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Table 1 Patient characteristics by diuretic exposure in 48–72 h after meeting acute respiratory distress syndrome criteria

From: Fluid management in ARDS: an evaluation of current practice and the association between early diuretic use and hospital mortality

Patient characteristicsa (units) No diuretic in 48–72 h after ARDS Received diuretic in 48–72 h after ARDS P value
No. of patients 118 116  
Demographics:
 Gender (female) 35 (30%) 42 (36%) 0.29
 Race (non-white) 26 (23%) 15 (13%) 0.07
 Age (years) 56 (17) 57 (15) 0.59
 Admission weight (kg) 82.5 [66.1-104.4] 82.5 [70.1-102.4] 0.63
Comorbidities:
 Congestive heart failure 38 (32%) 61 (53%) 0.002
 Chronic lung disease 38 (32%) 37 (32%) 0.96
 Cirrhosis 5 (4%) 4 (3%) 0.75
ARDS risk factors:
 Sepsis 57 (48%) 55 (47%) 0.89
 Trauma 46 (39%) 26 (22%) 0.006
ICU admission from operating room 17 (14%) 21 (18%) 0.44
ICU type: - - 0.0003b
 Medical ICU 37 (31%) 18 (16%)  
 Cardiothoracic ICU 12 (10%) 33 (28%)  
 Trauma-surgical ICU 38 (32%) 27 (23%)  
 Other ICU 31 (26%) 38 (33%)  
Prior to ARDS:
 Hospital length of stay (days) 1 [0–4] 1 [0–3.5] 0.44
 Mechanical ventilation (days) 0 [0–1] 0 [0–1] 0.15
 SOFA score, day 0 10.3 (2.9) 10.5 (2.9) 0.64
During ARDS hours 0–48:
 Shock 85 (78%) 88 (76%) 0.51
 Acute Kidney Injury 22 (19%) 15 (13%) 0.23
 Lowest PaO2:FiO2 ≤ 150 118 (100%) 116 (100%)  
 Any CVP measured 24 (20%) 44 (38%) 0.0031
 Any transfusion 32 (27%) 31 (27%) 0.95
Volume overload at 48 h 30 (25%) 19 (16%) 0.09
During ARDS hours 48–72:
 Shock 55 (47%) 48 (41%) 0.42
 Acute Kidney Injury 19 (16%) 12 (10%) 0.19
 Lowest PaO2:FiO2 ≤ 150 11 (9%) 16 (14%) 0.28
 Any CVP measured 10 (8%) 32 (28%) 0.0001
 Any transfusion 13 (11%) 6 (5%) 0.1
 Weight measured 68 (58%) 85 (73%) 0.012
 Total furosemide dosec (mg/24 h) – 40 [20-80] –
Outcomes
 RRT in first 7 days after ARDS 5 (4%) 2 (2%) 0.26
 Duration of MV, all (days) 7 [3–13] 5 [3–9] 0.034
 Duration of MV, survivors (days) 5 [3–13] 5 [3–8.5] 0.13
 Discharge home self-care 37 (31%) 47 (41%) 0.15
 Died in hospital 30 (25%) 16 (14%) 0.026
  1. Acute kidney injury is defined as serum creatinine ≥2 mg/dL or urine output <500 mL/day
  2. Shock is defined as vasopressor use or mean arterial pressure <60 mmHg for two measurements
  3. Abbreviations: ARDS acute respiratory distress syndrome, ICU intensive care unit; SOFA Sequential Organ Failure Assessment, CVP central venous pressure, RRT renal replacement therapy
  4. aData shown as n (%), mean (standard deviation) or median [inter-quartile range] if not normally distributed
  5. bp value for ICU type represents chi-square test for independence across ICU types
  6. cOf patients who received diuretics in 48–72 h after ARDS, 108 (93%) received furosemide
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Journal of Intensive Care

ISSN: 2052-0492