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Table 3 Correlation of early heparin use with in-hospital mortality in an ARDS cohort

From: Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis

Variables

Before PSM

After PSM

 

HR

(95% CI)

P-value

HR

(95% CI)

P-value

Model 1

0.714

0.545–0.936

0.015

0.643

0.466–0.889

0.007

Model 2

0.741

0.563–0.975

0.032

0.638

0.462–0.882

0.007

Model 3

0.711

0.539–0.938

0.016

0.646

0.467–0.894

0.008

Model 4

0.701

0.531–0.925

0.012

0.636

0.459–0.881

0.006

Model 5

0.706

0.536–0.930

0.013

0.630

0.455–0.873

0.005

  1. Adjusted covariates: Model 1 = gender + age at admission + ethnicity + comorbidities (cancer, diabetes, sepsis, chronic obstructive pulmonary disease, hypertension, acute pancreatitis, acute renal failure) Model 2 = Model 1 + clinical scoring systems(Sequential Organ Failure Assessment score measured within 24 h, Simplified Acute Physiology Score II, Oxford Acute Severity of Illness Score) Model 3 = Model 2 + vital signs upon admission (mean heart rate, mean blood pressure, mean respiratory rate, minimum PaO2/FiO2 ratio at diagnosis) Model 4 = Model 3 + treatment interventions (use of vasopressors, mechanical ventilation, RRT, CRRT) Model 5 (Lasso Regression Selected Variables) = gender + age at admission + cancer + diabetes + sepsis + acute pancreatitis + acute renal failure + Sequential Organ Failure Assessment score measured within 24 h + Simplified Acute Physiology Score II + Oxford Acute Severity of Illness Score + mean heart rate + mean respiratory rate + mechanical ventilation + CRRT + mean blood pressure