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Table 1 Descriptive statistics for the whole ICU population, the sepsis-3 subgroup, the cardiac arrest subgroup and the trauma subgroup. If not stated otherwise, values represent medians (interquartile ranges, IQR)

From: Circulating dipeptidyl peptidase 3 on intensive care unit admission is a predictor of organ dysfunction and mortality

  ICU Sepsis Cardiac arrest Trauma
Number of patients 1978 632 (32%) 190 (9.6%) 157 (7.9%)
Women (%) 39 40 27 23
ICU length-of-stay (days) 1.7 (0.8–3.8) 2.5 (1.1–5.5) 2.4 (0.97–4.3) 1.8 (0.93–4.1)
ICU mortality (%) 11 14 34 4.5
30-day mortality (%) 22 28 54 12
SAPS-3 score 59 (47–71) 66 (57–77) 76 (66–87) 48 (39–59)
Day-one SOFA score 7 (4–10) 8 (6–11) 10 (8–13) 5 (2–7)
Day-two SOFA score (n = 995) 8 (5–10) 8 (6–11) 10 (8–12) 6 (4–9)
CRRT during ICU stay (%) 9.2 15 7.4 0.6
Box I     
Age (years) 66 (54–74) 69 (61–76) 68 (60–76) 55 (33–70)
Comorbidities     
- Cancer therapy (%) 4.6 6.3 4.2 0.6
- Chronic heart failure (%) 5.5 7.0 10 1.3
- Haematological cancer (%) 2.6 5.2 1.0 0
- Liver cirrhosis (%) 1.1 1.6 0 0
- Cancer (%) 10.4 10.4 7.9 1.3
Vasoactive drugs before ICU (%) 44 47 64 21
Box II     
Surgical status at ICU admission     
- No surgery (%) 74 85 94 83
Box III     
GCS 13 (10–15) 13 (10–15) 3 (3–8) 10 (6–15)
Total bilirubin (μmol/L) 9 (6–15) 10 (7–19) 8 (5–12) 8 (5–12)
Max. temperature (∘C) 37.0 (36.3–37.6) 37.3 (36.5–38.1) 36.0 (35.5–36.8) 37.0 (36.0–37.5)
Max. creatinine (μmol/L) 93 (70–145) 119 (79–205) 112 (87–149) 87 (74–111)
Max. heart rate (bpm) 100 (80–118) 107 (90–122) 98 (80–115) 90 (80–110)
Max. leukocyte count (×109/L) 13 (8.8–18) 13 (8.4–19) 16 (12–21) 14 (11–19)
Min. pH 7.34 (7.24–7.41) 7.32 (7.20–7.40) 7.19 (7.04–7.3) 7.34 (7.29–7.40)
Min. platelet count (×109/L) 221 (161–286) 218 (147–304) 222 (165–270) 212 (171–261)
Min. systolic blood pressure (mmHg) 100 (80–120) 91 (75–115) 85 (68–109) 104 (90–130)
Oxygenation     
- Respiratory support (%) 58 59 86 53
- FiO2 (%) 50 (40–70) 60 (40–80) 60 (50–80) 45 (40–57)
- PaO2 (kPa) 13 (9.8–18) 11 (9.0–15) 13 (11–22) 16 (11–24)
Other     
cDPP3 (ng/mL) 19 (13–33) 19 (13–31) 44 (28–69) 22 (14–38)
  1. Box I-III refers to the subsections of the SAPS-3 scoring system. ICU intensive care unit, SAPS-3 simplified acute physiology score III, SOFA Sequential Organ Failure Assessment, CRRT continuous renal replacement therapy, GCS Glasgow coma scale, FiO2 fraction of inspired oxygen, PaO2 arterial partial pressure of oxygen, cDPP3 circulating dipeptidyl peptidase 3
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Journal of Intensive Care

ISSN: 2052-0492