Table 3 Secondary outcomes
| Â | Standard rate (n = 48) | Limited rate (n = 48) | Point estimates (95% CI)* | p value |
|---|---|---|---|---|
6-h lactate clearance (%) | (n = 46) 26.8 (39.8) | (n = 46) 26.4 (38.1) | Mean difference − 0.5% (− 16 to 15.6%) | 0.95 |
Patients with MAP ≥ 65 mmHg at 1 h | 36/47 (77%) | 42/47 (89%) | RR 1.17(0.97–1.41) | 0.049 |
Patients with MAP ≥ 65 mmHg at 6 h | 43/47 (92%) | 43/48 (90%) | RR 0.98(0.86–1.12) | 0.73 |
P/F ratio at 6 h (mmHg) | (n = 46) 337 (178) | (n = 46) 363 (159) | Mean difference 26( − 44 to 96) | > 0.99 |
Fluid input in 6 h (ml) | (n = 47) 2600 (2100, 3489) | (n = 48) 2238(1898, 2488) | Â | 0.003 |
Fluid input per body weight in 6 h (ml/kg) | (n = 47) 53 (46, 64) | (n = 48) 39 (35, 52) | Â | < 0.001 |
Fluid input per body weight in 24 h (ml/kg) | (n = 40) 115 (86, 146) | (n = 45) 88 (63, 111) | Â | 0.02 |
Fluid balance in 24 h (ml) | (n = 40) 3758 (1237, 4975) | (n = 43) 2896 (1520, 4535) | Â | 0.68 |
Fluid input per body weight in 72 h (ml/kg) | (n = 37) 175 (124, 220) | (n = 37) 150 (108, 229) | Â | 0.70 |
Fluid balance in 72 h (ml) | (n = 37) 3140 (377, 5524) | (n = 36) 4100 (2636, 7090) | Â | 0.13 |
Requirement for vasopressors | 27/42 (64%) | 20/46 (43%) | RR 0.68 (0.45–1.01) | 0.05 |
Days alive and free from vasopressors up to 28 days | (n = 44) 26 (0, 28) | (n = 46) 27.5 (22, 28) | Â | 0.13 |
Requirement for mechanical ventilation | 21/42 (50%) | 19/46 (41%) | RR 0.83 (0.52–1.31) | 0.41 |
Days alive and free from mechanical ventilation up to 28 days | (n = 44) 27.5 (0, 28) | (n = 46) 27 (9, 28) | Â | 0.91 |
Requirement for new RRT | 4/42 (10%) | 6/46 (13%) | RR 1.34 (0.41–4.52) | 0.74 |
Days alive and free from RRT up to 28 days | (n = 44) 28 (0, 28) | (n = 46) 28 (21, 28) | Â | 0.60 |
Days alive and free from organ failure up to 28 days | (n = 44) 25 (0, 27.5) | (n = 46) 26 (9, 28) | Â | 0.37 |
Hospital LOS (day) | 6 (5, 14) | 11 (3.5, 25) | Â | 0.23 |
28-day mortality | 12/48 (25%) | 8/48 (17%) | RR 0.67 (0.30–1.48) | 0.32 |
90-day mortality | 15/48 (31%) | 9/48 (19%) | RR 0.60 (0.29–1.24) | 0.16 |