Table 3 Effect of the antimicrobial administration either within 1 or 3 hours of admission to the ED, matched by PS, on in-hospital mortality
Antimicrobials ≤ 1 h vs. > 1 h, OR (95% CI) | Antimicrobials ≤ 3 h vs. > 3 h, OR (95% CI) | |
|---|---|---|
Models | n = 680 | n = 1562 |
No adjustment | 1.09 (0.69; 1.72) | 0.98 (0.74; 1.32) |
Adjusted for propensity score | 1.05 (0.66; 1.67) | 0.86 (0.63; 1.17) |
Adjusted for covariates* | 1.07 (0.65; 1.75) | 0.93 (0.67; 1.28) |
Adjusted for propensity score + covariates * | 1.03 (0.63; 1.70) | 0.85 (0.61; 1.20) |
Patients with confirmed infection | n = 548 | n = 1260 |
No adjustment | 1.00 (0.61; 1.64) | 1.00 (0.73; 1.38) |
Adjusted for propensity score | 0.99 (0.61; 1.63) | 0.89 (0.64; 1.25) |
Adjusted for covariates** | 0.92 (0.54; 1.58) | 0.91 (0.64; 1.30) |
Adjusted for propensity score + covariates** | 0.90 (0.53; 1.56) | 0.88 (0.61; 1.26) |
Patients with adequate antibiotics | n = 593 | n = 1288 |
No adjustment | 0.96 (0.59; 1.56) | 0.98 (0.71; 1.36) |
Adjusted for propensity score | 0.93 (0.57; 1.53) | 0.82 (0.58; 1.16) |
Adjusted for covariates*** | 0.88 (0.51; 1.50) | 0.89 (0.62; 1.27) |
Adjusted for propensity score + covariates*** | 0.86 (0.50; 1.46) | 0.82 (0.56; 1.19) |
Patients with shock—Rivers | n = 342 | n = 702 |
No adjustment | 0.96 (0.54; 1.73) | 0.98 (0.66; 1.44) |
Adjusted for propensity score | 0.91 (0.50; 1.66) | 0.87 (0.57; 1.32) |
Adjusted for covariates* | 0.92 (0.49; 1.74) | 0.92 (0.59; 1.42) |
Adjusted for propensity score + covariates* | 0.87 (0.46; 1.66) | 0.85 (0.54; 1.35) |
Patients with shock—Sepsis-3 | n = 91 | n = 170 |
No adjustment | 0.85 (0.34; 2.15) | 0.74 (0.39; 1.43) |
Adjusted for propensity score | 0.70 (0.26; 1.84) | 0.56 (0.27; 1.15) |
Adjusted for covariates* | 0.86 (0.31; 2.37) | 0.86 (0.40; 1.85) |
Adjusted for propensity score + covariates* | 0.75 (0.26; 2.14) | 0.65 (0.28; 1.51) |