Table 1 Baseline characteristics according to CFH grouping
Characteristic | Mean CFH < 11 mg/dl (n = 277) | Mean CFH > 11 mg/dl (n = 165) | P value |
|---|---|---|---|
Mean CFH (mg/dl) | 6.42 [4.75, 8.35] | 19.00 [14.29, 31.00] | < 0.001 |
ICU mortality, n (%) | 105 (37.9) | 115 (69.7) | < 0.001 |
ECMO duration (days) | 14.00 [8.00, 27.00] | 13.00 [6.00, 26.00] | 0.118 |
Age (years) | 49.00 [38.00, 61.00] | 48.00 [36.00, 59.00] | 0.386 |
Male sex, n (%) | 180 (65.0) | 104 (63.0) | 0.683 |
Body mass index (kg/m2) | 24.84 [21.60, 29.39] | 25.95 [22.86, 30.86] | 0.168 |
PBW (kg) | 70.46 [59.63, 74.99] | 67.75 [59.63, 74.99] | 0.289 |
Charlson comorbity index | 2.00 [1.00, 4.00] | 2.00 [1.00, 5.00] | 0.926 |
Immunocompromised, n (%) | 68 (24.5) | 48 (29.1) | 0.315 |
SOFA at ARDS onset | 11.00 [8.00, 14.00] | 14.00 [11.00, 16.00] | < 0.001 |
APACHE at ARDS onset | 26.00 [20.00, 33.00] | 29.00 [23.00, 38.00] | 0.001 |
SAPS at ARDS onset | 53.00 [38.00, 68.00] | 61.00 [46.00, 76.00] | < 0.001 |
RASS at ARDS onset | − 5.00 [− 5.00, − 4.00] | − 5.00 [− 5.00, − 4.50] | 0.001 |
Pulmonary origin, n (%) | 253 (91.3) | 142 (86.1) | 0.110 |
ARDS severity, n (%) | 0.924 | ||
Mild | 1 (0.4) | 1 (0.6) | |
Moderate | 18 (6.5) | 9 (5.5) | |
Severe | 258 (93.1) | 155 (93.9) | |
ARDS etiology, n (%) | 0.058 | ||
Pneumonia | 195 (70.4) | 110 (66.7) | |
Aspiration | 18 (6.5) | 22 (13.3) | |
Other | 64 (23.1) | 33 (20.0) | |
ECMO initiation (ICU day) | 0.00 [0.00, 1.00] | 0.00 [0.00, 0.00] | 0.416 |
Ventilation parameters at ECMO Initiation | |||
PaO2/FiO2 (mmHg) | 68.12 [54.72, 91.32] | 63.65 [50.68, 76.53] | 0.054 |
PaO2 (mmHg) | 66.50 [54.45, 86.85] | 61.95 [49.98, 73.70] | 0.049 |
PaCO2 (mmHg) | 66.70 [55.10, 84.90] | 64.05 [51.98, 79.15] | 0.314 |
pH | 7.25 [7.17, 7.35] | 7.22 [7.13, 7.29] | 0.009 |
PIP (cmH2O) | 38.00 [34.15, 43.00] | 41.31 [37.30, 46.27] | < 0.001 |
Pplat (cmH2O) | 36.00 [31.00, 38.93] | 37.33 [34.89, 41.00] | 0.001 |
PEEP (cmH2O) | 18.00 [14.00, 20.00] | 20.00 [16.30, 22.00] | < 0.001 |
Driving pressure (cmH2O) | 17.60 [13.05, 20.70] | 17.97 [15.27, 22.13] | 0.074 |
Respiratory rate (breaths/min) | 25.00 [21.04, 27.94] | 23.55 [20.00, 27.00] | 0.295 |
Compliance (ml/cmH2O) | 29.76 [19.86, 44.55] | 29.36 [21.64, 45.27] | 0.847 |
Tidal volume (ml) | 368.09 [264.67, 473.33] | 392.69 [296.90, 528.57] | 0.129 |
Septic shock, n (%) | 151 (54.5) | 127 (77.0) | < 0.001 |
RRT, n (%) | 160 (57.8) | 132 (80.0) | < 0.001 |
PRBC units transfused (number) | 17.00 [8.00, 31.00] | 23.00 [13.00, 42.00] | < 0.001 |
Lactate (mg/dl) | 16.00 [10.00, 35.00] | 27.00 [14.00, 87.00] | < 0.001 |
Further rescue therapies, n (%) | |||
Inhaled nitric oxide | 192 (69.3) | 136 (82.4) | 0.002 |
Prone positioning | 203 (73.3) | 127 (77.0) | 0.429 |