Analysis of urinary C–C motif chemokine ligand 14 (CCL14) and first-generation urinary biomarkers for predicting renal recovery from acute kidney injury: a prospective exploratory study

Table 2 Predictive accuracy of urinary biomarkers on day 0 for renal non-recovery

Urinary Biomarkers	AUC	p value	Cutoff	Sensitivity (%)	Specificity (%)
Urinary Biomarkers	(95% CI)	p value	Cutoff	(95% CI)	(95% CI)
[TIMP-2] × [IGFBP7]	0.78	< 0.001	0.72 (ng/mL)²/1000	65.6	85.0
[TIMP-2] × [IGFBP7]	(0.71–0.84)	< 0.001	0.72 (ng/mL)²/1000	(52.7–77.1)	(76.5–91.4)
CCL14	0.71	< 0.001	625.69 (pg/mL)	65.6	72.0
CCL14	(0.63–0.77)	< 0.001	625.69 (pg/mL)	(52.7–77.1)	(62.1–80.5)
NGAL	0.53	0.562	37.69 (pg/mL)	34.4	81.0
NGAL	(0.45–0.60)	0.562	37.69 (pg/mL)	(22.9–47.3)	(71.9–88.2)
[TIMP-2] × [IGFBP7] + CCL14	0.77	< 0.001	0.224	90.6	51.0
[TIMP-2] × [IGFBP7] + CCL14	(0.70–0.83)	< 0.001	0.224	(80.7–96.5)	40.8–61.1

Day 0 means the day of AKI diagnosis. AUC area under the receiver operating characteristic, CI confidence interval, TIMP-2 tissue inhibitor of metalloproteinases-2, IGFBP-7 insulin-like growth factor-binding protein 7, CCL14 C–C motif chemokine ligand 14, NGAL neutrophil gelatinase-associated lipocalin

ISSN: 2052-0492