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Table 4 Baseline characteristics of ARDS patients in different MLR levels

From: Monocyte-to-lymphocyte ratio is associated with 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study

Variables Low MLR
(MLR < 0.90, n = 186)
High MLR
(MLR ≥ 0.90, n = 82)
P value
Age (years) 67 (60.75–72) 68 (62–73) 0.448
Male, n (%) 131 (70.4) 61 (74.4) 0.507
Smoking, n (%) 61 (32.8) 24 (29.3) 0.567
Alcohol abuse, n (%) 47 (25.3) 16 (19.5) 0.306
Hypertension, n (%) 82 (44.1) 34 (41.5) 0.690
Diabetes mellitus, n (%) 50 (26.9) 24 (29.3) 0.687
Coronary artery disease, n (%) 39 (21) 15 (18.3) 0.615
Risk factor, n (%)    0.263
 Pneumonia 167 (89.7) 79 (96.3)  
 Aspiration 8 (4.3) 2 (2.4)  
 Sepsis 5 (2.8) 1 (1.3)  
 Others 6 (3.2) 0 (0)  
Types of infection, n (%)    0.629
 Bacteria 138 (74.2) 65 (79.3)  
 Virus 7 (3.8) 1 (1.2)  
 Fungus 26 (14) 11 (13.4)  
 Unknown 15 (8) 5 (6.1)  
PaO2/FiO2 (mmHg) 142 (101–194) 138 (87.61–184.25) 0.386
Categories of ARDS, n (%)    0.546
 Mild 40 (21.5) 17 (20.7)  
 Moderate 101 (54.3) 40 (48.8)  
 Severe 45 (24.2) 25 (30.5)  
WBC, 109/L 9.56 (6.86–11.75) 9.7 (6.67–11.89) 0.944
Hemoglobin, g/L 112.5 (98–129.25) 105 (91.5–124.25) 0.091
RDW, % 13.75 (12.9–15.1) 13.9 (13–14.9) 0.775
Lactate, mmol/L 2.2 (1.4–3.83) 2.6 (1.5–3.73) 0.192
Albumin, g/L 32.9 (28.9–37.7) 32.15 (28.58–37.3) 0.349
MLR 0.41 (0.26–0.59) 1.49 (1.15–2.24) <0.001
NLR 8.45 (4.47–16.09) 20.62 (13.11–35.12) <0.001
RDW/albumin, %/g/L 0.43 (0.36–0.51) 0.43 (0.37–0.49) 0.903
AST 50.45 (21.03–139.13) 75.25 (28.7–151.78) 0.106
ALT 54.55 (20–125.93) 62.45 (25.28–149.53) 0.465
Cr, μmol/L 94.35 (58.28–181.88) 134.7 (71.78–197.98) 0.025
BUN, mmol/L 13.28 (7.4–17.8) 13.57 (9.79–19.2) 0.154
APACHE II score 12 (9–16) 14 (10–17.25) 0.308
SOFA score 7 (6–9) 8 (7–9) 0.046
Interventions, n (%)    
 Steroida 129 (69.4) 55 (67.1) 0.711
 Hypoglycemic 58 (31.2) 23 (28) 0.607
 Alimentotherapy 113 (60.8) 66 (80.5) 0.002
 Albumin infusion 82 (44.1) 55 (67.1) 0.001
 Transfusion 51 (27.4) 32 (39) 0.058
 CRRT 23 (12.4) 16 (19.5) 0.126
 ECMO 7 (3.8) 4 (4.9) 0.672
 Mechanical ventilation 109 (58.6) 50 (61) 0.715
28-day mortality, n (%) 38 (20.4) 47 (57.3) <0.001
Duration of ventilation 6 (2–12) 10 (3.75–14) 0.008
Hospital length of stay 19 (12–24.25) 18.5 (12.75–25) 0.787
  1. aSteroid therapy was defined as at least a dose (≥ 0.5mg/kg) of methylprednisolone during hospitalization
  2. ARDS, acute respiratory distress syndrome; WBC, white blood cell; RDW, red cell distribution width; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Cr, creatinine; BUN, blood urea nitrogen; APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation