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Table 4 Other discriminations of the HACOR score and ROX index

From: External validation of the HACOR score and ROX index for predicting treatment failure in patients with coronavirus disease 2019 pneumonia managed on high-flow nasal cannula therapy: a multicenter retrospective observational study in Japan

Time point

HACOR score

ROX index

Sensitivity

Specificity

PPV

NPV

Sensitivity

Specificity

PPV

NPV

2 h

0.18

0.91

0.61

0.60

0.039

1

1

0.59

6 h

0.12

0.96

0.63

0.64

0.058

0.99

0.86

0.64

12 h

0.16

0.94

0.6

0.67

0.022

0.99

0.67

0.65

24 h

0.22

0.93

0.54

0.74

0.077

1

1

0.73

48 h

0.34

0.95

0.65

0.83

0.16

0.99

0.86

0.80

  1. NPV: negative predictive value; PPV: positive predictive value
  2. we evaluated the predictive performance, including sensitivity, specificity, and positive and negative predicted values, utilizing the threshold criteria, which the HACOR score versus those for the ROX index as follows: > 5 versus < 2.85 at 2 h; > 5 versus < 3.47 at 6 h; and > 5 versus < 3.85 at 12 h, respectively. Because of limited evidence regarding the cutoff points at 24 and 48 h, we employed the threshold established at 12 h