Table 4 Clinical data during the entire hospitalization in ICU
Non-frail at 6 months (n = 34) | Frail or death at 6 months (n = 54) | P* | Frail at 6 months (n = 29) | P** | |
|---|---|---|---|---|---|
Norepinephrine, yes | 17 (49) | 34 (63) | 0.230 | 17 (59) | 0.494 |
Norepinephrine, max dose, μg/kg min−1 | 0.3 (0.2–0.6) | 0.5 (0.3–0.7) | 0.123 | 0.4 (0.3–0.5) | 0.500 |
ARDS | 0.698 | 0.594 | |||
No | 30 (88) | 47 (87) | 26 (90) | ||
Moderate | 3 (9) | 3 (6) | 1 (3) | ||
Severe | 1 (3) | 4 (7) | 2 (7) | ||
Creatinin max, μmol l−1 | 106 (71–172) | 95 (70–169) | 0.687 | 75 (66–105) | 0.121 |
Score RIFLE | 0.902 | 0.532 | |||
No renal aggression | 12 (35) | 21 (39) | 15 (52) | ||
“Risk” | 7 (21) | 11 (20) | 6 (21) | ||
“Injury” | 7 (21) | 7 (13) | 3 (10) | ||
“Failure” | 8 (23) | 14 (26) | 5 (17) | ||
“Loss” | 0 (−) | 1 (2) | 0 (−) | ||
Extra renal support | 6 (18) | 13 (24) | 0.475 | 4 (14)) | 0.741 |
Mechanical ventilation | 28 (82) | 43 (79) | 0.753 | 25 (86) | 0.741 |
Length of mechanical ventilation, days | 2 (1–5) | 10 (3–21) | 0.002 | 5 (3–17) | 0.006 |
Sedation use | 23 (68) | 40 (74) | 0.515 | 21 (72) | 0.681 |
Length of sedation, days | 1 (1–3) | 3 (2–6) | 0.002 | 1 (1–4) | 0.095 |
Mean dose of midazolam, mg h−1 | 1.2 (1.0–1.5) | 1.3 (0.9–1.6) | 0.793 | 1.2 (0.9–1.5) | 0.902 |
Mean dose of morphine, mg h−1 | 1.9 (1.0–2.9) | 2.7 (1.5–3.8) | 0.178 | 2.1 (1.2–4.3) | 0.488 |
Use of neuro-blocking agent | 3 (9) | 9 (17) | 0.356 | 3 (10) | 1.000 |
Rehabilitation† | |||||
Mobilization | 19 (56) | 40 (74) | 0.125 | 20 (69) | 0.420 |
Out of bed | 15 (44) | 31 (57) | 0.319 | 19 (65) | 0.148 |
Enteral nutrition | 26 (77) | 46 (85) | 0.302 | 26 (90) | 0.170 |
Median daily dose of enteral nutrition delivered, Kcal/kg day−1 | |||||
Between day 0 and day 5 | 8 (5–12) | 11 (7–15) | 0.050 | 11 (6–16) | 0.151 |
Between day 6 and day 10 | 16 (11–22) | 15 (7–21) | 0.547 | 15 (6–22) | 0.599 |
Median daily protein delivered via enteral nutrition, g/kg day−1 | |||||
Between day 0 and day 5 | 0.3 (0.2–0.5) | 0.5 (0.3–0.6) | 0.025 | 0.5 (0.2–0.6) | 0.064 |
Between day 6 and day 10 | 0.7 (0.5–0.8) | 0.7 (0.4–0.8) | 0.532 | 0.6 (0.5–0.9) | 0.463 |