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Table 3 Secondary outcomes

From: The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial

  Standard rate (n = 48) Limited rate (n = 48) Point estimates (95% CI)* p value
6-h lactate clearance (%) (n = 46) 26.8 (39.8) (n = 46) 26.4 (38.1) Mean difference − 0.5% (− 16 to 15.6%) 0.95
Patients with MAP ≥ 65 mmHg at 1 h 36/47 (77%) 42/47 (89%) RR 1.17(0.97–1.41) 0.049
Patients with MAP ≥ 65 mmHg at 6 h 43/47 (92%) 43/48 (90%) RR 0.98(0.86–1.12) 0.73
P/F ratio at 6 h (mmHg) (n = 46) 337 (178) (n = 46) 363 (159) Mean difference 26( − 44 to 96) > 0.99
Fluid input in 6 h (ml) (n = 47) 2600 (2100, 3489) (n = 48) 2238(1898, 2488)   0.003
Fluid input per body weight in 6 h (ml/kg) (n = 47) 53 (46, 64) (n = 48) 39 (35, 52)   < 0.001
Fluid input per body weight in 24 h (ml/kg) (n = 40) 115 (86, 146) (n = 45) 88 (63, 111)   0.02
Fluid balance in 24 h (ml) (n = 40) 3758 (1237, 4975) (n = 43) 2896 (1520, 4535)   0.68
Fluid input per body weight in 72 h (ml/kg) (n = 37) 175 (124, 220) (n = 37) 150 (108, 229)   0.70
Fluid balance in 72 h (ml) (n = 37) 3140 (377, 5524) (n = 36) 4100 (2636, 7090)   0.13
Requirement for vasopressors 27/42 (64%) 20/46 (43%) RR 0.68 (0.45–1.01) 0.05
Days alive and free from vasopressors up to 28 days (n = 44) 26 (0, 28) (n = 46) 27.5 (22, 28)   0.13
Requirement for mechanical ventilation 21/42 (50%) 19/46 (41%) RR 0.83 (0.52–1.31) 0.41
Days alive and free from mechanical ventilation up to 28 days (n = 44) 27.5 (0, 28) (n = 46) 27 (9, 28)   0.91
Requirement for new RRT 4/42 (10%) 6/46 (13%) RR 1.34 (0.41–4.52) 0.74
Days alive and free from RRT up to 28 days (n = 44) 28 (0, 28) (n = 46) 28 (21, 28)   0.60
Days alive and free from organ failure up to 28 days (n = 44) 25 (0, 27.5) (n = 46) 26 (9, 28)   0.37
Hospital LOS (day) 6 (5, 14) 11 (3.5, 25)   0.23
28-day mortality 12/48 (25%) 8/48 (17%) RR 0.67 (0.30–1.48) 0.32
90-day mortality 15/48 (31%) 9/48 (19%) RR 0.60 (0.29–1.24) 0.16
  1. Data are mean (SD), n/total n (%) and median (Q1, Q3)
  2. MAP mean arterial pressure, P/F PaO2/FiO2, RR relative risk, RRT renal replacement therapy, LOS length-of-stay
  3. *Point estimates are for the limited-rate group compared to the standard-rate group