Table 1 Differences between the two guidelines

Target audience

Medical professionals

Medical professionals and policymakers

Evidence to decision table

8 Domains

12 Domains

Categories of clinical question

BQ, GPS, GRADE, EC

BPS, GRADE, EC

Number of recommendations

125

93

 Definition and diagnosis of sepsis

2

Appendix

 Diagnosis of infection

5

1

 Source control

9

2

 Antimicrobial therapy

11

18

 Intravenous immunoglobulin therapy

3

1

 Initial resuscitation/inotropes

15

20

 Corticosteroid therapy

3

1

 Blood transfusion therapy

4

1

 Respiratory management

6

12

 Management of pain, agitation, and delirium

6

0

 Acute kidney injury/blood purification

7

4

 Nutrition support therapy

10

2

 Blood glucose management

2

1

 Body temperature control

2

0

 Diagnosis and treatment of DIC

6

0

 Venous thromboembolism countermeasures

3

3

 ICU-AW and early rehabilitation

3

0

 Pediatric considerations

13

0

 Neuro intensive care

1

0

 Patients-and family-centered care

7

0

 Sepsis treatment system

5

4

 Stress ulcer prophylaxis

2

1

 Bicarbonate therapy

0

2

 Long-term outcomes and goals of care

0

20