Fig. 1
From: Is early goal-directed therapy associated with a higher risk of adverse events?
Forest plot of the risk difference of serious adverse events (SAEs) between early goal-directed therapy (EGDT) and usual care. The risk difference of individual studies is represented by a square through which runs a horizontal line (95% confidence interval). The diamond represents the pooled effect size. Data were extracted from the supplementary appendix of each trial and analyzed by RevMan 5. Events refer to number of SAEs not the number of patients (some patients might experience more than one SAE). ProCESS reported all SAEs occurring in the first 72 h post-randomization and after 72 h SAEs were limited to a specific list of events that could be related to the intervention at that point in time (e.g., central line infection, or arterial line complication), or events that the site principal investigator considered potentially related to the study intervention. ARISE reported SAEs up to 72 h post-randomization only. ProMIse reported SAEs within 30 days