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Table 1 Differences between the two guidelines

From: New avenues of sepsis research: obtaining perspective by analyzing and comparing SSCG 2021 and J-SSCG 2020

  J-SSCG2020 SSCG2021
Target audience Medical professionals Medical professionals and policymakers
Evidence to decision table 8 Domains 12 Domains
Categories of clinical question BQ, GPS, GRADE, EC BPS, GRADE, EC
Number of recommendations 125 93
 Definition and diagnosis of sepsis 2 Appendix
 Diagnosis of infection 5 1
 Source control 9 2
 Antimicrobial therapy 11 18
 Intravenous immunoglobulin therapy 3 1
 Initial resuscitation/inotropes 15 20
 Corticosteroid therapy 3 1
 Blood transfusion therapy 4 1
 Respiratory management 6 12
 Management of pain, agitation, and delirium 6 0
 Acute kidney injury/blood purification 7 4
 Nutrition support therapy 10 2
 Blood glucose management 2 1
 Body temperature control 2 0
 Diagnosis and treatment of DIC 6 0
 Venous thromboembolism countermeasures 3 3
 ICU-AW and early rehabilitation 3 0
 Pediatric considerations 13 0
 Neuro intensive care 1 0
 Patients-and family-centered care 7 0
 Sepsis treatment system 5 4
 Stress ulcer prophylaxis 2 1
 Bicarbonate therapy 0 2
 Long-term outcomes and goals of care 0 20
  1. J-SSCG Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock, SSCG Surviving Sepsis Campaign Guideline, BQ background question, GPS good practice statement, GRADE Grading of Recommendations, Assessment, Development and Evaluation, EC expert consensus, BPS best practice statement, DIC disseminated intravascular coagulation, ICU-AW intensive care unit-acquired weakness