Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes

Table 1 Characteristics of patients submitted to NIMV as primary ventilatory assistance, stratified according to the response to this method (success or failure) in the prospective cohort

Characteristics (n = 59)	NIMV failure (n = 30)	NIMV success (n = 29)	P
Age (years)	50.2 (± 16.7)	53.4 (± 17.4)	0.48
Sex	17 (56.7%)	14 (48.3%)	0.51
Lactate	1.4 (1.1–3.7)	1.4 (1.1–2.2)	0.63
PaO₂ upon inclusion (mmHg)	86.1 (73.7–115.9)	80.2 (74.2–109)	0.57
P/F upon inclusion	266.5 (222.8–336.3)	275 (243.5–335)	0.77
SaO₂	90 (86.5–95)	92 (90–96.5)	0.11
Overall leukocyte count (cells/mm³)	1020 (150–4233)	1794 (650–9210)	0.07
CRP	261.6 (128.5–361.6)	169.3 (99.5–251.7)	0.09
RR (rpm)	34 (29–39)	29 (27.5–34)	0.042
APACHE II	21 (17–27)	21 (17.5–24)	0.53
SAPS 3	64.5 (53.7–71.2)	63 (55–71)	0.85
SOFA admission	7.0 (5.0–8.2)	5.0 (3.5–7.0)	0.007
Use of vasopressor	27 (90%)	8 (27.6%)	< 0.001
Use of ATB	28 (93.3%)	25 (86.2%)	0.36
Use of ATF	24 (80 %)	22 (75.9%)	0.70
Use of corticosteroids	10 (33.3%)	13 (44.9%)	0.36
NT-proBNP	3255 (1055–13727)	4650 (1440–11905)	0.516
Comorbidities
COPD	4 (13.3%)	2 (6.9%)	0.42
HF	3 (10%)	7 (24.1%)	0.14
Follow-up data
HD	3 (10%)	2 (6.9%)	0.66
CT	17 (56.7%)	12 (40%)	0.24
Exclusive palliative care	2 (6.7%)	6 (20.7%)	0.11

ATB antibiotics, ATF antifungal, NT-proBNP biomarker portion N-terminal of pro-hormone of B-type natriuretic peptide, COPD chronic obstructive pulmonary disease, HF heart failure, PaO₂ arterial pressure of oxygen; P/F PaO₂/FIO₂ ratios, ICU intensive care unit, NIMV non-invasive mechanical ventilation, SaO₂ oxygen saturation, cells/mm³ cells per cubic millimeter, mmHg millimeters of mercury, CRP reactive protein, RR respiratory rate (incursion per minute), APACHE II Acute Physiology and Chronic Health Evaluation II; SAPS 3 Simplified Acute Physiology Score 3, SOFA Sequential Organ Failure Assessment, HD hemodialysis, CT chemotherapy
Except for age, presented as mean ± standard deviation, all continuous variables are presented as median (Q1–Q3). Categorical variables are presented as n (%)
Significance was considered when P < 0.05

ISSN: 2052-0492