Table 3 Results of subgroup analyses for in-hospital mortality
Analyses | In-hospital mortality, n (%) | Difference, % | P value | |
|---|---|---|---|---|
ICU | HDU | (95% CI) | ||
Overall cohort | 6,696/62,352 (10.7) | 7,101/62,352 (11.4) | − 0.6 (− 1.5 to 0.2) | 0.14 |
Subgroups | ||||
Respiratory support | ||||
No supplemental oxygen | 1,087/12,005 (9.1) | 1,055/12,106 (8.7) | 0.3 (− 0.8 to 1.4) | 0.54 |
Supplemental oxygen | 2,393/24,121 (9.9) | 2,241/23,535 (9.5) | 0.4 (− 0.3 to 1.1) | 0.29 |
Noninvasive ventilation | 2,171/23,015 (9.4) | 2,442/23,351 (10.5) | − 1.0 (− 1.9 to − 0.1) | 0.026 |
Intubation | 1,045/3,211 (32.5) | 1,363/3,360 (40.6) | − 8.0 (− 14.5 to − 1.5) | 0.015 |
Intravenous vasodilator | ||||
Yes | 2,958/42,058 (7.0) | 3,146/41,971 (7.5) | − 0.5 (− 1.0 to 0.1) | 0.097 |
No | 3,738/20,294 (18.4) | 3,955/20,381 (19.4) | − 1.0 (− 3.1 to 1.1) | 0.36 |
Diuretic | ||||
Yes | 3,873/43,123 (9.0) | 4,010/43,155 (9.3) | − 0.3 (− 0.9 to 0.3) | 0.30 |
No | 2,823/19,229 (14.7) | 3,091/19,197 (16.1) | − 1.4 (− 3.6 to 0.8) | 0.21 |
Inotrope | ||||
Yes | 1,527/8,735 (17.5) | 1,549/8,843 (17.5) | 0.0 (− 1.5 to 1.4) | 0.96 |
No | 5,169/53,617 (9.6) | 5,552/53,509 (10.4) | − 0.7 (− 1.7 to 0.2) | 0.13 |
Vasopressor | ||||
Yes | 1,434/5,047 (28.4) | 1,522/4,985 (30.5) | − 2.1 (− 4.4 to 0.2) | 0.070 |
No | 5,262/57,305 (9.2) | 5,579/57,367 (9.7) | − 0.5 (− 1.4 to 0.3) | 0.19 |
Mechanical circulatory support | ||||
Yes | 150/583 (25.7) | 172/609 (28.2) | − 2.5 (− 7.9 to 2.9) | 0.36 |
No | 6,546/61,769 (10.6) | 6,929/61,743 (11.2) | − 0.6 (− 1.5 to 0.2) | 0.16 |
Renal replacement therapy | ||||
Yes | 306/3,052 (10.0) | 282/3,087 (9.1) | 0.9 (− 0.8 to 2.6) | 0.31 |
No | 6,390/59,300 (10.8) | 6,819/59,265 (11.5) | − 0.7 (− 1.6 to 0.1) | 0.12 |