Skip to main content

Table 1 Characteristics of study cohort

From: Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)

Clinical parameter

Control

Surgical trauma

Sepsis

Septic shock

P value*

n

7

20

63

17

N/A

Age, years

31 (24–52)

61 (51–68)

60 (49–70)

60 (54–72)

ns

Male, n (%)

3 (42)

11 (55)

37 (62)

10 (58)

ns

SOFA score

N/A

4 (2–7)

5 (3–7)

11 (8–13)

< 0.0001

Leucocytes, ×109/L

6.3 (5.8–7.9)

13.0 (12.0–15.1)

14.0 (9.9–18.5)

14.6 (9.4–24.9)

ns

Interleukin-6, ng/L

N/D

129.4 (61.7–263.3)

123.4 (46.2–304.5)

464.9 (132.7–1568)

< 0.05#

Procalcitonin, μg/L

N/D

0.81 (0.28–3.06)

0.73 (0.25–1.76)

4.19 (1.53–9.27)

< 0.01#

C-reactive protein, mg/L

5.0 (5.0–5.5)

97.5 (68.2–190.8)

145 (72.0–239.0)

128 (100.5–222.0)

ns

Lactat, mmol/L

N/D

1.2 (0.92–1.7)

1.3 (1.0–1.6)

2.8 (2.2–5.4)

< 0.0001

ICU length of stay, days

N/A

2 (1–5)

7 (3–10)

13 (8–31)

< 0.0001

Invasive ventilation, n (%)

N/A

1 (5)

19 (30)

8 (47)

< 0.01#

Dialysis, n (%)

N/A

0 (0)

4 (6)

6 (35)

< 0.001#

Died, n (%)

N/A

0 (0)

10 (16)

5 (30)

< 0.05#

  1. SOFA Sequential Organ Failure Assessment score, ICU intensive care unit, N/A not applicable, N/D not determined, ns not significant. Data are presented as median (IQR). *P value for trend between patient groups using a non-parametric ANOVA Kruskal-Wallis test if not otherwise indicated. #Chi-square for trend analysis