|
6-h lactate clearance (%)
|
(n = 46) 26.8 (39.8)
|
(n = 46) 26.4 (38.1)
|
Mean difference − 0.5% (− 16 to 15.6%)
|
0.95
|
|
Patients with MAP ≥ 65 mmHg at 1 h
|
36/47 (77%)
|
42/47 (89%)
|
RR 1.17(0.97–1.41)
|
0.049
|
|
Patients with MAP ≥ 65 mmHg at 6 h
|
43/47 (92%)
|
43/48 (90%)
|
RR 0.98(0.86–1.12)
|
0.73
|
|
P/F ratio at 6 h (mmHg)
|
(n = 46) 337 (178)
|
(n = 46) 363 (159)
|
Mean difference 26( − 44 to 96)
|
> 0.99
|
|
Fluid input in 6 h (ml)
|
(n = 47) 2600 (2100, 3489)
|
(n = 48) 2238(1898, 2488)
| |
0.003
|
|
Fluid input per body weight in 6 h (ml/kg)
|
(n = 47) 53 (46, 64)
|
(n = 48) 39 (35, 52)
| |
< 0.001
|
|
Fluid input per body weight in 24 h (ml/kg)
|
(n = 40) 115 (86, 146)
|
(n = 45) 88 (63, 111)
| |
0.02
|
|
Fluid balance in 24 h (ml)
|
(n = 40) 3758 (1237, 4975)
|
(n = 43) 2896 (1520, 4535)
| |
0.68
|
|
Fluid input per body weight in 72 h (ml/kg)
|
(n = 37) 175 (124, 220)
|
(n = 37) 150 (108, 229)
| |
0.70
|
|
Fluid balance in 72 h (ml)
|
(n = 37) 3140 (377, 5524)
|
(n = 36) 4100 (2636, 7090)
| |
0.13
|
|
Requirement for vasopressors
|
27/42 (64%)
|
20/46 (43%)
|
RR 0.68 (0.45–1.01)
|
0.05
|
|
Days alive and free from vasopressors up to 28 days
|
(n = 44) 26 (0, 28)
|
(n = 46) 27.5 (22, 28)
| |
0.13
|
|
Requirement for mechanical ventilation
|
21/42 (50%)
|
19/46 (41%)
|
RR 0.83 (0.52–1.31)
|
0.41
|
|
Days alive and free from mechanical ventilation up to 28 days
|
(n = 44) 27.5 (0, 28)
|
(n = 46) 27 (9, 28)
| |
0.91
|
|
Requirement for new RRT
|
4/42 (10%)
|
6/46 (13%)
|
RR 1.34 (0.41–4.52)
|
0.74
|
|
Days alive and free from RRT up to 28 days
|
(n = 44) 28 (0, 28)
|
(n = 46) 28 (21, 28)
| |
0.60
|
|
Days alive and free from organ failure up to 28 days
|
(n = 44) 25 (0, 27.5)
|
(n = 46) 26 (9, 28)
| |
0.37
|
|
Hospital LOS (day)
|
6 (5, 14)
|
11 (3.5, 25)
| |
0.23
|
|
28-day mortality
|
12/48 (25%)
|
8/48 (17%)
|
RR 0.67 (0.30–1.48)
|
0.32
|
|
90-day mortality
|
15/48 (31%)
|
9/48 (19%)
|
RR 0.60 (0.29–1.24)
|
0.16
|
