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Table 1 Characteristics of the biological effects of oxygen molecules

From: Biological effects of the oxygen molecule in critically ill patients

 • Increase in arterial oxygen content and hence systemic oxygen delivery
 • Variable efficacy depending on the type of hypoxia
 • Systemic vasoconstriction
  • Increase in systemic vascular resistance and hence systemic arterial pressure
  • Decrease in cardiac stroke volume and cardiac output
  • Possible decrease in tissue blood flow
 • Pulmonary vasodilation in affected area by inhaled oxygen
  • Decrease in pulmonary vascular resistance and hence pulmonary arterial pressure
  • Increase in pulmonary blood flow
  • Decrease in right-to-left intracardiac shunt flow, if it exists
 • Regional perfusion
  • Decrease in coronary blood flow
  • Aggravation of ischemic damage in myocardial infarction
Cellular toxicity
 • Inflammation: Induction of pro-inflammatory cytokines
 • Production of reactive oxygen species
  • Enhanced neurological damage after ischemia reperfusion
  • Induced lung injury and possible dysfunction of other organs
 • Occurrence of resorption atelectasis
 • Impairment of mucociliary clearance in trachea/bronchus
 • Compromised innate immunity