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Table 2 Quality of evidence assessment

From: Neuromuscular blockade in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials

QuestionQuality assessmentQuality of evidence
BiasInconsistencyIndirectnessImprecision
28-day mortalitySeriousaModeratebNo serious indirectnessNo serious imprecisionModerate
90-day mortalitySeriousaModeratebNo serious indirectnessUndetectedModerate
ICU mortalitySeriousaUndetectedUndetectedDetectedcLow
Mechanical ventilation durationSeriousaUndetectedNo serious indirectnessNo serious imprecisionModerate
Ventilator-free days at day 28thSeriousaUndetectedNo serious indirectnessNo serious imprecisionModerate
ICU weaknessSeriousaUndetectedNo serious indirectnessNo serious imprecisionModerate
BarotraumaSeriousaUndetectedNo serious indirectnessNo serious imprecisionModerate
  1. aBias was rated high because of no blinding in four out of five studies (see Table 1)
  2. bInconsistency across studies in these two outcomes based on I2 was moderate
  3. cImprecision was detected for this outcome because there was no value for this outcome available for 1 out of 5 studies