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Table 3 Summary of the association between hypernatremia and clinical outcomes

From: Aneurysmal subarachnoid hemorrhage: intensive care for improving neurological outcome

Article Study design Definition of hypernatremia (mmol/L) Number of patient with hypernatremia/total number of patients In-hospital mortality Delayed cerebral ischemia Neurological outcome
Qureshi AI 2002 [68] Post hoc analysis of RCT > 145 58/298 (19.5%) NA NA Worse at 3 months
Wartenberg KE 2006 [69] Post hoc analysis of single-center, prospective cohort study > 150 91/576 (15.8%) NA NA Not significant at 3 months
Fisher LA 2006 [70] Post hoc analysis of single-center, prospective cohort study > 143 48/214 (22.4%) Not significant NA NA
Beseoglu K 2014 [67] Single-center, retrospective cohort study > 145 82/264 (31.1%) NA NA Worse at 12 months
Lantigua H 2015 [71] Post hoc analysis of single-center, prospective cohort study > 150 250/1200 (20.8%) Higher NA NA
Spatenkova V 2017 [72] Single-center, retrospective and prospective observational study > 150 41/334 (11.9%) Higher NA Worse at 12 months
Okazaki T 2017 [60] a Single-center, retrospective observational study  145 40/131 (30.5%) NA NA Worse at hospital discharge
  1. NA not applicable
  2. aResult from additional data analysis