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Table 3 Sensitivity analyses for in-hospital mortality between non-ICU and ICU patients

From: Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group

 

Number of patients

Difference (95% CI)

Non-ICU

ICU

Overall cohort

   

 Propensity score matching

165,344

165,344

\(-\)  3.4 (\(-\) 3.7 to \(-\) 3.1)

 Multivariable logistic regression

974,289

193,612

\(-\) 5.0 (\(-\) 5.2 to \(-\) 4.8)

Subcohort1: adults (20 ≤ age ≤ 64)

   

 Propensity score matching

42,628

42,628

\(-\) 2.7 (\(-\) 3.3 to \(-\) 2.2)

 Multivariable logistic regression

181,607

53,195

\(-\) 2.6 (\(-\) 3.0 to \(-\) 2.3)

Subcohort2: independent patients (Barthel index 100)

   

 Propensity score matching

40,488

40,488

\(-\) 5.8 (\(-\) 6.4 to \(-\) 5.2)

 Multivariable logistic regression

243,304

47,413

\(-\) 5.7 (\(-\) 6.1 to \(-\) 5.4)

Subcohort3: excluding patients with malignant tumor

   

 Propensity score matching

118,873

118,873

\(-\) 1.3 (\(-\) 1.7 to \(-\) 1.0)

 Multivariable logistic regression

660,935

142,509

\(-\) 2.6 (\(-\) 2.8 to \(-\) 2.3)

Subcohort4: excluding patients who were transferred to other hospitals

   

 Propensity score matching

118,680

118,680

\(-\) 1.5 (\(-\) 1.8 to \(-\) 1.1)

 Multivariable logistic regression

798,575

136,042

\(-\) 3.2 (\(-\) 3.5 to \(-\) 3.0)

Subcohort5: excluding patients on RRT

   

 Propensity score matching

135,069

135,069

\(-\) 6.2 (\(-\) 6.5 to \(-\) 5.9)

 Multivariable regression analysis

936,636

149,059

\(-\) 7.7 (\(-\) 8.0 to \(-\) 7.5)

Subcohort6: patients on vasopressor

   

 Propensity score matching

38,585

38,585

\(-\) 2.8 (\(-\) 3.5 to \(-\) 2.1)

 Multivariable logistic regression

94,823

54,529

\(-\) 3.7 (\(-\) 4.2 to \(-\) 3.1)

Subcohort7: patients on ventilators

   

 Propensity score matching

73,123

73,123

\(-\) 11.1 (\(-\) 11.6 to \(-\) 10.6)

 Multivariable logistic regression

114,689

103,265

\(-\) 12.1 (\(-\) 12.5 to \(-\) 11.7)

Subcohort8: patients on vasopressor and ventilators

   

 Propensity score matching

11,958

11,958

\(-\) 8.4 (\(-\) 9.5 to \(-\) 7.3)

 Multivariable logistic regression

65,666

12,133

\(-\) 8.6 (\(-\) 9.4 to \(-\) 7.8)

  1. ICU: intensive care unit; CI: confidence interval; RRT: renal replacement therapy