Table 2 Plasma syndecan-1 (Syn-1) level and organ failure

 Creatinine, median (IQR), mg/dL

2.2 (1.3, 4)

1.1 (0.7, 2.5)

0.119

1.9 (1.0, 4.0)

1.9 (0.8, 2.8)

0.669

 DIC score, median (IQR)

6 (5, 8)

5.5 (3.3, 7.8)

0.151

6 (4, 8)

6 (5, 8)

0.945

 Total bilirubin, median (IQR), mg/dL

1.78 (1.20, 3.27)

1.19 (0.83, 1.68)

0.051

1.94 (1.17, 3.46)

1.3 (0.79, 2.03)

0.113

 Glasgow coma scale, median (IQR)

14 (6.8, 15)

14.5 (12, 15)

0.235

14.5 (9, 15)

14 (8.8, 15)

0.578

 Norepinephrine dose, median (IQR), mcg/kg/min

0.6 (0.4, 0.8)

0.4 (0.2, 0.5)

0.063

0.6 (0.3, 0.8)

0.4 (0.3, 0.6)

0.14

 PaO₂/FiO₂, median (IQR)

340 (248, 420)

0.032

194 (161, 274)

330 (204, 420)

0.032

 ARDS, n (%)

15/21 (71)

5/17 (29)

0.01

10/11 (91)

10/27 (37)

0.006

 Cumulative fluid balance, median (IQR), ml/kg/d

120 (42, 154)

0.003

157 (132, 220)

134 (76.6, 198)

0.221

 Ventilator-free days, median (IQR)

22 (15, 25)

25 (23, 28)

0.025

23 (19, 25)

25 (20, 28)

0.305

 APACHE II^a, median (IQR)

31 (28, 35)

27.5 (24.3, 31)

0.082

30 (26, 34)

30 (26, 35)

0.636

 Maximum SOFA^b, median (IQR)

12 (10, 17)

9 (7, 15)

0.071

15 (9, 15)

11 (7.8, 15)

0.229

 Syn-1, median (IQR), ng/mL

1022 (612, 1473)

253 (168, 415)

<0.001

805 (546, 899)

177 (142, 250)

<0.001