Table 1 Characteristics of overall population according to fluid overload status
Characteristics | All subjects, (n = 129) | No fluid overload, (n = 73) | Fluid overload, (n = 47) | p value |
|---|---|---|---|---|
Age, years, mean (SD) | 65.7 (12) | 66.9 (10) | 63.2 (13) | 0.091§ |
Weight at baseline, kg, mean (SD) | 77.3 (19.6) | 80 (20.6) | 72.3 (17) | 0.035§ |
Site of infection, n (%) | ||||
 Pneumonia | 94 (75.2) | 55 (78.6) | 32 (69.6) | 0.381 |
 Peritonitis | 32 (25.6) | 16 (22.9) | 14 (30.4) | 0.487 |
Comorbidities, n (%) | ||||
 Immunosuppression | 32 (25.4) | 19 (26.4) | 11 (23.9) | 0.933 |
 Cardio vascular disease | 65 (51.6) | 43 (59.7) | 16 (34.8) | 0.014§ |
 Neurological disease | 27 (21.4) | 14 (19.4) | 11 (23.9) | 0.728 |
 Psychiatric disorder | 24 (19.0) | 12 (16.7) | 11 (23.9) | 0.465 |
 Neoplasm | 37 (29.4) | 19 (26.4) | 17 (37.0) | 0.312 |
 Chronic respiratory disease | 41 (32.5) | 26 (36.1) | 12 (26.1) | 0.350 |
 Chronic liver failure | 23 (18.3) | 14 (19.4) | 8 (17.4) | 0.971 |
 Metabolic disorder | 36 (28.6) | 23 (31.9) | 10 (21.7) | 0.320 |
 Chronic renal insufficiency | 19 (15.1) | 5 (6.9) | 9 (19.6) | 0.076§ |
SOFA score at baseline, mean (SD) | 8.90 (2.99) | 8.60 (3.15) | 9.09 (2.72) | 0.390 |
APACHE II at baseline, mean (SD) | 25.28 (4.84) | 25.3 (4.85) | 25.1 (4.93) | 0.88 |
Daily FB, ml, mean (SD) | ||||
 Day 1 | 1604 (2806) | 1163 (1848) | 2117 (3915) | 0.075§ |
 Day 2 | 1618 (1547) | 1142 (1431) | 2387 (1443) | < 0.001§ |
 Day 3 | 1263 (2955) | 608 (1387) | 2475 (4213) | 0.001§ |
 Day 4 | 459 (1642) | 88 (1561) | 1041 (1653) | 0.002§ |
 Day 5 | 91 (1325) | − 272 (1184) | 691 (1410) | < 0.001§ |
Cumulative FB from day 1 to day 5, mL, mean (SD) | 5041 (6789) | 2738 (4217) | 8715 (8619) | < 0.001§ |
Delta SOFA score from day 0 to day 5, mean (SD) | 3.55 (4.01) | 4.52 (3.74) | 2.15 (3.50) | 0.001§ |
Outcomes | ||||
 ICU length of stay, mean (SD) | 17.15 (19.06) | 11.71 (10.61) | 27.66 (25.35) | < 0.001§ |
 28-day mortality, n (%) | 44 (34.1) | 21 (28.8) | 15 (31.9) | 0.870 |
 90-day mortality, n (%) | 55 (42.6) | 25 (34.2) | 22 (46.8) | 0.236 |
 Ventilator free at day 28, mean (SD) | 10.81 (10.59) | 13.84 (10.96) | 7.19 (8.43) | 0.001§ |
 Duration of RRT, mean (SD) | 4.50 (3.17) | 5.21 (3.18) | 3.85 (2.83) | 0.019§ |
 Catecholamine free at day 10, mean (SD) | 1.77 (4.47) | 1.47 (4.92) | 2.45 (4.04) | 0.257 |