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Table 2 Probability of target attainment based on Monte Carlo simulations

From: Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study

CrCl (mL/min) Total daily dose (mg) Dose (mg) Dosing interval (h) Perfusion duration (h) Probability of Cmin (%)
> 12 mg/L  > 46 mg/mL
160 3000 1500 12 0.5 51 0
   4 62  < 0.5
   6 70  < 0.5
1000 8 0.5 65 0
   4 81  < 0.5
   6 88 1
3000 24 24 98 1
4500 1500 8 0.5 89 5
200 3000 1000 8 6 69  < 0.5
3000 24 24 89  < 0.5
4500 1500 8 4 84 1
   6 92 2
6000 2000 8 0.5 84 5
240 3000 3000 24 24 68  < 0.5
4500 1500 8 4 61  < 0.5
   6 74  < 0.5
4500 24 24 96 1
6000 2000 8 4 80 2
   6 89 3
6000 24 24 99 7
  1. Cmin minimum levetiracetam concentration, CrCl creatinine clearance. In bold, PTA (probability of Cmin higher than 12 mg/L) > 80%