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Table 2 Univariate and multivariate linear regression analyses of factors associated with plasma TMAO concentration (log transformation to achieve normality before analysis) in septic patients

From: Paradox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients

  Univariate analysis Multivariate analysis*
  Std β p value Std β p value
Age 0.018 0.866   
Male gender 0.153 0.139   
Smoker 0.145 0.161   
APACHE II scores − 0.090 0.387   
SOFA scores − 0.045 0.663   
Mean arterial pressure − 0.248 0.015 − 0.215 0.001
Septic shock − 0.202 0.050 − 0.155 0.019
Respiratory tract infection − 0.007 0.943   
Urinary tract infection 0.124 0.231   
Intra-abdominal infection − 0.161 0.119   
Bloodstream infection − 0.131 0.205   
Antibiotic pre-treatment, numbers − 0.644  < 0.001 − 0.337  < 0.001
Antibiotic pre-treatment, days − 0.375  < 0.001   
Hypertension 0.170 0.100   
Diabetic mellitus 0.088 0.398   
Heart failure − 0.030 0.773   
COPD − 0.114 0.270   
Cirrhosis − 0.041 0.691   
Prior CAD 0.294 0.004   
Prior stroke or PAD 0.145 0.162   
Malignancy − 0.110 0.291   
Autoimmune disease 0.113 0.276   
White blood cells (K) 0.047 0.653   
Hemoglobin 0.011 0.916   
eGFR at ICU admission − 0.357  < 0.001 − 0.156 0.015
Total bilirubin − 0.161 0.120   
Glucose 0.082 0.427   
Lactate − 0.059 0.573   
C-reactive protein 0.261 0.011   
Enteral intake of calories 0.602  < 0.001 0.279  < 0.001
Enteral intake of protein 0.566  < 0.001   
Total calories (% of target) 0.573  < 0.001   
Total protein (% of target) 0.500  < 0.001   
Body mass index 0.380  < 0.001   
Albumin 0.397  < 0.001   
Prealbumin 0.456  < 0.001 0.157 0.025
Nutrition risk index 0.519  < 0.001 0.187 0.007
NRS 2002 scores − 0.453  < 0.001   
  1. TMAO trimethylamine-N-oxide; APACHE Acute Physiology and Chronic Health Evaluation; SOFA Sequential Organ Failure Assessment; CAD coronary artery disease; CI confidence interval; COPD chronic obstructive pulmonary disease; PAD peripheral arterial disease; eGFR estimated glomerular filtration rate; HR hazard ratio; NRS-2002 Nutritional Risk Screening 2002
  2. *Adjusted for variables with p < 0.1 in the univariate analysis