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Table 1 Characteristics of the included studies

From: Recruitment maneuver does not provide any mortality benefit over lung protective strategy ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis and systematic review of the randomized controlled trials

Author Participants Intervention Control
ART investigators 2017 Patients receiving invasive mechanical ventilation with moderate to severe ARDS (AECC definition) of < 72 h duration LRM with incremental PEEP levels, followed by decremental PEEP titration according to the best respiratory system Cs and by a second LRM Low PEEP strategy
Hodgson 2011 Adult patients (age > 15years) with PaO2/FiO2 < 200 LRM to Ppeak of 55 cm H2O and decremental PEEP titration to determine optimal PEEP ARDSnet protocol
Kacmarek 2016 ARDS patients with PaO2/FiO2 < 200 at FiO2 ≥ 0.5 and PEEP ≥ 10 LRM to Ppeak of ≤ 60 cm H2O for 2 min and decremental PEEP titration to determine optimal PEEP. ARDSnet protocol
Liu 2011 Adult patients with ARDS (PaO2/FiO2 ≤ 250 mmHg) with FiO2 ≥ 0.5 and PEEP ≥ 10 cm H2O) at least 30 min LRM with PEEP 35 cm H2O and Ppeak up to 50 cm H2O maintained for 2 min, then PEEP was set higher at 2 cm H2O above closing pressure Lung protective ventilation strategy
Xi 2010 Adult patients with ARDS (PaO2 ≤ 200 mmHg at FiO2 1.0 and PEEP ≥ 10 cm H2O) LRM with CPAP 40 cm H2O for 40 s Lung protective ventilation strategy
Meade 2008 Adult patients with ARDS (PaO2/FiO2 < 250) LRM by CPAP of 40 cm H2O for 40 s with FiO2 1.0. PEEP was adjusted as per FiO2 requirement. Low tidal volume ventilation with standard PEEP
Huh 2009 ARDS patients with PaO2/FiO2 < 200 LRM to Ppeak of 55 cm H2O and 25% tidal volume reduction and decremental PEEP titration to determine optimal PEEP ARDSnet protocol
  1. ARDS acute respiratory distress syndrome, AECC American European Consensus Conference Criteria, PaO 2 arterial oxygen tension, FiO 2 fraction of oxygen in inspiration, PEEP positive end-expiratory pressure, P peak peak airway pressure, LRM lung recruitment maneuver, CPAP continuous positive airway pressure