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Table 4 Subgroup analysis for hospital mortality by quartile of the timing of tracheostomy

From: Association between early tracheostomy and patient outcomes in critically ill patients on mechanical ventilation: a multicenter cohort study

  Q1
Tracheostomy ≤ 6 days
Q2
Tracheostomy 7–10 days
Q3
Tracheostomy 11–14 days
Q4
Tracheostomy > 14 days
OR for quartile increment (95% CI) p value for trend p value for interaction*
Level of consciousness at ICU admission        0.310
GCS score < 8 (n = 498)
 n (%) 36/160 (22.5%) 32/161 (19.9%) 29/98 (29.6%) 24/79 (30.4%)    
 Crude OR (95% CI) 1 (reference) 0.85 (0.5–1.46) 1.45 (0.82–2.56) 1.5 (0.82–2.76) 1.19 (0.98–1.44) 0.081  
GCS ≥ 8 (n = 1040)
 n (%) 43/286 (15.0%) 71/244 (29.1%) 67/225 (29.8%) 94/285 (33.0%)    
 Crude OR (95% CI) 1 (reference) 2.32 (1.51–3.55) 2.4 (1.56–3.69) 2.78 (1.85–4.18) 1.33 (1.18–1.51) < 0.001  
Diagnosis for ICU admission (respiratory failure)        0.218
Patients with respiratory failure (n = 834)
 n (%) 52/255 (20.4%) 74/238 (31.1%) 62/172 (36.0%) 56/169 (33.1%)    
Crude OR (95% CI) 1 (reference) 1.76 (1.17–2.65) 2.2 (1.42–3.4) 1.93 (1.24–3.01) 1.25 (1.09–1.43) 0.001  
Patients without respiratory failure (n = 704)
 n (%) 27/191 (14.1%) 29/167 (17.4%) 34/151 (22.5%) 62/195 (31.8%)    
 Crude OR (95% CI) 1 (reference) 1.28 (0.72–2.26) 1.77 (1.01–3.08) 2.83 (1.71–4.7) 1.43 (1.21–1.67) < 0.001  
Diagnosis for ICU admission (cardiovascular surgery)        0.681
Patients after cardiovascular surgery (n = 202)
 n (%) 2/13 (15.4%) 5/32 (15.6%) 13/45 (28.9%) 35/112 (31.3%)    
 Crude OR (95% CI) 1 (reference) 1.02 (0.17–6.11) 2.23 (0.43–11.5) 2.5 (0.53–11.9) 1.41 (0.98–2.03) 0.063  
Other patients (n = 1336)
 n (%) 77/433 (17.8%) 98/373 (26.3%) 83/278 (29.9%) 83/252 (32.9%)    
 Crude OR (95% CI) 1 (reference) 1.65 (1.18–2.31) 1.97 (1.38–2.81) 2.27 (1.58–3.26) 1.3 (1.17–1.46) < 0.001  
  1. *p value for interaction is calculated between the timing of the tracheostomy and the diagnosis for ICU admission
  2. OR odds ratio, CI confidence interval, ICU intensive care unit, GCS Glasgow Coma Scale