Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis

Table 4 Correlation of early heparin use with patient 60-day mortality in an ARDS cohort

Adjusted covariates: Model 1 = gender + age at admission + ethnicity + comorbidities (cancer, diabetes, sepsis, chronic obstructive pulmonary disease, hypertension, acute pancreatitis, acute renal failure) Model 2 = Model 1 + clinical scoring systems(Sequential Organ Failure Assessment score measured within 24 h, Simplified Acute Physiology Score II, Oxford Acute Severity of Illness Score) Model 3 = Model 2 + vital signs upon admission (mean heart rate, mean blood pressure, mean respiratory rate, minimum PaO2/FiO2 ratio at diagnosis) Model 4 = Model 3 + treatment interventions (use of vasopressors, mechanical ventilation, RRT, CRRT) Model 5 (Lasso Regression Selected Variables) = gender + age at admission + cancer + diabetes + sepsis + chronic obstructive pulmonary disease + acute pancreatitis + acute renal failure + Sequential Organ Failure Assessment score measured within 24 h + Simplified Acute Physiology Score II + Oxford Acute Severity of Illness Score + Mean heart rate + mean respiratory rate + use of vasopressors + mechanical ventilation

ISSN: 2052-0492