Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study

Table 4 Survival analysis assessing 28-day mortality, patient characteristics, and circadian rhythm parameters of the temperature according to head trauma

	Head trauma				No head trauma
	Univariate		Multivariate		Univariate		Multivariate
	HR [95% CI]	p	HR [95% CI]	p	HR [95% CI]	p	HR [95% CI]	p
Clinical variables
Age	1.04 [1.02–1.06]	< 0.001	1.04 [1.02–1.06]	< 0.001	1.07 [1.03–1.12]	< 0.001	1.10 [1.04–1.17]	< 0.001
Sex (male)	1.68 [0.74–3.82]	0.22			2.36 [0.29–19.17]	0.42
Body mass index	0.91 [0.82–1.01]	0.07			0.90 [0.73–1.10]	0.30
Glasgow Coma Scale	0.96 [0.87–1.05]	0.33			0.84 [0.75–0.95]	0.004	0.77 (0.65–0.91)	0.003
Intracranial hypertension^a	7.55 [3.15–18.12]	< 0.001			–	–	–	–
Surgery at admission	0.90 [0.47–1.72]	0.75			0.71 [0.14–3.52]	0.68
ISS	1.01 [0.98–1.04]	0.47			1.01 [0.97–1.06]	0.57
Temperature rhythm
Period	1.00 [0.97–1.02]	0.74			1.05 [0.99–1.11]	0.11
Mesor	0.41 [0.25–0.65]	< 0.001	0.40 [0.23–0.70]	0.001	0.73 [0.23–2.29]	0.59
Amplitude	4.48 [1.24–19.20]	0.02	4.73 [1.38–16.22]	0.01	6.10 [1.06–35.25]	0.04	2.94 [0.50–17.25]	0.23

The analyses were performed using Cox regression model to estimate hazard ratios (HR) and their 95% confidence intervals (95% CIs)
^aIntracranial hypertension not included in the multivariate analysis owing to collinearity with head trauma

ISSN: 2052-0492