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Table 1 Characteristics of included randomized control trials

From: Efficacy and safety of tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis

Author, year

No. of sites

No. of patients

Age (years)

Female (%)

Traffic accident (%)

Polytrauma (%)

GCS on arrival

ISS

Initial TXA

Maintenance TXA

sBP (mmHg)

Initial hemorrhage volume (mL)

Chakroun-Walha et al. 2018 [15]

1

180

41 ± 19

9

91

57

9 vs 10

22 vs 24

1 g/10 min

1 g/8 h

Mean BP 87 vs 89

N/A

Fakharian et al. 2018 [16]

1

149

42 vs 39

11

85

N/A

13 vs 12

N/A

1 g/10 min

1 g/8 h

118 vs 120

N/A

Jokar et al. 2017 [17]

1

80

35 vs 36

25

21

N/A

N/A

N/A

1 g/10 min

1 g/8 h

160/162

22 vs 22

Yutthakasemsunt et al. 2013 [18]

1

238

35 vs 34

12

N/A

85

12 and under 42%

23 vs 25

1 g/30 min

1 g/8 h

N/A

N/A

CRASH-2 2010 [10]

10

270

36 vs 37

15

N/A

N/A

12 and under 53%

N/A

1 g/10 min

1 g/8 h

Less than 90 mmHg 7%

17 vs 20

CRASH-3 2019 [9]

175

9202

42 vs 42

20

N/A

N/A

12 and under 71%

N/A

1 g/10 min

1 g/8 h

Less than 90 mmHg 2%

N/A

Ebrahimi et al. 2019 [19]

1

80

32 vs 33

15

N/A

N/A

12 and under 68%

N/A

1 g/10 min

1 g/8 h

N/A

N/A

  1. No. number, GCS Glasgow Coma Scale, TXA tranexamic acid, sBP systolic blood pressure, N/A not available, ISS Injury Severity Score, CRASH-2 CRASH-2 Collaborators, Intracranial Bleeding Study