Characteristic | RBC transfusion strategy | P value | |
---|---|---|---|
Restrictive (n = 216) | Liberal (n = 195) | ||
Age (years), median (IQR) | 61.0 (44.0–74.0) | 57.0 (42.5–73.5) | 0.585 |
Male sex, n (%) | 145 (67.1) | 130 (66.7) | 1.000 |
Comorbidity (yes/no/unknown), n (%) | |||
 Chronic heart failure | 5 (2.3)/211 (97.7)/0 (0.0) | 2 (1.0)/192 (98.5)/1 (0.5) | 0.354 |
 Chronic renal failure | 1 (0.5)/215 (99.5)/0 (0.0) | 1 (0.5)/193 (99.0)/1 (0.5) | 0.737 |
 Chronic liver failure | 2 (0.9)/214 (99.1)/0 (0.0) | 0 (0.0)/194 (99.5)/1 (0.5) | 0.356 |
 Chronic respiratory failure | 1 (0.5)/215 (99.5)/0 (0.0) | 3 (1.5)/191 (97.9)/1 (0.5) | 0.231 |
 Immunosuppression | 2 (0.9)/213 (98.6)/1 (0.5) | 2 (1.0)/192 (98.5)/1 (0.5) | 1.000 |
Antithrombotic agents prior to injury, n (%) | |||
 None | 191 (88.4) | 174 (89.2) | 0.994 |
 Antiplatelet agents | 17 (7.9) | 14 (7.2) | |
 Anticoagulation agents | 3 (1.4) | 3 (1.5) | |
 Antiplatelet + anticoagulation agents | 2 (0.9) | 2 (1.0) | |
 Unknown | 3 (1.4) | 2 (1.0) | |
Type of injury, n (%) | |||
 Blunt trauma | 193 (89.4) | 170 (87.2) | 0.767 |
 Penetrating trauma | 22 (10.2) | 24 (12.3) | |
 Blunt + penetrating trauma | 1 (0.5) | 1 (0.5) | |
Time from injury to arrival at the ED (min), n (%) | |||
  ≤ 30 | 50 (23.1) | 38 (19.5) | 0.544 |
 31–60 | 94 (43.5) | 83 (42.6) | |
 61–90 | 40 (18.5) | 31 (15.9) | |
 91–120 | 10 (4.6) | 14 (7.2) | |
  > 120 | 8 (3.7) | 11 (5.6) | |
 Unknown | 14 (6.5) | 18 (9.2) | |
Injury Severity Score, median (IQR) | 24.5 (14.0–34.0) | 24.0 (14.0–29.0) | 0.797 |
Abbreviated Injury Scale score, median (IQR) | |||
 Head/neck | 0.5 (0.0–3.0) | 0.0 (0.0–3.0) | 0.324 |
 Face | 0.0 (0.0–0.0) | 0.0 (0.0–0.5) | 0.356 |
 Chest | 3.0 (0.0–3.0) | 2.0 (0.0–3.0) | 0.368 |
 Abdomen | 2.0 (0.0–3.0) | 2.0 (0.0–3.0) | 0.657 |
 Extremities/pelvic girdle | 2.0 (0.0–3.0) | 2.0 (0.0–3.0) | 0.825 |
 External | 0.0 (0.0–1.0) | 0.0 (0.0–1.0) | 0.258 |
Physiological status on arrival at the ED, median (IQR) | |||
 Glasgow Coma Scale score | 13.0 (10.0–15.0) | 13.0 (9.0–14.0) | 0.159 |
 Respiratory rate (/minute) | 23.0 (19.0–28.0) | 24.0 (19.0–30.0) | 0.436 |
 Heart rate (/minute) | 95.0 (76.8–117.2) | 94.0 (79.5–116.0) | 0.916 |
 Systolic blood pressure (mmHg) | 103.5 (83.0–131.5) | 110.0 (86.0–132.5) | 0.557 |
Laboratory tests on arrival at the ED, median (IQR) | |||
 Hemoglobin (g/dL) | 12.20 (10.88–13.90) | 11.90 (10.60–13.50) | 0.112 |
 Platelet count (× 103/μL) | 221.0 (173.8–268.2) | 232.0 (179.5–278.0) | 0.203 |
 Prothrombin-INRa | 1.080 (1.005–1.175) | 1.060 (1.010–1.170) | 0.678 |
 Fibrinogen (mg/dL)b | 215.0 (168.0–257.0) | 207.0 (168.5–254.0) | 0.565 |
 Lactate (mmol/L)c | 3.100 (2.200–4.700) | 3.260 (2.085–5.208) | 0.602 |