Table 1 Parameters used in these models of virtual AKI patients receiving CRRT [14,15,16,17,18]
Pharmacokinetic parameters Mean ± SD (range limits) | ||
|---|---|---|
Hemofiltration (HF) | Hemodialysis (HD) | |
Weight (kg) | 60.72 ± 14.5 (40–230) | |
Vd (L/kg) | 0.5 ± 0.23 (0.21–1.11) | |
CLNR (mL/min) | 24.33 ± 11.25 (13–44) | |
Free fraction | 0.79 ± 0.09 (0.72–0.85) | |
SC or SA | 0.79 ± 0.15 (0.47–0.92) | 0.77 ± 0.09 (0.65–0.97) |