Table 4 Optimal lacosamide dosing regimens for critically ill patients receiving continuous renal replacement therapy with different effluent flow rates and modalities
From: Lacosamide dosing in patients receiving continuous renal replacement therapy
Effluent flow rates/modalities | Standard PD targets (Ctrough 5–10 mg/L or AUC 80.25–143 mg*h/L) | High PD targets (AUC 143–231 mg*h/L) | ||
|---|---|---|---|---|
CVVHD | CVVH | CVVHD | CVVH | |
20 mL/kg/h | 100–150 mg every 8 h | 250 mg every 12 h OR 250 mg LD followed by 150 mg every 8 h | ||
25 mL/kg/h | 150 mg every 8 h | 300 mg LD followed by 250 mg every 12 h | 250 mg every 12 h OR 250 mg LD followed by 150 mg every 8 h | |
35 mL/kg/h | 200 mg every 8 h | 300 mg every 12 h | 300 mg every 12 h OR 250 mg LD followed by 200 mg every 8 h | 350 mg LD followed by 250 mg every 12 h |