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Table 3 Multivariable regression analyses for primary outcomes

From: Saline versus 5% dextrose in water as a drug diluent for critically ill patients: a retrospective cohort study

Outcome Adjusted OR/β-coefficient (95% CI) p value
Hyperglycemiaa
 Diluent group (saline) 1.08 (0.77–1.5) 0.671
 Blood glucose at ICU admission, mg/dL 1.01 (1.01–1.02) < 0.001
 Age, year 1.01 (1.0–1.02) 0.097
 Weight, kg 1.0 (0.99–1.01) 0.926
 APACHE III score 1.02 (1.01–1.03) < 0.001
 Time from hospitalization to ICU, days 1.01 (0.99–1.02) 0.339
 Patient category
  Planned surgical Reference  
  Nonplanned surgical 0.73 (0.48–1.13) 0.158
  Medical from ward 1.11 (0.65–1.91) 0.700
  Medical from ED 0.87 (0.54–1.42) 0.582
Hypernatremiab
 Diluent group (Saline) 2.43 (1.54–3.82) < 0.001
 Sodium at ICU admission, mmol/L 1.18 (1.11–1.26) < 0.001
 Age, year 1.01 (0.99–1.02) 0.373
 Weight, kg 1.0 (0.98–1.02) 0.997
 APACHE III score 1.02 (1.01–1.03) < 0.001
 Time from hospitalization to ICU, days 1.01 (1.0–1.02) 0.070
 Patient category
  Planned surgical Reference  
  Nonplanned surgical 1.74 (0.97–3.12) 0.061
  Medical from ward 2.53 (1.33–4.82) 0.005
  Medical from ED 1.70 (0.89–3.27) 0.109
  1. APACHE III Acute Physiology and Chronic Health Evaluation III, ED emergency department, ICU intensive care unit, OR odds ratio
  2. aPatients with baseline blood glucose ≥ 180 mg/dL were excluded (189 patients)
  3. bPatients with baseline sodium ≥ 145 mmol/L were excluded (109 patients)