ART investigators 2017
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Patients receiving invasive mechanical ventilation with moderate to severe ARDS (AECC definition) of < 72 h duration
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LRM with incremental PEEP levels, followed by decremental PEEP titration according to the best respiratory system Cs and by a second LRM
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Low PEEP strategy
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Hodgson 2011
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Adult patients (age > 15years) with PaO2/FiO2 < 200
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LRM to Ppeak of 55 cm H2O and decremental PEEP titration to determine optimal PEEP
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ARDSnet protocol
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Kacmarek 2016
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ARDS patients with PaO2/FiO2 < 200 at FiO2 ≥ 0.5 and PEEP ≥ 10
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LRM to Ppeak of ≤ 60 cm H2O for 2 min and decremental PEEP titration to determine optimal PEEP.
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ARDSnet protocol
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Liu 2011
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Adult patients with ARDS (PaO2/FiO2 ≤ 250 mmHg) with FiO2 ≥ 0.5 and PEEP ≥ 10 cm H2O) at least 30 min
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LRM with PEEP 35 cm H2O and Ppeak up to 50 cm H2O maintained for 2 min, then PEEP was set higher at 2 cm H2O above closing pressure
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Lung protective ventilation strategy
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Xi 2010
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Adult patients with ARDS (PaO2 ≤ 200 mmHg at FiO2 1.0 and PEEP ≥ 10 cm H2O)
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LRM with CPAP 40 cm H2O for 40 s
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Lung protective ventilation strategy
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Meade 2008
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Adult patients with ARDS (PaO2/FiO2 < 250)
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LRM by CPAP of 40 cm H2O for 40 s with FiO2 1.0. PEEP was adjusted as per FiO2 requirement.
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Low tidal volume ventilation with standard PEEP
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Huh 2009
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ARDS patients with PaO2/FiO2 < 200
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LRM to Ppeak of 55 cm H2O and 25% tidal volume reduction and decremental PEEP titration to determine optimal PEEP
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ARDSnet protocol
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