Risk modifiers of acute respiratory distress syndrome in patients with non-pulmonary sepsis: a retrospective analysis of the FORECAST study

Table 3 Multivariable analysis for having ARDS associated with non-pulmonary sepsis (n = 594)

Variable		Odds ratio (95% CI)	P value
Age at admission—per year		0.99 (0.97–1.01)	0.29
Male gender		1.33 (0.71–2.49)	0.37
Admission source	Hospital wards and other hospitals	Reference
	Emergency department	1.89 (1.06–3.40)	0.03
	Intensive care unit	0.96 (0.25–3.65)	0.95
Body mass index—kg/m²		1.04 (0.98–1.09)	0.19
Smoking	Never	Reference
	Former	0.77 (0.39–1.54)	0.46
	Current	0.18 (0.06–0.59)	0.004
Coexisting conditions	Congestive heart failure	0.72 (0.26–1.88)	0.50
	COPD	1.54 (0.46–5.21)	0.49
	Diabetes mellitus	0.69 (0.35–1.37)	0.29
Regular medication	Glucocorticoids	0.48 (0.19–1.22)	0.12
Regular medication	Statin	0.36 (0.10–1.24)	0.11
Site of infection	Abdomen	Reference
	Urinary tract	0.71 (0.33–1.55)	0.39
	Soft tissue	2.37 (1.04–5.40)	0.04
	Other than abdomen, urinary tract, or soft tissue	1.57 (0.74–3.32)	0.24
Septic shock		1.43 (0.74–2.78)	0.29
APACHE II score—per point		1.08 (1.05–1.12)	< 0.001

ARDS acute respiratory distress syndrome, CI confidence interval, COPD chronic obstructive pulmonary disease, APACHE II acute physiology and chronic health evaluation II
Definition of categorical variables: other than abdomen, urinary tract, or soft tissue = central nervous system, intravenous catheter, osteoarticular, endocardium, wound, implant device, and others
Missing data (due to missing data of each outcome measures): admission source = 1; body mass index = 9; smoking = 45; APACHE II score = 53

ISSN: 2052-0492