yoshida, Naoki Matsumaru, Izumi Toyoda and Shinji Ogura
    Citation: Journal of Intensive Care 2015 3:24
  11. The aim of this study was to establish the pharmacokinetics of levofloxacin (LVFX) and determine the optimal dose of this drug in critically ill patients receiving continuous hemodiafiltration (CHDF). The resu...

    Authors: Takeshi Wada, Masaki Kobayashi, Yuichi Ono, Asumi Mizugaki, Kenichi Katabami, Kunihiko Maekawa, Daisuke Miyamoto, Yuichiro Yanagida, Mineji Hayakawa, Atsushi Sawamura, Ken Iseki and Satoshi Gando
    Citation: Journal of Intensive Care 2015 3:22
  12. Organophosphate poisoning (OP) results in various poisoning symptoms due to its strong inhibitory effect on cholinesterase. One of the occasional complications of OP is pancreatitis.

    Authors: Shozo Yoshida, Hideshi Okada, Shiho Nakano, Kunihiro Shirai, Toshiyuki Yuhara, Hiromasa Kojima, Tomoaki Doi, Hisaaki Kato, Kodai Suzuki, Kentaro Morishita, Eiji Murakami, Hiroaki Ushikoshi, Izumi Toyoda and Shinji Ogura
    Citation: Journal of Intensive Care 2015 3:21
  13. Atrial fibrillation (AF) is a common arrhythmia in the ICU. The aim of this review is to summarize relevant information on new-onset AF in non-cardiac critical illness with respect to epidemiology, prevention,...

    Authors: Takuo Yoshida, Tomoko Fujii, Shigehiko Uchino and Masanori Takinami
    Citation: Journal of Intensive Care 2015 3:19
  14. Snake bites are life-threatening injuries that can require intensive care. The diagnosis and treatment of venomous snake bites is sometimes difficult for clinicians because sufficient information has not been ...

    Authors: Toru Hifumi, Atsushi Sakai, Yutaka Kondo, Akihiko Yamamoto, Nobuya Morine, Manabu Ato, Keigo Shibayama, Kazuo Umezawa, Nobuaki Kiriu, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Kenya Kawakita and Yasuhiro Kuroda
    Citation: Journal of Intensive Care 2015 3:16
  15. High-flow nasal cannula (HFNC) oxygen therapy comprises an air/oxygen blender, an active humidifier, a single heated circuit, and a nasal cannula. It delivers adequately heated and humidified medical gas at up...

    Authors: Masaji Nishimura
    Citation: Journal of Intensive Care 2015 3:15
  16. Polymyxin B-immobilized fiber column hemoperfusion (PMX) has been reported to be effective for patients with septic shock. It remains unclear, however, how the efficacy of PMX varies according to the character...

    Authors: Makiko Sugiura, Chieko Mitaka, Go Haraguchi, Makoto Tomita and Naohiko Inase
    Citation: Journal of Intensive Care 2015 3:14
  17. Direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) has been widely used for patients with septic shock around the world, but the prognostic factors have not been fully understood. We conducted a...

    Authors: Satoshi Matsukuma, Kazuhiko Sakamoto, Mitsuo Nishiyama, Takao Tamesa, Shigefumi Yoshino, Shoichi Hazama, Rumi Oshibuchi, Norimasa Matsuda, Satoshi Matsumoto, Hiroya Wakamatsu, Ryosuke Tsuruta, Mishiya Matsumoto and Masaaki Oka
    Citation: Journal of Intensive Care 2015 3:13
  18. Methyl bromide (CH3Br) is a colorless and odorless volatile gas, used as an insecticide, fire extinguisher, fumigant, and refrigerant. Although forbidden since 1987 for domestic use, it is still used in indust...

    Authors: Sylvain Lecailtel, Céline Broucqsault-Dedrie, Clément Vanbaelinghem, Martine Nyunga, Delphine Colling and Patrick Herbecq
    Citation: Journal of Intensive Care 2015 3:12
  19. Journal of Intensive Care is very grateful for the generously-provided time and constructive, insightful reports provided by the journal’s highly-qualified reviewers. We would like to show our a...

    Authors: Satoshi Gando
    Citation: Journal of Intensive Care 2015 3:11
  20. Diffuse alveolar hemorrhage (DAH) from systemic lupus erythematosus (SLE) is a rare but potentially life-threatening condition. We report the case of a 14-year-old female with SLE who developed hypoxia and sho...

    Authors: Dai Kimura, Samir Shah, Mario Briceno-Medina, Shyam Sathanandam, Brent Haberman, Jie Zhang, Linda Myers, TK Susheel Kumar and Christopher Knott-Craig
    Citation: Journal of Intensive Care 2015 3:10
  21. Ventilator-associated pneumonia (VAP) caused by drug-resistant Acinetobacter baumannii is associated with high mortality in critically ill patients. We identified the prognostic factors of 30-day mortality in pat...

    Authors: Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Atikun Limsukon, Weerayut Khositsakulchai and Chalerm Liwsrisakun
    Citation: Journal of Intensive Care 2015 3:9
  22. In autumn 2014, with great effort by the Ministry of Health, Labour and Welfare, the research group will obtain several vials of redback spider (RBS) antivenom for emergency use. However, these small amounts o...

    Authors: Toru Hifumi, Hisashi Taki, Akihiko Yamamoto, Manabu Ato, Yuichi Koido and Yasuhiro Kuroda
    Citation: Journal of Intensive Care 2015 3:7
  23. Up to 40% of infants with persistent pulmonary hypertension (PPHN) remains refractory to conventional therapies, and extracorporeal membrane oxygenation (ECMO) is offered as an effective support for this group...

    Authors: Sule Doymaz, Marcia Zinger and Todd Sweberg
    Citation: Journal of Intensive Care 2015 3:6
  24. Peripheral venoarterial extracorporeal membranous oxygenation (ECMO) support is effective in patients with cardiogenic shock or fatal arrhythmia due to fulminant myocarditis. The clinical courses of fulminant ...

    Authors: Tomohiro Nakamura, Kohki Ishida, Yousuke Taniguchi, Tomu Nakagawa, Masaru Seguchi, Hiroshi Wada, Yoshitaka Sugawara, Hiroshi Funayama, Takeshi Mitsuhashi and Shin-ichi Momomura
    Citation: Journal of Intensive Care 2015 3:5
  25. Increasing incidence of resistance of gram-negative bacteria against even newer antibiotic including carbapenem has generated interest in the old antibiotic colistin, which are being used as salvage therapy in...

    Authors: Mohan Gurjar
    Citation: Journal of Intensive Care 2015 3:3
  26. Microparticles (MPs) are small membrane vesicles that are released from many different cell types by exocytic budding of the plasma membrane in response to cellular activation or apoptosis. MPs may also be inv...

    Authors: Shosaku Nomura and Michiomi Shimizu
    Citation: Journal of Intensive Care 2015 3:2
  27. There are few reports detailing the importance of extracorporeal membrane oxygenation (ECMO) for pediatric cardiac arrest in Japan. We investigated the status and issues surrounding extracorporeal cardiopulmon...

    Authors: Kohei Tsukahara, Chiaki Toida and Takashi Muguruma
    Citation: Journal of Intensive Care 2014 2:68
  28. Neutrophil elastase plays an important role in the development and progression of acute respiratory distress syndrome (ARDS). Although the selective elastase inhibitor, sivelestat, is widely used in Japan for ...

    Authors: Takashi Tagami, Ryoichi Tosa, Mariko Omura, Hidetada Fukushima, Tadashi Kaneko, Tomoyuki Endo, Hiroshi Rinka, Akira Murai, Junko Yamaguchi, Kazuhide Yoshikawa, Nobuyuki Saito, Hideaki Uzu, Yoichi Kase, Makoto Takatori, Hiroo Izumino, Toshiaki Nakamura…
    Citation: Journal of Intensive Care 2014 2:67
  29. Antithrombin (AT) is known as an important physiological anticoagulant. AT inactivates thrombin and multiple other coagulation factors, thereby strongly inhibiting the over-activation of the coagulation system...

    Authors: Toshiaki Iba and Daizoh Saitoh
    Citation: Journal of Intensive Care 2014 2:66
  30. Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role...

    Authors: Takashi Ito
    Citation: Journal of Intensive Care 2014 2:65
  31. Here, we measured presepsins (PSPs) in four patients with acute kidney injury (AKI) or chronic kidney disease (CKD) and discuss the relationship between PSP and kidney dysfunction.

    Authors: Atsushi Kotera, Katsuyuki Sagishima, Takahiro Tashiro, Daisuke Niimori, Hidenobu Kamohara and Yoshihiro Kinoshita
    Citation: Journal of Intensive Care 2014 2:63
  32. Fresh frozen plasma transfusion is widely utilized in pediatric clinical practice to correct mild coagulopathy. Several studies on adult population have shown that transfusion of plasma cannot effectively corr...

    Authors: Esther Paula Soundar, Ronald Besandre, Sarah Kate Hartman, Jun Teruya and Shiu-Ki Rocky Hui
    Citation: Journal of Intensive Care 2014 2:64
  33. Initial distribution volume of glucose (IDVG), which is not associated with significant modification of glucose metabolism, has been proposed as an indicator of the central extracellular fluid volume status in...

    Authors: Hironori Ishihara, Eiji Hashiba, Hirobumi Okawa, Junichi Saito, Toshinori Kasai and Toshihito Tsubo
    Citation: Journal of Intensive Care 2014 2:59
  34. Redback spiders (Latrodectus hasselti) (RBSs) are venomous spiders that have recently spread to Asia from Australia. Since the first case report in 1997 (Osaka), RBS bites have been a clinical and administrative ...

    Authors: Toru Hifumi, Satoshi Fujimi, Takuya Yamagishi, Satoru Arai, Kyoko Sawabe, Akihiko Yamamoto, Manabu Ato, Keigo Shibayama, Akihiko Ginnaga, Nobuaki Kiriu, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Masanobu Kishikawa, Yuko Abe, Kenya Kawakita…
    Citation: Journal of Intensive Care 2014 2:62
  35. This is a guideline for the management of sepsis, developed by the Sepsis Registry Committee of The Japanese Society of Intensive Care Medicine (JSICM) launched in March 2007. This guideline was developed on t...

    Authors: Shigeto Oda, Mayuki Aibiki, Toshiaki Ikeda, Hitoshi Imaizumi, Shigeatsu Endo, Ryoichi Ochiai, Joji Kotani, Nobuaki Shime, Osamu Nishida, Takayuki Noguchi, Naoyuki Matsuda and Hiroyuki Hirasawa
    Citation: Journal of Intensive Care 2014 2:55
  36. Initial fluid resuscitation is an important hemodynamic therapy in patients with septic shock. The Surviving Sepsis Campaign Guidelines recommend fluid resuscitation with volume loading according to central ve...

    Authors: Takako Sasai, Hiroaki Tokioka, Tomihiro Fukushima, Takeshi Mikane, Satoru Oku, Etsu Iwasaki, Mizue Ishii, Hideyuki Mieda, Tomoki Ishikawa and Eriko Minami
    Citation: Journal of Intensive Care 2014 2:58
  37. Ventilator-induced lung injury (VILI) is associated with inflammatory responses in the lung. Thrombomodulin (TM), a component of the coagulation system, has anticoagulant and anti-inflammatory effects. We hypo...

    Authors: Yoshiaki Iwashita, Erquan Zhang, Junko Maruyama, Ayumu Yokochi, Yasuharu Yamada, Hirofumi Sawada, Yoshihide Mitani, Hiroshi Imai, Koji Suzuki and Kazuo Maruyama
    Citation: Journal of Intensive Care 2014 2:57