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Table 1 Patient characteristics by diuretic exposure in 48–72 h after meeting acute respiratory distress syndrome criteria

From: Fluid management in ARDS: an evaluation of current practice and the association between early diuretic use and hospital mortality

Patient characteristicsa (units)

No diuretic in 48–72 h after ARDS

Received diuretic in 48–72 h after ARDS

P value

No. of patients

118

116

 

Demographics:

 Gender (female)

35 (30%)

42 (36%)

0.29

 Race (non-white)

26 (23%)

15 (13%)

0.07

 Age (years)

56 (17)

57 (15)

0.59

 Admission weight (kg)

82.5 [66.1-104.4]

82.5 [70.1-102.4]

0.63

Comorbidities:

 Congestive heart failure

38 (32%)

61 (53%)

0.002

 Chronic lung disease

38 (32%)

37 (32%)

0.96

 Cirrhosis

5 (4%)

4 (3%)

0.75

ARDS risk factors:

 Sepsis

57 (48%)

55 (47%)

0.89

 Trauma

46 (39%)

26 (22%)

0.006

ICU admission from operating room

17 (14%)

21 (18%)

0.44

ICU type:

-

-

0.0003b

 Medical ICU

37 (31%)

18 (16%)

 

 Cardiothoracic ICU

12 (10%)

33 (28%)

 

 Trauma-surgical ICU

38 (32%)

27 (23%)

 

 Other ICU

31 (26%)

38 (33%)

 

Prior to ARDS:

 Hospital length of stay (days)

1 [0–4]

1 [0–3.5]

0.44

 Mechanical ventilation (days)

0 [0–1]

0 [0–1]

0.15

 SOFA score, day 0

10.3 (2.9)

10.5 (2.9)

0.64

During ARDS hours 0–48:

 Shock

85 (78%)

88 (76%)

0.51

 Acute Kidney Injury

22 (19%)

15 (13%)

0.23

 Lowest PaO2:FiO2 ≤ 150

118 (100%)

116 (100%)

 

 Any CVP measured

24 (20%)

44 (38%)

0.0031

 Any transfusion

32 (27%)

31 (27%)

0.95

Volume overload at 48 h

30 (25%)

19 (16%)

0.09

During ARDS hours 48–72:

 Shock

55 (47%)

48 (41%)

0.42

 Acute Kidney Injury

19 (16%)

12 (10%)

0.19

 Lowest PaO2:FiO2 ≤ 150

11 (9%)

16 (14%)

0.28

 Any CVP measured

10 (8%)

32 (28%)

0.0001

 Any transfusion

13 (11%)

6 (5%)

0.1

 Weight measured

68 (58%)

85 (73%)

0.012

 Total furosemide dosec (mg/24 h)

40 [20-80]

Outcomes

 RRT in first 7 days after ARDS

5 (4%)

2 (2%)

0.26

 Duration of MV, all (days)

7 [3–13]

5 [3–9]

0.034

 Duration of MV, survivors (days)

5 [3–13]

5 [3–8.5]

0.13

 Discharge home self-care

37 (31%)

47 (41%)

0.15

 Died in hospital

30 (25%)

16 (14%)

0.026

  1. Acute kidney injury is defined as serum creatinine ≥2 mg/dL or urine output <500 mL/day
  2. Shock is defined as vasopressor use or mean arterial pressure <60 mmHg for two measurements
  3. Abbreviations: ARDS acute respiratory distress syndrome, ICU intensive care unit; SOFA Sequential Organ Failure Assessment, CVP central venous pressure, RRT renal replacement therapy
  4. aData shown as n (%), mean (standard deviation) or median [inter-quartile range] if not normally distributed
  5. bp value for ICU type represents chi-square test for independence across ICU types
  6. cOf patients who received diuretics in 48–72 h after ARDS, 108 (93%) received furosemide